科目名 Course Title [Modern Trends in Chemical Sciences and ... · Organometallics, Organic Chemistry, Organofluorine Chemistry, Organic Synthesis, Radiochemistry 授業の目標

科目名 Course Title 先端総合化学特論Ⅰ [Modern Trends in Chemical Sciences and Engineering I]

講義題目 Subtitle 総合化学特論Ⅰ [Modern Trends in Physical and Material Chemistry]

責任教員 Instructor 村上洋太 [Yota MURAKAMI] (大学院理学研究院)

担当教員 Other Instructors

開講年度 Year 2019 時間割番号Course Number 095111

期間 Semester Spring 単位数 Number of Credits 1

授業形態 Type of Class Lecture 対象年次 Year of Eligible Students ～

ナンバリングコード Numbering Code CHEM_REQEL 7111

キーワード Key Words

Advanced Physical Chemistry, Catalytic Transformation, Photochemistry, Theoretical Chemistry, Chemical Energy Conversion, Separation

Process Engineering, Process Engineering, Catalyst Design, Analysis of Physical Properties of Materials, Nano-Photonics Materials, Inorganic

Solid State Chemistry, Mesoscopic Material Chemistry, Interfacial Electrochemistry, Physical Chemistry of Electronic Materials, Solid State

Chemistry of Functional Materials, Applied Inorganic Materials Chemistry

授業の目標 Course Objectives

Lectures on scientific research in physical chemistry and materials chemistry will be given in English. In this course, the basic concepts and an

overview necessary for understanding the advanced research are introduced, followed by explanations of cutting-edge researches in various

fields of chemistry.

到達目標 Course Goals

Through a series of lectures in various fields of chemistry in English, students will learn a broad perspective and an international sense in

chemical researches.

授業計画 Course Schedule

Lectures will be provided by young assistant and associate professors in the Graduate School of Chemical Sciences and Engineering. A

schedule of lecturers and titles will be informed in the first lecture of the course.

準備学習（予習・復習）等の内容と分量 Homework

Assignment is required for every lecture.

成績評価の基準と方法 Grading System

It is required to attend at least 70% of the lectures. Evaluation as pass/fail will be based on the level of attendance (20%) and submitted reports

(each time, 80% in total).

テキスト・教科書 Textbooks

なし。適宜資料を配布する。

講義指定図書 Reading List

参照ホームページ Websites

研究室のホームページ Website of Laboratory

備考 Additional Information

科目名 Course Title 先端総合化学特論Ⅰ [Modern Trends in Chemical Sciences and Engineering I]

講義題目 Subtitle 総合化学特論Ⅱ [Modern Trends in Organic Chemistry and Biological Chemistry]




期間 Semester Summer 単位数 Number of Credits 1




Structural and Physical Organic Chemistry, Macromolecular Science, Organometallic Chemistry, Physical Chemistry of Organic Materials,

Genetic Regulation, Disease Regulation, Synthetic Organic Chemistry, Biophisycal Chemistry, Biosynthetic and Metabolic Engineering,

Biosystem Engineering, Analytical Biochemistry, Functional Polymer, Cell Processing Engineering


Lectures on scientific research in Organic Chemistry and Biological Chemistry will be given in English. In this course, the basic concepts and

an overview necessary for understanding the advanced research are introduced, followed by explanations of cutting-edge researches in various

fields of chemistry.


Through a series of lectures in various fields of chemistry in English, students will learn a broad perspective and an international sense in

chemical researches.


Lectures will be provided by young assistant and associate professors in the Graduate School of Chemical Sciences and Engineering. A schedule

of lecturers and titles will be informed in the first lecture of the course.




It is required to attend at least 70% of the lectures. Evaluation as pass/fail will be based on the level of attendance (20%) and submitted reports

(each time, 80% in total).






科目名 Course Title 先端総合化学特論Ⅱ [Modern Trends in Chemical Sciences and Engineering II]

講義題目 Subtitle Leading and Advanced Molecular Chemistry and Engineering IA - 2019 [Leading and Advanced

Molecular Chemistry and Engineering IA - 2019]

責任教員 Instructor 村越敬 [Kei MURAKOSHI] (大学院理学研究院)

担当教員 Other Instructors Hogan YU (Simon Fraser University)


期間 Semester Intensive 単位数 Number of Credits 1




Molecular spectroscopy and microscopy, Bioanalytical Chemistry, Optical biosensors, Electrochemical biosensors, Microfluidic and microarray

techniques


By the end of this course the students will be able to ;

1. understand the basic principle of modern microscopy for imaging microassasys and microarrays.

2. understand the basic principle and state-of-art techniques in surface analysis.

3. understand the basic principles of biosensors and their applications.

4. improve the scientific presentation skills.


By the end of this course, the instructor will be able to

1. provide the students an overview of the modern techniques that are essential for today's bioanalytical and materials chemistry research.

2. improve the students' capability of understanding scientific lectures in English.

3. improve the students' confidents in communicating with the instructor and fellow students.


Lecture I: Modern optical microscopy

Lecture II: Surface analysis: from composition to morphology

Lecture III: DNA microarray biochips to microfluidic techniques

Lecture IV: Electrochemical biosensors

Seminar: Mobile electronics as point-of-care diagnostic tools: from disc player to smartphone


to be announced


Your grade will be determined by how well you demonstrate your achievement of the course goals through

1. Daily course quizzes. 20%

2. Course discussions on specific topics. 40%

3. Short presentations on selected literature. 40%


Lecture notes will be distributed at the class.




http://www.sfu.ca/chemistry/people/profiles/hhyu/

https://wwwchem.sci.hokudai.ac.jp/~pc/



講義題目 Subtitle Leading and Advanced Molecular Chemistry and Engineering IB - 2019 [Leading and Advanced

Molecular Chemistry and Engineering IB - 2019]

責任教員 Instructor 村越敬 [Kei MURAKOSHI] (大学院理学研究院)

担当教員 Other Instructors David LEWIS (Flinders University), Hidenori NOGUCHI[Hidenori NOGUCHI](物質・材料研究機構)






nanao-particles, functionalistion of surfaces, organic electronics, solar cell, polymer properties.


By the end of this course you will be able to ;

1. understand the basic principle of polymer materials for device applications.

2. understand basic principle and state-of-art techniques on organic electronics.

3. understand basic principles of nanoparticles.

4. understand the challenges of commercialising research.


By the end of this course you will be able to

1. understand the basic properties of polymers and why polymers behave as they do.

2. understand the underlying principles of nanotechnology.

3. understand how to synthesise and functionalise nanoparticles with polymers.

4. understand the challenges in converting research to a commercial product.


Lecture I and II: Nanotechnology – what is it and where is it going?

Lecture III and IV: Fundamentals of Polymeric Materials

Lecture V: Functional Nanoparticles – synthesis to functionalisation

Lecture VI: Materials and Processes in Organic Solar Cell Fabrication

Lecture VII: What can be so difficult in commercialising research? The commercial realities!

.......

Seminar: Nanotechnology and Polymer Science; Converting research and ideas into new products and technologies


Students will be expected to have some basic chemistry and physics background.

You will be asked to write brief answers to questions posed at th eend of the lectures.


Your grade will be determined by how well you demonstrate your achievement of the course goals through

1. Daily course quizs. 50%.

2. Course discussions on specific topics. 50%.


to be announced



This course will be provided as part of the Hokkaido Summer Institute., For more information (invited lecturers, course details, etc.), please

visit the website below:, https://hokkaidosummerinstitute.oia.hokudai.ac.jp/courses/CourseDetail=G008


https://www.flinders.edu.au/people/david.lewis

https://www.nims.go.jp/nanointerface/iecmc_nims/index.html

https://wwwchem.sci.hokudai.ac.jp/~pc/



講義題目 Subtitle Leading and Advanced Molecular Chemistry and Engineering II - 2019 [Leading and Advanced Molecular

Chemistry and Engineering II - 2019]

責任教員 Instructor 伊藤肇 [Hajime ITOH] (大学院工学研究院)

担当教員 Other Instructors Eunsung LEE (POSTECH)






Organometallics, Organic Chemistry, Organofluorine Chemistry, Organic Synthesis, Radiochemistry


Fluorinated compounds have been of great interest for many applications such as pharmaceuticals, agrochemicals, fluoro plastics (Teflon), and

18F-labeled radiopharmaceutical imaging agents because of the benefits from fluorine’s unique properties such as thermal and oxidative stability

and lipophilicity to enhance bioavailability. For example, strong C-F bonds on the fluorine-containing material such as Teflon®, Nafinon, and

PFA (perfluoroalkoxy) enable a low polarity, small surface tension and reflective index, which are desired properties of waterproof and insulating

materials. Approximately 25% of current pharmaceuticals and 30% of agrochemicals contain fluorine. Although there was considerable demand

for facile preparation of fluorinated compounds, the methods have been significantly developed only for the past two decades. From these

lectures, I will discuss the early fluorination history and then move on the recent development including reagent based and transition metal

catalyzed fluorination. In addition, [18F]fluorination methods will be discussed. Finally, the efforts to disconnect the strong C-F bonds will be

described for useful applications.


By the end of this course, you will be able to

1. understand the importance of C-F bonds in many applications.

2. design a new synthetic route for fluorinated organic molecules.

3. have knowledge about radiochemistry.

4. understand different views on C-F bond cleavage.


The first aim is to get advanced knowledge for fluorination of organic compounds.

The second aim is to understand application of organofluorine compounds.

1. Early Fluorination

2. Fluorination Reagents

3. Nucleophilic and Electrophilic Fluorination

4. Aliphatic and Aromatic fluorination

5. Fluorination for Positron-Emission Tomography (PET)

6. Activation and functionalization of C-F bonds


Students need the preparations for discussion about fluorination.

You will be asked to write two pages (A4) of report at the end of each lecture.


Assignment on a specified subject regarding to "Development of Synthesis and Reaction of Organofluorine Compounds " (60%).

In addition, we also consider it as the important factor for assessment how actively students participate in each class (40%).


No textbook required. Handouts will be distributed.


Organotransition Metal Chemistry: From Bonding to Catalysis／John F. Hartwig

The Organometallic Chemistry of the Transition Metals／Robert H. Crabtree


http://ioml.postech.ac.kr/

http://labs.eng.hokudai.ac.jp/labo/organoelement/



講義題目 Subtitle Leading and Advanced Molecular Chemistry and Engineering III - 2019 [Leading and Advanced Molecular

Chemistry and Engineering III - 2019]

責任教員 Instructor 安住和久 [Kazuhisa AZUMI] (大学院工学研究院)

担当教員 Other Instructors Hiroki HABAZAKI[Hiroki HABAZAKI]( 工学研究院 ), Kiyoharu TADANAGA[Kiyoharu

TADANAGA](工学研究院), Kei MURAKOSHI[Kei MURAKOSHI](理学研究院), Ichizo YAGI[Ichizo

YAGI](地球環境科学研究院), Hisayoshi MATSUSHIMA[Hisayoshi MATSUSHIMA](工学研究院),

Satoru TAKAKUSAGI[Satoru TAKAKUSAGI](触媒科学研究所)




対象学科・クラス Eligible Department/Class


Nanostructure, Functionalization, Catalyst, Fuel cell, Solid battery, Photo-electrochemistry, High-speed atomic level microscopy


Electrochemistry is an one of basic science supporting our modern society in various fields. Advantage in electrochemistry is that chemical

reaction can be controlled via operation of electric parameter as voltage and current. This concept is applied to wide application from basic

engineering such as battery, plating, corrosion and refining to advanced science in atomic level reaction, photo-synthesis, catalysts and

innovative new functions. In this lecture, seven researchers working in electrochemistry-related field present fundamental principle, function,

mechanism and recent topics of selected subject.


By the end of this course, students will be able to

• understand fundamental concept of electrochemistry,

• know how electrochemistry is used in many scenes in our life,

• explain how Li-ion battery and fuel cell work to supply high energy,

• imagine how atomic level phenomena provide macroscopic functions,

• and think about new ideas using advanced electrochemistry for future.


Seven professors will lecture on various topics. In the final lecture, student will discuss about the subject their interest in related to lectures.

• Concept and basics of electrochemistry (Jun.25)

• Controlling nano-scale physico-photo-electro-phenomena (Jun.25)

• Controlling nanostructure of surface to provide new functions (Jun.26)

• Very-fast atomic-scale imaging (Jun.26)

• Exploration into the horizon of catalyst (Jun.27)

• Deep understanding of fuel cell (Jun.27)

• Development of innovative all-solid-state battery (Jun.28)

• General discussion (Jun.28)


Students will be asked to write a report at the end of each lecture.


Grading will be done based on report for each topic.







講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering I - 2019 [Leading and Advanced Materials

Chemistry and Engineering I - 2019]

責任教員 Instructor 島田敏宏 [Toshihiro SHIMADA] (大学院工学研究院)

担当教員 Other Instructors Nicolas CLEMENT (CNRS)






Nanotechnology, Molecular Devices, Electronics, Bioanalysis


Molecular scale electronic devices are one of the dreams of chemist and electronic engineers. It is becoming possible to make and use those

devices for the application to medical/biological analysis. The technology must be something combining top-down lithographical approach and

bottom-up molecular self assembly. In this lecture, we start from basic physics and chemistry of molecular-scale devices, such as electronic

rectification at nanojunctions, ballistic transport, tunnel effect, and molecular recognition. Then we will review the technologies for the

molecular-scale device fabrication. Prof. Nicolas Clement is one of the young leading figures in this field. Application and future prospects will

be discussed.



1. explain the basic concepts in nanodevice fabrication.

2. explain basic physics and chemistry behind molecular-scale electronic devices.

3. know how to make international collaboration.

4. design molecular-scale devices for bioanalysis.


This course is focused on two subjects: principles and fabrication techniques for molecular-scale devices.

In the principle part, we will provide three lectures on basic knowledge about electronic transport at nanoscales and influence of the molecular

structures to it.

In the fabrication part, we will provide three lectures on lithography and self assembly.

Finally the application to the analytical devices will be given.

The course is organized as follows:

1. Introduction: molecular electronics

2. Basic concepts of electronic transport in nano and molecular junctions

3. Micro-nano fluidics

4. Top down device fabrication techniques

5. Bottom up device fabrication techniques

6. Application of molecular / nanofluidic electronic devices to bio analytical chemistry

7. Lab tour, showing equipment for nanomaterials synthesis and various characterization techniques

8. Seminar by Prof. Nicolas Clement


It will be provided after each classes, if any.


Grading will be based on the final reports requested to submit some period after the lecture.

Participation to the class (such as short quiz) will also be considered.







http://nicolasclement.blog/

http://www.eng.hokudai.ac.jp/labo/kotai/


Other Instructor: Nicolas Clement (CNRS)


講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering IIA - 2019 [Leading and Advanced Materials

Chemistry and Engineering IIA - 2019]

責任教員 Instructor 忠永清治 [Kiyoharu TADANAGA] (大学院工学研究院)

担当教員 Other Instructors Li LU (National University of Singapore), Akira MIURA[Akira MIURA](工学研究院), NATALY

CAROLINA ROSERO NAVARRO[NATALY CAROLINA ROSERO NAVARRO](工学研究院)






Electrochemical devices; Electrolyte; Electrode; Nano-structure; Batteries


Recently, safe, low cost, high energy density, and long-lasting electrochemical devices for energy conversion and energy storage are highly

required for the application to mobile devices, electric vehicles, and energy storage system for the renewable energy. Development of novel

materials and morphology control of these materials are key issues. The aim of this course is to describe the importance of electrochemical

devices and materials science involved in the development of such electrochemical devices.

Fundamental concepts in electrochemical energy conversion and storage are firstly overviewed, and then the materials chemistry for the

electrochemical devices will be described. Preparation process for materials of electrochemical devices, effect of nano-structures in electrodes

for lithium and sodium ion batteries, development of all solid-state lithium secondary batteries are also described.



1. explain and compare the electrochemical energy conversion and storages systems.

2. understand the basic requirements for materials used in electrochemical energy conversion and energy storage devices.

3. explain the effects of nanostructures on the properties of electrochemical devices.

4. understand and discuss materials and electrochemical devices in future energy storage system.


Following topics will be covered during this course.

1. Fundamental concepts about electrochemical energy conversion and storage

2. Introduction of inorganic materials science for electrochemical devices

3. Introduction to defects chemistry – dopants in materials for electrochemical storage

4. Nanostructured materials applied to electrodes for lithium and sodium ion batteries

5. Fundamentals of solid electrolyte

6. All-solid-state lithium/sodium secondary batteries

7. Overview of recent trends in materials for electrochemical devices and future energy storage system

8. Students presentation on topics in electrochemical devices


Students will be expected to download class notes from WEB page and read designated chapter in advance.

Students should read some papers on electrochemical devices during this course and make presentation.


Grade will be determined by how well one’s achievement in this course through

1. a report on nanostructured materials in electrochemical devices (weightage 80%), and

2. a presentation on one’s research or some topics in electrochemical devices (weightage 20%).




"Recent Advances in Energy Storage Materials and Devices", Li Lu edited, Materials Research Forum LLC, ISBN 978-1945291265 (2017).

"Ceramic Electrolytes for All-Solid-State Li Batteries", M. Kotobuki, S. Song, C. Chen, and Li Lu, World Scientific Pub Co Inc ISBN: 978-

9813233881(2018).



http://me.nus.edu.sg/

http://www.eng.hokudai.ac.jp/labo/inorgsyn/


Other Instructor: Li LU (National University of Singapore)


講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering IIB - 2019 [Leading and Advanced Materials

Chemistry and Engineering IIB - 2019]

責任教員 Instructor 加藤昌子 [Masako KATO] (大学院理学研究院)

担当教員 Other Instructors Vivian Wing-Wah YAM (University of Hong Kong)






luminescence, photochemistry, photopysics, supramolecule, metal complexes


This course is designed to acquire basic knowledge in coordination chemistry and photochemistry/photopysics of coordination compounds, and

applications as new materials towards device, photocatalytic, and bio-medicinal fields.


Students will gain not only knowledge of photofunctional coordination and supramolecular chemistry, but also acquire problem-solving ability

for exploring functionality of metal-based materials.


Day 1 Lecture 1: Introduction – Luminescent metal-based materials

Day 1 Lecture 2: Basic concepts and principles of photophysics and photochemistry

Day 2 Lecture 3: Energy transfer and electron transfer processes

Day 2 Lecture 4: Nature of selected excited states

Day 3 Lecture 5: Utilization of luminescent metal-based materials for energy

Day 3 Lecture 6: Utilization of luminescent metal-based materials for biomedical applications

Day 4 Lecture 7: Discussion

Day 4 Lecture 8: Open Seminar


To be announced


Assignment on a specified subject regarding "luminescent metal-based materials" (60%).

Assessment how actively students participate in each class (40%).


Handouts will be distributed.




http://hub.hku.hk/cris/rp/rp00822

https://wwwchem.sci.hokudai.ac.jp/~cc/


Other Instructor: Vivian Wing-Wah YAM (University of Hong Kong)


講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering IIC - 2019 [Leading and Advanced Materials

Chemistry and Engineering IIC - 2019]

責任教員 Instructor 島田敏宏 [Toshihiro SHIMADA] (大学院工学研究院)

担当教員 Other Instructors Fei CHEN (Wuhan University of Technology), Taro NAGAHAMA[Taro NAGAHAMA](工学研究院)






ceramics, gradient materials, solid electrolytes, all-solid-state battery, energy storage, spintronics


The modern life is impossible without using materials and chemical technology. In this course, we will shed light on the ceramics and composite

materials, by inviting a leading researcher Prof. Fei CHEN from China. Ceramic applications are limited due to materials properties. Through

the compounding of ceramics and other materials, such as metals and organic materials, the application fields of ceramics are greatly enriched.

He will introduce the applications of ceramic composites in the energy field, including grid scale energy storage, all-solid-state battery, and

explain the basic ideas behind the modern processes and the fundamentals of the functions. Prof. Fei CHEN had studied in MIT and has become

a famous professor in China. Profs. Shimada and Nagahama will talk about the related inorganic materials and their properties.



1. explain the basic concepts in electronics, mechanical and energy applications of ceramics and composite materials.

2. explain the basic chemistry and physics behind ceramics preparation and materials processing.

3. know how to study and work in overseas.


This course is focused on two subjects: materials processing and functions. In the materials processing part, we will provide three lectures and

one lab tour including short demonstration experiments. The materials function part, we will provide four lectures. The course is organized as

follows:

1. Introduction: How ceramics materials are used in the modern life.

2. Basic concepts behind the fabrication technology in atomic scales - interplay between the thermodynamics and kinetics, with the aid from

chemistry

3. High energy processes focusing on grid scale energy storage

4. Electronics and optical properties focusing on semiconductor circuits

5. Electrochemistry properties focusing on solid electrolytes and solid batteries

6. Spintronics

7. Lab tour, showing plasma CVD, high pressure synthesis and various characterization techniques

8. Seminar by Prof. Fei CHEN


It will be provided after each classes, if any.


Grading will be based on the final reports submitted some period after the lectures.

Participation to the lecture (short quiz etc.) will also be used for evaluation.









http://www.eng.hokudai.ac.jp/labo/kotai/



講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering IID - 2019 [Leading and Advanced Materials

Chemistry and Engineering IID - 2019]

責任教員 Instructor 幅﨑浩樹 [Hiroki HABAZAKI] (大学院工学研究院)

担当教員 Other Instructors Byungjin CHO (Chungbuk National University), Chunyu ZHU (工学研究院)






Inorganic nanomaterials, nanoporous materials, nanocarbons, energy conversion and storage, nanoelectronics


Diverse inorganic nanomaterials are becoming more and more important in modern technology. In this lecture, we invite Prof. Byungjin Cho

from Chungbuk national University, Korea, who is a leading young scientist in advanced inorganic materials. Th synthesis, characterization,

functionalization and device applications of a range of nanomaterials are briefly introduced to get fundamental knowledge on 1D and 2D

nanomaterials with various functionalities. Basic concepts for electronic and energy applications will be proposed in this lecture.



1. explain the basic concepts for diverse applications of inorganic nanomaterials.

2. explain the synthesis methods of diverse inorganic nanomaterials and their applications.

3. explain the basic chemistry and physics behind the fabrication and characterization of nanomaterials.


This course is focused on fabrication, properties and applications of advanced inorganic materials. The course is organized as follows:

1. Introduction: How inorganic nanomaterials are used in modern technology.

2. Synthesis of 2D nanostructures

3. Characterization methods for physical and chemical properties of nanomaterials

4. Diverse applications of 2D inorganic nanomaterials

5. Fabrication and applications of nanocomposite materials

6. Self-organized fabrication of nanostructured materials and their applications

7. Lab tour, showing various characterization techniques of nanomaterials

8. Seminar by Prof. Byungjin Cho


To be announced


Grading will be based on the final reports submitted some period after the lectures.




Not required. Handouts will be distributed.



https://bjcho6885.wixsite.com/mnlab

http://labs.eng.hokudai.ac.jp/labo/elechem/



講義題目 Subtitle Leading and Advanced Materials Chemistry and Engineering III - 2019 [Leading and Advanced Materials

Chemistry and Engineering III - 2019]

責任教員 Instructor 坂口和靖 [Kazuyasu SAKAGUCHI] (大学院理学研究院)

担当教員 Other Instructors Kazunari YAMAURA[Kazunari YAMAURA](物質・材料研究機構), Yoshihiro TSUJIMOTO[Yoshihiro

TSUJIMOTO](物質・材料研究機構)






Solid state chemistry, superconductivity, strongly correlated electrons, magnetic properties


Solid-state chemistry is a common background for developing research fields such as quantum materials, materials engineering, and condensed

matter science. By mastering knowledge of solid-state chemistry and deepening your understanding, you can strengthen research abilities and

activities in the latest fields. This course is designed as an introduction to solid state chemistry useful for materials development for hands-on

properties mostly for superconductivity and correlated electrons properties.



1. present fundamental knowledge of solid state chemistry.

2. carry out a laboratory work for solid-state materials synthesis.

3. reveal the lattice structure and local coordination of solid-state materials by diffraction.

4. explain fundamental magnetic properties and practical functions of solid-state materials.


1. Introduction for solid-state and crystal chemistry

2. Introduction for materials synthesis and phase diagram

3. Structure principles and structure characterization of solid-state compounds

4. Magnetic and electrical properties of solid-state compounds

5. Introduction for superconductivity


No specific requirements for this course, but recommended to read text books for solid state chemistry at undergraduate level.


Written assignment on a specified topic in solid state chemistry or related fields (60%).

Class participation (40%).






https://www.nims.go.jp/research/group/quantum-solid-state/index.html



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering IA - 2019 [Leading and

Advanced Biological and Polymer Chemistry and Engineering IA - 2019]

責任教員 Instructor 佐田和己 [Kazuki SADA] (大学院理学研究院)

担当教員 Other Instructors Kostas SARAKINOS (Linkoping University), Akira KAKUGO[Akira KAKUGO](理学研究院)






Atomic Layer, Crystal Growth, Thin Films, Metal, Epitaxy, Nucleation, Layer-by-Layer, Polymers, Self-assembly, Supramolecular Chemistry,

Organogels, Organic Crystals, Soft Crystals, Kinesin, Tubline, Microtubles


Atomic or molecular level thin films are key materials for modern technology and related science. Learning the thin films should be of

importance for material researchers. In particular, this lecture covers science and technology of both physics and chemistry aspects.

In the former, definition of thin films for surface physics and engineering is provided with reference to specific examples of applications and

devices founded upon thin films. Then, physical- and chemical-vapor deposition techniques used for thin-film synthesis are discussed on a

conceptual level, and film-formation stages. The atomic-scale mechanisms that lead to vapor condensation on solid substrate surfaces are

discussed from the view point of thermodynamics and kinetics. The atomistic theory of nucleation of the thin film is introduced and explained.

The concept of epitaxy, both homo- and heteroepitaxy, is also introduced for film morphological evolution such as 2D and 3D islands. Strategies

for manipulating growth of morphology evolution using surfactants, energetic ions, and temporally modulated vapor fluxes are also discussed.

Finally, revisiting the film-formation stages, the atomic-scale processes that control film morphological evolution are discussed. Film

morphologies are then classified in the framework of the so-called structure zone models (SZMs) which describe the effect of growth temperature

and impurity concentration of fundamental structure-forming processes.

In the latter, starting from the applications of the polymer thin films in the daily life, the fabrication of polymer thin films and layer-by-layer

method fro hybrid polymer thin film are discussed. Then, the topics moves to chemistry of molecular assemblies. Many examples of two

dimmensional crystallization of organic molecules on a substarte are reviewed in relation to formation of organic crystals and fibrious aggregates.

Their formation are discussed from the view point of the nucleartion-growth theory similar to the formar part. The role of the moelcualr

structures and weak intermolecular interactions are also discussed. Finally, one-dimensional biological molecular assemblies such as

microtubles are reviewed.


Atomic or molecular level thin films are key materials for modern technology and related science. Learning the thin films should be of

importance for material researchers. In particular, this lecture covers science and technology of both physics and chemistry aspects.

In the former, definition of thin films for surface physics and engineering is provided with reference to specific examples of applications and

devices founded upon thin films. Then, physical- and chemical-vapor deposition techniques used for thin-film synthesis are discussed on a

conceptual level, and film-formation stages are explained. The atomic-scale mechanisms that lead to vapor condensation on solid substrate

surfaces are discussed from the view point of thermodynamics and kinetics. The atomistic theory of nucleation of the thin film is introduced

and explained. The concept of epitaxy, both homo- and heteroepitaxy, is also introduced, followed by a discussion on shape evolution of

2Dislands and 3D film morphological evolution. Strategies for manipulating growth of morphologicalevolution using surfactants, energetic ions,

and temporally modulated vapor fluxes are also discussed. Finally, revisiting the film-formation stages, the atomic-scale processes that control

morphological evolution in polycrystalline films are discussed. Film morphologies are then classified in the framework of the so-called structure

zone models (SZMs) which describe the effect of growth temperature and impurity concentration on fundamental film structure-forming

processes.

In the latter, starting from the applications of the polymer thin films in the daily life, the fabrication of polymer thin films and layer-by-layer

method fro hybrid polymer thin film are discussed. Then, the topics moves to chemistry of molecular assemblies. Many examples of two

dimmensional crystallization of organic molecules on a substarte are reviewed in relation to formation of organic crystals and fibrious aggregates.

Their formation are discussed from the view point of the nucleartion-growth theory similar to the formar part. The role of the moelcualr

structures and weak intermolecular interactions are also discussed. Finally, one-dimensional biological molecular assemblies such as

microtubles are reviewed.


(Topic I) Thin films, atomic and physical aspcet

Lecture 1: Introduction to inroganic thin-film science and technology

Lecture 2: Thin-film nucleation from the view point of thermodynamics and kinetics

Lecture 3: Growth evolution and growth manipulation of epitaxial films

Lecture 4: Growth and microstructural evolution of polycrystalline films

(Topic II) Thin films and related molecular assembly, organic and biological aspect

Lecture 5: Fabrication of polymer thin films basic and applications

Lecture 6: Two-dimensinal crystal growth of organic molecules on the substrate

Lecture 7: Growth of organic crystals and fibrous aggregates

Lecture 8: Fibrous aggregates of biomacromolecules and its applications

PBL(Problem Based Learning) type discussion will be done in the two topics.


Students will read reviews and the primary literature on each topic, and submit questions for instructor after every classes and some written

reports on the topics.


Attendance more than 70% classes is requisite for evaluation of the credit. The grade is evaluated in the following two items;(1) reports on each

class with learning attitude (40%), (3) term examination or paper or PBL presentation (60%).






http://www.ifm.liu.se/materialphysics/nanoeng/

https://wwwchem.sci.hokudai.ac.jp/~matchemS/english/index.html



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering IB - 2019 [Leading and

Advanced Biological and Polymer Chemistry and Engineering IB - 2019]

責任教員 Instructor 山本拓矢 [Takuya YAMAMOTO] (大学院工学研究院)

担当教員 Other Instructors Michael TURNER (University of Manchester), Toshifumi SATOH[Toshifumi SATOH](工学研究院)






polymer chemistry; conjugated polymers; organic electronics; OLEDs, OFETs, solar cells


On successful completion of this course students should be able to: (i) Understand how to prepare conjugated polymers with control of the

microstructure; (ii) Understand how the polymer microstructure influences the polymer electronic and optical properties; (iii) Describe the

operation of light emitting diodes, transistors and solar cells and (iv) Understand how the conjugated polymer microstructure and morphology

can influence the performance of organic electronic and optoelectronic devices.


The goals of the course are to: (i) Provide students with a solid underpinning of the synthetic methods used to prepare conjugated polymers;

(ii) Introduce students to the relationship between conjugated polymer structures and electronic/optical properties; (iii) Provide students with

a basic understanding of how OLEDs, OFETs and OPV device operate and (iv) Enable students to relate the structure of conjugated polymers

to the performance of the material in a device.


1st lecture:

• Introduction to course

• Introduction to polymers

• Introduction to bulk electronic properties

• Organic conductors and applications of conducting polymers

2nd lecture

• Organic semiconductors, applications of conjugated polymers

• Organic electroluminescence, conjugated polymers for OLEDs, device efficiencies.

3rd lecture

• Donor acceptor polymers, polymer blends, thin film morphology

• Conjugated polymers for organic photovoltaics, power conversion efficiencies and figures of merit

4th lecture

• Extended conjugation in conjugated polymers

• Organic electronics and conjugated polymers for OFETs, device performance.

Seminar: Conjugated polymers of many shapes and sizes: rings, chains and nanoparticles.


None


Assignment on a specified subject regarding to "Novel Synthesis of π-Conjugated Polymers" (100 %).

We consider it as the important factor for assessment of three short tests (90%) and final report (10%).


Lecture notes in PDF files will be provided.


References suitable for this course:

(1) M.P. Stevens, Polymer Chemistry - An Introduction, OUP

(2) A. R. West, Basic Solid State Chemistry, Wiley.

(3) W. J. Feast, J. Tsibouklis, K. L. Pouwer, L. Groenendaal, and E. W. Meijer, Polymer, 1996, 37, 5017.

(4) R. H. Friend, R. W. Gymer, Holmes, AB, J. H. Burroughes, R. N. Marks, C. Taliani, D. Bradley, D. A. Dos Santos, J. L. Bredas, M.

Logdlund, and W. R. Salaneck, Nature, 1999, 397, 121-128

(5) D. Braun, Materials Today, 2002, 5, 32-39.

(6) C.D. Dimitrakopoulos, D.J. Mascaro, IBM J. Res. & Dev., 2001, 45, 11.

(7) H. Sirringhaus, Adv. Mater., 2014, 26, 1319-1335.

(8) I. Osaka and R.D. McCullough, Acc. Chem. Res., 2008 41 (9), 1202-1214.

(9) I. McCulloch, M. Heeney, et al. Nat Mater, 2006, 5, 328-333

(10) C. B. Nielsen, M. Turbiez, and I. McCulloch, Adv. Mater., 2013, 25, 1859-1880.

(11) X. Guo, A. Facchetti, and T. J. Marks, Chem. Rev., 2014, 114, 8943-9021.

(12) J. Mei, Y. Diao, A. L. Appleton, L. Fang, and Z. Bao, J. Am. Chem. Soc., 2013, 135, 6724-6746.



https://www.research.manchester.ac.uk/portal/michael.turner.html

http://cma.eng.hokudai.ac.jp/index.html



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering IIA - 2019 [Leading and

Advanced Biological and Polymer Chemistry and Engineering IIA - 2019]

責任教員 Instructor 坂口和靖 [Kazuyasu SAKAGUCHI] (大学院理学研究院)

担当教員 Other Instructors Jianxin LI (Nanjing University), Yota MURAKAMI[Yota MURAKAMI](理学研究院)





大分類コード・名 Major Category Code, Title CHEM_REQEL Chemical Sciences and Engineering_Required Electives Course


Interdiscipline; Natural Products; Bioactivity; Chemical Biology; Drug Target; Discovery


The outline includes an introduction:

1. The main types and major biological activities of natural products.

2. New drugs and drug targets.

3. The intersection of chemistry and biology.

4. The objectives and tasks of chemistry and biology.

5. Examples of bioactive natural products and target discovery.


1. To understand the basics of natural products and the importance of drug discovery.

2. To master the characteristics of chemical biology and its role in human health.

3. To learn the importance of bioactive natural products in the discovery of new drug targets.


Day 1: The bioactive natural products and the importance.

• Introduction of importance of natural products.

• Main types and main bioactivity of natural products.

• Famous natural products closely related to human survival.

Day 2: Chemical biology and drug discovery.

• Basic knowledge on chemical biology.

• The main process of drug discovery.

• Drug target discovery and the relations with human health.

Day 3: The natural product based drug discovery.

• Interactions between bioactive natural products and protein.

• The main method of discovering biological proteins that interact with natural products.

• Drug target validation.

Day 4 & 5: Important samples.

Introduce typical and important examples on natural products and novel drug target discovery.


Scan through a few of the articles in the reading list.


Problem-based learning and assignment on a specific topics of this course (60%).




1. Nature, 561, 189-194, 2018.

2. Biotechnology Advances, 36(6), 1559-1562, 2018.



http://chem.nju.edu.cn/english/facultylr.asp?fln=LI,Jianxin

https://wwwchem.sci.hokudai.ac.jp/~biochem/

http://wwwchem.sci.hokudai.ac.jp/~bo/reseach/



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering IIB - 2019 [Leading and

Advanced Biological and Polymer Chemistry and Engineering IIB - 2019]

責任教員 Instructor 佐藤敏文 [Toshifumi SATOH] (大学院工学研究院)

担当教員 Other Instructors Guey-Sheng LIOU (National Taiwan University)






functional high-performance polymers, polyimides/metal oxides hybrids, triphenylamine (TPA), optical, electrochromic, and optoelectronic

applications.


This course aims to be a comprehensive, authoritative, and general interest to the polymer chemistry and provides the understanding on (i)

high-performance polymers and their representative nanocomposites (ii) specific functionality and its relations to molecular structures, and

characterization skills of these advanced functional polymers.


Get knowledge on (1) How to prepare and characterize the high-performance polymers and their hybrid films via sol-gel approaches and their

related application; (2) A variety of strategies and approaches for obtaining the high-performance polymers with different specific functions; (3)

The characterizations and relationships between the structural units and functions in the polymer chains and the investigation of some advanced

applications in terms of their unique functionality. Overall, to build up the background in polymer chemistry and related polymeric physical

chemistry.


1st lecture: Highly transparent polyimide hybrids for optoelectronic applications

1. Preparation and modification of polyimides.

2. Functional organic-inorganic hybrid nanocomposites via sol-gel reaction.

3. Titania-, Zirconia-based nanocomposites and AgNws/polymers hybrid film.

2nd lecture: Recent advances in triphenylamine-based electrochromic derivatives and polymers

Triphenylamine-containing electrochromic materials revealing significant color changes by electrochemically induced redox reactions are

attractive with great potential for low energy-consumption displays, light-adapting mirrors in vehicles, and smart window applications. These

materials have experienced an exponential growth of research interests and have rapidly developed into an emerging field. In this lecture, the

newly developed triphenylamine-based derivatives and polymers in the past few years are summarized, with emphasis on the synthetic

approaches as well as their potential applications.

3rd lecture: Triphenylamine-based Materials for Electrofluorochromic Devices

The term "electrofluorochromism (EFC)", which deals with the electrically driven reversible optical changes in the fluorescence, has only

recently been coined by combination of two functions of electrochromism and photoluminescence in one molecular chain. How to design the

materials with both electroactive and PL-active characters are necessary for such interesting application.

4th lecture: Solution-processable triarylamine-based high-performance polymers for polymeric memory devices

By carefully designing the polymeric structures based on the switching mechanisms, different types and memory characteristics can be produced,

and these memory properties show extremely high endurance during long-term operation, which makes these high-performance polymers very

suitable materials for memory applications.

Seminar: Design and Preparation of Triphenylamine-based Polymeric Materials Towards Emergent Optoelectronic Applications


Three short tests and final report


Assignment on a specified subject regarding to "high-performance polymers for advanced applications".

We consider it as the important factor for assessment of three short tests (90%) and final report (10%).


Lecture notes in PDF files will be provided.


Recent advances in triphenylamine-based electrochromic derivatives and polymers (Polym. Chem., 2018, 9, 3001-3018)

Highly transparent polyimide hybrids for optoelectronic applications (React. Funct. Polym., 2016, 108, 2-30)

Triarylamine-based high-performance polymers for resistive switching memory devices (Polymer Journal, 2016, 48, 117-138)



http://homepage.ntu.edu.tw/~gsliou/FPML/main.htm

http://poly-ac.eng.hokudai.ac.jp/index.html



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering IIC - 2019 [Leading and

Advanced Biological and Polymer Chemistry and Engineering IIC - 2019]

責任教員 Instructor 及川英秋 [Hideaki OIKAWA] (大学院理学研究院)

担当教員 Other Instructors Tao YE (Peking University)






Natural Products, Organic Synthesis, Stereochemistry, Drug Discovery


Natural products can be broadly defined as the set of small molecules derived from the environment that are not involved in primary metabolism.

Many of today’s small molecule therapeutics trace their origins to natural products, estimated variably as providing or inspiring the development

of between 50–70% of all agents in clinical use today. Although nature provides us with many natural products that have interesting medicinal

properties, the amounts of these compounds that is isolated is usually quite low, making their development into useful medicinal agents very

difficult. The total chemical synthesis of these compounds is therefore important and has been a key tool in drug discovery and development.

The synthesis allows verification of the primary structure proposed on the basis of studies of the marine natural product, and can be employed

to study and address some of shortcomings of natural products through manipulation of pharmacological properties, structure activity

relationship studies, and the preparation of drug candidates for mechanistic studies.



1. understand advanced retrosynthesis principles for the synthesis of complex molecules.

2. have an advanced knowledge about synthetic strategies.

3. make a new synthetic plan for target molecule using selective transformations.

4. understand key principles behind enantio- and diastereoselectivity, and asymmetric approaches.


The aim is to get advanced knowledge for synthesis of natural products.

Retro-synthesis and synthesis of different classes of natural products important for their structure and/or bioactivity. Complex natural products

are chosen to illustrate the evolution of the state-of-the-art of the field.


No required textbooks. Handouts will contain reference to the primary literature. Students need the preparations for discusion about organic

synthesis.

Students will be asked to choose two total synthesis papers on the same natural product. Analyse each route, identify the key steps, and write

a report explaining important aspects of these syntheses.


Assignment on a specified topic regarding to "Total Synthesis of Natural Products" (60%).





Organic Synthesis: The Disconnection Approach, 2nd Edition

Workbook for Organic Synthesis: Strategy and Control

Classics in Total Synthesis: Targets, Strategies, Methods

Classics in Total Synthesis II: More Targets, Strategies, Methods

Classics in Total Synthesis III: Further Targets, Strategies, Methods



http://web.pkusz.edu.cn/ye/

https://wwwchem.sci.hokudai.ac.jp/~yuhan/



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering IID： - 2019 [Leading and

Advanced Biological and Polymer Chemistry and Engineering IID: - 2019]

責任教員 Instructor 松本謙一郎 [Kenichiro MATSUMOTO] (大学院工学研究院)

担当教員 Other Instructors Sudesh KUMAR (Universiti Sains Malaysia)






biobased plastics, biodegradable materials, biosynthesis, biomass


Development of bio-based materials is important and urgent research target as an essential piece of the sustainable social system. Tropical

area plays important role in the biomass production due to its huge capacity of the production. It should be noted that large portion of the

biomass is used for human foods and animal feed, which is also indirectly used for the human food production. In fact, the increasing demand of

animal protein is a serious issue in terms of global food problem. Recently insects attract research interest as a potent solution of the problem.

Based on the background, we should know about the components of edible and non-edible biomass for better design of bio-based material

production. For practical use of the materials, their physical properties are a critical issue. The physical properties of the polymer materials are

determined by structure of the molecules. Thus, fine regulation of synthetic system is required. On the other hand, it should be noted that

biomass is complex mixture and normally is not suitable as starting substance for chemical synthesis. Thus, biological process plays an important

role in the conversion of biomass into useful materials. This lecture focuses on bacterial polyester polyhydroxyalkanote (PHA). PHAs are

processed into film and fiber with pliable property and used as bio-based and biodegradable plastic. In industrial scale production, the cost of

downstream process greatly contributes to the total cost of the production. This course aims to study broad range of field involved in PHA

including feedstock, a basic mechanism of biosynthesis, downstream processes, and polymer chemistry.


1. Know the global problems of food, energy and materials

2. Learn about the biomass production

3. Learn the biological and chemical methods to utilize biomass resources

4. Understand the basic biology and chemistry of polyhydroxyalkanoates

5. Know about the latest technology using insects


1. Introduction to the concept of sustainability

2. Life: from microbe (single cell) to human and impact on resources (food, energy, materials)

3. Single cell protein (SCP) and other sources of protein

4. Problems caused by plastics

5. Introduction to PHA: synthesis and properties

6. Challenges in the large scale production of PHA

7. Applications of PHA (environment, medical, diagnostics, cosmetics)

8. Sustainable production of PHA


Students will be expected to download class notes using ELMS and read designated chapter in advance.

You will be asked to write a page (A4) of essay at the end of each lecture.


Your grade will be determined by how well you demonstrate your achievement of the course goals in the report.





https://bio.usm.my/staff/k-sudesh-kumar-professor/

https://labs.eng.hokudai.ac.jp/labo/seika/



講義題目 Subtitle Leading and Advanced Biological and Polymer Chemistry and Engineering III - 2019 [Leading and

Advanced Biological and Polymer Chemistry and Engineering III - 2019]


担当教員 Other Instructors Tamiki KOMATSUZAKI[Tamiki KOMATSUZAKI], Masayuki TAKAHASHI[Masayuki TAKAHASHI](理

学研究院 ), Yohei SHIMIZU[Yohei SHIMIZU]( 理学研究院 ), Yukihiro TAKAHASHI[Yukihiro

TAKAHASHI]( 理学研究院 ), Kenta KOKADO[Kenta KOKADO]( 理学研究院 ), Masaki

YOSHIDA[Masaki YOSHIDA](理学研究院)






Biochemistry, Biological Physics, Molecular Biology, Organic chemistry, Physical Chemistry, Complex Chemistry, Polymer Chemistry


1) Know the way to synthesize molecular functional materials for electronics.

2) Know a fundamental theory and a molecular design for thermoresponsive polymers, and their applications.

3) Know the details of transition metal complexes showing stimuli-controlled reversible color-changing phenomena.

4) Know one of the most striking consequences in single molecular biology, termed as molecular individuality or dynamic disorder.

5) Know a power of catalysts for novel molecular transformations.

6) Know the molecular basis of the cellular motile events and the differential roles of nonmuscle myosin II isoforms on cell migration.

7) Know the basics of epigenetic regulation of the genome and its involvement in production of iPS cells and tumorgenesis.



1. understand basics of chemistry for making useful molecules/materials .

2. understand methods to investigate the behavior of biomolecules and molecular mechanisms of various reactions in living cells.

3. understand basics and progress of structural organic chemistry.


Day 1

Catalysts for novel molecular transformations. (Y. Shimizu)

Day 2

A fundamental theory and a molecular design for thermoresponsive polymers, and their applications.(K. Kokado)

The way to synthesize molecular functional materials for electronics. (H. Takahashi)

Day 3

The details of transition metal complexes showing stimuli-controlled reversible color-changing phenomena. (M. Yoshida)

The molecular basis of the cellular motile events and the differential roles of nonmuscle myosin II isoforms onon cell migration. (M. Takahashi)

Day 4

One of the most striking consequences in single moleculebiology, termed as molecular individuality or dynamic disorder. (T. Komatsuzaki)

The basics of epigenetic regulation of the genome and its involvement in production of iPS cells and tumorgene. (Y. Murakami)

Day 5

Discussion (Y. Murakami)


N/A


Reports of two lectures (100%)








Recommended Course (Course highly recommended to be taken together with this course):

Leading and Advanced Biological and Polymer Chemistry and Engineering IA, IB

Leading and Advanced Biological and Polymer Chemistry and Engineering IIA, IIB, IIC, IID

科目名 Course Title 総合化学特別研究第二 [Research in Chemical Sciences and Engineering II]

講義題目 Subtitle




期間 Semester Irregular 単位数 Number of Credits 1




Advanced Chemistry, Special Topics in Chemistry, Various Fields of Chemistry


In this course, foreign researchers from abroad give a lecture in chemistry. This course will provide students with an overview of advanced

researches in chemistry.


Students should acquire an international sense in chemical researches, as well as the ability for discussion in English which should be required

at the international conference.


This course is given by a lot of guest researchers who visit laboratories in the Graduate School of Chemical Sciences and Engineering in

Hokkaido University. The schedule will be informed every time when the lecture is open.




Class participation (more than 7 lectures) and report.






科目名 Course Title 総合化学研究・指導法 [Research in Chemical Sciences and Engineering III]

講義題目 Subtitle

責任教員 Instructor 武次徹也 [Tetsuya TAKETSUGU] (大学院理学研究院)

担当教員 Other Instructors Provided by supervisor


期間 Semester Full-year 単位数 Number of Credits 2

授業形態 Type of Class Seminar 対象年次 Year of Eligible Students 1～3



Development and improvement of experimental techniques: teaching and research skills: presentation skills: Chemical English


Graduate course students are requested to play leaderships in both teaching and research. This course examines how to manage research

experiments and to present student's achievements in Japanese and English. Also, the course examines how to gain teaching skills and abilities.


Through the course, students will be able to

- get abilities on development and/or improvement of experimental techniques and equipments

- get high teaching and research skills

- get high presentation skills in both Japanese and English

- play leadership in each reseach field and teaching


On the basis of evaluating the teaching and research achievements of each student, the course offers on-the-job-training to

- get abilities in development and/or improvement of experimental skills and/or experimental equipments

- get high oral and poster presentation skills

- get speaking, hearing, and writing abilities in English

- get high teaching and research skills

- play leaderships in both research and teaching


Preparatory works for laboratory experiments


Evaluate based on total attitudes in teaching (50%), experimental and scientific achievements (50%).






Documents

科目名 Course Title [Modern Trends in Chemical Sciences and ... · Organometallics, Organic Chemistry, Organofluorine Chemistry, Organic Synthesis, Radiochemistry 授業の目標