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27th June , 2014 Volume No.: 35 Issue No.: 01

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASED

LEARNING AND PRACTICE

Contents • Message from

PRINCIPAL• Editorial board• Historical article• News Update• Knowledge based Article• Disease Related

Breaking News• Upcoming Events• Drugs Update• Campus News• Student’s Section• Editor’s Note• Archive

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

Website: http://gnipst.ac.in

GNIPST Photo Gallery For your comments/contribution OR For Back-Issues, mailto:gnipstbulletin@gmail.com

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MESSAGE FROM PRINCIPAL

"It can happen. It does happen. But it can't happen if you quit." Lauren Dane. ‘We are what we repeatedly do. Excellence then is not an act, but a habit.’ Aristotle It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the last year’s editors and congratulate the newly selected editors for the current year. Our first consideration is always in the best interest of the students. Our goal is to promote academic excellence and continuous improvement. I believe that excellence in education is aided by creating a learning environment in which all learners are supported in maximizing their potential and talents. Education needs to focus on personalized learning and instruction, while promoting an education system that is impartial, universally accessible, and meeting the needs of all students. It is of paramount importance that our learners have sufficient motivation and encouragement in order to achieve their aims. We are all very proud of you, our students, and your accomplishments and look forward to watching as you put your mark on the profession in the years ahead. The call of the time is to progress, not merely to move ahead. Our progressive Management is looking forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in this direction and fruits of these efforts will be received by our students in the near future. Our Teachers are committed and dedicated for the development of the institution by imparting their knowledge and play the role of facilitator as well as role model to our students. The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic needs of our students. I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the opportunities and meet the challenges with purpose and determination. Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on this path. My best wishes to all. Dr. A. Sengupta

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTA EDITOR MS. JEENATARA BEGUM ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE History of Traditional Chinese Medicine The history of traditional Chinese medicine can be traced through archaeological excavations extending back millions of years.

Primitive people spent most of their time on basic survival: hunting, locating and preparing plants forfood, building shelters, and defending themselves. It's easy to imagine that over time, they'd have sampled most of the local plants in their search for food. In time, an oral record evolved that identified those plants that made good food, those that were useful for building, those that had an effect on illness, and those that were poisonous. Through trial and error, a primitive form of herbal medicine and dietary therapy was taking shape in China.

Fire also played a central role in their lives as a source of warmth, fuel, and light. As they huddled around fires, it was only natural that our ancestors would discover the healing powers of heat. Those powers would have been especially evident for cold, damp ailments such as arthritis, for which heat provides immediate relief. This was the origin of the art of moxibustion, the therapeutic application of heat to treat a wide variety of conditions.

These ancient people must have experienced a variety of injuries during their rugged lives. A natural reaction to pain is to rub or press on the affected area. This hands-on therapy gradually evolved into a system of therapeutic manipulation. People discovered that pressing on certain points on the body had wide-ranging effects. They began to use pieces of sharpened bone or stone to enhance the sensation, and acupuncture was born.

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As Chinese society developed a written history, documenting the powers of medicine moved from an oral to a written system.

NEWS UPDATE

International Day against Drug abuse and Illegal Trafficking: (26th June)

Illicit drugs threaten people’s health and welfare. Up to 200,000 people die every year due to illicit drugs; but drugs do not just affect the user, they cause tremendous hardship and misery to families and loved ones.

Drug use disorders undermine close relationships, damage home lives, including those of children, and can ruin education and employment opportunities. Their impact is felt in communities, criminal justice systems and across society.

UNODC’s theme for this year’s International Day Against Drug Abuse and Illicit Trafficking offers a message of hope: Drug use disorders are preventable and treatable.

'Nanosubmarine' designed that delivers complementary molecules inside cells: (25th June, 2014) Nanoparticles that under the right conditions, self-assemble -- trapping complementary guest molecules within their structure -- have been recently created by scientists. Like tiny submarines, these versatile nanocarriers can navigate in the watery environment surrounding cells and transport their guest molecules through the membrane of living cells to sequentially deliver their cargo.

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Vegetarian diets produce fewer greenhouse gases and increase longevity, say new studies: (25th June, 2014) Consuming a plant-based diet results in a more sustainable environment and reduces greenhouse gas emissions, while improving longevity, according to new research. Based on findings that identified food systems as a significant contributor to global warming, the study focuses on the dietary patterns of vegetarians, semi-vegetarians and non-vegetarians to quantify and compare greenhouse gas emissions, as well as assess total mortality.

Watching too much TV may increase risk of early death: Three hours a day linked to premature death from any cause: (25th June, 2014) Adults who watch TV three hours or more a day may double their risk of premature death from any cause. Researchers suggest adults should consider getting regular exercise, avoiding long sedentary periods and reducing TV viewing to one to two hours a day.

People with tinnitus process emotions differently from their peers, researchers report: (25th June, 2014) Patients with persistent ringing in the ears -- a condition known as tinnitus -- process emotions differently in the brain from those with normal hearing, researchers report. Tinnitus afflicts 50 million people in the United States, and causes those with the condition to hear noises that aren't really there. These phantom sounds are not speech, but rather whooshing noises, train whistles, cricket noises or whines. Their severity often varies day to day.

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Scientists unearth what may be secret weapon against antibiotic resistance: (25th June, 2014) A fungus living in the soils of Nova Scotia could offer new hope in the pressing battle against drug-resistant germs that kill tens of thousands of people every year, including one considered a serious global threat. Seeking an answer to the riddle of resistance in the natural environment is a far more promising approach than trying to discover new antibiotics, a challenge which has perplexed scientists for decades. No new classes of antibiotics have been discovered since the late 1980s, leaving physicians with very few tools to fight life-threatening infections.

Master regulator of key cancer gene found, offers new drug target: (25th June, 2014) A key cancer-causing gene, responsible for up to 20 percent of cancers, may have a weak spot in its armor, according to new research. The partnership of MYC, a gene long linked to cancer, and a non-coding RNA, PVT1, could be the key to understanding how MYC fuels cancer cells.

New material improves wound healing, keeps bacteria from sticking: (25th June, 2014) As many patients know, treating wounds has become far more sophisticated than sewing stitches and applying gauze, but dressings still have shortcomings. Now scientists are reporting the next step in the evolution of wound treatment with a material that leads to faster healing than existing commercial dressings and prevents potentially harmful bacteria from sticking.

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Virus infection supports organ acceptance: (26th June, 2014) Chronic hepatitis C virus infections are among the most common reasons for liver transplants. Because existing viruses also infect the new liver, the immune system is highly active there. Despite this, the new organ is not rejected, as scientists have now discovered. The long-term stimulation of the innate immune system by the virus actually increases the probability of tolerance.

Researchers find portable, low-cost optical imaging tool useful in concussion evaluation: (26th June, 2014) Two separate research projects, published recently, represent important steps toward demonstrating on patients the utility of portable, optical brain imaging for concussion and substantiating -- via a large-scale statistical analysis -- computerized neurocognitive testing for concussion.

For detail mail to editor

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KNOWLEDGE BASED ARTICLE HOW VACCINATION HAS BECOME THE PART OF

SOCIAL MARKETING

There is a disease to which the horse, from his state of domestication, is frequently subject. It is an inflammation and swelling in the heel, from which issues matter possessing properties of a very peculiar kind, which seems capable of generating a disease in the human body which bears so strong a resemblance to the smallpox.

In this dairy country a great number of cows are kept, and the office of milking is performed indiscriminately by men and maid servants. One of the former having been appointed to apply dressings to the heels of a horse affected with the grease, and not paying due attention to cleanliness, incautiously bears his part in milking the cows, with some particles of the infectious matter adhering to his fingers. When this is the case, it commonly happens that a disease is communicated to the cows, and from the cows to the dairymaids, which spreads through the farm until the most of the cattle and domestics feel its unpleasant consequences. This disease has obtained the name of the cow-pox. These pustules, unless a timely remedy is applied, frequently degenerate into ulcers, which prove extremely troublesome. The animals become indisposed, and the secretion of milk is much lessened.

Inflamed spots now begin to appear on different parts of the hands of the domestics employed in milking, and sometimes on the wrists,

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which quickly run on to suppuration. Most commonly they appear about the joints of the fingers and at their extremities; but whatever parts are affected, if the situation will admit, these superficial suppurations put on a circular form, with their edges more elevated than their centre, and of a colour distantly approaching to blue. Absorption takes place, and tumours appear in each axilla. The system becomes affected — the pulse is quickened; and shivering, succeeded by heat, with general lassitude and pains about the loins and limbs, with vomiting, come on. The head is painful, and the patient is now and then even affected with delirium. These symptoms, varying in their degrees of violence, generally continue from one day to three or four, leaving ulcerated sores about the hands, which, from the sensibility of the parts, are very troublesome, and commonly heal slowly, The lips, nostrils, eyelids, and other parts of the body are sometimes affected with sores; but these evidently arise from their being rubbed or scratched with the patient’s infected fingers. Thus the disease makes its progress from the horse to the nipple of the cow, and from the cow to the human subject, known as Small Pox.

Edward Jenner was an English country doctor in the late 1700s. In his practice, smallpox was one of the most common and worst problems he encountered. Smallpox at that time was greatly feared and was a major killer of the young. Jenner used keen observation skills and a lot of daring that wouldn’t be possible today to pave the way for all vaccinations. In the farm community where Jenner worked, a large majority of the farmers were cattle farmers. In 1788, an epidemic hit the small town of Gloucestershire where he practiced medicine and he noticed that the cattle farmers were not the ones dying from smallpox. The only treatment available at the time was to inoculate healthy people with the liquid from the pustules of people with mild cases of the disease. This worked sometimes, but often had fatal results. Jenner

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theorized that cowpox (a much milder but similar disease to smallpox) was somehow protecting the farmers. In 1796 he had the opportunity to prove his theory correct.

A young milkmaid named Sarah Nelmes came to see him about sores she had developed on her hands. He identified them as cowpox. He carefully extracted some liquid from the sores and set about proving that cowpox could protect against smallpox. His method would be illegal today but he bravely or foolishly (depending on your perspective) persevered. He approached a local farmer and asked if he could inoculate his son, James Phipps, with the cowpox. He explained that if he was correct, his son would never catch smallpox. Given the fear that surrounded smallpox, the farmer agreed. So, Dr. Jenner made two small cuts on the boy’s arm and poured in the cowpox and bandaged the arm. Soon, the boy was ill with cowpox, but not terribly ill and he made a complete recovery. Then Dr. Jenner really made a rash and dangerous move. He repeated his prior experiment but this time he used liquid he had extracted from a patient with a mild case of smallpox. If his theory was correct, the boy would not get sick, if he was wrong the patient could die and he would be a murderer. Everyone was thrilled when the boy did not get smallpox and Jenner had proved his theory. The remarkable thing about Jenner’s discovery of vaccination, is that it came before people knew that viruses existed, or much about the immune system. He used his observation of case studies to fit the puzzle pieces together and start a truly lifesaving procedure. His idea was met with widespread scepticism but he persisted in spite of the resistance he met. There was even a cartoon drawn making fun of his theory showing people developing cow parts after vaccination.

Thus Dr. Edward Jenner had made vaccination essential for each healthy human being but its’ universal acceptance and implementation (for the benefit of the society) was too tough on that time.

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As acceptance of his discoveries grew, Jenner was praised and feted by the British aristocracy and quickly became a celebrity in the cosmopolitan town of Cheltenham. In the first decades of the nineteenth century, the British Parliament awarded Jenner the equivalent of more than a million dollars in today’s currency, and Oxford, Cambridge, and Harvard Universities, as well as many scientific societies, bestowed honours on him.

As Jenner became a celebrated figure across Europe, “Jennerian inoculation” became the sine qua non for burgeoning national health programs. Kings and presidents seized upon mass-scale vaccination campaigns in an effort to demonstrate their forward-looking stance toward science and their commitment to the health of their citizenry. By 1800, for instance, 100,000 people had been vaccinated in Europe, and vaccination had begun in the United States, spearheaded by Harvard professor Benjamin Waterhouse and President Thomas Jefferson.

So in this way Dr. Edward Jenner had started social marketing by the means of vaccination for the benefit of the society.

Ms. Sanchari Bhattacharjee

Asst. Prof., GNIPST

DISEASE RELATED BREAKING NEWS Middle East respiratory syndrome coronavirus

(MERS-CoV): (26th June, 2014) On 19, 20, 22 and 23 June 2014, National IHR Focal Point of Saudi Arabia notified WHO of 4 additional laboratory-confirmed cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV). Globally, 707 laboratory-confirmed cases of infection with

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MERS-CoV, including at least 252 related deaths have officially been reported to WHO. Read more

UPCOMING EVENTS 5th International Conference on Stem Cells and Cancer 2014, JNU Convention Centre, New Delhi,India from 8-10 November 2014.

DRUGS UPDATES FDA Approves Sivextro (tedizolid phosphate) to

Treat Skin Infections: (20th June, 2014)

The U.S. Food and Drug Administration today approved Sivextro (tedizolid phosphate), a new antibacterial drug, to treat adults with skin infections. Sivextro is approved to treat patients with acute bacterial skin and skin structure infections (ABSSSI) caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcusspecies, and Enterococcus faecalis. Sivextro is available for intravenous and oral use.

Read more

CAMPUS NEWS

On 23rd June, 2014 the final year M.Pharm students presented their final seminar.

Reminiscence, 2014(GNIPST Reunion) was held in College campus on 2nd February,2014.

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1st Annual Sports of GNIPST was held on 3rd February,2014 in College campus ground.

An industrial tour and biodiversity tour was conducted in Sikkim for B.Pharm and B.Sc. students under the supervision of Mr. Asis Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

B.Pharm 3rd year won the GNIPST Football Champions trophy, 2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd year. Deep Chakraborty was the only scorer of the final.

Students of GNIPST organized pre puja celebration programme, ‘Saaranya’ on 7th October, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28th September, 2013 at Dakshineswar Kali Temple and Adyapith, Kolkata. On this remarkable event about hundred people have received garments. More than hundred students and most of the faculties participated on that day with lot of enthusiasm.

STUDENTS’ SECTION

WHO CAN ANSWER FIRST????

The name of which South American city literally translate to Fair Winds?

The MCA has renamed the KANDIVILI cricket

ground after which crickter?

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Answer of Previous Issue’s Questions:

A) The Battle of Nuremberg (also known as Massacre of Nuremberg) is the nickname of a football match played in Round 2 of the 2006 FIFA World Cup between Portugal & Netherlands at the Frankenstadion in Nuremberg on 25th June 2006

B) Tomato

Identify the person

Answer of Previous Issue’s Image: Johan Cruyff

Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for Students’ Section& answers of this Section at gnipstbulletin@gmail.com

EDITOR’S NOTE

It is a great pleasure for me to publish the 1st issue of 35th Volume of GNIPST BULLETIN. All the followers of GNIPST BULLETIN are able to avail the bulletin through facebook account ‘GNIPST bulletin’

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I am very much thankful to all the GNIPST members and readers who are giving their valuable comments, encouragements and supports.

I am also thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr. Soumya Bhattacharya for their kind co-operation and technical supports. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

ARCHIVE

GNIPST celebrated World Heart Day (29th September) and Pharmacist’s Day (25th September) on 25th and 26th September, 2013 in GNIPST Auditorium. A seminar on ‘Violence against woman’ and ‘female foeticide’ was held on GNIPST Auditorium on 25th September organized by JABALA Action Research Organization. On 26th September an intra-college Oral and Poster presentation competition related to World Pharmacist’s day and Heart day was held in GNIPST. Ms. Purbali Chakraborty of B.Pharm 4th year won the first prize in Oral Presentation. The winner of Poster presentation was the group of Ms. Utsa Sinha, Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year). A good number of students have participated in both the competition with their valuable views.

Teacher’s day was celebrated on 5th September, 2013 by the students of GNIPST in GNIPST Auditorium.

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Azalea (exotic flower ) , the fresher welcome programme for newcomers of GNIPST in the session 2013-14 was held on 8th August in GNIPST Auditorium.

One day seminar cum teachers’ development programme for school teachers on the theme of “Recent Trends of Life Sciences in Higher Education” organized by GNIPST held on 29th June, 2013 at GNIPST auditorium. The programme was inaugurated by Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit Sengupta, Director cum Principal of GNIPST with lamp lighting. The programme started with an opening song performed by the B.Pharm students of this institute. The seminar consists of a series of lectures, video presentations and poster session. On the pre lunch session 4 lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty respectively. On their presentation the speakers enlighten the recent development of Pharmacy, Genetics and Microbiology and their correlation with Life Sciences. On the post lunch session, Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the recent development and career opportunities in Biotechnology and Hospital Management. The programme was concluded with valedictory session and certificate distribution. About 50 Higher secondary school teachers from different schools of Kolkata and North& South 24 Parganas district of West Bengal participated in this programme. A good interactive session between participants and speakers was observed in the seminar. The seminar was a great success with the effort of faculties, staffs and students of our Institute. It was a unique discussion platform for school teachers and professional of the emerging and newer branches of Life Science.

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The general body meeting of APTI, Bengal Branch has been conducted at GNIPST on 15th June, 2012. The program started with a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for conducting the two years’ post graduate course (M.Pharm) in PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to 120.

AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below: a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. LopamudraDutta. c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d. Approved duration: 3 years

e. Title of the project: Screening and identification of potential medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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