CARBUTEROL EQUATES WITH SALBUTAMOL IN BRONCHIAL ASTHMA

But its ~2 selectivity may have less effect on the cardiovascular systemIn a dou ble-blind crossover study . 27 bronchial as thma pat ients , with more than 20 % airway obst ruction fol lowingisop renaline( isoprote renol) inhalation , received the new ftl·adrene rgic bronchodi lator carbuterct . 3mg tid, 2rng tid, andsalbutamcl 4mg tid orally . Patients were given each dru g for 6 days. with an intervening I-da y wash-our period . ObjeaiYeIncrovenems in respira tory function we re significa nt on all 3 act ive regimens. but there were no significant differences betweenthem. Ca rbuterol 2rre showed sUbjective i rrorcverre m in 19 patients, a 3mg dose resulted in 21 patients impro\'ed, while 20patients i"",nwed on sa lbutaltDl 4mg. Ca rbuterol 3rng t id was prefer red by 11 oft he 27 patients . and only 6 pat ient s neededaddit iona l drugs. Salbuta rrol 4mg produced increases in heart rates an d blood pressure. which fell whe n pat ients crossed mer toboth dosa ge schedules ofca rbuterol (although the higher dose produced less of a decrea se). Neither drug exhibit ed any furthers ide effects on the ca rdiovascular system. and ot her effects were minor . consisting mainl y of tr emors with ca rbutero t 2~ andlmg ( 3 pat ients each) and restlessn ess wi th sa lbuta lOOl ( 3 patients).MISnI. N P, et al.: Journa l of l nlernatioroal Medical Research 9: 161( No 4. 19811

0 156·2703 / 8 1/08 21-0009 $OO,SOl o C ADIS Press lNPHARMA 22 Aug 1981 9