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Non-Invasive Pulse Monitor for Assessing Hypertension
PI: Dr. John K-J. Li
Junhyeok Choi, Samson Huang, Olivia Ko, Richard Shen, Hana Hamdi
Why Hypertension?
http://www.cdc.gov/bloodpressure/infographic.htm
http://www.cdc.gov/bloodpressure/infographic.htm
Medical CostsCost of
Cardiologist per visit
Catheterization
$350
$2,700
Problem: Terminal hypertension patients require invasive surgical procedures in order to accurately diagnose the cause of hypertension.
Need: A noninvasive pulse pressure device that enables health providers to monitor and diagnose the cause hypertension in the clinical setting.
Objective
Omron blood pressure monitor
Catheterization SphygmaCor J-Li Monitor
Price $2,700 (procedure) $17,000 ~$50
Diagnosis• Direct diagnoses
of the heart (i.e. BP, blood flow)
• Blood Press.• PWV• HRV
• Blood Pressure
• PWV• HRV
User-Friendly Specialized Cardiologist Expert Patient
Accuracy High High High
Size - Textbook Size Wireless Router Size
Current Technology
Current Technology
SphygmaCor
J-Li Monitor
Text book sized
Wireless router sized
Prototyping Using a tonometer
Pulse pressure waveforms Piezoelectric
transducer(MPX5010DP) Power source (~5V) Small $12.83 on Digi-key AirPositive
Pressure
Clean Signal
Diaph
GainFilter
Prototyping Building the device
Sensitivity Higher gain (1000x) Improve filtering (0.05-0.25hz) Diaphragm & Rubber tubing
Prototyping
DiaphramAir
Positive Pressure
4mm (inner)Gain & Filter
Prototyping
Arduino UNO
USB Cable
J-LI Monitor
Pulse Pressure Pulse waveform of a 25-year old
Dr. Ting Choon Meng (December 2009). Pulse Wave, CASP, and the BPro Device. Retrieved from https://www.youtube.com/watch?v=i3UQ7oTIlfQ.
Arterial Stiffness 47-year old
Stiff Fast
80-year old Even Stiffer Faster
Dr. Ting Choon Meng. ”47-year old pulse wave." Youtube. 11 December 2009. Photograph. 20 April 2014.
Dr. Ting Choon Meng. "80-year old pulse wave." Youtube. 11 December 2009. Photograph. 20 April 2014.
Application
• Pulse Transit Time• Arterial Compliance
• Carotid artery• Radial artery• ECG
• BIOPAC• BSL Analysis
BIOPACCollect Pulse
PressureExtract Data
Preliminary Results Valsalva Maneuver
Normal arterial pressure response during the Valsalva Maneuver Characterized by a sinusoidal pattern
Strain caused by slowly breathing out
mV
mV
Time (s)Start of Valsalva
Peak Detection
Calculating PTT
Preliminary Results Finding Pulse Transit Time (PTT)
ECG
ECG
Pulse Pressure(carotid artery)
Pulse Pressure(radial artery)
.165s
.270s
PTT = 0.105 s
mV
mV
mV
mV
Time (s)
Time (s)
Male Female Male (std) Female (std)SBP (mmHg) 126 124 117.8 ±9.2 110.8 ±8.7**DBP (mmHg) 82 82 79.1 ±7.6 74.3 ±7.7**Pulse Pressure(mmHg)
44 42 38.7 36.5
PTT (s) 0.103 0.90 0.117 ±0.024
0.103 ±0.031**
Compliance (mL/mmHg)SV = 75mL
1.85 1.88 2.0 (avg) 2.0 (avg)
Preliminary Results Sample Physiological Values
113 men and 153 women; age 18–78 years
Zhang et al [8]
Conclusion & Future Work Future Iterations
Housing PCB circuit board User-friendly interface Clinical trials
Hypertensive vs Normal Patients
Commercial Potential Routine screening Preventative treatment
Thank You!
Special thanks to our faculty mentor, Dr. Li Any Questions?
References1. Li, J. K-J. Dynamics of the Vascular System. World Scientific, 2004.
2. García, Manuel Ignacio Monge, Anselmo Gil Cano, and Juan Carlos Díaz Monrové. "Arterial Pressure Changes during the Valsalva Maneuver to Predict Fluid Responsiveness in Spontaneously Breathing Patients." Intensive Care Medicine 35.1 (2009): 77-84. Print.
3. Chemla, Denis, Jean-Louis Hébert, Catherine Coirault, Karen Zamani, Isabelle Suard, Patrice Colin, and Yves Lecarpentier. "Total Arterial Compliance Estimated by Stroke Volume-to-aortic Pulse Pressure Ratio in Humans." American Journal of Physiology-Heart and Circulatory Physiology 274 (1998): H500-505.
4. "Coronary CT Imaging Can Predict Need For Invasive Heart Catheterization." Coronary CT Imaging Can Predict Need For Invasive Heart Catheterization. Web. 25 Jan. 2014.
5. "Global Burden of Disease Profile: United States." Institute for Health Metrics and Evaluation. 2010. Web. 05 Mar. 2014.
6. "High Blood Pressure Facts." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, n.d. Web. 26 Feb. 2014.
7. Liu, Z. R., C. T. Ting, S. X. Zhu, and F. C. Yin. "Aortic Compliance in Human Hypertension." Hypertension 14.2 (1989): 129-36.
8. Zhang Y, Zheng Y, Ma Z, Sun Y. Radial pulse transit time is an index of arterial stiffness. Hypertension Research: Official Journal Of The Japanese Society Of Hypertension [serial online]. July 2011;34(7):884-887. Available from: MEDLINE, Ipswich, MA. Accessed April 16, 2014.