Сборник научных тезисов и статей "Здоровье и образование в XXI Веке" №2, 2010г. (Т.12)

Материалы XI международного конгресса «Здоровье и образование в XXI веке» РУДН, Москва, 2010 Стр. [111]

CAN DIET INFLUENCE EPIGENETIC INHERITANCE? M.A. NIAZ, R.B. Singh, F. De Meestr, A. wilczynska,Wilson D.W., Hungin A.P.S., Halberg Hospital and Res Institute Moradabad, India; Tsim Tsoum Institute, Krakow, Poland, Durham University, Durham, UK It is well known that genotype manifests due to interaction of environment on genes resulting into phenotypes. These authors have discussed, for the last two decades, those environmental factors in general and nutrition in particular, could be important in the pathobiology of genetic variations and epigenetic inheritance, leading to emergence of chronic diseases of affluence. However, it is not yet clear if the increase in chronic diseases is due to epigenetic inheritance or development of a phenotypes such as proinflammatory cytokines and transcription factors, due to interaction of thrifty gene (developed during scarcity) with environmental factors; excess of fat, refined carbohydrates in the diet (Figure 2). It is possible that alteration in the methylation of genes can influence epigenetic inheritance. It has been proposed that dramatic adaptations can also occur, for instance in the form of major morphological changes which appear to be the cause of changes in structure from apes to man and various human races. It is not clear whether such adaptations may be responsible for the development of diseases or health or for development of man to humans.Phenotypic changes have been observed to occur rapidly in the last 100 years, among many species, although The Modern Synthesis emphasized that “ populations containing some level of genetic variations evolve via changes in gene frequency, induced mostly by natural selection. Evolutionary biology, biochemistry, genomics, developmental biology, systems biology and the impact of the environment on genes concerning mechanism of evolution have grown significantly. It is possible that some lineages have greater ‘evolvability’ than others, independent of how much baseline genetic variation is present. In this connection, heritable phenotype variations may depend on the biology and biochemistry of the genes as well as on their status of methylation and remethylation. Some populations have more genetic variations and greater susceptibility to environmental factors and enormous evolvability for adaptations than others. Therefore, they are expected to generate phenotypic variation more rapidly within a few generations. The influence of photosynthesis, flight and multicellularity can enhance the evolvability resulting into rapid inheritance. The ability to evolve at a different speed than other species needs some particular characteristics related to epigenetic inheritance which is being emphasised in the Tsim Tsoum Concept.

Correspondence: Dr MA NIAZ,PhD

Director, Center of Nutrition Research, Halberg Hospital and Res Institute Civil Lines, Moradabad,India, Email rbs@tsimtsoum.net tel in India:0591 2417437