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Home </> > Comment </channels/comment.dtl> > BMJ 2001;323(7321):1136 (10November), doi:10.1136/bmj.323.7321.1136

------------------------------------------------------------------------/BMJ/ 2001;323:1136 ( 10 November )

  Reviews

/Press/

  Cannabis the *wonder* drug?

At a secret location in the home counties of England, 15 000 cannabisplants are being grown quite legally. They are being^ bred from strainswhose names---Hindu Kush, Skunk, Northern Lights,^ Gloria---are redolentof the Amsterdam coffee house scene. Their^ psychoactive seed heads,which stand over two metres high, are^ carefully studied---but never

smoked. For these plants are being^ cultivated as part of the world'sfirst commercial trial of medicinal^ cannabis.

The company behind the trial, GW Pharmaceuticals, based at Porton DownScience Park in Wiltshire, has had a rather good fortnight.^ Firstly,the home secretary, David Blunkett, announced on 23 October^ that thegovernment would liberalise the law concerning possession^ and use ofcannabis. He also indicated that he would be ready^ to license cannabisfor medicinal use to treat multiple sclerosis^ and other conditions assoon as research trials were completed.^ Most commentators (including,albeit grudgingly, the /Daily Mail/^ leader writers) seemed to approve.On 24 October shares in GW^ Pharmaceuticals jumped from 13p to^ 108p.

Secondly, the press this week hailed cannabis as a *wonder* drug and amiracle cure. Under the headline "Cannabis proves a medical^ miracle,"the /Observer/, a newspaper not normally known for its^ hype, reportedon 4 November that the first clinical trials of^ cannabis were showingthat it was "capable of transforming the^ lives of very sick^ people."

After decades of cannabis being condemned as one of the scourges ofWestern society, this all seemed a bit too good to be^ true. Were theseclaims going too far? What sort of evidence was^ available?

The source of the /Observer/'s story was the BBC 1 /Panorama/documentary "Cannabis from the chemist," broadcast on 4 November.^ Theprogramme looked at two separate trials---a pilot study (n=23)^ in East

Anglia of the effects of cannabis on the pain caused by^ nerve damage,and the early stages of a much larger trial in Oxford^ of the effects ofcannabis on people with multiple sclerosis.^ The programme did not makeclear the total number involved in^ the latter trial---its medicaldirector said in passing that he^ had initially seen 20 patients---andbased its conclusions on the^ experiences of Sandra, Tyrone, and Jo (n=3).

GW Pharmaceuticals is the only company in the United Kingdom that hasbeen given a licence to grow cannabis for medicinal^ use. /Panorama/'sjournalists were the only ones to have access^ to those taking part in

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the company's trials. Alex, who had a^ spinal injury, and Sandra,Tyrone, and Jo, who all had multiple^ sclerosis, received daily doses ofcannabis sprayed under the^ tongue. They all showed remarkable progress.Although none of^ them had expected to be cured, they all experiencedrelief from^ pain. Jo, the 58 year old wife of a school chaplain, hadstruggled^ to lift her legs before the trial but afterwards was able tolift^ them 25 times. She hailed the drug's effects as "miraculous,"^ andher husband said, "It's not a word that either of us would^ use^ lightly."

Dr Willy Notcutt of the East Anglian pilot study said, "The results sofar have exceeded what I dared hope for . . . we are^ seeing 80% of ourpatients getting good quality benefit from the^ cannabis." Some weregetting almost total pain relief, he said.^ "We have seen their painscores go down to zero."

</cgi/content/full/323/7321/1136/Fu1>*View larger version* (126K):[in this window] </cgi/content/full/323/7321/1136/Fu1>[in a new window] </cgi/content-nw/full/323/7321/1136/Fu1>  */Panorama /*reporter Steve Bradshaw amid legally grown cannabis

More dramatic claims were made by Professor Lester Grinspoon of HarvardMedical School, one of the world's leading proponents^ of medicinal

cannabis. Although not involved in the trials, Grinspoon^ claimed thatcannabis would "eventually be used by millions of^ people around theplanet." Just as penicillin "was considered^ the *wonder* drug of the1940s," he said, cannabis "will eventually^ be seen as the *wonder* drugof the 21st^ century."

On /Panorama/'s website (www.bbc.co.uk/panorama<http://www.bbc.co.uk/panorama>) the next day, Philip Robson, medicaldirector of the Oxford trials, expressed^ concern about newspaper"*wonder* drug" headlines. He said: "We^ have to keep this inperspective. This seems to be a medicine^ which is incredibly useful forpeople who haven't had very much^ luck with the standard medicines, andthat is really good, but^ I think to talk about *wonder* drugs and

miracle cures is way over^ the^ top."

But newspaper headline writers can hardly be blamed for their "*wonder*drug" approach to the story. /Panorama /had given them^ plenty to go on,concluding: "We could see the drug in the chemist^ in just two years."Admittedly, Grinspoon's wild optimism was^ balanced with words ofcaution from, among others, Susan Greenfield,^ professor of pharmacologyat Oxford University, who said: "The^ very term *wonder* drug is veryfrightening." And it would have^ been odd if /Panorama/ had not embracedthe opportunity to follow^ this historic experiment. But the result wasrather like a commercial^ for GW Pharmaceuticals, even though thecompany's name was never^ mentioned.

Footnotes

tjackson@bmj.com <mailto:tjackson@bmj.com>

*Trevor Jackson*.

/BMJ/

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*A miracle but no miracle drug*  William Notcutt  bmj.com, 10 Nov 2001 [Full text] </cgi/eletters/323/7321/1136#17417>

*CANNABINOID HYPEREMESIS OR" MARIJUANA MORNING SICKNESS"*  James H Allen  bmj.com, 17 Nov 2001 [Full text] </cgi/eletters/323/7321/1136#17481>*Drugs vs. Herbs*  Paul J. von Hartmann  bmj.com, 5 Feb 2005 [Full text] </cgi/eletters/323/7321/1136#95636>

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