Upload
hanhsoai
View
232
Download
0
Embed Size (px)
Citation preview
7/21/2019 Cac Loai Bom Tren Mang Te Bao
1/32
I HC THI NGUYNTRNG I HC KHOA HC
KHOA KHOA HC S SNG
CC LOI BM C TRN MNGSINH HC T BO
Ging vin: GS! TS L"#ng T$% H&ng '(n
N$)* +$,- $i.n: Ng/01n H23ng Lin$ Ng/01n B4-$ L25n '6n T$% M5i
Ng/01n T$% Min$
7/21/2019 Cac Loai Bom Tren Mang Te Bao
2/32
N7i 8/ng 92 -2 g&*
Bm ion Na+-K+ ATPase
Bm Ca2+ ATPase
Bm proton ATP synthase
7/21/2019 Cac Loai Bom Tren Mang Te Bao
3/32
I. Bm ion Na+ -K+ATPase
Bm Na + / K +-ATPasec pht hin bi nh
kha h!c"ens #h$istian%k& ' n(m )*, ti %%inh . h!c0 1i h!c
Aa$h&s0 1an 2ch3 N(m )**,0 4n5 c nh6n5i7i Nbe. 89a h!c3
;! L%-$ 5 ?@i A
7/21/2019 Cac Loai Bom Tren Mang Te Bao
4/32
2. :; t$c c?a bm
2.1 V tr T6p t$&n5 cc thnh ph@n mn5 nh mn5 t b th@n
kinh0 mn5 cc m40 cc c C&an nh 5an0 th6n0 c0 m4nD0 m4 cc t&En0333F
G3G #=& t$>c H mIt .i p$tein 5Jm n '; c=& thnh tet$ame$F .iLn
kt kiM& G-GO0 c9 khi .n5 phQn tR G,S Ka.
1n '; .Un * Ka.F c9 chVa mIt ph@n c9 chVc n(n5 c;nh ' th?E phQn ATP0 .iLn kt 'Ui in Na+0 mIt ph@n .iLnkt 'Ui K+ ' cc ch=t ste$i cWn5 tim
1n '; bX OS KaF . mIt 5.Ecp$tein0 bY t$ ht In5
c?a tiM& ph@n
7/21/2019 Cac Loai Bom Tren Mang Te Bao
5/32
24 hZnh bm Na+0K+ATPase
7/21/2019 Cac Loai Bom Tren Mang Te Bao
6/32
.(mBUc )[ :Ui s\ c9 m]t c?a in 25G+ bm tiM& ph@n D
5^n 'Ui ATPF s_ .iLn kt 'Ui ` in Na+ nm t$n5 t b ch=t3
BUc G[ ATPase c k
7/21/2019 Cac Loai Bom Tren Mang Te Bao
7/32
8t In5 c?a bm c id& khiMn bi mIt h thn5 phVc tp cccn Wn5 t$&Edn t
7/21/2019 Cac Loai Bom Tren Mang Te Bao
8/32
2.) Ch*! nn& !'a (m
8t In5 c?a bm Nat$i-Ka.i 5i>p 7m b7 s\ cQn bn5 5iaC& t$Znh fE ' h>t cc ch=t C&a mn50 5i ch p s&=t thfmth=& t$n5 t b Yn ;nh0 t b kh4n5 b; t$n5 ' cht3
1in th mn5 c t $a bi bm Na+-K+ATPase . c sch s\ gn t$&Edn th@n kinh ' ht In5 c3
%\ .i b Na+ $a khi t b bi bm Na+-K+ATPase cn5
c&n5 c=p .\c k
7/21/2019 Cac Loai Bom Tren Mang Te Bao
9/32
II. Bm Ca2+ ATPase )3 :; t$c c?a bm
)3) :; t$< Bm nE thWn5 5]p .Ui %l c?a t b c ' t$Ln mn5 c?a t
b hJn5 c@&3
Bm cani mn5 sinh ch=t n5 ) P2#A)F[ phQn b t$n5 cc m4' cc t b
Bm cani mn5 sinh ch=t n5 G P2#AGF[ .i nE c tZm th=Ech? E& h th@n kinh t$&n5 n50 cc m4 c C&an c9 chVc n(n5]c hi&3
Bm cani mn5 sinh ch=t n5 ` P2#A`F[ .i nE c tZm th=E'Ui mVc I ca nh=t t$n5 ' nD ' tiM& nD3
Bm cani mn5 sinh ch=t n5 P2#AF[ chim S thnh ph@n
bm cani mn5 sinh ch=t c?a hJn5 c@&3
7/21/2019 Cac Loai Bom Tren Mang Te Bao
10/32
7/21/2019 Cac Loai Bom Tren Mang Te Bao
11/32
G3G #=& t$>c c?a bm
-/ +>- -D5 9#* i2n -5nEi F"i -# +"#ng
Bm #aG+ ATPase .Ui c tn5 c9 hai ch&oi p.Epepti n'Ui khi .n5 ))S a0 5Jm hai tiM& n ';[
- TiM& n '; .Un t$!n5 .n5 5@n )SS3SSS a.tnF . tiM& n'; >c tc
- TiM& n '; nh kt hp 'Ui Wn5 5.EcsE.ateF 'gn cha $qchVc n(n53 TiM& n '; .Un . ch&oi po,ypeptit !h! !hn
7/21/2019 Cac Loai Bom Tren Mang Te Bao
12/32
7/21/2019 Cac Loai Bom Tren Mang Te Bao
13/32
2. #c n5 bm cani
Bm #aG+ ATPase mn5 sinh ch=t P2#AF fEcani $a khi t b3
Bm #aG+ ATPase .Ui nIi ch=t ' .Ui c tn5 c9chVc n(n5 c4 .6p cani t$n5 an5 c?a cc b C&annIi b3
Bm cani c?a cn Wn5 k
7/21/2019 Cac Loai Bom Tren Mang Te Bao
14/32
. o ng - 5 #*canx ctn! 8ai in cani tr ;ch b c?a t b c .iLn kt 'Ui cc '; t$< i
.\c ca c?a bm Jn5 thWi th?E phQn ATP M .=E n(n5 .n5
ch bm
BUc tip the . bm cani ' t$n5 an5
%a& 9 .iLn kt P- ATPase s_ c th& phQn ' bm C&aE 'dn5 ban @&
:anaat kZm ch s\ '6n ch&EMn in #a ' ht In5 c?aenEm ATPase
3 %\ kiMm st c?a ch& t$Znh ph7n Vn5 c 7m b7 bi s\ kt
c]p 5ia cc '; t$< .iLn kt cani 'Ui '; t$< phsph$E. h3
7/21/2019 Cac Loai Bom Tren Mang Te Bao
15/32
7/21/2019 Cac Loai Bom Tren Mang Te Bao
16/32
M7 J 8 9. $ F ) Fi ? 9 i
7/21/2019 Cac Loai Bom Tren Mang Te Bao
17/32
Bnh tiM& Wn5 .iLn C&an n %Al#A - un #aG+ . mIt E& t C&Et ;nh chVc n(n5 c?a t
b O 7 t&v3
- NJn5 I b=t thWn5 c?a in cani nIi b . mItthi& hwt ch&n5 t$n5 c7 hai tp bnh tiM& Wn53
- %\ t$a Yi in cani khc nha& cn5 D cn5hiLn cV& . 7nh hn5 tUi chVc n(n5 t b O
7 t&v0 C&a 9 7nh hn5 tUi c7 s\ tYn5 hp ins&.in3
! M7+
7/21/2019 Cac Loai Bom Tren Mang Te Bao
18/32
B.n$ H5iF0P H5iF0 v3 9.n$ Q5>i> Bnh 8ai.eE- 8ai.eE
- H mIt kiM& bnh It bin t$Ii thM nhixm s^c3- BnhnE 5QE $a bi s\ It bin t$Ln 5en ATPG#) . 5enmD h ch mIt bm in cani khc thWn53
7/21/2019 Cac Loai Bom Tren Mang Te Bao
19/32
7/21/2019 Cac Loai Bom Tren Mang Te Bao
20/32
Bnh /arier
- Bnh nE 5QE $a s\ kt
7/21/2019 Cac Loai Bom Tren Mang Te Bao
21/32
7/21/2019 Cac Loai Bom Tren Mang Te Bao
22/32
III. Bm p$tn ATP sEnthaseBm nE &i0i th!h c ch enEm c?a C& t$Znh tYn5 hp ATP
c hai nh bc h!c tZm $a
Pa&. 3 BEe$ "hn 3 za.ke$
7/21/2019 Cac Loai Bom Tren Mang Te Bao
23/32
1. V tr
1QE . enEme mn5 TZm th=E [
- 2n5 p.asma t b 'i kh&fn - 2n5 thE.aci c?a .wc .p
- 2n5 bLn t$n5 tE thM c?a t
b nhQn th6t
7/21/2019 Cac Loai Bom Tren Mang Te Bao
24/32
7/21/2019 Cac Loai Bom Tren Mang Te Bao
25/32
2. C=& t
yJm c9 hai ph@n {S ' {)| Ph@n @& {) . ph@n a nUc nh4 $a tr mn5 nm t$n5 c
ch=t0 chVa \n5 cc phQn tR >c tc0 th\c hin s\ tYn5 hp' th& phQn ATP3 Ba 5Jm ` ch&oi en k_ nha& ' cc
tiM& ph@n }3
| Ph@n 7i .m nhim 'w .iLn kt {) ' {3
| {S . mIt kLnh p$tn0 kX i ht I E c?a mn50 .thnh ph@n kv nUc nm t$Ln mn53 Th\c hin s\ '6nch&EMn p$tn3
7/21/2019 Cac Loai Bom Tren Mang Te Bao
26/32
7/21/2019 Cac Loai Bom Tren Mang Te Bao
27/32
M hnh lp ghp cc n v ca ATPsynthase
7/21/2019 Cac Loai Bom Tren Mang Te Bao
28/32
. C ch ht In5 c?a bm
1@& tiLn . c95$aien in 8E$| un 8E$
P$tns F
c '6nch&EMn 'd mItph
7/21/2019 Cac Loai Bom Tren Mang Te Bao
29/32
ATP sEnthase . bm p$tn .m 'icthe kiM& hai chid&
2 c=& t$>c[ 2 c=& t$>c
7/21/2019 Cac Loai Bom Tren Mang Te Bao
30/32
2 c=& t$>c[ATP c 5i7i
ph9n50 ch& t$Znhb^t @&
#=& t$>c
9n5[AP0 Pi .iLnkt ch]t0t
ATP
2 c=& t$>c
#=& t$>c
m0AP0 Pi.iLn ktE&
7/21/2019 Cac Loai Bom Tren Mang Te Bao
31/32
). ChVc n(n5 c?a bm
T $a ATP tr AP ' phtphat '4 c P iF
Q i n6ng F"ng + -$ vi.- 8/0 +>Z XH -D5 +i/ +$W 9[ng --$ 9#*i2n H v32 +i/ +$W
\ *3ng +$0F5]2i+ -D5 F- FKX 9#* +K2 *7+ g>58in+ ?i.n$)5 gi^5 $5i X$45 -D5 *3ng +$0F5]2i+
7/21/2019 Cac Loai Bom Tren Mang Te Bao
32/32