CATALOGUE · 2020. 10. 26. · CATALOGUE ThalesNano î ì í9. 1 Table of contents ... Pricat™ Nickel ñ ñ/ ñP – Nickel catalyst on Diatomaceous earth _____ 81 Nickel Sponge

CATALOGUE ThalesNano

2019

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Table of contents Table of contents __________________________________________________________________ 1

About Us _________________________________________________________________________ 5

Instruments and system setups from ThalesNano ________________________________________ 6

H-Cube® Pro ______________________________________________________________________ 7

H-Cube® Mini Plus__________________________________________________________________ 9

H-Cube® Midi ____________________________________________________________________ 11

Phoenix Flow Reactor™ ____________________________________________________________ 13

Modules for the Phoenix Flow Reactor™ systems _______________________________________ 14

PhotoCube™ _____________________________________________________________________ 15

Gas Module™ ____________________________________________________________________ 18

IceCube™ ________________________________________________________________________ 20

Ozone Module™ __________________________________________________________________ 22

Flash Pyrolysis Platform™ ___________________________________________________________ 24

CatCart® Changer _________________________________________________________________ 26

CatCart® Packer ___________________________________________________________________ 28

Autosampler™ ____________________________________________________________________ 30

H-Genie™ ________________________________________________________________________ 32

Distributor Network of ThalesNano _______________________________________________ 34

Service and Maintenance _______________________________________________________ 35

Care Platform™ Memberships ___________________________________________________ 36

CatCart® ____________________________________________________________________ 38

CatCart® Packages ____________________________________________________________ 42

CatCart® “call for papers” ______________________________________________________ 43

Choosing the right catalyst for tuning the reaction outcome ___________________________ 44

Commercially available CatCarts® From ThalesNano _________________________________ 46

Ti, Quartz sand – Inert materials _____________________________________________________ 47

10% Pd/C – Palladium on charcoal ____________________________________________________ 49

20% Pd(OH)2/C – Pearlman’s catalyst _________________________________________________ 50

5% Pd/Al2O3 – Palladium on alumina __________________________________________________ 51

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10% Pd/CaCO3 – Palladium on calcium carbonate _______________________________________ 52

5% Pd/CaCO3– Palladium on calcium carbonate _________________________________________ 53

5% Pd/BaCO3– Palladium on barium carbonate _________________________________________ 54

5% Pd/C (S) – Palladium on charcoal (sulfided) _________________________________________ 55

5% Pd/C – Palladium on charcoal _____________________________________________________ 56

5% Pd/CaCO3-Pb – Lindlar’s Catalyst __________________________________________________ 57

5% Pd/BaSO4 – Palladium on barium sulfate ___________________________________________ 58

1% Pd/Al2O3 – Palladium on alumina __________________________________________________ 59

10% Pd/Al2O3 – Palladium on alumina _________________________________________________ 60

Pd/C – ethylenediamine ____________________________________________________________ 61

5% Pd/SiO2 – Palladium on silica _____________________________________________________ 62

1% Pd/C – Palladium on charcoal _____________________________________________________ 63

2% Pd/SrCO3– Palladium on strontium carbonate _______________________________________ 64

PdO– Palladium oxide______________________________________________________________ 65

Pd Black – Palladium metal _________________________________________________________ 66

10% Pt/C – Platinum on charcoal _____________________________________________________ 67

1% Pt/SiO2 – Platinum on silica ______________________________________________________ 68

1% Pt/SiO2 polyethyleneimine– Platinum on modified silica _______________________________ 69

5% Pt/C (Bi) – Platinum on charcoal, doped with bismuth _________________________________ 70

1% Pt/C (V) – Platinum on charcoal, doped with vanadium ________________________________ 71

5% Pt/CaCO3 – Platinum on calcium carbonate _________________________________________ 72

1% Pt/SBA – Platinum on mesoporous silica ____________________________________________ 73

5% Pt/Al2O3 – Platinum on alumina ___________________________________________________ 74

5% Pt/C (S) – Platinum on charcoal, poisoned with Sulphur _______________________________ 75

1% Pt/Al2O3 – Platinum on alumina ___________________________________________________ 76

1% Pt/C – Platinum on charcoal ______________________________________________________ 77

5% Pt/C – Platinum on charcoal ______________________________________________________ 78

Raney Nickel – Al/Ni _______________________________________________________________ 79

Nickel Sponge ____________________________________________________________________ 80

Pricat™ Nickel 55/5P – Nickel catalyst on Diatomaceous earth _____________________________ 81

Nickel Sponge with 1% Mo __________________________________________________________ 82

Ni/SiO2-Al2O3 –Nickel on Silica-alumina support _________________________________________ 83

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5% Rh/C – Rhodium on charcoal _____________________________________________________ 84

1% Rh/SiO2-Polyethyleneimine – Rhodium on modified silica ______________________________ 85

5% Rh/Al2O3 – Rhodium on alumina __________________________________________________ 86

1% Au/Fe2O3 – Gold on Iron Oxide ____________________________________________________ 87

1% Au/C – Gold on charcoal _________________________________________________________ 88

1% Au/TiO2 – Gold on Titanium dioxide _______________________________________________ 89

Ru black – Ruthenium metal ________________________________________________________ 90

5% Ru/Al2O3 – Ruthenium on Alumina ________________________________________________ 91

5% Ru/C – Ruthenium on charcoal ____________________________________________________ 92

RuO2 – Ruthenium oxide ___________________________________________________________ 93

5% Re/C – Rhenium on charcoal _____________________________________________________ 94

Raney-Cu – Raney type Copper ______________________________________________________ 95

CuO/Al2O3 – Copper(II)oxide on alumina _______________________________________________ 96

5% Cu in graphite – Copper metal powder mixed with graphite powder _____________________ 97

Raney Cobalt _____________________________________________________________________ 98

0.5% Ir/C – Iridium on charcoal ______________________________________________________ 99

1% Ir/C – Iridium on charcoal _______________________________________________________ 100

IrO2 – Iridium oxide _______________________________________________________________ 101

5% Ir/CaCO3 – Iridium on calcium carbonate __________________________________________ 102

Zinc powder ____________________________________________________________________ 103

1% Pd – 0.3% Cu/Al2O3– Palladium and copper on alumina _______________________________ 104

Pricat™ CZ 30/18T – Copper and Zinc on Diatomaceous earth _____________________________ 105

5% Pd – 1% Fe/C– Palladium and Iron on charcoal ______________________________________ 106

2.5% Pd – 2.5% Pt/C– Palladium and platinum on charcoal _______________________________ 107

4.5% Ru – 0.5% Pd/C– Ruthenium and palladium on charcoal _____________________________ 108

Pt(0) EnCat® – Platinum encapsulated catalyst _________________________________________ 109

Rh(COD)(dppf)/SiO2 – Rhodium complex catalyst on silica _______________________________ 110

Pd(0) EnCat® NP30 – Palladium encapsulated catalyst ___________________________________ 111

Pd(II) EnCat® 30 – Palladium encapsulated catalyst _____________________________________ 112

Pd(II) EnCat® TPP30 – Palladium encapsulated catalyst __________________________________ 113

Pd(II) EnCat® BINAP30 – Palladium encapsulated catalyst ________________________________ 114

Pd(PPh3)4 – Palladium Tetrakis – DVB resin bound ______________________________________ 115

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Pd(II) EnCat® TOTP30 – Palladium encapsulated catalyst _________________________________ 116

RhCl(PPh3)3 – polymer bound – Wilkinson’s catalyst ____________________________________ 117

Pd(Cl)2(PPh3)2 - DVB – Palladium complex on PS-DVB resin _______________________________ 118

SiliaCat® DPP-Pd – immobilized complex Pd ___________________________________________ 119

Triamine tetraacetate, silica-supported (TAA) _________________________________________ 120

Quadrapure® TU – Immobilized Thiourea _____________________________________________ 121

Quadrapure®-AEA, Immobilized Aminoethyl aminobut-2-enoate ester _____________________ 122

Quadrapure®-AMPA, Aminomethylphosphonic acid ____________________________________ 123

Quadrapure®-IDA, Immobilized Iminodiacetate ________________________________________ 124

Quadrapure®-IMDAZ, Immobilized Imidazol-1-yl propylaminobut-2-enoate ester ____________ 125

Quadrapure®-MPA, Immobilized Mercaptophenylaminobut-2-enoate ester _________________ 126

Quadrasil®-AP, Aminopropyl _______________________________________________________ 127

Quadrasil®-TA, Triamine ___________________________________________________________ 128

Quadrasil®-MTU, Methylthiourea ___________________________________________________ 129

Quadrasil®-MP, Mercaptopropyl ____________________________________________________ 130

Quadrasil®-PHI, phenolic functionalized silica gel _______________________________________ 131

Quadrapure®-PHE, phenolic functionalized polystyrene _________________________________ 132

Mercaptopropyl modified silica _____________________________________________________ 133

Amberlite® IR-120 – Hydrogen form _________________________________________________ 134

QuadraPure™-BZA – Immobilized benzylamine ________________________________________ 135

Amberlyst® 36 resin ______________________________________________________________ 136

Amberlite® IRA-910, chloride form __________________________________________________ 137

Amberlyst® 35 Dry resin ___________________________________________________________ 138

NaIO4 – Sodium Periodate _________________________________________________________ 139

n-Bu4NIO4 – Tetrabutylammonium (meta) periodate ____________________________________ 140

Full list of ThalesNano Inc’s CatCart® technology enabled literatures ___________________ 144

Certifications of ThalesNano Products ____________________________________________ 168

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About Us

ThalesNano Inc. is an innovation-driven company focusing on the development of bench-top flow

chemistry instruments and solutions for synthetic chemical challenges.

The company was founded in 2002 in Budapest, Hungary. Since then, ThalesNano operates

globally, with the help of our US office and worldwide distributor network. Currently, more than

1300 of our instruments are used worldwide. Our mission is to make flow chemistry the part of

the daily laboratory routine and to make chemical processes safer, easier and more effective. We

put a great emphasis to support research and development by aiding scientific collaborations and

education.

Our first instrument on the market, the H-Cube® continuous flow hydrogenation reactor was

launched in 2004. The instrument was ground-breaking with its innovative hydrogen generator

coupled with the advantages of flow chemistry technology. It has received the R&D Top 100

Award and is used in hundreds of laboratories globally. During the recent years, the H-Cube® has

become the new industry standard for hydrogenation.

In response to market needs, ThalesNano has developed new continuous flow reactors to cover

an extended chemical space in terms of both pressure and temperature. Nowadays, the company

has the widest portfolio of laboratory-scale instruments for pharmaceutical, biotechnology, fine

chemical, flavor and fragrance, agrochemical and petrochemical markets, as well as for academic

research groups and education.

Our family of products solves daily problems with difficult or dangerous reactions. We offer a convenient and safe alternative with easy reproducibility. In addition, with temperature range from -70 to 1000°C and pressure from vacuum to 200 bar a new chemical parameter window is achievable that is otherwise unreachable in batch processes.

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Instruments and system setups from

ThalesNano

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H-Cube® Pro General product information

The H-Cube® Pro, the most popular instrument of ThalesNano, is the easily adjustable and more

professional version of our award winner H-Cube® reactor system. With the help of the fast parameter

setting, the instrument allows fast reaction optimization of multiple variables (temperature, pressure, flow

rate (residence time), hydrogen amount (equivalence), catalyst amount, concentration, solvent).

Technical specifications

Temperature range: 10 °C – 150 °C, 1 °C step setting option

Pressure range: atmospheric – 100 bar, 1 bar step setting option

Flow rate range: 0.3 mL/min – 3 mL/min, 0.1 mL/min step setting option

CatCarts®: 30x4 mm, 70x4 mm and MicroCart™ H-Cube type cartridges

Hydrogen production: maximum 60 mL/min, 1% precision addition (volume)

Productivity range: mg – g scale, depending on the chemical reaction

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Instrument enabled technologies and reactions

Technical features

The H-Cube® Pro has a built-in reaction optimization algorithm (Simplex) which leads the reaction to a

local maximum production in 10-15 steps by changing three parameters automatically, according to the

previous results. Also, based on our company’s experiences, a built-in reaction parameter option is

available which gives an initial parameter set to the chemist to start with for numerous reaction types.

The system has a ’timer’ option as well. The calculated dead volumes, washing times and priming

parameters can be adjusted by the user and the instrument carries out the reaction by automatically

changing the valves.

The H-Cube® Pro can be connected to other modules and reactors, like the Gas Module™, the Phoenix

Flow Reactor™ or the Autosampler™. These instruments can be operated through the touch screen of the

H-Cube® Pro. By this, a wider chemical space and new opportunities for synthesis become available, like

the addition of different gases to the reaction mixture, working on temperatures up to 450 °C and the

complete automation of the system.

In H-Cube® Pro’s software the user can set all the applied parameters and save the reaction conditions.

Therefore, anytime when needed, they can be searched back and set again as a reproduction run, or

checked for the conditions. The system automatically saves all reaction log files according to date and time

when the reaction started. These saved files can be exported as .csv file to a PC through flash-drive.

Chemical resistance and compatibility

The H-Cube® Pro is typically built with SS316 tubing (stainless steel alloy), which contains nickel. Mineral

acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly

advice to avoid using mineral acids as solvents and use base as quench material, if such acid leaving group

forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the

tubing. Otherwise, the H-Cube® Pro can operate with almost all the commercially available solvents. The

limiting factors are the viscosity, the melting point and the pH of the used solvents.

For further information please contact us at [email protected].

mailto:[email protected]

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H-Cube® Mini Plus General product information

The H-Cube® Mini Plus is an easy-to-use instrument designed primarily for routine hydrogenation

reactions. This instrument is the modern, advanced and improved variant of the company’s award winner

H-Cube® reactor system. The design emphasizes the small footprint and versatility.


Temperature range: room temperature – 100 °C, 1 °C step setting option



CatCarts®: 30x4 mm, 70x4 mm and MicroCart™ H-Cube type cartridges

Hydrogen production: maximum 25 mL/min, maximum volume added at all time


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Technical features

The features of the H-Cube® Mini Plus include a built-in reaction parameter function which offers an

initial parameter set, based on our research and experiences, to start with for numerous reaction types.

In the software of the H-Cube® Mini Plus the user can set all the applied parameters and save the

reaction conditions. Therefore, anytime when needed, they can be searched back and set again as a

reproduction run, or checked for the conditions. The system automatically saves all reaction log files

according to date and time when the reaction started. These saved files can be exported as .csv file to a

PC through flash-drive.


The H-Cube® Mini Plus is typically built with SS316 tubing (stainless steel alloy), which contains nickel.

Mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we

strongly advice to avoid using mineral acids as solvents and use base as quench material, if such acid

leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the

alloy of the tubing. Otherwise, the H-Cube® Pro can operate with almost all the commercially available

solvents. The limiting factors are the viscosity, the melting point and the pH of the used solvents.



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H-Cube® Midi General product information

The H-Cube® Midi is designed for scaling up reactions optimized on the H-Cube® series reactors. The

reactor operates with MidiCart™ catalyst cartridges. The reactions parameters (temperature, pressure,

flow rate (residence time), hydrogen amount (equivalence)) can be automatically controlled.

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Temperature range: room temperature – 150 °C, 5 °C step

setting option


Flow rate range: 3 mL/min – 25 mL/min, 0.5 mL/min step setting option

CatCarts®: MidiCart™ type cartridges

Hydrogen production: maximum 120 mL/min, 10% precision addition (volume)

Productivity range: g – ½ kg scale, depending on the chemical reaction


Technical features

H-Cube® Midi operates with MidiCarts™ which have 10 times bigger inner volume than the 70x4 mm

CatCarts®. This allows the chemists to scale up the optimized reaction directly with minor changes just by

multiplying the parameters from the smaller scale reactors.


The H-Cube® Midi is typically built with SS316 tubing (stainless steel alloy), which contains nickel.


strongly advice to avoid using mineral acids as solvents and use base as quench material, if such acid

leaving group forms during the reaction. Also, high temperature aqueous basic solutions can attack the

alloy of the tubing. Otherwise, the H-Cube® Pro can operate with almost all the commercially available


For further information please contact us at [email protected] e-mail address.


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Phoenix Flow Reactor™ General product information

The Phoenix Flow Reactor™ is a versatile high capacity heater system. This reactor widens the commercial

chemical space towards extreme high temperatures and high pressure. It can be used as a module for the

H-Cube® Pro or as part of an advanced continuous flow system for both homogeneous and heterogeneous

reactions.


Temperature range: room temperature – 450 °C, 1 °C step setting option



CatCarts®: works with all cartridges from ThalesNano

Productivity range: mg – kg scale depending on the chemical reaction

Working modes: Standalone reactor or connected to H-Cube® Pro

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Technical features

The Phoenix Flow Reactor™ has a 250mm x 50mm heated zone. With different inner metal blocks, the

size of the applied cartridge can vary from MicroCart™ volume to the 250 mm long cartridge with 1” width.

This versatility makes the implementation of scale-up processes possible, from mg to kg scale with one

instrument. (For more information, please take a look into the maximum working temperatures listed at

the cartridge types and the catalyst catalogue.)

The reactor can be used connected to the H-Cube® Pro and controlled by its touch screen. In this case,

the liquid transportation and the pressure regulation (100 bar) is provided and controlled by H-Cube® Pro.

The second option is to use the reactor as part of more complex continuous flow system, in which a

backpressure regulator (up to 200 bar) and a high pressure HPLC pump (from 0.1 to 50 mL/min flow rate

depending on the type of the pump, always with built-in pressure sensor) provide the reactant transport

and the pressure regulation.

The Phoenix Flow Reactor™ is designed for rapid heating and precise temperature control: the system

heats up within 10 minutes from ambient temperature to 450 °C.


The tubing used for the Phoenix Flow Reactor™ is made of SS316 (stainless steel alloy). Since this alloy

contains nickel, mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall.

Therefore, we strongly advice to avoid using mineral acids as solvent, and use base as quench material, if

such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can

attack the alloy of the tubing. Otherwise, the Phoenix Flow Reactor™ can operate with almost all the

commercially available solvents. The limiting factors are the viscosity, the melting point and the pH of the

used solvents.


Modules for the Phoenix Flow Reactor™

systems

HPLC PUMP

HPLC pump 10 mL/min

HPLC pump 50 mL/min

The HPLC pump is a 10 mL/min or 50 mL/min capacity unit with built-in pressure sensor (inlet pressure

sensor). It is recommended to have an extra HPLC pump if multiple inlets are needed for the application.

THS – 09037


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BACK PRESSURE MODULE™

The Back Pressure Module™ generates the pressure in the reaction chamber. The module contains a

system valve, a pressure sensor and a 3-way valve to set the outlet (to waste or to product collection).

The maximum pressure is 200 bar (300 bar for custom request).

THS – 09042

CONTROL MODULE™

The Control Module™ allows the control and visualization of the records of any connected modules via a

touch screen. The automatic control of the parameters for the whole system plays an essential role in

safety.

THS – 61049

GAS MODULE™

When the Gas Module™ is connected to the Phoenix Flow Reactor™, it allows the introduction of gases,

such as hydrogen, carbon monoxide, oxygen, syngas, etc. 14 different gases can be used up to 100 bar

pressure, or any gas which characteristics are under the safety parameters of the system, widening the

reactor’s chemistry capabilities significantly. It is also possible to use more than one Gas Module™ and

mixers to introduce more than one gas at the same time.

THS-09027

GAS PREHEATER

Gas preheater for Gas Module necessary in case CO2 is used in the system.

Max pressure: 200 bar

Power: 230V / 50Hz, 200 W

IN: W21.8×1 / 14 ”F, OUT: W21.8×1 / 14M.

THS – 51010

https://thalesnano.com/products-and-services/back-pressure-module-300/https://thalesnano.com/control-module/https://thalesnano.com/products-and-services/gas-module/

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PhotoCube™ Batch and flow reactions in one reactor with several wavelengths

• Batch, flow, stop-flow and CSTR reactions

• 7+1 wavelengths in one instrument

The PhotoCube™ is the first multi-wavelength instrument available for advanced photochemical

applications.

This reactor enables the implementation of multi-wavelength batch and continuous flow

photochemical reactions. The multicolour option ranges from UVA to red. With the opportunity

to select the colour of the LEDs, the system can be fine-tuned for specific wavelengths and

applications, furthermore, multiple wavelengths can be utilized at the same time.

Available wavelengths: 365, 395, 457, 500, 523, 595, 623 nm and white

Available batch reactor volumes: 4 mL and 30 mL glass vials

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Available loop volumes: 2-20 mL

Standard size: 1/16" OD, 1 mm ID

Available loop material of Construction: FEP or PFA

Temperature range: 20 to 80 °C

LED input power: up to 128 W/colour

Other Key features:

o User defined parameters, including wavelength, light intensity and speed of stirring

o Temperature feedback

o External temperature control option: external thermoregulation can be attached to the

system.

o Built-in safety features: to prevent the user from exposure to high-intensity light, the

LEDs automatically switch off when the photochemical reactor chamber is opened

during operation.

Accessories: HPLC Pump (THS-09037H): For customers who wish to integrate the ThalesNano HPLC pump with the PhotoCube™ or even other flow systems. The flow rate range is: 0.01-10 mL/min. Comes with full 1-year warranty. Loops

o 20mL

o 10mL

o 15mL

o 8mL

o 5mL

o 2mL

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Gas Module™ General product information

The Gas Module™ is an automatic gas flow controller unit designed by ThalesNano. The system can work

standalone as a precise gas dosing instrument, or connected to other ThalesNano instruments as an outer

gas source reducer. 14 different gases can be used with the system: the basic software contains predefined

data about the applicable gases and a custom mode for gas-mixture regulation.


Temperature range: can work with slightly heated or cooled gases from 10-50 °C


Gas flow rate range: 1 mL/min – 100 mL/min, 1 mL/min step setting option

Gas types: H2, CO, N2, NO, N2O, O2, Air, SynGas, Ar, He, CH4, C2H6, C2H4, CO2, Custom

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Technical features

Gas Module™ technology is based on mass flow controllers (MFC) which introduce gases to the batch

or flow reaction precisely. By calculating the gas factor, the chemist can regulate the gas flow for custom

gas mixtures also.

The Gas Module™ can be connected to the H-Cube® Pro, the Phoenix Flow Reactor™ and the

Autosampler™ systems. In case of using it with the H-Cube® Pro, the Gas Module™ can be operated

through its touch screen. By these, a wider chemical space is achievable with the use of different gases

and temperatures up to 450 °C, or with complete automation.


The Gas Module™ is generally built SS316 tubing (stainless steel alloy). Since this alloy contains nickel,

mineral acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we

strongly advice to avoid using HCl as gas. Also, due to its low supercritical parameters, CO2 has special

precautions as gas source.



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IceCube™ General product information

IceCube™ is an instrument designed for high energy exothermic reactions. The wetted parts of the system

are made of PTFE, from the addition point to the product collection. This feature enables the use of highly

flammable or volatile materials without risking the reaction between the reagent and the system’s tubing.

The IceCube™ reactor can cool its reaction zone down to -50 or -70 °C, and also heating it up to 80 °C,

covering the commercial reaction temperatures of a normal batch chemistries. The IceCube™ reactor has

two separable cooling zones, one for completing the reaction and the second one for quenching the

reaction.

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Temperature range: -70 (-50) °C – 80 °C in the reaction zone, 1 °C step setting option

-30 °C – 80 °C in the quench zone, 1 °C step setting option


Flow rate range: 0.2 mL/min – 4 mL/min, 0.1 mL/min step setting option, two pumps

Loop system Variable volume, depending on the needs of the customer

Productivity range: mg – kg scale, chemistry dependent


Technical features

IceCube™ has two reactor zones with separate temperature control. The cooled/heated area is made

of aluminium plates in which the chemist can place PTFE tubing as the reaction zone. Typical volumes vary

from µL to mL scale.

The reactor can be connected to ThalesNano’s Ozone Module™, which allows to perform ozonolysis

reactions in safe manner. It has a built-in quenching calculation option; setting the quenching

concentration the system sets the quenching flow rate automatically, and vice versa, helping the chemist

cease the excess ozone which remains unreacted during the reaction.

The different parts of the system can be operated individually with their touchscreens or connected to

the Control Module™, and by this, the whole reactor setup can be controlled through one screen

automatically.

The IceCube™ has a stackable reaction zone which can handle three individual aluminium panels.

Through CAN communication, multiple pumps can be integrated into the system with PTFE mixers, and

multistep reactions can be performed in one sequence.


The IceCube™ is generally built with PTFE tubing (poly-tetrafluoro ethylene) with 1/8” or 1/16” outer

diameter. Therefore, the system can operate with any solvents and reactants without restrictions. This

polymer also enables the transportation of materials like Grignard reagents or organolithium solutions.

Since it is a closed tube-system, the reaction space is protected from air or moisture contaminations.



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Ozone Module™ General product information

The Ozone Module™ is a gas generator which produces ozone from oxygen. Due to the small internal

volumes, the instrument minimizes the risks of ozonolysis reactions. The instrument can be used as a

standalone gas generator and also as part of ThalesNano’s IceCube™ Reactor system.


Temperature range: room temperature

Pressure range: atmospheric – 6 bar

O2 flow rate range: 1 mL/min – 100 mL/min, 1 mL/min step setting option

Productivity range: mg – kg scale, depending on the chemical reaction

Working modes: Standalone reactor or connected to the IceCube™ Reactor

O3 mode or just carrying O2 gas

O3 concentration: 10-16% (volume), depending on O2 flow rate and cell temperature

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Technical features

The built-in ozone generator cell of the Ozone Module™ produces O3 from oxygen. As a gas source, any

size of oxygen cylinders can be used with minimum 2.5 gas purity (99.5%). Higher gas purity can help to

prolong the ozone cell’s lifetime. For introducing the oxygen gas, the cylinder should be applied with a

low-pressure reducer. The Ozone Module™ can handle 3-5 bar gas addition. Higher gas pressure can

damage the ozone cell and low pressure setting on a high-pressure reducer causes alteration in the gas

pressure and the system cannot change into stable state.

The IceCube™ Reactor is designed as an effective cooling system (down to -50 °C or -70 °C) for high

energy reactions. The Ozone Module™ can be easily connected to it and by this, chemists can run their

ozonolysis reaction in small volumes, continuously quenching the excess ozone gas from the line.


All wetted parts of the Ozone Module™ are made of PTFE. This plastic is completely inert and can hold

several bar pressures. The instrument’s exit lines (waste or product) are equipped with check valves to

prevent reaction solution to flow back into the instrument. Any liquid that enters the ozone cell can

permanently damage the instrument.



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Flash Pyrolysis Platform™ General product information

ThalesNano’s Flash Pyrolysis Platform™ is a high temperature and low-pressure reactor for fast reactions

which require high energy input to form the reactive intermediates. The reactor works in two modes:

sublimation method for solid materials or spray method for dissolved starting materials.


Temperature range: r.t – 1000 °C, 1 °C step setting option in the furnace

r.t – 400 °C in the preheater unit (sublimation mode)

Pressure range: atmospheric – 10-3 mbar

Flow rate range: in spray mode: pump dependent parameter


Carrier gas: in spray mode: N2 or Ar

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Technical features

The Flash Pyrolysis Platform™ is a powerful flash vacuum pyrolysis instrument which is capable to work

at 1000 °C. The vacuum is maintained by a high-performance pump, down to 1x10-3 mbar pressure.

The applied cooled trap system is capable to collect the products at the end of the reactor system, and

the chemist can gather the liquid or solid material by washing the trap with a suitable solvent.

The system can be applied for unimolecular reactions, such as ring closure, ring opening and

rearrangement reactions.


When used in sublimation mode (or liquid evaporation mode), the Flash Pyrolysis Platform™ is built

from quartz glass and therefore, it is applicable to the implementation of reactions up to 1000 °C.

When going in spray mode, the tubing used for carrying the solution is made of SS316 alloy. Since this

alloy contains nickel, mineral acids (i.e. hydrochloric acid) can dissolve the metal as salt from the tube wall.

Therefore, we strongly advice to avoid using mineral acids as solvent, and use base as quench material, if

such acid leaving group forms during the reaction. Also, high temperature aqueous basic solutions can

attack the alloy of the tubing.



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CatCart® Changer General product information

The CatCart® Changer is a modular unit which can be combined with the H-Cube® series instruments (PEEK,

SS, Pro, Mini Plus) and it controls the temperature of six individual chambers parallel. The system is

controlled by a PC or by the software of the H-Cube® Pro and helps fasten the catalyst screening and

reaction optimization.

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Temperature range: r.t. – 100 °C, 1 °C step setting option


Flow rate range: attached instrument depending flow rates

CatCarts®: 30x4 mm, 70x4 mm and MicroCart™ H-Cube® type cartridges

Productivity range: mg – g scale, used for sublimation mode (or liquid evaporation).


Technical features

The CatCart® Changer is made for fasten optimization processes. The automatic injector changes the

reaction lines when the heating block is ready and stable.

With the CatCart® Changer, multiple catalysts and different cartridge sizes can be used after each other

without stopping the flow or the reaction.


The CatCart Changer™ is built with SS316 (stainless steel alloy) or PEEK tubing. The alloy contains nickel.


strongly advice to avoid using mineral acids as solvent, and use base as quench material, if such acid leaving

group forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of

the tubing. Otherwise, the CatCart® Changer can operate with almost all the commercially available




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CatCart® Packer General product information

The CatCart® Packer system is made of two major parts. The first is the vacuum pump assisted CatCart®

filling unit, which enables customers to fill their own CatCarts® with heterogeneous catalysts. The second

unit is the CatCart® Closer: a mechanical press for closing the filled cartridges – this part can be purchased

separately as well. With the help of this system, chemists can fill their own manufactured catalyst for

research purposes.

Packing the CatCarts®

CatCart® closing system has 5 elements:

1) thin carbon filled PTFE ring,

2) 8 micron pore size stainless steel filter

3) 1.2 micron pore size PTFE membrane,

4) 8 micron pore size stainless steel filter,

5) thick carbon filled PTFE membrane for sealing the above parts

29

The parts have to be placed in the listed order at both ends of the cartridge and with the help of the Closer

unit, sealed in carefully. After pressing the sealing ring, the overextended PTFE has to be cut off and the

CatCart® is ready to use.


Technical features

The CatCart® Packer is designed primarily for customers who would like to use their own catalysts with

ThalesNano’s instruments. The system creates an opportunity for the chemists to fill and test the catalysts

promptly after manufacturing.

With the CatCart® Packer, the customer can fill 30x4 mm, 70x4 mm and MicroCart™ type catalysts also,

varying the catalyst amount through packed bed length.


The CatCart® Packer works with ThalesNano provided one-end-sealed cartridges, the chemical

compatibilities and restrictions are matching to the ones listed at the CatCart® information page.



30

Autosampler™ General product information

ThalesNano’s Autosampler™ is an automated system combining a Gilson liquid handler to other modular

ThalesNano instruments, such as the H-Cube®, the H-Cube® Pro, the Gas Module™, the CatCart® Changer

and the Phoenix Flow Reactor™. The setup helps the chemist optimize reaction conditions automatically.


Temperature range: 10 – 450 °C, 1 °C step setting option, depending on the connected

instruments

Pressure range: atmospheric – 100 bar

Flow rate range: 0.3 – 3 mL/min

H2 production: no H2 – 60 mL/min, depending on the connected instruments

Productivity range: mg – g scale, depending on the chemistry

Vial number: Vial rack dependent, up to 56 vials

31


Technical features

Autosampler™ is capable of performing reactions automatically. The liquid handler injects the starting

solution through a high-pressure valve (up to 10 mL sample volume at a time) and collecting the product

mixtures after the reactions.

Sampling and collecting with the Autosampler™ can happen from 4 mL to 35 mL vials, depending on

the applied rack. Changing the racks in the liquid handler also varies the reaction number the system can

perform during one complete series from 1 to more than 100.

The whole system can be operated through a PC on a graphical interface, where all the parameters,

graphs and system performance can be followed and logged.

Connecting the CatCart® Changer to the system makes possible to run reactions on 6 different catalysts

in one series. This makes catalyst research and optimization faster.


The wetted parts of the Autosampler™ are made of SS316 alloy. Since this alloy contains nickel, mineral

acids (i.e. hydrochloric acid) can dissolve the alloy metal as salt from the tube wall. Therefore, we strongly

advice to avoid using mineral acids as solvent, and use base as quench material, if such acid leaving group

forms during the reaction. Also, high temperature aqueous basic solutions can attack the alloy of the

tubing.

For more information about the chemical resistance of the connected modular reactors, please read

the instrument’s introducing page in this catalogue.



32

H-Genie™ by General product information

The H-Genie is a compact standalone high-pressure hydrogen generator that produces hydrogen by the

electrolysis of deionized water, with the available gas flow rate range between 100-1000 NmL/min and

pressure range between 1-100 bar. The hydrogen purity is 99.99% at 100 bar.

The H-Genie is designed to supply hydrogen to both batch and flow reactors at maximum safety. Even

balloons can be filled safely and quickly. The total internal H2 volume is only 150 mL and is generated on-

demand. In the case of any power shortage or malfunction, the production halts and mechanical valves

ensure the safe release of the remaining hydrogen from the generator to the fume hood. A built-in H2

detector along with a full pressure test conducted at start-up guarantee safe and secure usage.

Hydrogen flow is measured using a mass flow controller. All data is displayed in a graph, which can be

exported as a .csv file. An RS232 port allows remote access.

Working parameters

Pressure range: atmospheric – 100 bar (± 1 bar)

Up to 90 bar in flow mode

(depending on the pressure drop of the cartridge)

Hydrogen production: 100 mL/min – 1000 mL/min (± 1 mL/min)

Productivity range: g – kg scale, depends on the reaction

33


Technical features

Due to H-Genie’s™ high volume hydrogen production, it enables the user to fill up several autoclaves at

the same time or run multiple flow reactions.

H-Genie™ is equipped with a gas check valve which maintains the pressure difference between the gas

and the liquid line. Therefore, no liquid can go backwards into the instrument.

High Pressure Hydrogen Safety

H-Genie™ parameters:

Max. internal pressure (p): 110 bar

Internal gas volume (V): 0,15 L

p*V: 16,5 (bar*L)

For further information please contact us at [email protected] and

[email protected] e-mail addresses.

mailto:[email protected]:[email protected]

34

Distributor Network of

ThalesNano ThalesNano Inc. is dedicated to deliver a good and quick service to our customers. For this purpose, a

worldwide distributor network is working in the favor of both sides.

Europe Distributor Country Webpage

Anamed & Analitik Grup

TR http://www.anamed.com.tr/thalesnano

Beun de Ronde BV. NL, LUX https://www.beunderonde.nl/flowsynthese.html

Beun de Ronde Serlabo BE https://www.brs.be/flow_chemistry.html

TECHNOPROCUR CZ, Spol. s r.o.

CZ http://www.technoprocur.cz/sortiment/farmaceuticky-prumysl/

Serlabo Technologies FR http://www.serlabo.fr/fr/305-chimie-de-flux

Stepbio Srl IT http://www.stepbio.it/skproduttore.asp?IDProduttore=33

LaboChema LT EE, LT, LV https://www.labochema.lt/

Selwa Sp. z o.o. PL http://selwa-lab.pl/main

Paralab P http://www.paralab.pt/partner/thalesnano

ANALITIC LABORATORY RO http://www.analiticlaboratory.ro/

Galachem Ltd. RU

Net Interlab, S.A. E https://net-interlab.es/categoria-producto/thalesnano/

Labotal Scientific Equipment LTD

IL http://labotal.co.il/firms_posts/thalesnano/

Asia Distibutor Country Webpage

PyNN Corporation CN http://www.pynnco.com/

INKARP Instruments Private Limited

IN

ITS Science Inc. ID, MY, PH, TH, VN

http://its-sciencemedical.com/its_cat/flow-chemistry-reactors/

Ikeda Scientific Co., Ltd.

JP http://www.ikedarika.co.jp/product/original/ThalesNano/h-cube-pro.html

CM Corporation Ltd. KR http://www.cm-corp.co.kr/

UTEK International Corporation

TW

For more detailed information, please visit our website at https://thalesnano.com/our-distributors/

address.

http://www.anamed.com.tr/thalesnanohttps://www.beunderonde.nl/flowsynthese.htmlhttps://www.brs.be/flow_chemistry.htmlhttp://www.technoprocur.cz/sortiment/farmaceuticky-prumysl/http://www.technoprocur.cz/sortiment/farmaceuticky-prumysl/http://www.serlabo.fr/fr/305-chimie-de-fluxhttp://www.stepbio.it/skproduttore.asp?IDProduttore=33http://www.stepbio.it/skproduttore.asp?IDProduttore=33https://www.labochema.lt/http://selwa-lab.pl/mainhttp://www.paralab.pt/partner/thalesnanohttp://www.analiticlaboratory.ro/https://net-interlab.es/categoria-producto/thalesnano/http://labotal.co.il/firms_posts/thalesnano/http://www.pynnco.com/http://its-sciencemedical.com/its_cat/flow-chemistry-reactors/http://its-sciencemedical.com/its_cat/flow-chemistry-reactors/http://www.ikedarika.co.jp/product/original/ThalesNano/h-cube-pro.htmlhttp://www.ikedarika.co.jp/product/original/ThalesNano/h-cube-pro.htmlhttp://www.cm-corp.co.kr/https://thalesnano.com/our-distributors/

35

Service and Maintenance We can provide our services for your H-Cube®, H-Cube Pro™, H-Cube Mini Plus™, Phoenix Flow Reactor™,

Gas Module™ or IceCube™ upon your preferences, for Preventive Maintenance or fully comprehensive

post-warranty support, Service Plus. Our team of service engineers is always at your service. Feel free to

ask questions or share your eventual request with them!

The available service packages

Contact

ThalesNano HQ

Service line: +36 1 8808 589

Service line is working: from 8 am to 6 pm CET/CEST

E-mail: [email protected]

North America

Alan Boyle

Director of Operations and Service

E-mail: [email protected]

Service line: +1 215 534 3365

Service line is working: from 8 am to 6 pm EST

mailto:[email protected]:[email protected]

36

Care Platform™ Memberships

Heading towards a more personalized approach of customer care, we doubled up on the number of

specialists who are eager to help addressing your challenges. Our new product selector tool also meant

to be a convenient option to find the best fit to your lab’s needs.

In line with our intention taking customer care to the next level, we are also launching Care Platform™

Memberships. On top of an annual preventive maintenance visit, complimentary software updates and

the second to none technical support, extensive set of services and allowances are now also on offer:

• Remote AskTheChemist™ specialist support, workflow optimization and training

• Complimentary Journal of Flow Chemistry subscription

• Pre-release access to Application Notes

• Assistance with your Centre of Excellence accreditation

• Flexible finance solutions to support your purchase and ease on the Capex budget

• On-site AskTheChemist™ flow chemistry knowledge support in your lab at reduced rates

• Solving flow chemistry challenges in our own laboratory with a discount

• Reduced CatCart® prices and fastest delivery from the widest selection in our webshop

• Preferential rates with our chemical CRO sister company, ComInnex

We remain at your disposal in terms of sharing knowledge and expertise, acquired over nearly two

decades, to help you make the most of flow chemistry. Feel free to contact us for further details and

introductory offers.

https://thalesnano.com/support-and-knowledge/ask-the-chemist/https://thalesnano.com/product-selector/https://thalesnano.com/products/service-and-maintenance/https://thalesnano.com/support-and-knowledge/ask-the-chemist/https://www.springer.com/chemistry/journal/41981https://thalesnano.com/support-and-knowledge/application-notes/https://thalesnano.com/support-and-knowledge/ask-the-chemist/https://thalesnano.com/products/catcarts/https://cominnex.com/https://thalesnano.com/support-and-knowledge/ask-the-chemist/https://thalesnano.com/support-and-knowledge/ask-the-chemist/

37

Care Platform™ Memberships Value added and service components

38

CatCart® General product information

CatCart® is ThalesNano’s packed catalyst cartridge system. The heterogeneous catalysts are filled in a

stainless steel tube and sealed on both sides with a complex sealing system, containing graphite filled PTFE

sealing rings, SS filters and PTFE membrane.

CatCarts® are available in different sizes, depending on which instrument the chemists like to use and how

big the reaction scale is:

39

Advised particle sizes to fill the cartridges with

For H-Cube type CatCarts® (30x4mm, 70x4mm, MicroCart): 40-200 µm

For MidiCarts™: 100-400 µm

For MMS cartridges: 40-500 µm, depending on column size

CatCart® filled chamber sizes and inner volumes (empty cartridge): Cartridge type Length ID Volume

(empty) Instrument

MicroCart™ 8 mm 4 mm 100 µL H-Cube Pro™, H-Cube Mini Plus™, H-Cube® SS/PEEK, Phoenix Flow Reactor™

30x4 mm 24 mm 4 mm 300 µL H-Cube Pro™, H-Cube Mini Plus™, H-Cube® SS/PEEK, Phoenix Flow Reactor™

70x4 mm 64 mm 4 mm 804 µL H-Cube Pro™, H-Cube Mini Plus™, H-Cube® SS/PEEK, Phoenix Flow Reactor™

MidiCart™ 90 mm 9.5 mm 6376 µL H-Cube MIDI™, Phoenix Flow Reactor™

125 mm 1/8” MMS 101 mm 1.65 mm 216 µL Phoenix Flow Reactor™






Custom Cartridges In the case of Phoenix Flow Reactor™, all cartridges of ThalesNano can be applied. Moreover, when the

customer needs a unique size cartridge, our team is happy to develop and manufacture the required parts.

The CatCart columns are made of stainless steel, but our company also manufactures cartridges from

Hastelloy or PTFE, following customer requirements.


Technical features

The CatCart® technology is designed to keep the heterogeneous catalysts inside the cartridge during

the whole process. The chemist does not have to work directly with the hazardous materials at the

beginning of the reaction, and also does not have to filter out the active and often pyrophoric catalyst

during the work-up.

All shipped CatCarts® come with a deactivating solution filled additional tube. The chemist has to place

the used CatCart® into the deactivating solution, and it poisons the transition metal, preventing it to cause

any trouble after the reaction.

40

The used CatCarts® can be shipped back to ThalesNano for processing.


CatCarts® are made of SS316 alloy. Since this alloy contains nickel, we advise to avoid mineral acid or

base containing solutions during the reaction.

For further information please contact us at [email protected] or at

[email protected] e-mail addresses.

How to acquire CatCarts®?

1) Ordering from ThalesNano Inc. or from local distributor

A) ThalesNano has more than 100 types of catalyst off the shelf to fill CatCarts® with. All the catalysts

are tested for activity, and the filled batches are tested for physical parameters to match the

criteria our instruments require to run seamlessly.

For official quotation or information about our services and prices, please contact us at

[email protected], [email protected] or [email protected]. In Europe,

local distributors are helping our work, to serve customers faster. The list of distributors and

countries please look for page 31.

B) CatCarts® are directly available from our webshop: www.webshop.thalesnano.com.

2) Custom catalyst filling

A) When you cannot find the catalyst you would like to use in our list, we can order and fill cartridges

if the catalyst is commercially available. In this case delivery times can be longer than usual.

B) ThalesNano Inc. also offers fill-for-fee service that makes possible for the users to send their own

catalysts to us and our team can pack the CatCarts® with the catalyst in the requested amount for

a certain fee. This option creates opportunity for catalyst researcher groups to test their catalyst

in flow. This service always works under CDA (confidential disclosure agreement). Please find more

information about the fill-for-fee prices and regulations below.

C) The third option is to buy a CatCart® Closer or CatCart® Packer. In this case the customer can use

their own instrument to fill and close the CatCarts® on site. Empty cartridges and the

corresponding sealing system can be bought from ThalesNano Inc. or from local distributors.

mailto:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]://www.webshop.thalesnano.com/

41

Fill-for-fee prices and rules

30x4mm CatCart®: 35 EUR or 40 USD/pc

70x4mm CatCart®: 60 EUR or 70 USD/pc

Physical testing (optional): 610 EUR or 700 USD/catalyst type

- For every catalyst type the customer has to send the MSDS documentation.

- The filled CatCarts® are only for in-house use for the customer, they cannot sell it further to a

third party.

- Shipping cost must be covered by the customer for both directions.

- Without physical testing option ThalesNano does not warrant the flow compatibility of the filled

cartridges.

- There is no minimal amount of CatCart® for this service.

CatCart® warranty and shelf-life

ThalesNano guarantees the quality of the CatCarts® for one year. The warranty’s starting date is

indicated on the side of the delivery box.

CatCarts® should be held in a dry and cold place to prolong the shelf-life of the catalyst. However, after

the warranty period expires, ThalesNano cannot take responsibility for the activity of the CatCarts®.

Safety and hazards

CatCarts® are sealed containers of catalysts. Opening the cartridges can be dangerous due to the

pyrophoric nature of the catalysts inside. Our company does not take any responsibility for the accidents

and injuries made by an opened cartridge.

For every piece of CatCart® our shipments contain a deactivating vial. After using a CatCart® we

recommend to place the cartridge in the deactivating solution (sodium metabisulfite aqueous solution) to

neutralize the activated catalyst.

Disposing the used cartridges

ThalesNano Inc. provides an opportunity to accept back the used cartridges for handling the waste. Every

customer has the opportunity to send back the used goods for disposal to our headquarters.

The used CatCarts® should be considered as hazardous chemical waste and should be send to the

correspondent company for disposal, closed and placed in the neutralizing tubes.

42

CatCart® Packages Starter package – THS-01050

CatCart® THS Code Pcs in the package Reference page

10% Pd/C THS-01111 6 46

Raney Nickel THS-01112 3 76

5% Rh/C THS-01114 3 81

20% Pd(OH)2/C THS-01115 3 47

5% Ru/C THS-02115 3 89

5% Pt/C (S) THS-02117 3 72

5% Pt/C THS-08112 3 75

70x4mm Starter Package – THS-61060

CatCart® THS Code Pcs in the package Reference page

10% Pd/C THS-01131 3 46

Raney Nickel THS-01132 3 76

20% Pd(OH)2/C THS-01135 3 47

5% Ru/C THS-02135 3 89

These packages are selections of the most popular and often used catalysts. The packages contain

several pieces of each catalyst types to allow the chemists to run parallel projects or optimize the

reaction on a specific cartridge. More information about the individual CatCarts® can be found on the

given reference page.

43

CatCart® “call for papers”

The CatCart® is ThalesNano’s packed catalyst cartridge system. Naturally, there are preferred, favorite

catalysts that the industry and research groups are applying more often than the other types. These

catalysts, like Pd/C or Raney Nickel, have a wide range of literature with our instruments.

In this catalogue we listed the literature of each CatCarts® and picked one or two to show the chemistry

at the bottom of the catalyst page. When you are starting your work and you are curious which catalyst

you should use, we hope this list will help you decide and find the initial parameter set.

However, more extreme or rarely used CatCarts® have no literature as we know it. We try to make these

catalysts more appealing for our customers so we decided to start a competition which benefits both our

customers and our company.

Rules of the “game” When you are working with our instruments and CatCarts®, and you publish an article about your results,

we kindly ask you to send us a reminder or copy of your accepted manuscript. Let us mention here, that

only those manuscripts count that contains the commercial CatCart® and the work was done on a

ThalesNano instrument.

- The first incoming manuscript’s writers and company get 20% discount for their next CatCart®

order.

- The second incoming manusript’s writers and company get 15% discount for their next CatCart®

order.

- The third incoming manusript’s writers and company get 10% discount for their next CatCart®

order.

We hope that with this action we can encourage researchers and chemists to step out from the comfort

zone of catalytic transformations and try a bit more extreme catalyst to achieve their goal with more

sophisticated and selective ways.

44

Choosing the right catalyst for

tuning the reaction outcome Transition metal catalysts have different reaction activities and selectivity towards saturated products

when the staring compound has more sensitive groups attached. While planning the reaction chemists

have to think also picking the optimal catalyst for the reaction to synthesize the required material and the

same time avoid side-product formation. Applying the same conditions, changing the catalyst has

significant effect on the reaction outcome. (Figure 1)

Figure 1: different catalytic effect on the same parameter set. (Viviano et al., RSC Adv., 2015,5, 1268-1273)

As will be seen in this catalogue, considering the amount of publications, the most used catalyst is still

palladium on charcoal. However, other catalysts have different attributes and selectivity for fine-tuned

chemical reactions.

ThalesNano’s instruments also give the chemists opportunity for quick and safe reaction condition

optimization. As in the CatCarts® contains super-stoichiometric amount of catalyst, the reactions happen

fast with even very small amount of starting material. This property offers a fast reaction condition

screening, even with automated systems connected. Changing the parameter sets and the catalyst from

the same starting material a variety of product can be synthesized easily. (Figure 2)

Figure 2: fast optimizing with easy catalyst and parameter changes. (Spare et al., Adv. Synth. Catal., 2018, 360(6), 2109-1217)

45

Other chemical examples

Complex screening with catalyst and parameter scope:

Cossar et al., Org. Biomol. Chem., 2015, 13, 7119-7130

Thorough catalyst screening with the same parameter set:

Catalyst A B C D

10% Pd/C 0 % 0 % 15 % 85 %

Pd Tetrakis 6 % 0 % 83 % 11 %

20% Pd(OH)2/C 0 % 0 % 31% 69 %

RuO2 0 % 0 % 42 % 58 %

Raney Nickel 40 % 15 % 45 % 0 %

5% Rh/C 66 % 3 % 0 % 31 %

5% Rh/Al2O3 42 % 2 % 0 % 56 %

5% Pt/C (Sulfided) 87 % 0 % 7 % 6 %

5% Re/C 100 % 0 % 0 % 0 %

Re2O7 100 % 0 % 0 % 0 %

0.5% Ir/C 100 % 0 % 0 % 0 %

Hizartzidis et al., RSC Adv., 2014, 4, 56743-56748

46

Commercially available

CatCarts® From ThalesNano

47

Ti, Quartz sand – Inert materials CAS No: 7440-32-6 (Ti)

7631-86-9 (SiO2)

Available sizes and specifications for Ti

Part No. Size Filling mass Particle size Void

Volume

Max. working

temp. Instrument

THS-01110 30x4 mm 190±5 mg 40-100 µm 65 µL 250 °C H-Cube Mini Plus™, H-Cube Pro™, PHX


THS-D1140 MidiCart 4130±20 mg 200-800 µm 2000 µL 150 °C H-Cube MIDI™, PHX

Available sizes and specifications for quartz sand


Volume

Max. working

temp. Instrument

THS-01049 microCC 210±5 mg 40-100 µm 20 µL 150 °C H-Cube Mini Plus™, H-Cube Pro™, PHX




This product is also available in Metal-Metal Sealed (MMS) cartridges made for PHX reactor in various sizes

(length and outer diameter data can be found at the CatCart® introduction page). The parameters and

physical data vary according to the chosen cartridge.

Inert materials have no catalytic effect on the reaction. However, when going with homogeneous catalysts

or catalyst free, the CatCart® provides excellent mixing in the reaction zone which gives better

performance on the reaction.

INER

T

48

Chemical examples

Spare et al., Adv. Synth. Catal., 2018, 360(6), 2109-1217

Vaddula et al., J. Flow Chem. 2015, 5(3), 172–177

INER

T

49

10% Pd/C – Palladium on charcoal CAS No: 7440-05-3

Available sizes and specifications


Volume

Max. working

temp. Instrument








Chemical examples

Ponomarev et al., Bioorganic Chemistry, Vol. 76, 2018, 392-399

Tsagris et al., Bioorganic & Medicinal Chemistry Letters, Vol. 28, 19, 2018, 3168-3173

PA

LLA

DIU

M

50

20% Pd(OH)2/C – Pearlman’s catalyst CAS No: 12135-22-7



Volume

Max. working

temp. Instrument








Chemical examples

Cloutier et al., Natural Products Reports, 2018, DOI: 10.1039/C8NP00046H

Nishimura et al., Journal of Medicinal Chemistry, 61, 2018, 5949−5962

PA

LLA

DIU

M

51

5% Pd/Al2O3 – Palladium on alumina CAS No: 7440-05-3



Volume

Max. working

temp. Instrument








Chemical examples

Gutmann et al., Eur. J. Org. Chem. 2017, 914–927

PA

LLA

DIU

M

52

10% Pd/CaCO3 – Palladium on calcium

carbonate CAS No: 7440-05-3



Volume

Max. working

temp. Instrument






Chemical examples

Spare et al., Adv. Synth. Catal., Vol. 360, (6), 2018, 1209-1217

PA

LLA

DIU

M

53

5% Pd/CaCO3– Palladium on calcium carbonate CAS No: 7440-05-3



Volume

Max. working

temp. Instrument






Chemical examples

According to our research, there are no literature including this kind of CatCart®. Be the first who publishes

an article about your work on this CatCart® and get discount for your next order.

For further information please look at page 40.

PA

LLA

DIU

M

54

5% Pd/BaCO3– Palladium on barium carbonate CAS No: 7440-05-3



Volume

Max. working

temp. Instrument






Chemical examples




PA

LLA

DIU

M

55

5% Pd/C (S) – Palladium on charcoal (sulfided) CAS No: 7440-05-3



Volume

Max. working

temp. Instrument







Chemical examples




P

ALL

AD

IUM

56




Volume

Max. working

temp. Instrument








Chemical examples

Garcia-Olmo et al., Catal. Sci. Technol., 2016, 6, 4705–4711

Feiz et al., Sci. Rep. 2016, 6, 32719

PA

LLA

DIU

M

57

5% Pd/CaCO3-Pb – Lindlar’s Catalyst CAS No: 7440-05-3



Volume

Max. working

temp. Instrument







Chemical examples

Moreno-Marrodan et al., Beilstein Journal of Organic Chemistry. 2017, 13, 734–754

Ötvös et al., ChemPlusChem, Vol. 83, 2, 2018, 72-76

PA

LLA

DIU

M

58

5% Pd/BaSO4 – Palladium on barium sulfate CAS No: 7440-05-3



Volume

Max. working

temp. Instrument








Chemical examples

Mándity et al., Chem. Rec. 2016, 16, 1018–1033

Ötvös et al., Molecules 2016, 21, 318

PA

LLA

DIU

M

59




Volume

Max. working

temp. Instrument








Chemical examples




P

ALL

AD

IUM

60




Volume

Max. working

temp. Instrument







Chemical examples

Spare et al., Adv. Synth. Catal., Vol. 360, (6), 2018, 1209-1217

Örkényi et al., Eur.J. Org. Chem. 2017,6525–6532

PA

LLA

DIU

M

61

Pd/C – ethylenediamine CAS No: 7440-05-3



Volume

Max. working

temp. Instrument







Chemical examples

Manikowski et al., Carbohydrate Research, 2012, 361, 155-161

PA

LLA

DIU

M

62

5% Pd/SiO2 – Palladium on silica CAS No: 7440-05-3



Volume

Max. working

temp. Instrument








Chemical examples




PA

LLA

DIU

M

63




Volume

Max. working

temp. Instrument







Chemical examples

Favia et al., J. Med. Chem. 2012, 55, 20, 8807-8826

PA

LLA

DIU

M

64

2% Pd/SrCO3– Palladium on strontium

carbonate CAS No: 7440-05-3



Volume

Max. working

temp. Instrument







Chemical examples




PA

LLA

DIU

M

65

PdO– Palladium oxide CAS No: 1314-08-5



Volume

Max. working

temp. Instrument








Chemical examples




P

ALL

AD

IUM

66

Pd Black – Palladium metal CAS No: 7440-05-3



Volume

Max. working

temp. Instrument








Chemical examples




PA

LLA

DIU

M

67

10% Pt/C – Platinum on charcoal CAS No: 7440-06-4



Volume

Max. working

temp. Instrument





This product is

Documents

CATALOGUE · 2020. 10. 26. · CATALOGUE ThalesNano î ì í9. 1 Table of contents ... Pricat™ Nickel ñ ñ/ ñP – Nickel catalyst on Diatomaceous earth _____ 81 Nickel Sponge