B.Tech - BioTechnology - SATHYABAMA UNIVERSITYfiles.sathyabamauniversity.ac.in/syllabus/2010 UG... · A student shall be declared to be eligible for the award of the B.E/B.Tech. degree

SATHYABAMA UNIVERSITY(Established under section 3 of UGC Act, 1956)

Jeppiaar Nagar, Rajiv Gandhi Road, Chennai – 119.

SYLLABUSBACHELOR OF TECHNOLOGY PROGRAMME

INBIOTECHNOLOGY (8 SEMESTERS)

REGULATIONS 2010

SATHYABAMA UNIVERSITYREGULATIONS – 2010

Effective from the academic year 2010-2011 and applicable to the students admitted to the Degree of Bachelorof Engineering / Technology. (Eight Semesters)

1. Structure of Programme

1.1 Every Programme will have a curriculum with syllabi consisting of theory and practical such as:

(i) General core courses comprising Mathematics, Basic Sciences, Engineering Sciences.

(ii) Core course of Engineering / Technology.

(iii) Elective course for specialization in related fields.

(iv) Workshop practice, Computer Practice, Engineering Graphics, Laboratory Work, IndustrialTraining, Seminar Presentation, Project Work, Educational Tours, Camps etc.

1.2 Each semester curriculum shall normally have a blend of lecture courses not exceeding 7 andpractical courses not exceeding 4.

1.3 The medium of instruction, examinations and project report will be in English.

2. Duration of the Programme

A student is normally expected to complete the B.E/B.Tech. Programme in 8 semesters but in any case notmore than 12 consecutive semesters from the time of commencement of the course (not more than 10semesters for those who join 3rd semester under Lateral entry system) The Head of the Department shallensure that every teacher imparts instruction as per the number of hours specified in the syllabus and that theteacher teaches the full content of the specified syllabus for the course being taught.

3. Requirements for Completion of a Semester

A candidate who has fulfilled the following conditions shall be deemed to have satisfied the requirement forcompletion of a semester.

3.1 He/She secures not less than 90% of overall attendance in that semester.

3.2 Candidates who do not have the requisite attendance for the semester will not be permitted to writethe University Exams.

4. Examinations

The examinations shall normally be conducted between October and December during the odd semesters andbetween March and May in the even semesters. The maximum marks for each theory and practical course(including the project work and Viva Voce examination in the Eighth Semester) shall be 100 with the followingbreakup.

(i) Theory Courses

Internal Assessment : 20 Marks

University Exams : 80 Marks

(ii) Practical Courses

Internal Assessment : - -

University Exams : 100 Marks

SATHYABAMA UNIVERSITY FACULTY OF BIOENGINEERING

B.Tech. (BIOTECHNOLOGY) i REGULATIONS 2010

5. Passing requirements

(i) A candidate who secures not less than 50% of total marks prescribed for the course (For all coursesincluding Theory, Practicals and Project work) with a minimum of 35 marks out of 80 in the UniversityTheory Examinations, shall be declared to have passed in the Examination.

(ii) If a candidate fails to secure a Pass in a particular course, it is mandatory that he/she shall reappearfor the examination in that course during the next semester when examination is conducted in thatcourse. However the Internal Assessment marks obtained by the candidate in the first attempt shallbe retained and considered valid for all subsequent attempts.

6. Eligibility for the Award of Degree

A student shall be declared to be eligible for the award of the B.E/B.Tech. degree provided the student hassuccessfully completed the course requirements and has passed all the prescribed examinations in all the 8semesters within the maximum period specified in clause 2.

7. Award of Credits and Grades

All assessments of a course will be done on absolute marks basis. However, for the purpose of reporting theperformance of a candidate, Letter Grades will be awarded as per the range of total marks (out of 100) obtainedby the candidate as given below:

RANGE OF MARKS FOR GRADES

Range of Marks Grade Grade Points (GP)

90-100 A++ 10

80-89 A+ 9

70-79 B++ 8

60-69 B+ 7

50-59 C 6

00-49 F 0

ABSENT W 0

CUMULATIVE GRADE POINT AVERAGE CALCULATION

The CGPA calculation on a 10 scale basis is used to describe the overall performance of a student inall courses from first semester to the last semester. F and W grades will be excluded for calculatingGPA and CGPA.

CGPA = Σi Ci GPi

Σi Ci

where Ci - Credits for the subject

GPi - Grade Point for the subject

Σi - Sum of all subjects successfully cleared during all the semesters

8. Classification of the Degree Awarded

1. A candidate who qualifies for the award of the Degree having passed the examination in all thecourses of all the semesters in his/her first appearance within a maximum period of 8 consecutivesemesters after commencement of study (maximum of 6 semesters for Lateral entry system whojoin the course in the third semester) securing a CGPA not less than 9.0 shall be declared tohave passed the examination in First Class – Exemplary.


B.Tech. (BIOTECHNOLOGY) ii REGULATIONS 2010

2. A candidate who qualifies for the award of the Degree having passed the examination in all thecourses of all the semesters in his/her first appearance within a maximum period of 8 consecutivesemesters after commencement of study (maximum of 6 semesters for Lateral entry system whojoin the course in the third semester) securing a CGPA not less than 7.5 shall be declared tohave passed the examination in First Class with Distinction.

3. A candidate who qualifies for the award of the Degree having passed the examination in all thecourses of all the semesters within a maximum period of 8 consecutive semesters aftercommencement of study (maximum of 6 semesters for Lateral entry system who join the course inthe third semester) securing a CGPA not less than 6.0 shall be declared to have passed theexamination in First Class.

4. All other candidates who qualify for the award of the Degree having passed the examination in allthe courses of all the 8 semesters within a maximum period of 12 consecutive semesters (10consecutive semesters for Lateral Entry system who join the course in the third semester) afterhis/her commencement of study securing a CGPA not less than 5.0 shall be declared to havepassed the examination in Second Class.

5. A candidate who is absent in semester examination in a course/project work after having registeredfor the same, shall be considered to have appeared in that examination for the purpose ofclassification of degree. For all the above mentioned classification of Degree, the break of studyduring the programme, will be counted for the purpose of classification of degree.

6. A candidate can apply for revaluation of his/her semester examination answer paper in a theorycourse, within 1 week from the declaration of results, on payment of a prescribed fee along withprescribed application to the Controller of Examinations through the Head of Department. TheController of Examination will arrange for the revaluation and the result will be intimated to thecandidate concerned through the Head of the Department. Revaluation is not permitted for practicalcourses and for project work.

Final Degree is awarded based on the following:

CGPA ≥ 9.0 - First Class - Exemplary

CGPA ≥ 7.50 < 9.0 - First Class with Distinction

CGPA ≥ 6.00 < 7.50 - First Class

CGPA ≥ 5.00 < 6.00 - Second Class

Minimum CGPA requirements for award of Degree is 5.0 CGPA.

9. Discipline

Every student is required to observe disciplined and decorous behaviour both inside and outside the Universityand not to indulge in any activity which will tend to bring down the prestige of the University. If a studentindulges in malpractice in any of the University theory / practical examination, he/she shall be liable for punitiveaction as prescribed by the University from time to time.

10. Revision of Regulations and Curriculum

The University may revise, amend or change the regulations, scheme of examinations and syllabi from time totime, if found necessary.


B.Tech. (BIOTECHNOLOGY) iii REGULATIONS 2010

B.Tech - BIOTECHNOLOGY

REGULATIONS 2010 – CURRICULUM

SEMESTER I

Sl.No. SUBJECT CODE SUBJECT TITLE L T P C Page No.

1 SCHX1001 Environmental Science and Engineering 3 0 0 3 1

2 SMTX1003 Statistics 3 1 0 4 2

3 SPHX1001 Physics of Materials 3 0 0 3 3

4 SCYX1001 Engineering Chemistry 3 0 0 3 4

5 SCSX1002 Programming in C 3 0 0 3 5

6 SBTX1001 Cell Biology 3 0 0 3 6

7 SBTX1002 Basic Microbiology 3 0 0 3 7

PRACTICALS

1 SPHX4001 Physics Lab I 0 0 2 1 8

2 SCYX4001 Chemistry Lab I 0 0 2 1 8

3 SCSX4002 Programming in C Lab 0 0 4 2 8

TOTAL CREDITS 26

SEMESTER II


1 SCSX1001 English for Science and Technology 3 0 0 3 9

2 SMTX1004 Engineering Mathematics 3 1 0 4 10

3 SPHX1002 Applied Physics 3 0 0 3 11

4 SCYX1004 Applied Bio - Organic Chemistry 3 0 0 3 12

5 SBTX1003 Genetics 3 0 0 3 13

6 SBTX1004 Molecular Biology 3 0 0 3 14

7 SCSX1003 Programming in C++ 3 0 0 3 15

PRACTICALS

1 SPHX4002 Physics Lab II 0 0 2 1 16

2 SCYX4002 Chemistry Lab II 0 0 2 1 16

3 SCSX4017 Programming in ‘C++’ Lab 0 0 2 1 16

4 SBTX4001 Microbiology Lab 0 0 2 1 16

TOTAL CREDITS 26L - Lecture hours; T - Tutorial hours; P - Practical hours; C - Credits


B.Tech. (BIOTECHNOLOGY) iv REGULATIONS 2010

SEMESTER III


1 SBTX1006 Molecular Biotechnology 3 0 0 3 17

2 SBTX1007 Introduction to Immunology 3 0 0 3 18

3 SMTX1009 Engineering Mathematics-III 3 1 0 4 19

4 SBTX1008 Concepts in Biotechnology 3 0 0 3 20

5 SCHX1011 Introduction to Unit operations for processcalculations

3 0 0 3 21

6 SCHX1012 Chemical Reaction Engineering 3 0 0 3 22

7 SBTX1009 Bioenergetics 3 1 0 4 23

PRACTICALS

1 SBTX4002 Basic Biochemistry and Immunology Lab 0 0 4 2 24

2 SCHX4003 Chemical Reaction Engineering Lab 0 0 4 2 24

TOTAL CREDITS 27

SEMESTER IV


1 SMTX1010 Engineering Mathematics-IV 3 1 0 4 25

2 SBTX1010 Genetic Engineering 3 0 0 3 26

3 SBTX1011 Protein Engineering 3 0 0 3 27

4 SCHX1013 Enzyme Engineering 3 0 0 3 28

5 SCHX1014 Chemical Engineering Thermodynamics 3 1 0 4 29

6 SCHX1015 Bioprocess Instrumentation Dynamics andControl

3 0 0 3 30

PRACTICALS

1 SBTX4003 Enzymology Lab 0 0 4 2 31

2 SBTX4004 Molecular Biology Lab 0 0 4 2 31

TOTAL CREDITS 24


B.Tech. (BIOTECHNOLOGY) v REGULATIONS 2010

SEMESTER V


1 SMTX1013 Discrete Mathematics and Numerical Methods 3 1 0 4 32

2 SCHX1016 Bioseparation and Down Stream Processing 3 0 0 3 33

3 SBTX1013 Analytical Techniques 3 0 0 3 34

4 SBIX1028 Bioinformatics and Molecular BiologyDatabases

3 0 0 3 35

5 SCHX1017 Modeling and Transport phenomena forBioprocesses

3 1 0 4 36

6 SCHX1018 Design and Operation of Bioreactors 3 0 0 3 37

7 SBTX1014 Plant Biotechnology 3 0 0 3 38

PRACTICALS

1 SBTX4005 Bioprocess Engineering Lab-I (Fermentation) 0 0 4 2 43

2 SBIX4010 Bioinformatics Lab 0 0 4 2 43

TOTAL CREDITS 27

SEMESTER VI


1 SBTX1016 Medical Biotechnology 3 0 0 3 39

2 SCHX1019 Mass transfer for Biological systems 3 0 0 3 40

3 SBIX1029 Fundamentals of Genomics and Proteomics 3 0 0 3 41

4 SBTX1017 Animal Biotechnology 3 0 0 3 42

5 Elective-I 3 0 0 3

6 Elective-II 3 0 0 3

PRACTICALS

1 SBTX4006 Advance Molecular Biology Lab 0 0 4 2 43

2 SBTX4007 Animal Tissue Culture lab 0 0 4 2 43

TOTAL CREDITS 22


B.Tech. (BIOTECHNOLOGY) vi REGULATIONS 2010

SEMESTER VII

Sl.No. SUB CODE TITLE L T P C Page No.

1 SBTX1015 Nanobiotechnology 3 1 0 4 44

2 SBTX1018 Plant Cell and Tissue Culture 3 0 0 3 45

3 SBAX1001 Principles of Management & Professional Ethics 3 0 0 3 46

4 SBTX1012 Environmental Biotechnology 3 0 0 3 47

5 Elective-III 3 0 0 3

6 Elective-IV 3 0 0 3

PRACTICALS

1 SBTX4008 Bioprocess Engineering lab-2(Down Stream Processing Lab)

0 0 4 2 51

TOTAL CREDITS 21

SEMESTER VIII


1 SBIX1030 Molecular Modeling and Drug Designing 3 1 0 4 48

2 SBTX1019 Pharmaceutical Biotechnology 3 0 0 3 49

3 SBTX1020 Marine Biotechnology 3 0 0 3 50

PRACTICALS

1 SBTX4009 Plant Tissue Culture Lab 0 0 4 2 51

PROJECT

1 S23XPROJ Project work and Viva-Voce 0 0 30 15 51

TOTAL CREDITS 27

TOTAL CREDITS FOR THE COURSE: 200


B.Tech. (BIOTECHNOLOGY) vii REGULATIONS 2010

ELECTIVES

Note: ONE SUBJECT IS TO BE CHOSEN FROM EACH GROUP COMPULSORILY


Group I

1 SBTX1021 Neuroscience 3 0 0 3 52

2 SBTX1022 Cancer Biology 3 0 0 3 53

3 SBTX1023 Microbial Pathogenesis 3 0 0 3 54

Group II

4 SMEX1017 Resource Management and Techniques 3 0 0 3 55

5 SCHX1020 Heat and Fluid Dynamics 3 0 0 3 56

6 SCHX1021 Industrial Safety 3 0 0 3 57

Group III

7 SCHX1022 Food Biotechnology 3 0 0 3 58

8 SCHX1023 Food Biochemistry and Nutrition 3 0 0 3 59

9 SCHX1024 Food Processing and Preservation 3 0 0 3 60

Group IV

10 SBTX1024 Stem Cell Biology 3 0 0 3 61

11 SBTX1025 Tissue Engineering 3 0 0 3 62

12 SBTX1026 Metabolites and Mechanism 3 0 0 3 63

13 SBTX1027 Bioethics Biosafety and IPR 3 0 0 3 64


B.Tech. (BIOTECHNOLOGY) viii REGULATIONS 2010

DUAL DEGREE IN COMPUTER SCIENCE

Provision for candidates from Non-IT Branches of B.E/B.Tech to undergo Dual Degree Programme leading toB.E in Computer Science.

A. Duration and Curriculum

Candidates selected for a Dual degree programme shall undergo additional courses pertaining to ComputerScience. These courses constitute with additional Curriculum as per annexure and consist of both core courseand electives. The additional courses are to be undergone concurrently from the 3rd semester of the B.E/B.Tech.(Non-IT) degree programme and extends for one more year beyond the fourth year of the regular B.E/B.Tech.(Non-IT) degree programme to which he/she was first admitted. The additional courses are to be offered from3rd to 8th Semester after normal working hours so that the regular B.E/B.Tech. (NonIT) remains unaffected.

B. A candidate undergoing dual degree programme should satisfy minimum attendance requirements for the courseof additional Curriculum for each semester, as stipulated for the regular B.E/B.Tech. Degree Programme.

C. For the courses of additional Curriculum, a candidate has to write the same examination that is held for theregular B.E. Computer Science.

D. The passing rules for the dual degree programme shall be same as that of the regular B.E/B.Tech. Degreeprogramme.

E. A candidate shall be declared to be eligible for the additional degree of B.E. Computer Science provided that

(i) The candidate has qualified for the regular B.E. or B.Tech. Degree in the non-IT branch in whichhe/she was originally admitted.

(ii) The candidate has successfully completed all the courses prescribed in the additional Curriculumwithin a maximum period of 12 semesters from the date of first admission.

(iii) There is no disciplinary action pending against the student.


B.Tech. (BIOTECHNOLOGY) ix REGULATIONS 2010

CURRICULUM

SUBJECTS FOR DUAL DEGREE PROGRAMME IN COMPUTER SCIENCE

THIRD SEMESTER

Sl.No. SUBJECT CODE NAME OF THE SUBJECT L T P C

THEORY

1 SCSX1004 Software Engineering 3 0 0 3

2 SCSX1005 Data Structures & Algorithms 3 1 0 4

PRACTICALS

3 SCSX4004 Data Structures Lab 0 0 4 2

TOTAL CREDITS 9

FOURTH SEMESTER

THEORY

1 SCSX1007 Java Programming 3 0 0 3

2 SCSX1009 Computer Architecture & Organization 3 0 0 3

PRACTICALS

3 SCSX4005 Java Programming Lab 0 0 4 2

TOTAL CREDITS 8

FIFTH SEMESTER

THEORY

1 SCSX1017 Data Communication and ComputerNetworks

3 1 0 4

2 SCSX1018 Database Systems 3 1 0 4

PRACTICALS

3 SCSX4011 RDBMS Lab 0 0 4 2

TOTAL CREDITS 10

SIXTH SEMESTER

THEORY

1 SCSX1019 System Programming 3 0 0 3

2 SCSX1022 J2EE 3 0 0 3

PRACTICALS

3 SCSX4010 System Programming Lab 0 0 4 2

TOTAL CREDITS 8


B.Tech. (BIOTECHNOLOGY) x REGULATIONS 2010

SEVENTH SEMESTER

THEORY

1 SCSX1008 C# and .Net 0 0 0 3

2 SCSX1011 Operating System 3 1 0 4

PRACTICALS

3 SCSX4006 C# and .Net Lab 0 0 4 2

TOTAL CREDITS 9

EIGHTH SEMESTER

THEORY

1 SCSX1024 Network Programming & Management 3 0 0 3

2 Elective I 3 0 0 3

3 Elective II 3 0 0 3

PRACTICALS

4 SCSX4012 Network Programming Lab 0 0 4 2

TOTAL CREDITS 11

NINETH SEMESTER

THEORY

1 SCSX1023 Computer Graphics & MultimediaSystems

3 0 0 3

2 SCSX1030 Datamining & Warehousing 3 0 0 3

3 SCSX1025 Wireless & Mobile Networks 3 0 0 3

4 SCSX1027 Hardware Peripherals and Interfacing 3 0 0 3

5 Elective III 3 0 0 3

6 Elective IV 3 0 0 3

PRACTICALS

7 SCSX4014 Hardware Peripherals Lab 0 0 4 2

8 SCSX4015 Case Tools & Testing Lab 0 0 4 2

TOTAL CREDITS 22

TENTH SEMESTER

1 S11XPROJ Project Work and Viva-Voce 0 0 30 15

TOTAL CREDITS 15

TOTAL COURSE CREDITS : 92


B.Tech. (BIOTECHNOLOGY) xi REGULATIONS 2010

ELECTIVES FOR DUAL DEGREE PROGRAMME IN COMPUTER SCIENCE

Sl.No. SUBJECT CODE NAME OF THE SUBJECT L T P C

1. SCSX1020 Component Based Technology 3 0 0 3

2. SCSX1026 Cryptography & Network Security 3 0 0 3

3. SCSX1028 Distributed Computing 3 0 0 3

4. SCSX1032 Management Information System 3 0 0 3

5. SCSX1036 FOSS 3 0 0 3

6. SCSX1038 Software Quality Assurance and Testing 3 0 0 3

7. SCSX1039 Unified Modeling Language 3 0 0 3

8. SCSX1042 Robotics 3 0 0 3

9. SCSX1043 Unix Internals 3 0 0 3

10. SCSX1044 Multicore Programming 3 0 0 3

11. SCSX1047 High Performance Network 3 0 0 3

12. SCSX1048 Grid Computing 3 0 0 3

13. SCSX1049 Client Server Architecture 3 0 0 3

14. SCSX1050 TCP/IP and Socket Programming 3 0 0 3

15. SCSX1057 Cloud Computing 3 0 0 3


B.Tech. (BIOTECHNOLOGY) xii REGULATIONS 2010

SCHX1001ENVIRONMENTAL SCIENCE AND ENGINEERING

(Common to All Branches)

L T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO ENVIRONMENTAL STUDIES AND NATURAL RESOURCES 12 hrs.

Definition, scope and importance - need for public awareness - forest resources: use and over-exploitation,deforestation, case studies. Timber extraction, mining, dams, floods, drought, conflicts over water, dams-benefits andproblems - mineral resources: use effects on forests and tribal people - water resources: use and over-utilization ofsurface and ground water - exploitation, environmental effects of extracting and using mineral resources, case studies- food resources: world food problems, changes caused by agriculture and overgrazing, effects of modern agriculture,fertilizer-pesticide problems, water logging, salinity, case studies - energy resources: growing energy needs, renewableand non renewable energy sources, use of alternate energy sources. Case studies - land resources: land as a resource,land degradation, man induced landslides, soil erosion and desertification - role of an individual in conservation ofnatural resources - equitable use of resources for sustainable lifestyles. UNIT II ECOSYSTEMS AND BIODIVERSITY 12 hrs.

Concept of an ecosystem - structure and function of an ecosystem - producers, consumers and decomposers- energy flow in the ecosystem - ecological succession - food chains, food webs and ecological pyramids - introduction,types, characteristic features, structure and function of the (a) forest ecosystem (b) grassland ecosystem (c) desertecosystem (d) aquatic ecosystems (ponds, streams, lakes, rivers, oceans, estuaries) - introduction to biodiversity -definition: genetic, species and ecosystem diversity - biogeographical classification of India - value of biodiversity:consumptive use, productive use, social, ethical, aesthetic and option values - biodiversity at global, national and locallevels - India as a mega-diversity nation - hot-spots of biodiversity - threats to biodiversity: habitat loss, poaching ofwildlife, man-wildlife conflicts - endangered and endemic species of India - conservation of biodiversity: in-situ andex-situ conservation of biodiversity.UNIT III ENVIRONMENTAL POLLUTION 10 hrs.

Definition - causes, effects and control measures of: (a) air pollution (b) water pollution (c) soil pollution (d)marine pollution (e) noise pollution (f) thermal pollution (g) nuclear hazards - solid waste management: causes, effectsand control measures of urban and industrial wastes - role of an individual in prevention of pollution - pollution casestudies - disaster management: floods, earthquake, cyclone and landslides.UNIT IV SOCIAL ISSUES AND THE ENVIRONMENT 8 hrs.

From unsustainable to sustainable development - urban problems related to energy - water conservation, rainwater harvesting, watershed management - resettlement and rehabilitation of people; its problems and concerns, casestudies - environmental ethics: issues and possible solutions - climate change, global warming, acid rain, ozone layerdepletion, nuclear accidents and holocaust, case studies. - wasteland reclamation - consumerism and waste products- environment protection act - air (prevention and control of pollution) act - water (prevention and control of pollution)act - wildlife protection act - forest conservation act - issues involved in enforcement of environmental legislation -public awareness.UNIT V HUMAN POPULATION AND THE ENVIRONMENT 8 hrs.

Population growth, variation among nations - population explosion - family welfare programme - environmentand human health - human rights - value education - HIV / AIDS - women and child welfare - role of informationtechnology in environment and human health - case studies.

Visit to a local area to document environmental assets-river/forest/grassland/hill/mountain. Visit to a local pollutedsite-urban/rural/ industrial/agricultural-study of common plants, insects, birds-study of simple ecosystems-pond, river, hillslopes etc.REFERENCES:1. Meenakshi.P, Elements of Environmental Science and Engineering, 1st edition, PHI New Delhi, 2009.2. Ravikrishnan. A, Environmental Science & Engineering, 3rdedition, Sri Krishna Publications, Chennai.3. Wrigh.R.T & Nebel B.J, Environmental science-towards a sustainable future by Richard 8th edition, prentice hall of India, Newdelhi4. Erach Bharucha, Text Book of Environmental Studies, University Press, Chennai.5. Anjanayelu.Y, Introduction to Environmental Engineering, B.S.Publications.

UNIVERSITY EXAM QUESTION PAPER PATTERN:Max. Marks: 80 Exam Duration: 3 hrs.

PART A : 2 Questions from each unit, each carrying 2 marks 20 marks

PART B : 2 Questions from each unit with internal choice, each carrying 12 marks 60 marks


B.Tech. (BIOTECHNOLOGY) 1 REGULATIONS 2010

SMTX1003STATISTICS

(Common to BIOGROUPS)


3 1 0 4 100

UNIT I BASIC STATISTICS 10 hrs.

Measures of central tendency: Mean, Median, Mode, Harmonic mean, Geometric mean- Measures of dispersion:Range, Mean deviation, Quartile deviation and Standard deviation- coefficients of variation, Skewness and Kurtosis.

UNIT II CORRELATION AND REGRESSION 10 hrs.

Karl Pearson’s Correlation coefficient, Spearman’s Rank correlation coefficient, Tied ranks- Linear RegressionAnalysis - Multiple and Partial Correlation - Multiple Linear Regression (Three variables) Problems only.

UNIT III INTRODUCTION TO PROBABILITY 10 hrs.

Definitions, sample space, events, Addition Law of probability, Multiplication law- conditional probability- Bayestheorem (without proof)

UNIT IV ONE DIMENSIONAL RANDOM VARIABLES 10 hrs.

Definition of a random variable- Discrete and continuous random variables, Probability Mass function, ProbabilityDensity Function, Cumulative Distribution Function- Mathematical expectation - Mean and Variance applications only.

UNIT V BASIC THEORETICAL DISTRIBUTIONS 10 hrs.

Binomial Distribution, Poisson Distribution and Normal Distribution, Mean and Variance (applications only)

REFERENCES:

1. Irivin Miller and John E Freund, Probability and Statistics for Engineers, Prentice Hall , 1977. 2. Veerarajan T, Probability, Statistics and Random Process, 4th edition, Tata Mcgraw Hill, 2008 3. Murray R. Spiegel, Schaum’s Outline of Theory and Problems of Probability and Statistics, Mcgraw-Hill,1975. 4. Ronald E. Walpole, Raymond H. Myers, Sharon L. Myers, Keying Ye , Probability & Statistics for Engineers & Scientists,8th

Edition, Prentice Hall, 2006 5. Stephen Bernstein, Schaum’s Outline of Elements of Statistics I: Descriptive Statistics and Probability, McGraw-Hill,1998.

UNIVERSITY EXAM QUESTION PAPER PATTERN

Max Marks : 80 Exam Duration : 3 hrs





SPHX1001PHYSICS OF MATERIALS

(Common to all Branches of B.E / B.Tech)


3 0 0 3 100

UNIT I CONDUCTING AND SUPERCONDUCTING MATERIALS 10 hrs.Classical Free electron theory of Metals-Derivation of Electrical and Thermal Conductivity- Deduction of

Wiedemann Franz law-Lorentz number. Introduction to Band theory, Difference between Conductors, Semiconductorsand Insulators - Superconductivity-Transition temperature - occurrence of superconductivity - BCS Theory(Qualitative),properties of superconductors -Type I &Type II superconductors, High Tc superconductors, AC & DC Josephson effects.Applications of superconductors – basic concepts of SQUID, cryotron, magnetic levitation.UNIT II MAGNETIC AND DIELECTRIC MATERIALS 10 hrs.

Types based on spin. Hard and soft magnetic materials, domain theory of Ferromagnetism, magnetic bubbles,formation and propagation of magnetic bubbles, applications of magnetic materials - Magnetic storage devices. Dielectricparameters, polarization, polarisability, types of polarization. Internal or local electric field - derivation of Lorentz Equationand Clausius - Mossotti Equation, dielectric loss and breakdown, types of dielectric breakdown, types of dielectricmaterials, applications.UNIT III OPTICAL MATERIALS 10 hrs.

Optical processes and Excitons - types, Traps - Trapping and recombination, types, Point defects –Frenkel andSchottky defects - Colour centers - types and their mechanisms, Luminescence - Photoluminescence - Types-Fluorescence and Phosphorescence- Mechanism and its applications, Cathodoluminescence, Electroluminescence.Non-linear Optical Materials – Basic Principle, Classifications, Properties - Frequency Doubling or Tripling, Optical Mixing- Applications.UNIT IV MODERN ENGINEERING MATERIALS 10 hrs.

Metals and alloys – steel and its properties - Iron-carbon phase diagram, Titanium and Aluminium based alloys- Introduction, properties and Applications. Shape Memory Alloys (SMA) - Principle of shape memory effects, Hysteresiscurve, Two way shape memory alloys, super-elasticity and thermo-mechanical behavior. Characterization methods toidentify the phase transformation of SMA, commercial SMA – Ni-Ti alloys, copper alloys and Cu-Al alloys, Applications.Ceramics – Classification, Properties, fabrication, advanced ceramics and applications. Composites – particle reinforcedcomposites and fiber reinforced composites – processing and applications.UNIT V CHARACTERIZATION OF MATERIALS 10 hrs.

Structural characterization – X-ray diffraction, electron diffraction and neutron diffraction – Determination of crystalstructure. Difference among these diffraction techniques.Micro structural characterization – optical microscope, scanningelectron microscope, transmission electron microscope, atomic force microscopy, micro and nano hardness testing –principle and applications.REFERENCES: 1. Ragavan.V, Material science and Engineerimg, 5th Edition, Eastern Eco, 2004. 2. Suresh.R and Jayakumar.V, Materials Science, 1st Edition, Lakshmi Publication, 2003. 3. Wilson.J and Hawkes.J.F.B, Optoelectronics- An Introduction, 2nd Edition, Prentice-Hall of India, 2001. 4. Dr.Arumugam M., Semiconductor Physics and Opto electronics, 1st Edition, Anuradha Publishers, 2003. 5. Gaur.R.K and Gupta.S.L, Engineering Physics, 8th Edition, Dhanbat Rai Publications,2007. 6. Palanisamy.P.K, Engineering Physics, 1st Edition, SCITECH Publications, 2007. 7. Sankar.B.N and Pillai.S.O, A text book of Engineering Physics, 1st Edition, New Age international Publishers, 2007. 8. Rajendran.V, Engineering Physics, 2nd Edition, Tata McGraw-Hill, 2008. 9. Avadhanulu.M.N and P.G. Kshirsagar.P.G, Engineering Physics, 2nd Edition, S. Chand & Company, 2007.10. Dr. Arumugam M., Engineering Physics, 2nd Edition, Anuradha Publications, 2002.11. William D.Callister,Jr, Materials Science and Engineering An introduction, 6th Edition, John-Wiley and Sons,2004.12. Cullity.B.D, Principles of X-ray diffraction, 3rd Edition, Prentice Hall, 2001

UNIVERSITY EXAM QUESTION PAPER PATTERNMax. Marks: 80 Exam Duration: 3 hrs.PART A : 2 Questions from each unit, each carrying 2 marks Out of 20 marks, maximum of 10% problems may be asked. 20 marksPART B : 2 Questions from each unit with internal choice, each carrying 12 marks 60 marks Out of 60 marks, maximum of 10% problems may be asked 60 marks ‘Applications’ mentioned in the syllabus refer to the basic applications and not to any specific case.



SCYX1001ENGINEERING CHEMISTRY



3 0 0 3 100

UNIT I WATER TECHNOLOGY 10 hrs.Introduction: Impurities present in water, Hardness: Types of hardness, Expression, Units. Estimation of hardness

by EDTA method, Problems. Boiler Troubles: Sludge & Scales, Boiler Corrosion. Water Softening: Zeolite process,Demineralization process, Merits and Demerits. Reverse osmosis, Merits and Demerits. Domestic water treatment: Flowchart diagram only.

UNIT II BATTERIES AND FUEL CELLS 10 hrs.Introduction - Battery terminology: Primary cells, Secondary batteries, Charging and Discharging characteristics,

Capacity, Energy density, Cycle life, Internal resistance. Secondary batteries: Lead-acid accumulator, Nickel-cadmiumbatteries , Lithium primary cells: Lithium-thionyl chloride cell, Lithium-iodine cell. Lithium secondary batteries: Lithium-ionbatteries. Fuel cells: Hydrogen-Oxygen fuel cell, Solid oxide fuel cell (SOFC): Principle, construction, anode cathodeand electrolyte. Proton Exchange Membrane Fuel Cell.

UNIT III CORROSION SCIENCE 10 hrs.Introduction - Electrochemical cell representation. Electrochemical series: Significance. Galvanic series.

Corrosion: Definition of corrosion, Dry corrosion: Mechanism of Dry corrosion, Pilling-Bedworth rule, Wet Corrosion:Mechanism. Types of corrosion: Galvanic corrosion, Differential aeration corrosion, Pitting corrosion, Microbial Corrosion.Factors influencing corrosion: Nature of the metal, nature of the environment. Corrosion control: Material selection andDesign, Cathodic protection. Corrosion inhibitors: Anodic, cathodic and Vapour phase inhibitors.

UNIT IV EXPLOSIVES AND ROCKET PROPELLANTS 10 hrs.Introduction - Explosives: Requirements, Classification of Explosives: Low explosives, primary explosives and

high explosives. Assessment of explosives.

Rocket engines: Types of rocket engines. Basic principle, Mass fraction, Specific impulse, Thrust, Effective exhaustvelocity, Specific propellant consumption. Chemical propellants: Requirements, Classification: Liquid fuels, Liquidoxidizers, Solid fuels, Solid oxidizers.

UNIT V SURFACE CHEMISTRY 10 hrs.Introduction. Adsorption: Types, Adsorption of gases on solids, Adsorption of solutes from solution. Adsorption

isotherms: Freundlich adsorption isotherm, Langmuir adsorption isotherm. Industrial adsorbent materials: Role ofadsorbents in catalysis and water softening. Emulsion: Types: water/oil, oil/water. Applications of adsorption: Cottrell’sprecipitator, Coating of rubber on metals, Electrostatic painting.

REFERENCES: 1. Jain P.C. and Monica Jain,Engineering Chemistry, 15th Edition Dhanpat Rai Publishing Co. 2009 2. Dara S.S., Text Book of Engineering Chemistry, S.Chand & Co, 2008 3. Sheik Mideen A., Engineering Chemistry (I & II),13th Edition, Shruthi Publishers, 2010 4. Parameswara Murthy C, Agarwal C V, Andra Naidu, Textbook of Engineering Chemistry, B S Publications, 2006 5. Kuriakose J.C. and Rajaram J., Chemistry in Engineering and Technology",. Vol.1 & 2, 5th reprint, Tata McGraw Hill Publishing

Company (P) Ltd., 2010. 6. Sharma B.K., Engineering Chemistry, 2nd Edition, Krishna Prakasam Media (P) Ltd., 2001 7. Puri Br, Sharma Lr, Madhan S Pathania, Principles of Physical Chemistry, 41st Edition, Vishal Publishing Co., 2004 8. Mars G Fontana, Corrosion Engineering, 3rd Edition, Tata McGraw Hill, 2008 9. David Linden, Thomas B Reddy, Handbook of Batteries, 4th Edition, McGraw-Hill, 201010. George Paul Sutton, Oscar Biblarz, Rocket Propulsion Elements, 8th Edition, John Wiley & Sons, 2010

UNIVERSITY EXAM QUESTION PAPER PATTERN:Max. Marks: 80 Exam Duration: 3 hrs


PART B : 2 Questions from each unit with internal choice, each carrying 12 marks 60 marks One problem for 5 marks may be asked in Unit 1 - Water Technology



SCSX1002PROGRAMMING IN C

(Common to all Branches of B.E / B.Tech.)


3 0 0 3 100

UNIT I 10 hrs.Introduction: Algorithms & flowcharts-Overview of C-Features of C-IDE of C Structure of C program-Compilation

& execution of C program-Identifiers, variables, expression, keywords, data types, constants, scope and life of variables,local and global variables. Operators: arithmetic, logical, relational, conditional and bitwise operators- Special operators:size of () & comma (,) operator-Precedence and associativity of operators & Type conversion in expressions.

Basic input/output and library functions: Single character input/output i.e. getch(), getchar(), getche() &putchar()-Formatted input/output: printf() and scanf()-Library Functions: concepts, mathematical and character functions.

UNIT II 10 hrs.Control structures: Conditional control-Loop control and Unconditional control structures.

Functions: The Need of a function-User defined and library function- Prototype of a function-Calling of afunction-Function argument-Passing arguments to function- Return values-Nesting of function- main()-Command linearguments and recursion. Storage class specifier – auto, extern, static, & register.

UNIT III 10 hrs.Arrays: Single and multidimensional arrays-Array declaration and initialization of arrays-Array as function

arguments.

Strings: Declaration-Initialization and string handling functions.

Structure and Union: Defining structure-Declaration of structure variable-Accessing structure members-Nestedstructures-Array of structures-Structure assignment-Structure as function argument-Function that returns structure- Union.

UNIT IV 10 hrs.Pointers: The ‘&’ and ‘* ’ operators-Pointers expressions-Pointers vs arrays-Pointer to functions-Function returning

pointers-Static and dynamic memory allocation in C.

DMA functions: malloc(), calloc(), sizeof(), free() and realloc()-Preprocessor directives.

UNIT V 10 hrs.File management: Defining, opening & closing a file, text file and binary file- Functions for file handling: fopen,

fclose, gets, puts,fprint, fscanf, getw, putw, fputs, fgets, fread, fwrite-Random access to files: fseek, ftell, rewind-Filename as Command Line Argument.

Graphics in PC-Initialize Graphics Mode-Functions used In Graphics - Drawing a Point on the Screen-Drawinglines, rectangles, ovals, circles, arcs, polygon, filling colors-Using Text in Graphics Display.

REFERENCES: 1. Balaguruswami.E, ‘Programming in C’, TMH Publications,1997 2. Behrouz A. Forouzan & Richard F. Gilberg, “Computer Science A Structured Programming using C”, Cengage Learning, 3rd Edition, 2007 3. Gottfried , ‘Programming with C’, schaums outline series, TMH publications,1997 4. Mahapatra , ‘Thinking in C’, PHI publications, 2nd Edition. 5. Stevens , ‘Graphics programming in C’, BPB publication,2006 6. Subbura.R , ‘Programming in C’, Vikas publishing, 1st Edition, 2000


Max Marks : 80 Exam Duration : 3 hrs.PART A : 2 Questions from each unit, each carrying 2 marks 20 marksPART B : 2 Questions from each unit with internal choice, each carrying 12 marks 60 marks



SBTX1001 CELL BIOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I CELL STRUCTURE AND FUNCTION OF THE ORGANELLES 10 hrs.

Structure and function of Eukaryotic and prokaryotic cells. Structure and function of cell organelles - mitochondria,nucleus, chloroplast ribosomes and golgibodies.

UNIT II MEMBRANES PROTEINS AND CELL DIVISION 10 hrs.

Structure, principles of membrane organization, membrane models, membrane protein types and its functions.Cell division, mitosis and meiosis, cell cycle and cell cycle control.

UNIT III TRANSPORT ACROSS CELL MEMBRANES 10 hrs.

Passive and active transports, permeases, sodium-potassium pumps, Ca2+ ATPase pumps, lysosomal andvascular membrane, ATP dependent proton pumps, co-transport: symport, antiport and transport into prokaryotic cell,endocytosis and exocytosis.

UNIT IV RECEPTORS AND MODELS OF EXTRA CELLULAR SIGNALING & SIGNAL TRANSDUCTION10 hrs.

Cystosolic, nuclear and membrane bound receptors, autocrine. Paracrine and endocrine models of action. Signalsimplification, CAMP, role of IP3, CAMP and G- proteins role in Signal transduction, calcium influx and is role in cellsignaling.

UNIT V CELL CULTURE 10 hrs.

Study of Cell line, types of cell line, generation of cell lines, maintenance of stock cells, characterization andmorphological analysis of cells.

TEXT BOOK:1. Rastogi S.C., Cell Biology, 3rd Edition, 2005.

REFERENCES:1. James E. Darnell, Harvey F. Lodish, David Baltimore, Molecular Cell Biology, Scientific American, 1986.2. Kimball, TW - Cell Biology, Addison Wesley Publishers, 1989.


Max Marks: 80 Exam Duration: 3 hrs





SBTX1002 BASIC MICROBIOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION 10 hrs.

Historical review of the foundation of microbiology. Whittaker’s five- kingdom concept of living organismClassification of microorganism and methods of classifying and identification of microorganism. Microscopy, light andlaser optic systems. Simple, differential and special stains.

UNIT II STRUCTURAL ORGANIZATION 10 hrs.

General structural organization of Bacteria, Virus, Fungi and Actinomycetes and their reproduction. Bacteriophages,multiplication of bacteriophages-lytic and lysogeny cycle.

UNIT III METHODS OF STERILISATION AND DISINFECTION 10 hrs.

Methods of Sterilisation and disinfection- Physical- dry heat, moist heat, UV light, vibration, radiation, filtration,HEPA filter, Chemical-phenol and phenolic compounds, (halogen aliphatic alcohol, formaldehyde, ethylene oxide, heavymetals) anionic and cationic detergents.

UNIT IV MICROBIAL NUTRITION AND ENVIRONMENT 10 hrs.

Growth of microorganisms in different media - growth curve of microbes and different methods of enumerationof multiplying microorganisms.

UNIT V ENVIRONMENTAL APPLICATION OF MICROBIOLOGY 10 hrs.

Ecology, Recycling of biomaterials, production of bio gas, leaching of ores by microorganisms. Application ofbiofertilizers and biopesticides. Pollution control through user consortium of microorganisms.

TEXT/REFERENCE BOOKS:

1. Pelzer. M.J ., Chan E.C.S., Krig, N., Microbiology Tata Megrew hill publishing company Ltd., New Delhi, 1996.2. Prescott., L.M.harley, J.P. & Klein .D.A., Microbiology, Browb publishers, 1990.3. Schelegel., H.G. General microbiology. Cambridge university press. 1993.4. Heywood, V.H., Watson, R.T. Global biodiversity assessment, Cambridge university press. 1998.


Max Marks: 80 Exam. Duration: 3 hrs.





SPHX4001 PHYSICS LAB - IL T P Credits Total Marks

0 0 2 1 50

1. Torsional pendulum- Determination of MI of the disc and rigidity modulus of the wire.

2. Quincke’s method - Determination of magnetic susceptibility of a liquid

3. Semiconductor diode - Determination of width of the forbidden energy gap

4. Ultrasonic interferometer – Determination of Compressibility of liquid

5. Lees disc - Determination of thermal conductivity of a bad conductor.

6. Optical Fiber – Determination of Numerical aperture and attenuation loss.

SCYX4001 CHEMISTRY LAB - IL T P Credits Total Marks

0 0 2 1 50

1. Determination of total, permanent and temporary hardness of a water sample.

2. Estimation of copper in an ore by iodometric titration.

3. Determination of strength of HCl by conductometric titration.

4. Estimation of the amount of ferrous ion by titrating with chromate ion using potentiometer.

5. Verification of the Freundlich isotherm by using acetic acid adsorption on charcoal.

6. Determination of the rate of corrosion of iron metal by hydrogen evolution method.

SCSX4002 PROGRAMMING IN C LABORATORYL T P Credits Total Marks

0 0 4 2 100

1. To write a simple menu driven calculator program using switch statement.

2. To write a program to calculate the nCr using functions.

3. To write a program to find the largest and smallest number using arrays.

4. To write a program to generate Fibonacci series.

5. To write a program to find the factorial of a number using recursion.

6. To write a program to print the sum of elements of an array using pointers.

7. To write a program to implement file handling

8. To write a program to perform matrix addition and multiplication.

9. To write a program to check for perfect number.

10. To write a program to implement string manipulation functions without using library functions.

11. To write a program to perform ASCII equivalent keystrokes.

12. To write a program to solve a polynomial equation.



SCSX1001 ENGLISH FOR SCIENCE AND TECHNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I 10 hrs.

Reading comprehension- Skimming and Scanning - Transcoding -Bar diagram, Tables and Pie chart –Discussingtopics of general interest or on current topics and making a presentation in the class - Conjunctions and discoursemarkers- cloze reading- affixes – definitions- tense- voice – jumbled sentences.

UNIT II 10 hrs.

Subject verb agreement - Idioms and phrases, reading passages to answer evaluative, inferential and hypotheticaltype of questions- Listening - Creative thinking and speaking- Formal letters - application for job- resume preparation-inviting dignitaries to department workshops, symposium and university functions - Letter to the editor.

UNIT III 10 hrs.

Reading and summarising reports - Writing a project proposal - Editing - Checking punctuation and grammaticalerrors- Types of Sentences – preparation of Check List- formulating questions and answers - communicating politely.

UNIT IV 10 hrs.

Reported speech- Parts of speech- confusable words - Report on industrial visit - project report - Making effectivePower Point presentations - speaking about the future plans-expressing opinions-reading and guessing meanings ofunknown words from the context – using appropriate verb forms

UNIT V 10 hrs.

Modal auxiliaries – Presentation of problems and solutions – wh- questions- question tags- punctuation- hyponymy-listening and taking notes – study skills – preparing notes

REFERENCES:1. Aeda Abidi & Ritu Chowdary, “English For Engineers Made Easy”, Cengage India Learning Limited, New Delhi. 20102. Geetha Nagaraj, “A Course In Grammar and Composition”, Foundation Books Pvt. Ltd., New Delhi, 2006.3. Hewings. M, “Advanced English Grammar”, Cambridge University Press, Chennai. 2000.4. Nagini, P S et al, “Excellence Through communication”, Shri Jai Publications, Chennai, 2005.5. Raman M & Sangeetha Sharma, “Technical Communication”, Oxford University Press, USA 2005.6. Reddy Devika and Chowdhary S, “Technical English”, Mac Millan, Chennai. 20097. Rizvi, M.A., “Effective Technical Communication”, Tata McGRaw Hill Publishing Company Limited, New Delhi, 2006.8. Verma. Shivendra K, “Interactive Grammar of Modern English”, Frank Brothers & Company, India, 2000.


Max Marks : 80 Exam Duration : 3 hrs.





SMTX1004ENGINEERING MATHEMATICS

(Common to Bio-Tech, Bio-Info and Bio-Med branches)


3 1 0 4 100

UNIT I MATRICES 10 hrs.

Characteristic equation of a matrix - Eigen values and Eigen vectors of a real matrix- Properties of Eigen valuesand Eigen vectors, Cayley-Hamilton theorem (without proof) verification - Finding Inverse and Power of a matrixusing it - Orthogonal transformation - Reduction of quadratic form to canonical form by Orthogonal transformation.

UNIT II DIFFERENTIAL CALCULUS 10 hrs.

Definitions - Derivative of standard functions (Results only) - Addition, subtraction, Multiplication and Quotientrules of differentiation - Differentiation of function of function - Logarithmic derivatives - Derivatives of implicit function.

UNIT III INTEGRAL CALCULUS 10 hrs.

Integral of standard functions (Results only) -Integration by the method of substitution- Integral of functions of

the type lx + m

ax2 + bx + c ,

lx + m

√ax2 + bx + c,

a sin x + b cos x

c sin x + d cos x. Integration using partial fractions - Integration by parts -

Generalization of integration by parts (Bernoulli’s formula) - Definite integral - Properties - Simple problems.

UNIT IV VECTOR CALCULUS AND BETA, GAMMA FUNCTIONS 10 hrs.

Differentiation of a vector function - Gradient, Divergence and Curl - Directional Derivative - Identities (withoutproof) - Irrotational and Solenoidal fields - Definitions of Beta and Gamma integrals - Relation between them - Properties- Evaluation of definite integrals in terms of Beta and Gamma function - (without the applications to double andtriple integral)

UNIT V PERMUTATION AND COMBINATION 10 hrs.

Fundamental principle of counting - Permutation - Circular permutation - Combination - Relation betweenpermutation and combination (Simple problems). Binomial Theorem (Positive Integral Index only) - General term -

Term independent of x - Coefficient of xn.

REFERENCES:

1. Vittal P R, Allied Mathematics, Margham Publications, 3rd Edition, 2002 2. Venkataraman M.K., Engineering Mathematics - First Year, 2nd Edition, National Publishing Co., Chennai, 2000. 3. Frank Ayres and NBSP Elliot Mendelson, Schaum’s Outline of Theory and Problems of Differential and Integral Calculus, Tata

Mcgraw Hill, 1990. 4. Narayanan S., Manicavachagom Pillay T.K., Ramanaiah G., Advanced Mathematics for Engineering students, Volume I, 2nd Edition,

S.Viswanathan Printers and Publishers, 1992. 5. Kreyszig.E, Advanced Engineering Mathematics, 8th Edition, John Wiley & Sons, Singapore, 2001.







SPHX1002APPLIED PHYSICS

(Common For All Branches)


3 0 0 3 100

UNIT I FIBER OPTICS 10 hrs.

Introduction - Principle and structure of optical fibers-Acceptance angle-Numerical aperture-Types of opticalfibers-Preparation of fiber – Double crucible technique-Types of rays-Theory of propagation of light-Energy loss inoptical fiber- Attenuation and distortion-Fiber splicing – Fusion and mechanical splicing-Fiber connectors -Butt joint andexpanded beam connectors-Optical fiber communication system (block diagram) - Advantages and its applications.UNIT II ACOUSTICS OF BUILDINGS 10 hrs.

Introduction – Musical sound & noise-Characteristics of musical sound : pitch, loudness, quality – Weber-Fechnerlaw-Relation between pitch & frequency-Factors on which intensity & loudness depend-Decibel scale-Sound intensitylevel and sound pressure level-Sound absorption-OWU-Sound absorption coefficient and its measurements –Reverberation - Reverberation time – Standard Reverberation time – Sabine’s formula to determine the Reverberationtime (Jaegar method)- Factors affecting the acoustics of a building and the remedies-Principles to be followed in theacoustical design of a good auditorium.UNIT III FUNDAMENTALS OF DIGITAL ELECTRONICS 10 hrs.

Number systems - Binary, decimal, Hexadecimal and Octadecimal-Conversion from one number system toanother-Binary addition-Subtraction - Subtraction by 1’s & 2’s complement- BCD-ASCII-Excess 3 code and gray code.UNIT IV NANO DEVICES 10 hrs.

Definition-Fabrication-Top down approach and bottom up approach-Nanomagnets – Particulate Nanomagnets,Geometrical Nanomagnets-Magneto Resistance – Ordinary Magneto Resistance, Giant Magneto Resistance, TunnelingMagneto Resistance- Probing Nanomagnetic Materials-Nanomagnetism in Technology-Nano Devices – Injection Laser– Quantum Cascade Laser – Optical Memories and Coulomb Blockade DevicesUNIT V MEDICAL PHYSICS 10 hrs.

Ultrasonics –Introduction- Production of ultrasonic waves - Piezo-electric method-properties-Doppler effect - Bloodflow meter – Determination of upward and downward transit time- A- scan, B-scan and M-scan-X-rays –Introduction-Units of X-rays- Diagnostic technologies of X-rays – Radiography-Fluoroscopy-Image intensifier-Nuclearmedicine – Introduction-units of radioactivity, m

99Tc generator, nuclear medicine imaging devices - Gamma camera.REFERENCES: 1. Mathur.D.S, Heat and Thermodynamics, 5th Edition, Sultan Chand & Sons, 2004. 2. Gerd Keiser, Optical fiber communication, 3rd Edition, Tata Mc Graw Hill, 2000. 3. John M. Senior, Optical fiber communications - Principle and Practice, 2nd Edition, Pearson Education, 2006. 4. Franz J.H, Jain V.K, Optical communication – Components and Systems,1st Edition, Narosa Publications, 2001. 5. Malvino,Leach & Gautam Saha, Digital Principles and applications, 6th Edition, McGraw Hill, 2006. 6. William H. Gothman, Digital electronics – An int. to theory and practice,2nd Edition, PHL of India, 2007. 7. Roy, Medical Bio Physics, 1st Edition, Saras Publications, 2001. 8. Vasantha Pattabhi, Bio Physics, 1st Edition, Narosa, 2004. 9. Gaur. R.K. and Gupta. S.L., Engineering Physics, 8th edition, Dhanbat Rai Publications,2007.10. Avadhanulu. M.N. and. Kshirsagar. P.G, Engineering Physics, 2nd Editionition, S. Chand & Company, 2007.11. Dr. Arumugam M., Engineering Physics, 2nd Editionition, Anuradha Publications, 2002.12. William D.Callister, Jr, Materials Science and Engineering An introduction, 6th Edition, John-Wiley and Sons, 2004.

UNIVERSITY EXAM QUESTION PAPER PATTERNMax. Marks: 80 Exam Duration: 3 hrs.


Out of 20 marks, maximum of 10% problems may be asked


Out of 60 marks, maximum of 10% problems may be asked

‘Applications’ mentioned in the syllabus refer to the basic applications and not to any specific case



SCYX1004APPLIED BIO-ORGANIC CHEMISTRY

(Common to BIO Groups)


3 0 0 3 100

UNIT I CARBOHYDRATES 10 hrs.

Introduction. Classification: Sugars and NonSugars. Glucose: Physical and chemical properties, epimerization,mutarotation, structural elucidation of glucose:open chain and closed chain structure. Sucrose: physical and chemicalproperties, structural elucidation of sucrose. Structure and biological importance of important polysaccharides: starch,cellulose, chitin, heparin and glycoproteins.

UNIT II AMINOACIDS AND PROTEINS 10 hrs.

Aminoacids: classification :α, β, and γ aminoacids, acidic, basic, neutral aminoacids, essential and non essentialamino acids. Preparation: HVZ reaction, Strecker synthesis, Gabriel Phthalamide synthesis. Physical properties:isoelectric point. Chemical properties: reaction of amino group, carboxyl group and both. Proteins: Classification: basedon shape and solubility. Structure of proteins: primary, secondary, tertiary and quaternary.

UNIT III ANTIBIOTICS 10 hrs.

Introduction, Importance, Classification of antibiotics. Pencillin : Production, isolation, properties, constitution andstructure of penicillin, different types of penicillin. Structure and uses of chloramphenicol, oxytetracyclin, ciprofloxacin.

UNIT IV BIOCHEMICAL TECHNIQUES 10 hrs.

Chromatography: classification, principles, adsorption and partition, paper, thin layer chromatography. Elutionanalysis. Gas chromatography (GC): Block diagram. Detectors: Flame Ionization detector (FID). Liquid chromatography:principles, adsorption and partition. HPLC: Block diagram only. Electrophoresis: High voltage Electrophoresis, GEL,PAGE.

UNIT V BIOMATERIALS 10 hrs.

Introduction: Definition. Metal implant materials: Composition and Properties of Titanium and Titanium basedalloys. Dental metals: Dental amalgam, Gold and Ni - Ti Alloys. Ceramic biomaterials : Resorbable ceramics:Hydroxyapetite, Al - Ca phosphate. Polymer biomaterials: PMMA, hydrogels, silicone rubber, nylon . Biologicalapplications of Gold, Silver nanoparticles and carbon nano tubes.

REFERENCES:

1. Powar C.B. and Chatwal G.R , Biochemistry, 5th Edition, Himalaya Publishing House, 2006.2. Charles P.Poole Jr, and Frank J Owens, Introduction to Nanotechnology, John Wiley and Sons, 2006.3. Gurdeep R Chatwal, Organic Chemistry of Natural Products Vol II , 2nd revised Edition, Himalaya Publishing House, 19864. Skoog, Holler and Nieman, Principles of Instrumental Analysis, 5th Edition, Thomas Inc., 2003.5. Tewari K.S., Vishnoi N.K. and Mehrotra S.N., A Text Book of Organic Chemistry, 2nd Revised Edition, Vikas Publications, 2004.6. Rastogi S.C., Biochemistry, 6th Reprint, Tata McGraw Hill Publishing Limited, 2007.7. Willard Merit Dean Settle, Instrumental Methods of Analysis, 7th Edition, CBS Publishers and Distributors, 2007.8. Leninger, Principle of Biochemistry, 5th Edition, Macmillan Worth Publications, 2008.9. Sujatha V Bhat, biomaterials, 2nd Edition, Narosa Publishing house, 2007.10. Joon Park, R.S. Lakes, Biomaterials Introduction, 3rd Edition, Springer 2007.

UNIVERSITY EXAM QUESTION PAPER PATTERNMax. Marks: 80 Exam Duration: 3 hrs.





SBTX1003 GENETICSL T P Credits Total Marks

3 0 0 3 100

UNIT I MENDELIAN PRINCIPLE 10 hrs.Mendel and his experiments and the laws of inheritance, Variation on Mendel’s Theme: Incomplete dominance;

Gene interactions (Epistasis; Duplicate, Complementary, Supplementary and Lethal factors)

UNIT II CHROMOSOMES 10 hrs.Structural organization, Variations in the number and structure of chromosomes: Haploids; Missing or extra

chromosomes (Euploids, Aneuploids); Deletion; Duplication; Aberrations; Translocation and other structuralrearrangements. Chromosomal studies - Karyotyping. The chromosomal theory of inheritance; Clues from inheritanceof sex; linkage and crossing over; gene mapping; Genetic recombination in Prokaryotes and Eukaryotes

UNIT III CHEMICAL BASIS OF HEREDITY 10 hrs.Evidence for DNA (and RNA) as genetic material; Basic equivalence in DNA; The Watson and Crick model of

DNA structure. Different physico-chemical properties of DNA (Tm value, cot values, Renaturation Kinetics, C-valueparadox)

UNIT IV BACTERIAL GENETICS 10 hrs.Genetic transfer of characters; Bacterial conjugation, Transformation - Cellular competence and environmental

conditions required for transformation - linkages; Transduction - general, restricted and abortive transductions; Finestructure study through transduction

UNIT V HUMAN GENETICS 10 hrs.Human Chromosomes, Dosage Compensation, Chromosomal abnormalities - sex chromosomal and autosomal.

Inherited disorders, Genetic counseling, Genetic engineering and gene therapy, inborn errors of metabolism.

TEXT BOOK:1. David Friefelder, Molecular Genetics, Narosa publishing house, India, 2006.

REFERENCES:1. Gardne, E.J, Principles of Genetics, 7th Edition John Wiby & Sons ltd, 1991.2. Griffith, Fundamentals of Genetics analysis, 7th Edition, W.H. Freeman & Company, Newyork, 2000.







SBTX1004 MOLECULAR BIOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I PROKARYOTES 10 hrs.

Structure of DNA, different forms of DNA and RNA, secondary structure in single stranded nucleic acids.

UNIT II REPLICATION 10 hrs.

Semi-conservative process, transcription and translation, codon usage, inhibitors of transcription and translation.

UNIT III MUTATION AND GENE REGULATION 10 hrs.

Mutation, DNA repair mechanism, Gene regulation, operon concept -gal, lac and trp.

UNIT IV EUKARYOTES 10 hrs.

Organization of genome, interaction with histones. transcription: Exon- intron concepts, transcription initiation -host of factors, and characteristics motifs in these factors, promotors and enhancers.

UNIT V SPLICING MECHANISMS AND CANCER CAUSING VIRUSES 10 hrs.

RNA splicing - Splicing of pre tRNA, pre mRNA and pre rRNA. Retroviruses, retroposons and oncogenes.

TEXT BOOK:1. David Freifelder, Molecular Biology, Narosa Publishing House, 2nd Edition. 1998

REFERENCE:1. De Roberties and De Roberties JR, Cell and Molecular Biology, BI publications, PVT Ltd., India. 8th Edition . 2005.







SCSX1003PROGRAMMING IN C++(Common to all Branches)


3 0 0 3 100

UNIT I INTRODUCTION TO C++ 10 hrs.

Object Oriented Programming Paradigms - Comparison of Programming Paradigms – Object Oriented Languages- Benefits of Object Oriented Programming - Comparison with C - Overview of C++ -Pointers-References and Structures- Functions - Scope and Namespaces - Source Files and Programs.

UNIT II CLASSES AND OBJECTS 10 hrs.

Working with classes – Classes and objects – Class specification-Class objects-Accessing class members-Definingclass members-Inline functions-Accessing member functions within class-Data hiding-Class member accessibility-Emptyclasses, constructors-Parameterized constructors-Constructor overloading-Copy constructors-new, delete operators-”this”pointer-friend classes and friend functions-Function overloading-Operator overloading.

UNIT III DERIVED CLASSES 10 hrs.

Base class and derived class relationship-Derived class declaration-Forms of inheritance-Inheritance and memberaccessibility- Constructors in derived class-Destructors in derived class-Multiple inheritance-Multi level inheritance-Hybridinheritance-Virtual base classes-Member function overriding-Virtual functions.

UNIT IV I/O AND LIBRARY ORGANIZATION 10 hrs.

I/O Stream - File I/O - Exception Handling - Templates - STL – Library Organization and Containers – StandardContainers - Overview of Standard Algorithms-Iterators and Allocators.

UNIT V OBJECT ORIENTED DESIGN 10 hrs.

Development Process – Management - Object Identification – Components - Object Oriented DesignFundamentals – Case Studies.TEXT BOOKS:1. Balagurusamy, ”Object Oriented Programming with C++”, Tata McGraw Hill, 4th Edition, 20102. Venu Gopal.K.R, Ravishankar.T, and Raj kumar, ”Mastering C++”, Tata McGraw Hill, 1999.REFERENCES:1. Bjarne Stroustrup, “The C++ programming language”, Addision Wesley, 3rd Edition, 1998.2. John R Hubbard, “Programming with C++”, Shaums Outline Series, McGraw Hill, 2nd Edition, 2000.3. James Martin & James J.Odell, “Object Oriented methods-A foundation”,Prentice Hall, 1997.4. Grady Booch, “Object Oriented Analysis and Design with application”, Addission Wesley, 2nd Edition, 1994.







SPHX4002 PHYSICS LAB IIL T P Credits Total Marks

0 0 2 1 50

1. Air wedge - Determination of thickness of a thin wire

2. B.H. Curve - Determination of energy loss.

3. Spectrometer- Hollow prism - Determination of refractive index of the given liquid

4. Non uniform bending - Determination of Young’s modulus of the material of the beam by Microscopic method.

5. Copper Voltameter - Determination of electrochemical equivalent of copper.

6. Hall effect -Determination of Hall coefficient.

SCYX4002 CHEMISTRY LAB IIL T P Credits Total Marks

0 0 2 1 50

1. Estimation of Glycine by Sorenson’s Formal titration method.2. Determination of Ferric ion by thiocyanate method using Calorimeter.3. Determination of Chemical oxygen demand in wastewater by dichromate titration method.4. Estimation of the strength of acid by pH titration.5. Determination of molecular weight of a polymer by viscosity measurement method.6. Determination of calorific value of a substance using Bomb calorimeter

SCSX4017 PROGRAMMING IN C++ LABL T P Credits Total Marks

0 0 2 1 50

1. Write a program to find the area of square, rectangle, circle using function overloading concept.

2. Write a program to change the sign of an operands using unary operator overloading concept.

3. Write a program to add two complex numbers using binary operator overloading concept.

4. Implement parametrized constructor, default conctructor, copy constructor and destructor

5. Write a program to enter the sale value and print the agent’s commission using single inheritance.

6. Write a program to count the words and characters in given text using virtual function.

7. Write a program to merge two files into one single file

8. Write a program to sort the numbers using class templates

SBTX4001 MICROBIOLOGY LABL T P Credits Total Marks

0 0 2 1 50

1. Preparation of glassware and sterilization

2. Preparation of culture media for bacteria

3. Aseptic transfer of pure cultures

4. Sterilization techniques

4. Pure culture of bacteria

5. Motility of bacterial cell

6. Simple staining

7. Gram staining

8. Antibiotic sensitivity test



SBTX1006 MOLECULAR BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO rDNA TECHNOLOGY 10 hrs.

Introduction to Recombinant DNA, Gene cloning, cloning strategies, restriction and modification, restrictionendonucleases, DNA ligases. Vectors for cloning – plasmids, phages, cosmids, phagemids, M13 phages, SV 40 vectors,Yeast artificial chromosomes, Shuttle Vector, expression vectors, Broad Host range vectors.

UNIT II BASIS OF rDNA TECHNOLOGY 10 hrs.

Enzymes involved in genetic engineering, isolation and separation of DNA to be cloned – agarose gelelectrophoresis, restriction digestion, and modification of cut ends of DNA, insertion of foreign DNA into vector (ligation),construction of gene library – genomic and cDNA library.

UNIT III DNA TRANSFORMATIONS 10 hrs.

Genetic Transformation Transferring DNA into host cells or DNA delivery methods- physical, biological andchemical methods.

UNIT IV SCREENING 10 hrs.

Selection and Screening of Recombinants - Methods for clone identification-direct screening (insertional inactivationof marker gene, visual screening methods), indirect screening (immunological techniques, rescue techniques, colonyhybridization and dot blot hybridization), hybridization techniques – southern blotting, Northern blotting, western blotting.

UNIT V APPLICATIONS OF RECOMBINANT DNA TECHNOLOGY: 10 hrs.

Applications of gene cloning in agriculture (transgenic animals and transgenic plants), applications of cloning inindustry (production of proteins, enzymes etc used in manufacturing processes), GEMs application in environmentalbiotechnology (generating microbes for remediation, oil eaters etc). Applications of rDNA technology in medicine(Production of antibiotics, insulin, somatostatin, interferons, vaccines, probes for infectious and genetic disease diagnosis,gene therapy).

REFERENCES:1. R. Glick and J. Pasternak, Molecular Biotechnology – 3rd Edition. ASM press, Washington, 2003.2. RW Old and SB Primrose, Principles of gene manipulation, 4th Edition. Blackwell scientific publications London, 1989.3. TA Brown, Gene cloning – An introduction – VNR (UK) Co. Ltd England, 1988


Max Marks: 80 Exam Duration: 3 hrs.





SBTX1007 INTRODUCTION TO IMMUNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION AND OVERVIEW 10 hrs.

History of the immune system, Types of immunity- Innate and acquired, Cells and Organs of the immune system.Antigens and their characterisitics.

UNIT II HUMORAL IMMUNITY 10 hrs.

Development, differentiation and maturation of B cells; Structure and Function of immunoglobulin, Immunoglobulinclasses and subclasses, Molecular biology of immunologlobulin synthesis, Complement pathways. Hybridoma technologyand application of monoclonal antibodies.

UNIT III CELL MEDIATED IMMUNITY 10 hrs.

Development, differentiation and maturation of T cells; Antigen presenting Cells (APC); Phagocytosis; MajorHistocompatibility complex – MHC Class I and II molecules; Antigen processing and presentation; Cytokines; T cellactivation; Immunological unresponsiveness; Immunosuppression.

UNIT IV IMMUNITY TO SELF AND NON – SELF INFECTION 10 hrs.

Hypersensitivity reactions – Type I, II, III and IV; Organ transplantation – Graft rejection, evidence and mechanismsof graft rejection, prevention of graft rejection, immunosuppressive drugs, HLA and disease; Cancer immunology.Autoimmunity

UNIT V IMMUNOLOGICAL TECHNIQUES 10 hrs.

Agglutination and Precipitation reactions, Immunofluorescence, Immunodiffusion, Immunoelectrophoresis, ELISA, RIA.

REFERENCES:1. Ivan M.Roitt, “Essential Immunology” Blackwell Scientific Publications, Oxford, London 4th Edition, 1980.2. Ivan M. Roitt, Jonathan Brostoff and David K.Male Glower “Immunology” Medical Publishers, London, 1st Edition., 1958.3. Richard A.Goldsby, Thomas J.Kindt, Barsara A.Osborne, Janis Kuby, “Immunology” 5th Edition, Freeman & Company,1991.


Max Marks: 80 Exam Duration: 3hrs





SMTX1009ENGINEERING MATHEMATICS III

(Common to all branches except Bioinformatics)


3 1 0 4 100

UNIT I LAPLACE TRANSFORM 10 hrs.

Transforms of simple functions – properties of transforms – Transforms of derivatives and Integrals – Periodicfunctions – Inverse transforms – Convolution theorems – Initial and final value theorems

UNIT II APPLICATIONS OF LAPLACE TRANSFORM 10 hrs.

Application of Laplace Transforms for solving : linear ordinary differential equations – simultaneous differentialequations – integral equations.

UNIT III COMPLEX VARIABLES 10 hrs.

Analytic functions – Cauchy – Riemann equations in Cartesian and Polar form – properties of analytic functions– construction of analytic functions – conformal mapping – standard types – bilinear transformations.

UNIT IV COMPLEX INTEGRATION 10 hrs.

Cauchy’s integral theorem – integral formula – Taylor’s and Laurent’s series (without proof) – Residues – Cauchy’sresidue theorem – Contour integration and the circle and semi circular contours.

UNIT V THEORY OF SAMPLING AND TEST OF HYPOTHESIS 10 hrs.

Test of Hypothesis – Large sample – test of significance – single proportion - difference of proportions – Singlemean - difference of means. Small sample – students ‘t’ test – single mean – difference of means – Fisher’s test –difference of variance, Exact sample – Chi square test – goodness of fit – independence of attributes.

REFERENCES: 1. Kandasamy, P., Thilagavathy, K., and Gunavathy, K., “Engineering Mathematics”, Volumes II & III (4th Revised Edition), S. Chand

& Co., New Delhi, 2001. 2. Venkataraman, M.K. “Engineering Mathematics” Volumes III - A & B, 13th Edition National Publishing Company, Chennai, 1998. 3. Veerarajan, T., “Engineering Mathematics”, Tata McGraw Hill Publishing Co., NewDelhi, 1999. 4. Grewal, B.S., “Higher Engineering Mathematics” (35th Edition), Khanna Publishers, Delhi, 2000. 5. Kreyszig, E., “Advanced Engineering Mathematics” (8th Edition), John Wiley and Sons (Asia) Pvt. Ltd., Singapore, 2001.







SBTX1008 CONCEPTS IN BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I BIOTECHNOLOGY: AN OVERVIEW 10 hrs.

What is Biotechnology? – an interdisciplinary pursuit, old Vs new biotechnology, scope and importance,commercial potential, public perception of Biotechnology, Biotechnology in India and Global.

UNIT II INDUSTRIAL APPLICATIONS OF BIOTECHNOLOGY 10 hrs.

Isolation and screening of micro-organisms, Bioreactors, process development, scale up and media design forfermentation processes, food and beverage fermentation, production of antibiotics (ß-lactum antibiotic), vitamin B12,Enzyme- amylase, protease, Biotransformation, SCP and its economical implications.

UNIT III BIOTECHNOLOGY IN AGRICULTURE AND ENVIRONMENT 10 hrs.

Biotechnology methods of crop improvement- plant tissue culture. Transgenic plants, applications of transgenicplants, transgenesis, transgenic animals, novel and better bioinsecticides. Biofertilizers, Biodegradation of Xenobioticcompounds.

UNIT IV BIOTECHNOLOGY AND HEALTH CARE 10 hrs.

Conventional vaccines, recombinant vaccines, DNA vaccines, monoclonal antibodies and their applications,interferons, drug designing, genetherapy, forensic medicine applications in human genetic research.

UNIT V BIOETHICS 10 hrs.

Legal aspects genetically manipualated organisms and environment, biosafety, Social, moral and EthicalConsiderations, IPR.

REFERENCES:1. H.D. Kumar, Modern Concepts of Biotechnology, Vikas Publishing House Pvt Ltd, 1998.2. P.K. Gupta, Elements of Biotechnology, Rastog Publications, 2003.3. John Smith, Biotechnology, Cambridge University Press, 1988.4. A.H. Patel, Industrial Microbiology, Macmillan Publishers, 1984.







SCHX1011INTRODUCTION TO UNIT OPERATIONS AND

PROCESS CALCULATIONSL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO CHEMICAL ENGINEERING CALCULATIONS 10 hrs.

Introduction to chemical engineering, units and systems, fundamental and derived units, basic chemicalcalculations, mole, atomic weight, molecular weight, concepts of units and conversion factors, dimensional analysis.

UNIT II MATERIAL BALANCE WITHOUT CHEMICAL REACTIONS 10 hrs.

Introduction, process flow sheet, recycling and bypass in material balance with chemical reactions, problems inmaterial balance of unsteady state operations.

UNIT III MATERIAL BALANCE WITH CHEMICAL REACTIONS 10 hrs.

Introduction, material balance, terms and definitions, recycling and bypassing in material balance with chemicalreactions, problems in industrial applications.

UNIT IV ENERGY BALANCE AND COMBUSTION 10 hrs.

Introduction, energy and thermo chemistry, concepts and units, heat capacity, heat capacities of gases at constantpressure, heat capacities of gas mixture, heat capacities of liquid mixture, fuels, calorific value, fuels - coal, proximateanalysis, ultimate analysis.

UNIT V UNIT OPERATIONS 10 hrs.

Unit operations, unit processes, schematic representations of unit operations, Industrial production of chemical– food and byproduct (Leather), Fermentation (Ethanol), Agrochemical (Urea), Pharmaceutical (Penicilin), Acid (Citricacid).

REFERENCES:1. David H.Himmelblau, Basic principles and calculations in chemical engineering, Eastern Economy Edition, 6th Edition, 2003.2. George T. Austine, Shreeves chemical process industries, McGraw Hill Internatinal Edition, 5th Edition, 1984. 3. Bhatt and Vora S.M., Stochiometry, Tata McGraw Hill Publishing Co., 3rd Edition, 2004 4. McCabe W.L., Smith J.C. and Harriott P., Unit Operations of Chemical Engineering, McGraw Hill International edition, Singapore, 5th

Editon, 1993.







SCHX1012 CHEMICAL REACTION ENGINEERINGL T P Credits Total Marks

3 0 0 3 100

UNIT I CHEMICAL KINETICS 10 hrs.

Introduction to chemical kinetics, rate equation, concentration dependent term of a rate equation: single andmultiple reaction. Elementary and non- elementary reactions. Molecularity and order, theories of reaction rate andtemperature dependency. Constant volume batch reactor.

UNIT II IDEAL REACTORS 10 hrs.

Variable volume, batch reactor by integeral and differential method of analysis. Types of reactor in practice, thethree ‘ideal” reactors; batch, cstr, plug flow and form of rate equations, space time and velocity.

UNIT III SINGLE AND MULTIPLE REACTIONS 10 hrs.

Design for single reaction: size comparison of single reactors, multiple reactor system, pfr in series/parallel, equalsize mfr in series, introduction to multiple reactions, qualitative analysis of product distribution.

UNIT IV NON-IDEAL REACTORS 10 hrs.

Residence time distribution as a factor performance, residence time function and relationship between them inreactor, basic models for non ideal reactor like dispersion model, tanks in series model.

UNIT V HETEROGENEOUS REACTIONS 10 hrs.

Fluid particle reactions: selection of a model, unreacted core models for spherical particles, determination of therate controlling step. Catalyst preparation, surface area and pore volume measurements: promoters, poisons.

REFERENCES:1. Octave Levenspiel, Chemical Reaction Engineering, John Wiley and sons. 3rd Edition, 1999.2. Gavhane K.A., Chemical Reaction Engineering – I, Nirali Prakashan Publishers, 2009.3. Foggler H.S., Elements of chemical reaction engineering, Prentice Hall Publishing Co. 4rd Edition, 2006.4. Smith J.M., Chemical Engineering Kinetics, McGraw-Hill Inc 2003







SBTX1009 BIOENERGETICSL T P Credits Total Marks

3 1 0 4 100

UNIT I BASIC THERMODYNAMICS 10 hrs.

General concepts of Thermodynamics -Laws of Thermodynamics, Enthalpy, Entropy, Free energy& ChemicalEquilibria, Energy yielding, energy requiring reactions, High Energy Bonds & Compounds, Biological Oxidation-reductionReactions, Energy yielding, energy requiring reactions.

UNIT II INTERMEDIARY METABOLISM-I 10 hrs.

Glycolysis, Glycogenesis, Glycogenolysis, Gluconeogenesis, Pentose Phosphate Pathway, Citric Acid Cycle, FattyAcid oxidation and lipid biosynthesis.

UNIT III INTERMEDIARY METABOLISM-II 10 hrs.

Biosynthesis of Amino Acids, Amino Acid Oxidation and the production of Urea, Biosynthesis and Degradationof Nucleotides,.

UNIT IV ENERGY PRODUCTION 10 hrs.

Oxidative Phosphorylation – Electron-Transfer Reactions in Mitochondria, ATP Synthesis. Photophosphorylation-The Central Photochemical Event: Light-Driven Electron Flow, ATP Synthesis by Photophosphorylation.

UNIT V APPLICATIONS OF BIOENERGETICS 10 hrs.

Enzymes as analytical reagents. Biosensors. Regulation and Integration of fuel metabolism, Inborn errors ofmetabolism-diagnosis and treatment. Metabolic Control Analysis: Quantitative Aspects. Tissue-Specific Metabolism –Assays for Tissue Damage.

REFERENCES:1. Lehninger, Nelson and Cox, Principles Of Biochemistry, W.H. Freeman, 4th Edition, 20052. Donald Voet, Judith Voet and Charlotte Pratt, Principles Of Biochemistry, John Wiley & Sons, 20083 Jeremy Mark, John Tymoczko and Lubert Stryer, Biochemistry, W.h. Freeman, 5th Edition, 20074. A.C. Deb, Fundamental Of Biochemistry, New Central Agency, Calcutta, 3rd Edition, 1989







SBTX4002 BASIC BIOCHEMISTRY AND IMMUNOLOGY LABL T P Credits Total Marks

0 0 4 2 100

1. Qualitative analysis of Carbohydrates, Amino acids and Lipids.

2. Titrimetric estimation of Glycine and Ascorbic acid

3. Working principle of pH meter and its calibration.

4. Preparation of buffer of a given pH and molarity.

5. Working principle and standardization of colorimeter.

6. Quantitative estimation of Protein by Lowry’s method.

7. Quantitative estimation of Urea by DAM method.

8. Estimation of saponification number.

9. Estimation of acid number.

10. Working principle of centrifuge.

11. ABO Blood Grouping

12. Identification of leucocytes

13. Widal slide test

14. RPR test

15. Slide test for pregnancy

16. Radial Immunodiffusion

17. Ouchterlony Double Diffusion – Antibody titration

18. ELISA – Quantification of Immunoglobulins

19. Haemoglobin estimation by Sahli’s method.

SCHX4003 CHEMICAL REACTION ENGINEERING LABL T P Credits Total Marks

0 0 4 2 100

1. Flow through venturimeter

2. Flow through orificemeter

3. Heat conduction through composite walls

4. Emissivity measurement

5. Test on heat exchanger

6. Heat transfer by natural convection

7. Plug flow reactor

8. Batch reactor

9. Stirred tank reactor

10. Effectiveness of screen (sieve analysis)

11. Ball mill

12. Vapour diffusivity of acetone air system



SMTX 1010ENGINEERING MATHEMATICS IV

(Common to all branches except Bio Informatics)


3 1 0 4 100

UNIT I PARTIAL DIFFERENTIAL EQUATION 10 hrs.

Formulation of equations by elimination of arbitrary constants and arbitrary functions-solutions byequations-general, particular and complete integrals-Lagrange’s linear equation-standard type of first orderequation-second and higher order equations with constant coefficients-homogenous equations.

UNIT II FOURIER SERIES 10 hrs.

Euler’s formula-Dirichlets conditions-convergence statement only-change of interval-odd and even functions-halfrange series-RMS value-Parseval’s formula-complex form of Fourier series-harmonic analysis.

UNIT III WAVE AND HEAT EQUATION 10 hrs.

One dimensional wave equation-Transverse vibration of finite elastic string with fixed ends-boundary and initialvalue problems-Fourier series solution-Derivation of one dimensional heat equation-steady and unsteady state-boundaryand initial value problems-Fourier series solutions. Two dimensional heat equation-steady state heat flow in twodimensions-Laplace equation in Cartesian coordinates - Fourier series solution.

UNIT IV FOURIER TRANSFORM 10 hrs.

The infinite Fourier transform-sine and cosine transform-Properties-Inversion theorem-Finite Fourier transform-sineand cosine transform-Convolution theorem-Parseval’s identity.

UNIT V Z – TRANSFORM AND DIFFERENCE EQUATIONS 10 hrs.

Z – Transforms – Elementary Properties – Inverse Z – transforms – Convolution theorem – Formation of differenceequations – Solution of difference equations using Z – transforms.

REFERENCES: 1. Kandasamy, P., Thilagavathy, K., and Gunavathy, K., “Engineering Mathematics”, Volumes II & III, 4th Revised Edition, S. Chand

& Co., New Delhi, 2001. 2. Venkataraman, M.K. “Engineering Mathematics” Volumes III - A & B, 13th Edition National Publishing Company, Chennai. 3. Veerarajan, T., “Engineering Mathematics”, Tata McGraw Hill Publishing Co., New Delhi, 1999. 4. Grewal, B.S., “Higher Engineering Mathematics” 35th Edition, Khanna Publishers, Delhi, 2000. 5. Kreyszig, E., “Advanced Engineering Mathematics” 8th Edition, John Wiley and Sons (Asia) Pvt Ltd., Singapore, 2001.







SBTX1010 GENETIC ENGINEERINGL T P Credits Total Marks

3 0 0 3 100


History of genetic engineering, restriction modifying and polymerase enzymes used in genetic engineering, vectorsused in genetic engineering of microbes, plants and animals. Bacterial and yeast hosts used in cloning and expression.PCR, optimization of PCR, gene specific and degenerate primer design

UNIT II DNA FINGERPRINTING 10 hrs.

Introduction to DNA fingerprinting, basic genetic principle. Variable Number of Tandem repeats (VNTRs) Minisatellite sequences, Short Tandom Repeats (STRs) Micro Satellite Sequences, Hybridization based DNA fingerprinting(RFLP) PCR-based fingerprinting, Single locus and multilocus DNA fingerprinting. Applications of DNA fingerprinting

UNIT III DNA SEQUENCING METHODS 10 hrs.

DNA sequencing methods – MAXAM AND GILBERT chemical method, SANGER AND COULSON enzymaticchain termination method, Automated DNA sequencing, Pyrosequencing, High throughput sequencing.

UNIT IV CLONING METHODS 10 hrs.

Cloning methods using restriction and modifying enzymes, cloning in expression vector, cloning of PCR products,Site directed mutagenesis. Construction of cDNA library, PCR based cDNA library, Subtractive cDNA library, NormalizedcDNA library, genomic DNA library, BAC library and YAC library. SDcreening the library by using probes, cloning ofgenes by PCR (gene specific and degenerate primers)Restriction mapping – Direct mapping, indirect mapping, DNAfoot printing, Chromosome Walking, Chromosome Jumping.

UNIT V EXPLOITATION OF GENETIC ENGINEERING 10 hrs.

Exploitation of genetic engineering- Expression and Purification of Recombinant Proteins in E.coli, Yeast, Animalcell lines, Transgenic plants and Transgenic animals, Metabolic Engineering. Gene Silencing Techniques; Introductionto siRNA; siRNA technology; Micro RNA;Construction of siRNA vectors; Principle and application of gene silencing;Gene knockouts and Gene Therapy; Creation of knockout mice. Genetic engineering -Hazards and impacts on society.

REFERENCES: 1. DM Glover: Genecloming: The mechanism of DNA manipulation IRC Press, Oxford University, 1984. 2. Primrose S.B., Twyman TM and Old RW, Principles of Gene Manipulation, Blackwell Science Ltd., USA, 6 th Edition, 2001. 3. Ray D.S., Dehardt DT, Dressler D., Single Stranded DNA phages, Cold Spring Harbor Monograph archeiver, Vol 8., 1978, 4. – Jose Cibelli, Robert P Lanza, Keith H.S. Campbell, Michael D. West, Principles of cloning, Academic press, 2002. 5. Ernet L Winnacker, From genes to clones, Panima publishing corporation, India, 2003. 6. S.S. Purohit, Biotechnology fundamentals and applications, Agrobios (Ind.) Jothpur 2002. 7. Brown T.A , Gene Cloning an Introduction, VNR (UK) Co.Ltd. 1988. 8. Sambrook A. and Russell D.W., Molecular Cloning. A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, USA,

3rd Edition, Volume 1-3, 2001. 9. Ausubel F.M., Brent R., Kingston R.E. and Moore D.D., Current Protocols in Molecular Biology, John Wiley & Sons, Inc., Brooklyn,

New York, 1st Edition, 1987 10. Benjamin Lewin, “Genes VI and Genes VII”, Oxford University Press, Cambridge, 1996.







SBTX1011 PROTEIN ENGINEERINGL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO PEPTIDES AND PROTEINS 10 hrs.

Why proteins are interesting? Amino acids as the building blocks of proteins, properties of amino acids, thepeptide bond, an example of protein structure; Insulin.

UNIT II METHODS FOR DETERMINATION OF 3-D STRUCTURE OF PROTEINS 10 hrs.

Primary structure of proteins, methods for determination of three dimensional structure structures of crystallineproteins by X-ray diffraction methods, Structure of proteins in solution from NMR methods. Structures, function andproperties, methods of determination and analysis of biomolecular structures: Optical spectroscopy, mass spectrometry,X-ray crystallography, cryo-electron microscopy

UNIT III THREE DIMENSIONAL STRUCTURE OF PROTEINS 10 hrs.

The three – dimensional structure of proteins – the structural building blocks, the Ramachandran diagram, motifor super secondary structures. Protein diversity – introns, exons and inteins and exteins, Sequence identity and structuralsimilarity.

UNIT IV PROTEIN STABILITY AND STRUCTURE PREDICTION 10 hrs.

Protein stability, protein denaturation – thermodynamics of protein folding, thermal denaturarion, solventdenaturation, energetics of formation of structure – alpha helices, betasheets propensitiers, the hydrophobicity, disulphidecross links prediction of three dimensional structures from primary structures.

UNIT V MODELING AND DESIGNING OF PROTEINS 10 hrs.

Protein folding, mechanism of protein folding, molecular modeling, model makeup and computer graphics, sitedirected mutagenesis used for protein studies, protein databases, designer enzymes.

REFERENCES: 1. LiLia Alberghina, Protein engineering in industrial biotechnology, Harwood academic publication, 2003. 2. Robert Horton, Lawrence A. Moran, Raymond, Ochs S., David Rawn J and Gray Scrimgeour K., Principles of biochemistry –

Prentice Hall, 4th Edition 2002. 3. Gary Walsh, Protein: Biochemistry and Biotechnology, John Wiley & Sons Ltd, 2004 4. Thomas E. Creighton, Protein Structure and Protein function, Oxford University Press, 2nd Edition, 2003







SCHX1013 ENZYME ENGINEERINGL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO ENZYMES 10 hrs.

Nature and function of Enzymes,Enzyme nomenclature, Classification of Enzymes, Chemical and enzymaticcatalysis, Properties of enzymatic catalysis, Molecular weight determination of Enzymes.

UNIT II ENZYME KINETICS 10 hrs.

Michaelis Menten kinetics, Determination of Km, Lineweaver Burk plot, Eadie-Hofstee plot, Hanes –Woolf plot,Enzyme inhibitors, Types of Enzyme Inhibition, Competitive inhibition, Uncompetitive inhibition, Non-competitive Inhibition,Mixed inhibition, Partial inhibition, Substrate inhibition, Allosteric inhibition, Irreversible inhibition, Inactivation kinetics.

UNIT III ENZYME IMMOBILISATION 10 hrs.

Classification of Enzyme immobilization, Physical and chemical techniques for enzyme immobilization-Adsorption,Matrix entrapment, Encapsulation, Cross-linking, Covalent bonding, Advantages and disadvantages, Application ofimmobilized enzymes, mass transfer effect on immobilization, Properties of immobilized enzymes.

UNIT IV ENZYME SPECIFICITY 10 hrs.

Turn over number, Extraction of soluble enzymes, membrane bound enzymes, Preliminary purification procedures,Advanced purification procedures, Criteria of purity.

UNIT V CLINICAL AND INDUSTRIAL APPLICATIONS OF ENZYMES 10 hrs.

Application of enzymes in medicine, Lactate dehydrogenase, alkaline phosphatase, Acid phosphatase, Enzymebiosensors, Design of enzyme electrodes.

REFERENCES:1. Trevor Palmer, Enzymes:Biochemistry, Biotechnology & Clinical Chemistry Horwood, East West Press, 2001.2. James E Bailey, David F., Ollis, Biochemical Engineering Fundamentals, McGraw Hill Intl. Edition, 2nd Edition, 1986.3. Ashok Pandey, Colin Webb, Carlos Ricardo Soccol, Christian Larroche, Enzyme Technology, Asiatech Publishers Inc., 2006.







SCHX1014 CHEMICAL ENGINEERING THERMODYNAMICSL T P Credits Total Marks

3 1 0 4 100

UNIT I FIRST LAW OF THERMODYNAMICS 10 hrs.

Introduction and fundamental concepts of thermodynamic terms. First law of thermodynamics- Work equivalentof heat -classification of energy, thermodynamic state function and path function- Enthalpy and specific heat- Applicationof first law to steady state flow processes and reversible process.

UNIT II SECOND LAW OF THERMODYNAMICS 10 hrs.

Entropy and second law of thermodynamics- Limitations of first law, statement of second law, heat reservoirs,heat engines and heat pumps, thermodynamic and ideal gas temperature scale, concept of entropy, entropy andunavailable energy.

UNIT III IDEAL GAS 10 hrs.

The ideal gas, ideal gas law, isobaric, isothermal, adiabatic and polytropic process. P-V-T relations of fluid,equation of state for gases, the principles of corresponding states, compressibility factors, gas mixtures, behaviour ofliquids, coefficient of expansion and isothermal compressibility, thermodynamic charts.

UNIT IV THERMODYNAMIC PROPERTIES 10 hrs.

Thermodynamic properties of fluids- Reference properties, energy properties, derived properties, path properties,Maxwell relations, heat capacity relations, effect of pressure and volume on heat capacities. Thermodynamics of flowprocess- Flow through pipes, nozzles and compressors.

UNIT V PROPERTIES OF SOLUTIONS 10 hrs.

Properties of solutions Relationship between the thermodynamic properties systems of variable compositionsbasic equations. Excess properties of mixtures temperature and pressure dependence of Gibb’s free energy partialmolar properties Chemical potential Gibbs Duhem equation fugacities and fugacity coefficients activity and activitycoefficients

REFERENCES:1. Smith J. M and Van Ness H.C., "Introduction to Chemical Engineering Thermodynamics", McGraw Hill, 20052. Barnett F. Dodge, Chemical Engineering Thermodynamics, McGraw Hill, 19443. Abbott and Van Ness, Schaums Outline of Theory and Problems of Thermodynamics, 1989. 4. Weber H.C. and Meissner H.P, Thermodynamics for Chemical Engineers, John Wiley, 2nd Edition, NewYork, 1957.







SCHX1015BIOPROCESS INSTRUMENTATION, DYNAMICS

AND CONTROLL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO LAPLACE TRANSFORM 10 hrs.

Properties of transforms, Linear open loop system: Examples of first order systems- mercury in glass thermometer-liquid level process- mixing process, Response of first order system to standard forcing function.

UNIT II SECOND ORDER SYSTEM 10 hrs.

Damping vibrator, first order system in series- interacting and non-interacting system, response of second ordersystem to standard forcing function.

UNIT III LINEAR CLOSED LOOP SYSTEM 10 hrs.

Introduction to Control system, open loop controller ,closed loop controller – P,PI,PID, controller mechanism,finalcontrol element- control valve, valve characteristics, Block diagram reduction, transient response of simple controlsystem, stability analysis -Routh stability.

UNIT IV FREQUENCY RESPONSE ANALYSIS OF LINEAR PROCESS 10 hrs.

Introduction, Concept- Bode diagram-Bode stability criteria – gain and phase margin, Ziegler – Nichols tuning,Cohen coon tuning.

UNIT V INSTRUMENTATION AND CONTROL 10 hrs.

Physical and chemical sensors for the medium and gases, online and offline sensors, process control- Conceptof Cascade control, Selective control system, split range control, Feed forward & Feedback control, Ratio control,Adaptive control and Inferential control. Computer based control – Basic functional elements, Computer interfaces forfermentation process and Cascade control of metabolism.

REFERENCES:1. Coughnowr and Koppel, Process Systems Analysis and Control, McGraw Hill, New York, 1986.2. George Stephanopoulos, Chemical Process Control, Prentice Hall of India Pvt Ltd., New Delhi, 1990.3. Ekman D.P., Industrial Instrumentation, Wiley, 1978.4. Control systems – A.Nagoorkani, RBA Publications, 1995.







SBTX4003 ENZYMOLOGY LABL T P Credits Total Marks

0 0 4 2 100

1. Extraction and estimation of enzymes from plant sourse

2. Acid and enzymatic hydrolysis of glycogen and starch

3. Biosynthesis of enzymes from fungi and bacteria

4. Effect of temperature on enzyme activity

5. Effect of pH on enzyme activity

6. Effect of substrate concentration on enzyme activity

7. Effect of enzyme concentration on enzyme activity

8. Effect of heat stability on enzyme activity

9. Immobilization of enzymes

SBTX4004 MOLECULAR BIOLOGY LABL T P Credits Total Marks

0 0 4 2 100

I. Nucleic acid Isolation Procedures:

1. Isolation of Plasmid DNA from E.coli.-Alkaline lysis method

2. Isolation of Genomic DNA from E.coli.-Phenol/Chloroform method

3. Isolation of genomic DNA from Onion extract-SDS method

II. Quantitation of Nucleic acids/proteins:

1. Estimation of DNA /RNA by diphenylamine method

2. Estimation of proteins by Bradfords method

III. Separation Techniques:

1. Agarose gel electrophoresis

2. PAGE -SDS/Native

IV. Staining techniques

1. Staining of proteins

• Silver staining

• Coomasie brilliant blue

2. Staining of Nucleic acids

• Fluorescent dyes

• Silver staining

V. Polymerase Chain Reaction-Amplification of DNA of interest/ RAPD

VI. Southern blotting / Western blotting / northern blotting



SMTX 1013DISCRETE MATHEMATICS AND NUMERICAL

METHODS(Common to Biotech, Bioinf, Biomed & IT)


3 1 0 4 100

UNIT I LOGIC 10 hrs.

Statements - Truth tables – Connectives – Equivalent Propositions - Tautological Implications - Normal forms -Predicate Calculus, Inference theory for Propositional Calculus and Predicate Calculus.

UNIT II SET THEORY 10 hrs.

Basic concepts of Set theory - Laws of Set theory - Partition of set, Relations - Types of Relations: Equivalencerelation, Partial ordering relation - Graphs of relation - Hasse diagram, Functions: Injective, Surjective , Bijectivefunctions, Compositions of functions, Identity and Inverse functions.

UNIT III GROUP THEORY 10 hrs.

Semi group and Monoid (definition and examples only) – Groups – Properties of groups – Subgroups - Cyclicgroups – Cosets - Lagrange’s theorem.

UNIT IV INTERPOLATION, NUMERICAL DIFFERENTIATION & INTEGRATION 10 hrs.

Interpolation – Gregory Newton’s Forward and Backward Interpolation for equal intervals - Lagrange’s Interpolationfor unequal intervals - Numerical differentiation: Newton’s forward and backward formula to compute the derivatives -Numerical Integration: Trapezoidal rule, Simpson’s 1/3rd rule and Simpson’s 3/8th rule.

UNIT V NUMERICAL METHODS FOR SOLVING EQUATIONS 10 hrs.

Numerical Solution of algebraic and transcendental equations: Regula Falsi method, Newton Raphson method& Secant method. Numerical Solution of simultaneous linear algebraic equations: Gauss Jordan method, Crout’s method,Gauss Jacobi method & Gauss Siedel method.

REFERENCES:1. Tremblay. S. Manohar. R. Discrete mathematics structure with application to computer science- McGraw-Hill, 1975.2. Kenneth H. Rosen, Discrete mathematics and its applications, Edition 6, McGraw-Hill, 2007.3. Venkatraman M K, Discrete Structures, National Pub. Co, Madras. 1992.4. Kandaswamy P & Co., Numerical Methods, S.Chand Publications, Chennai 2009.5. Venkataraman M K, Numerical Methods in Science and Engineering, National Pub. Co, Madras. 1992.







SCHX1016BIOSEPARATION AND DOWNSTREAM

PROCESSINGL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO BIOSEPARATION 10 hrs.

Role of downstream processing in biotechnological processes. Problems and requirements of bioproductpurification. Economics of downstream processing in Biotechnology, cost-cutting strategies, characteristics of biologicalmixtures, process design criteria for various classes of bioproducts, physico- chemical basis of bioseparation processes

UNIT II PRIMARY SEPARATION AND RECOVERY PROCESSES 10 hrs.

Cell disruption methods for intracellular products, removal of insolubles, biomass, separation techniques,flocculation and sedimentation, centrifugation and filtration methods.

UNIT III ENRICHMENT OPERATIONS 10 hrs.

Membrane – based separations, precipitation methods,extractive separation, aqueous two-phase extraction,supercritical extraction, in situ product removal, integrated bioprocessing

UNIT IV PRODUCT RESOLUTION / FRACTIONATION 10 hrs.

Adsorptive chromatographic separations processes, HPLC, electrophoretic separations, hybrid separationtechnologies, membrane chromatography, electrochromatograpy

UNIT V PRODUCT POLISHING 10 hrs.

Dialysis, Crystallisation, Types of crystallizer – Swenson walker, gel Permeation Chromatography, Drying, Typesof dryer – Rotary and spray dryer.

REFERENCES:1. Harrison R.G, Todd P., Rudge S.R and Petrides D.P, Bioseparation Science and Engineering, Oxford Press, 2003 2. Belter P.A., Cursler E.L, and Hu W.S., Downstream Processing for Biotechnology, John Wiley & Sons, 1988.3. Michael L Shuler, Fikret Kargi, Bioprocess engineering, PHI publishers, 2002







SBTX1013 ANALYTICAL TECHNIQUESL T P Credits Total Marks

3 0 0 3 100

UNIT I BASIC INSTRUMENTATION 10 hrs.

Determination of Growth and Cell Viability, Basics of Microscope, its types – Light Microscope, Dark fieldMicroscope, Phase contrast Microscope, Fluorescent Microscope, Electron Microscope (TEM, SEM, Tunnelling EM) &Confocal Microscope, Microtechnique, pH meter & Electronic balance

UNIT II BASIC SPECTROSCOPY 10 hrs.

Principles and Working of colorimetry, UV- Visible Spectrophotometry, Fluorescence Spectrophotometry, AtomicAbsorption Spectrophotometry, Raman Spectroscopy, Mass Spectrometry, Nuclear Magnetic Resonance (NMR)–Electron Spin Resonance(ESR), Spectroflourimetry.

UNIT III SEPARATION AND PURIFICATION TECHNIQUES 10 hrs.

Centrifugation, Electrophoresis of nucleic acids, Electrophoresis of proteins, 2D PAGE, Purification of nucleicacids, protein purification methods, Chromatography.

UNIT IV RADIO ISOTOPE TECHNIQUES 10 hrs.

Concept of P3 lab. Radioactive isotopes – storage, safety, handling and radioactive waste management. LiquidScintillation counter, alpha-counter and beta-counter. X- ray Diffraction Crystallography, Autoradiography.

UNIT V MOLECULAR TECHNIQUES 10 hrs.

Quantification of protein, DNA and RNA. Blotting techniques, gene transfer and transfection methods. PCR andits types. Techniques of gene mapping and Restriction mapping- RAPD, RFLP, Protein sequencing, site directedmutagenesis, transgenic techniques.

REFERENCES:1. David T. Plummer, An introduction to Practical Biochemistry, Tata McGraw Hill Edition, 19882. Keith Wilson and John Walker, Practical Biochemistry – Principles and techniques, Cambridge University Press, U.K; 5th Edition,

2003.3. Rapley and Walker, Molecular Biomethods Handbook, Humana Press, Totowa, NewYork, 2003.







SBIX1028BIOINFORMATICS AND MOLECULAR BIOLOGY

DATABASESL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO BIOINFORMATICS 10 hrs.

Introduction to Bioinformatics: Overview and Definition, Applications of Bioinformatics. Different fields inBioinformatics. Sequence formats used in Bioinformatics databases and tools.

UNIT II BIOLOGICAL DATABASES 10 hrs.

Biological Databases: Introduction. Classification of Biological Databases: Primary databases – Nucleic acids– NCBI, DDBJ, EMBL. Proteins – PIR, Swissprot. Secondary databases – PROSITE, PRINTS, PFAM. Structureclassification databases – SCOP, CATH.

UNIT III BIBLIOGRAPHIC DATABASES 10 hrs.

Bibliographic Databases – OMIM, PUBMED. WWW, Internet and its Uses in Bioinformatics. Introduction tocomputers: Introduction to computer architecture, Introduction to Operating Systems: Windows, LINUX / UNIX OperatingSystem.

UNIT IV SEQUENCE ANALYSIS 10 hrs.

Sequence Analysis: Introduction to sequence analysis and alignment - Global and Local Alignments - Pairwiseand Multiple sequence alignment. Tools for sequence alignments - BLAST, FASTA, clustalW. Phylogenetic analysis –rooted and unrooted trees.

UNIT V PREDICTION STUDIES 10 hrs.

Prediction studies: Introduction to protein structure - domains, motifs and their uses. Secondary structureprediction - tools used. Introduction to 3D structure prediction-Homology modeling, Threading & Ab initio Methods.Gene prediction

REFERENCES: 1. Arthur M. Lesk, Introduction to Bioinformatics, Oxford University Press, 2002. 2. Attwood T.K. and Parry D.J., Smith, Introduction to Bioinformatics, Pearson Education; 2001. 3. Andreas D Baxevanis, Francis Ouellete B.F., Bioinformatics, A practical guide to the analysis of genes and proteins; John Wley

and sons, 2nd Edition, 2004. 4. Jean Michel Claverie and Cedric Notrdame, BIOINFORMATICS - A BEGINNER’s GUIDE, Wiley dreamtech India Pvt. Ltd., 2nd

Edition, 2004.







SCHX1017MODELING AND TRANSPORT PHENOMENA FOR

BIOPROCESSESL T P Credits Total Marks

3 1 0 4 100

UNIT I IMPORTANCE OF TRANSFER PROCESS 10 hrs.

Introduction to Transport mechanisms of mass, energy and momentum, Convective transport, Molecular transport,Momentum transport, Transport coefficients, Dimensional analysis, Advantages, Buckingham – Π - theorem

UNIT II FLOW PHENOMENA AND HEAT TRANSPORT 10 hrs.

Laminar flow, Reynolds number, Turbulent flow, Steady state heat conduction, Flat geometry, Cylindrical geometry,Spheres, Unsteady state heat conduction, Penetration theory, Total and partial heat transfer coefficient

UNIT III FLOW REGIMES AND MASS TRANSPORT 10 hrs.

Flow around obstacles, Pressure drop in pipe systems, Flow pattern in stirred vessels, Non Newtonian liquids,Diffusion of molecules, Film theory, Inter phase mass transfer, Convective mass transfer

UNIT IV MATHEMATICAL MODELING OF BIOLOGICAL PROCESSES 10 hrs.

Modeling cycle, System and types, Macroscopic approach, Modeling of microbiological processes, Macroscopicbalance for - defined chemical compounds, intracellular compounds, Pseudo steady state approximation for intracellularcompounds, Black box description of microbial growth.

UNIT V APPLICATION OF CONSERVATION PRINCIPLES 10 hrs.

Application of metabolic information, Generalized treatment of aerobic microbial growth and product formation,Application of the principle of - element conservation and energy conservation.

REFERENCES:1. Butterworth-Heinemann, Bioprocess Technology: Modeling and transport phenomena, 19922. Babu B.V., Process Plant Simulation, Oxford University Press, India, 2004. 3. Franks R.G.E., Modeling and Simulation in Chemical Engineering, John Wiley & Sons Inc., New York, 1972.







SCHX1018 DESIGN AND OPERATION OF BIOREACTORSL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO BROAD SCOPE OF BIOCHEMICAL ENGINEERING 10 hrs.

Definitions, processes and everyday products. Medium optimization-Plackett Burman method. Introduction tobioreactor configuration-Basic mode of operation batch, fed-batch and continuous reactor-bioreactor lay out-Kinetics ofbatch and continuous culture.

UNIT II IDEAL CONTINUOUS STIRRED TANK BIOREACTOR 10 hrs.

Material balance-Evaluation of Monod Kinetic parameter-Comparison of batch and CSTB-Multiple CSTB connectedin series-CSTB with cell recycling.

UNIT III SUBSTRATE-LIMITED GROWTH 10 hrs.

Monod equation: alternatives to Monod equation-Blackman, Tessier, Moser, Contois equation.Unstructured andstructured models. Models with growth inhibitors- Substrate inhibition, Product inhibition-Competitive and Noncompetitiveproduct inhibition.

UNIT IV AGITATION AND AERATION DESIGN 10 hrs.

Henry’s Law-mass transfer-Two film Theory-Definitions of oxygen Transfer Rate -Oxygen Uptake Rate-SpecificOxygen Uptake Rate- Mass transfer and rheology: Rheology of broths - impact on transfer processes Oxygen transportfrom the bubble to the cell.

UNIT V DESIGN CONSIDERATIONS 10 hrs.

Animal and plant cell bioreactors. Determination of kLa - Correlation for kLa.

REFERENCES:1. Shuler.M.L. and Kargi.F, Bioprocess Engineering Basic concepts, Pearson Education India, 1st Edition, 2003.2. Stanbury P.F., Whitaker A., and Hall S.J., Principles of Fermentation Technology, 2nd Edition, 1997.







SBTX1014 PLANT BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO PLANT BIOTECHNOLOGY 10 hrs.Structure and organization of plant genome, Regulation of plant genome expression, Transcriptional, Translational

and post transcriptional regulation of plant genome. Chloroplast and mitochondrial genome.

UNIT II BASIC rDNA TECHNOLOGY IN RELATION TO PLANT 15 hrs.Totipotency-Definition and Concept. Culture environment, Plant cell culture media, Plant hormones in agriculture

and horticulture. Types of culture-solid and liquid, Factors affecting in vitro culture. Isolation of DNA, Vector, Transfermechanism and expression. Agrobacterium mediated gene transfer vectors-Ti plasmid, Organization of T-DNA,Molecular biology of Agrobacterium infection, Plant virus vectors-CaMV, Gemini viruses, TMV, Brome mosaic virus.Agrobacterium vectors-cointegerate and binary vectors.

UNIT III METHODS TO DEVELOP TRANSGENIC PLANTS 10 hrs.Cross pollination, Direct gene transfer-Chemical methods, Particle Bombardment, Electroporation, Microinjection,

Vacuum pressure, Pollen transformation, Lipofection, Macroinjection. Integration of transgenes, Inheritance of transgeneanalysis and Confirmation of transgene integration.

UNIT IV APPLICATIONS OF TRANSGENIC PLANTS 10 hrs.Production of transgenic plants for herbicide resistance, Insect resistance and stress tolerance. Plants as

bioreactors, Plant derived vaccines-edible vaccines, Plantibodies, Recombinant and subunit vaccines, Molecular basisof photosynthesis, gene expression in the developing seed.

UNIT V SAFETY, IPR AND ETHICAL ISSUES RELATED TO PLANT BIOTECHNOLOGY 5 hrs.Safety regulations for transgenic plants, Current issues related to transgenic plants, Strategies towards transgenic

plants, Biosafety, IPR and bioethics.

TEXT BOOK1. Adrian Slater, Nigel Scott, and Mark Fowler, Plant Biotechnology, Oxford University Press, NewYork, 2007.

REFERENCES:1. Old R.W. and Primrose S.B., An Introduction to Genetic Engineering, University of California press, 1980.2. Satyanarayana, U. Biotechnology, Allied Pvt. Ltd. Kolkata, 2007.3. Purohit S.S., Agricultural Biotechnology, Agrobios Indi., Jodhpur, 2002.







SBTX1016 MEDICAL BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO MEDICAL BIOTECHNOLOGY AND DRUG 10 hrs.

Basic medical terminology – Genomics, Proteomics, Pharmacogenomics, Pharmacokinetics, hereditary disorders,drugs. Basis of human physiology.

UNIT II DIAGNOSTICS 10 hrs.

Clinical samples – blood, urine, sputum, CSF, pus, swab, etc.. Clinical diagnosis – based on the signs &symptoms of the patients in clinics. Laboratory diagnosis – Hematology, Biochemistry (Serum & Tissue), Histology(Biopsy and Autopsy) and Endocrinology. Diagnosis of Bacteria (Mycobacterium), DNA virus (HBV/H1N1), RNA virus(HIV/HCV), Parasite (Malaria).

UNIT III TREATMENT AND PREVENTION 10 hrs.

Traditional medicine (AYUSH), Chinese and Modern medicine, Antibacterial, Antiviral, Antibiotics, use of interferon,immunomodulators. Food as medicine, vaccines and toxoids, active and passive immunization.

UNIT IV METABOLIC MECHANISMS 10 hrs.

Basics in Experimental medicine – receptor mediated signal transduction – primary messenger – hormones anddrugs- secondary messenger and neurotransmitters. G- Protein coupled receptors – cyclic AMP –calcium ions – Nitricoxide (NO) – prostaglandin and inositol triphosphates.

UNIT V DRUG DEVELOPMENT AND BIOINFORMATICS 10 hrs.

Introduction to conventional and futuristic developments in molecular and immunological basis of disease elevation-combinatorial antibody designing – Gene therapy- Anti sense therapy- RNAi. Drug designing process, receptor –ligandinteraction, ligand docking – bioinformatics tools.

TEXT BOOK:1. Judit Pongrácz and Mary Keen, Medical Biotechnology – Churchill Livingstone Elsevier 2009

REFERENCES:1. T.M.Devlin, Textbook of Biochemistry with Clinical correlations – John Wiley and Sons 20102. Arthur C. Guyton and John Edward Hall, Textbook of medical physiology – Elsevier Saunders 2006







SCHX1019 MASS TRANSFER FOR BIOLOGICAL SYSTEMSL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO MASS TRANSFER 10 hrs.

Principles of unsteady state and convective mass transfer, Convective mass transfer coefficients, Analogy betweenMass, Heat and momentum transfer, Mass transfer for flow inside pipes, Mass transfer to suspensions of small particles

UNIT II DIFFUSION 10 hrs.

Fick’s law, Molecular diffusion in gases, Molecular diffusion in liquids, Molecular diffusion in biological solutionsand gels, Molecular diffusion in solids.

UNIT III INTRODUCTION TO EVAPORATION 10 hrs.

Types of evaporators, Overall heat transfer coefficients in evaporators, Calculation methods for single effectevaporators, Effect of process variables on evaporator operation, Evaporation of Biological materials, Evaporation usingvapor recompression.

UNIT IV INTRODUCTION TO CRYSTALLIZATION 10 hrs.

Crystal types, Equilibrium solubility in crystallization, Crystallization theory, Equipments for crystallization, MSMPRCrystallizer.

UNIT V INTRODUCTION TO DRYING 10 hrs.

Equipments for drying, Vapor pressure of water and Humidity, Equilibrium moisture content of materials, Rateof Drying curves, Calculation methods for constant rate drying period, Calculation methods for falling rate dryingperiod, Freeze drying and Sterilization of Biological materials, Pasteurization.

REFERENCES:1. Christie John Geankoplis, Transport processes and separation process principles, Prentice hall, 4th Edition, 20032. Mc Cabe, W.L., Smith, J.C., and Harriott, P., Unit operations in Chemical Engineering, McGraw Hill, 6th Edition, 2005. 3. Treybal, R.E., Mass transfer operations, McGraw Hill, 2nd Edition. 1980







SBIX1029FUNDAMENTALS OF GENOMICS AND

PROTEOMICSL T P Credits Total Marks

3 0 0 3 100

UNIT I GENOME PROJECTS 10 hrs.

Brief outlook of various genome projects, Human Genome Project. Nucleotide sequencing methods – Chemical,enzymatic, high throughput method, Automated sequencing methods; Protein sequencing method – Edman’s degradation

UNIT II INTRODUCTION TO PROTEOMICS 10 hrs.

Concepts – Protein-Protein Interactions. Methods – Yeast Two hybrid analysis, Phage display. Protein-DNAInteractions – DNA binding Motifs. Factors affecting the interaction.

UNIT III GENOME MAPPING 10 hrs.

Genetic markers – RFLP, SSLP, STRs, VNTRs; Physical Markers – EST, STS, FISH, Radiation hybrids. Sequencemarkers – SNPs. Expression analysis – DNA microarray approach.

UNIT IV GENOMICS 10 hrs.

Transcriptomics – SAGE, Microarray. Concepts - Structural & Functional Genomics, Comparative & Populationgenomics, Metabolomics, Pharmacogenomics.

UNIT V PROTEOMIC TOOLS 10 hrs.

HPLC, PAGE, MALDI, ESI. Protein Expression Profiling - Protein Microarrays, Mapping Protein Modificatons.New Directions in Proteomics.

REFERENCES:1. Brown T.A, Gene Cloning, Chapman and Hall, 2004.2. Brown T.A, Genomes, Bios Scientific Publishers Ltd 2002.3. Greg Gibson and Spencer V. Muse, A Primer of Genome Science, 3rd Edition, Sinauer Associates, Inc., 2009







SBTX1017 ANIMAL BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I HISTORY AND SCOPE OF ANIMAL BIOTECHNOLOGY, MERITS AND DEMERITS 10 hrs.

Techniques of cell and tissue Culture-Primary culture, Cell lines and cloning, Somatic cell fusion, tissue cultures,organ culture, whole embryo culture, stem cell culture.

UNIT II GROWTH AND SCALE UP 10 hrs.Cell growth characteristics and kinetics, Micro-carrier attached growth, Cell culture in continuous, perfusion and

hollow fibre reactor.

UNIT III ANIMAL TRANSGENESIS 10 hrs.

Transgenic models-mice. Methods of producing transgenic mice-embryonic stem cell, pronucleus method-randomand target gene insertion, knockout and knockin mice.

UNIT IV IN VITRO FERTILIZATION TECHNIQUES 10 hrs.

Manipulation of reproduction in animals-artificial insemination, embryo transfer. In vitro fertilization technology-in vitro maturation of oocytes, culture of in vitro fertilized embryos, embryo cloning- quadriparental hybrid, nucleartransplantation (Dolly), embryonic stem cells

UNIT V TECHNOLOGY – PRESENT AND FUTURE 10 hrs.

Transfection of animal cells, Future tissue engineering, In vitro fertilization and embryo transfertechnology, Methods of gene transfer – Microinjection and viral mediated gene transfer techniques-Production oftransgenic animals and molecular pharming, Principles of Ex vivo and In vivo gene therapy.

TEXT BOOKS:1. Ian Freshney R., Culture of Animal Cells, 3rd Edition, Wiley-Liss, 2005.2. John R.W. Masters, Animal Cell Culture – Practical Approach, Oxford University Press, 3rd Edition, 2000.

REFERENCES:1. Butler M. & Dawson M., Cell Culture Labfax, Bios Scientific Publications Ltd., 1992 2. Martin Clynes, Animal Cell Culture Techniques, Springer, 1998.3. Jenni P. Mather and David Barnes, Methods in Cell Biology, Vol. 57, Animal Cell Culture Methods. Academic Press, 1998.4. R. Basega, Cell Growth and Division: A Practical Approach, IRL Press. 1989.







SBTX4005BIOPROCESS ENGINEERING LAB -1

(FERMENTATION)L T P Credits Total Marks

0 0 4 2 100

1. Growth

(a) Estimation of biomass, calculation of specific growth rate, yield coefficient of Bacteria.

(b) Estimation of biomass, calculation of specific growth rate, yield coefficient of Yeast.

2. Optimization of growth conditions – physical & chemical (pH, temperature, time, nutrients – carbon, nitrogen & phoshorous)

(a) Medium optimization by placket burman design.

(b) Medium optimization – response surface methodology.

3. Biological Activity analysis

(a) Enzyme activity – effect of temperature and pH.

(b) Enzyme inhibition kinetics.

4. Immobilization

(a) Entrapment Techniques

SBIX4010 BIOINFORMATICS LABL T P Credits Total Marks

0 0 4 2 100

1. Search And Retrieval of Nucleic Acid Sequence. 2. Search And Retrieval of Protein Sequence.

3. Structural Database-pdb. 4. Bibliographic Database.

5. Homology Searches-blast and Fasta. 6. Pairwise Alignment.

7. Multiple Sequence Alignment. 8. Secondary Structure Prediction.

SBTX4006 ADVANCED MOLECULAR BIOLOGY LABL T P Credits Total Marks

0 0 4 2 100

1. Isolation of RNA / DNA 2. Separation and identification using Agarose Gel

3. Quantification of RNA /DNA by physical and chemical methods

4. Amplification (PCR) of Nucleic acid 5. Elution of DNA from gel

6. Restriction of DNA 7. Restriction digestion of λ DNA

8. RAPD and RFLP

SBTX4007 ANIMAL TISSUE CULTURE LABL T P Credits Total Marks

0 0 4 2 100

1. Media Preparation for animal tissue culture. 2. Primary cell culture-Chick Embryo Fibroblast

3. Subculturing of Normal Cell/Cancer cell 4. Preservation and retrieval of animal cells

5. Viability checking (Trypan Blue) and cell counting by Hemocytometer

6. Cytotoxicity assay

(a) Direct Microscopic Observation

(b) MTT assay



SBTX1015 NANOBIOTECHNOLOGYL T P Credits Total Marks

3 1 0 4 100

UNIT I INTRODUCTION TO NANO SCIENCE 10 hrs.

Definition, concepts and principles, types of approaches, four generations, self assembly, properties and applicationof nanotechnology.

UNIT II PRODUCTION OF NANOPARTICLES 10 hrs.

Physical, chemical, biological methods, fabrication technology, characterization, micro fluidic- concepts, nanomechanics

UNIT III NANO BIO-TECHNOLOGY 10 hrs.

Proteins, DNA, biological molecular complexity, biocompatibility, bionanopore, nanomotors- production of artificialnano motors, drug delivery, biological nano containers and nanoversatility construction.

UNIT IV INTRODUCTION TO NANO ELECTRONICS 10 hrs.

Biosensing- nano circuitry, nano photonics, digital logic, mechano chemical power conversion, diamond mechanosynthesis, neuronal network- electronic interface, surface force and component manipulation, nanofactories.

UNIT V NANOBIOCHIP 10 hrs.

Sensor, environmental impact of nano dimension to society and implication of nano technology, new trends andapplication of nano technology.

TEXT BOOKS:1. C.M Niemeyer and C.A. Mirkin, Nano biotechnology – concepts, applications and perspectives, Wiley-VCH, Verlag Publication, 2001.2. K.K. Jain, Nano biotechnology in molecular diagnostics – current techniques and applications. Taylor and Francis publications, (2006).







SBTX1018 PLANT CELL AND TISSUE CULTUREL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO PLANT CELL AND TISSUE CULTURE 10 hrs.

Definition, Principle and history of Plant tissue culture, Laboratory organization and steps involved in generaltechniques. Methods of sterilization. Tissue culture media: Composition, types and preparation. Culture initiation andregeneration through different pathways.

UNIT II GENERAL PROPAGATION METHODS IN PLANTS 10 hrs.

Micropropagation technique, factors affecting micropropagation, general applications and in forestry and horticulturecrop. Micrografting and its application. Production of virus free plants through meristem culture and methods of viruselimination.

UNIT III CELL AND CALLUS CULTURE 10 hrs.

General technique, methodology and its application. Secondary metabolite production through cell suspensionculture: Principle and technology, applications. Protoplast isolation, culture and regeneration. Somatic hybrid and cybrids.

UNIT IV HAPLOID PRODUCTION THROUGH ANDROGENESIS AND GYNOGENESIS 10 hrs.

General technique, factors affecting technique and its applications. Embryo culture: Methodology and itsapplications and Embryo rescue methods in agricultural and horticultural crops. In vitro pollination and fertilization

UNIT V SOMACLONAL VARIATION 10 Hrs.

Genetic and Epigenetic causes, stability and utilization. Ex situ conservation of germplasm throughCryopreservation method. Commercialization of tissue culture technology: Concept of commercialization, needs andmanagement. Plant tissue culture industries in India.

TEXT BOOKS: 1. Chawla, R. Introduction to Plant Biotechnology, Oxford & IBM Publishing,. Co.Pvt. Ltd, New Delhi, 2001. 2 Bhojwari. S.S & M.K. Razdan., Plant Tissue Culture, Raju Praimlani for Oxford of I&M Publishing. co. Pvt. Ltd, New Delhi, 2002

REFERENCES: 1. John H. Dodds and Lorin W. Robert, Experiment in Plant Tissue culture, Oxford Blackwell Publication, 2003 2. Adrian Slater, Scoot N., Plant Biotechnology: the genetic manipulation of plants – Cambridge, Newyork, Cambridge University Press,

1982







SBAX1001PRINCIPLES OF MANAGEMENT AND

PROFESSIONAL ETHICSL T P Credits Total Marks

3 – – 3 100

UNIT I MANAGEMENT FUNCTIONS & STRUCTURE 10 hrs.

Management – Definition – Basic Function – Contribution of Taylor & Fayol. Types of structure – Line, staff,Functional, Committee, Project & Matrix – Structures.

Departmentalization – Centralization – Decentralization – span of control. Management By Objectives –Management By Exception.

UNIT II MANAGEMENT OF ORGINASATION 10 hrs.

Forms of Business / Industrial Ownership – Sole Trader, Partnership, Company, Performance Appraisal – BasicPrinciples – Pitfalls – Methods to Overcome. Industrial Safety – Causes of Accidents – Cost of Accident – How tominimize Accidents. Plant Layout & Maintenance – Need, Types & Managerial Aspects.

UNIT III ORGANISATIONAL BEHAVIOUR 10 hrs.

OB – Definition – Nature & Scope – Contributing Disciplines – Importance of OB to Managers. Personality –Definition – Theories – Factors Influencing Personality. Motivation – Definition – Theories. Theory X & Y – TransactionalAnalysis. Morale & Job Satisfaction – Factors Influencing Job Satisfaction.

UNIT IV GROUP DYNAMICS 10 hrs.

Group – Definition – Types – Determinants of Group Cohesiveness – Communication – Process – Barriers –Effective Communication. Leadership Theories – Factors Contributing to Effective Leadership – Role of Trade Unionin Organizations – Functions of Trade Union – Why Trade Union is required? – Types of Trade Union.

UNIT V PROFESSIONAL ETHICS 10 hrs.

Ethics in Workplace – Formulation of Ethics – Managerial Ethics – Managing Ethical Behaviour – Codes ofEthics – Encouraging Ethical Behaviour – Social Responsibility – Spirituality.

REFERENCES:1. Gupta C.B., Management Theory and Practice, 14th Edition, Sultan Chand & Sons, 2009.2. Dr. Prasad L.M., Principle & Practice of Management, 7th Edition, Sultan Chand & Sons, 2008.3. Aswathappa, Organisational Behaviour, 8th Edition, Himalaya Publishing House, 2010.4. Dr. Prasad L.M., Organisational Behaviour, 4th Edition, Sultan Chand & Sons, 2008.5. Harold Koontz, Principles of Management, 1st Edition, Tata McGraw Hill, 2004.







SBTX1012 ENVIRONMENTAL BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I POLLUTION 10 hrs.

Environmental pollution- pollutants – types- water, soil and air pollution, health and environmental hazards ofpollution. Industries causing pollution, e-wastes.

UNIT II SOLID WASTE MANAGEMENT 10 hrs.

Concepts, types - sanitary land fills, composting, incineration, pyrolysis, bio-venting, soil forming, prepared beds,soil piles.

UNIT III LIQUID WASTE MANAGEMENT 10 hrs.

Bioremediation of liquid, sewage wastes- concepts, types, aerobic treatment system. Activated sludge process,trickling filters, packed bed columns, fluidized bed reactors.

UNIT IV AIR POLLUTION 10 hrs.

Wastes – aerosols, droplet nuclei- for removal of airborne contaminants, quality control techniques of air samplers– use of filters, radiation techniques.

UNIT V BIOSAFETY AND ETHICS 10 hrs.

Release of genetically engineered microbes in the environment, impact of GEM on environment, role of GEMin degradation of industrial pollutants.

REFERENCES:1. Alan Scragg Environmental Biotechnology, Longman Publications, 1999.2. Milton Wainwright, An Introduction to Environmental Biotechnology, Kluwer Academic Press. 1999







SBIX1030 MOLECULAR MODELING AND DRUG DESIGNINGL T P Credits Total Marks

3 1 0 4 100

UNIT I CONCEPTS IN MOLECULAR MODELING 10 hrs.

Introduction, Coordinate systems, Energy surfaces. Introduction to Quantum mechanics - Schrodinger waveequation, Born-Oppenheimer Approximation.

UNIT II MOLECULAR MECHANICS 10 hrs.

Force field - Bond Stretching, Angle bending and Torsion angle, Non-bonding interactions. Introduction to Energyminimization, Computer simulations, Conformational analysis.

UNIT III DRUGS 10 hrs.

Prodrugs- classification, Soft drugs. Drug targets - Enzymes, Receptors, Proteins, Nucleic acids, Lipids. Drugsolubility - Effect of pH, Effect of polarity and pKa. Drug Metabolism – Absorption, Distribution, Metabolism, Elimination.

UNIT IV DRUG DESIGN 10 hrs.

Steps in drug Development, Lead discovery. Molecular modeling in drug design: Concepts - Pharmacophore,Molecular docking. Structure based methods to identify lead compound, De novo ligand design, QSAR.

UNIT V COMPUTATIONAL REPRESENTATION OF MOLECULES 10 hrs.

Chemical Databases – PDB LIGAND, PUBCHEM. Sources of data for 3D structures – PDB, PDB Sum. SMILESNotation.

REFERENCES:1. Andrew Leach - Molecular Modelling: Principles and Applications, 2nd Edition. Pearson Education EMA, 2001.2. R.K. Prasad - Quantum Chemistry, 3rd Edition, 2006.







SBTX1019 PHARMACEUTICAL BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100


Development of Drug and Pharmaceutical Industry -Therapeutic agents, their uses and economics; Routes ofdrug administration.

UNIT II DRUG METABOLISM AND PHARMACOKINETICS 10 hrs.

Drug metabolism – physico chemical principles, radioactivity – pharmacokinetics-action of drugs on human bodies.

UNIT III IMPORTANT UNIT PROCESSES AND THEIR APPLICATIONS 10 hrs.

Bulk drug Manufactures, Types of Reactions in Bulk drug Manufacture and Processes. Special Requirementsfor Bulk Drug Manufacture and its regulatory aspects.

UNIT IV PRODUCT FORMS AND DEVELOPMENT 10 hrs.

Compressed tables, wet granulation-dry granulation or slugging-direct compression-tablet presses, coating oftablets, capsules sustained action dosage forms-parental solutions-oral liquids-injections-ointments-Topical Application,Preservation, analytical methods and test for various drugs and pharmaceuticals, Labeling, Packing-Packing Techniques,Quality Management, GMP.

UNIT V PHARMACEUTICAL PRODUCTS 10 hrs.

Therapeutic categories such as vitamins, laxatives, analgesics, non-steroidal contraceptives, Antibiotics, biological,hormones examples with respect to system.

REFERENCES:1. Leon Lachman Theory and Practice of Industrial Pharmacy, 3rd Edition, Lea and Febiger, 1986.2. Remington’s Pharmaceutical Sciences, 17th Edition, Mark Publishing & co, 1985







SBTX1020 MARINE BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO MARINE ENVIRONMENT & BIODIVERSITY 10 hrs.World oceans and seas – ocean currents, physical and chemical properties of sea Water, ecological divisons

of the sea- Euphotic – mesopelagic – bathopelagic- benthos – deep sea, Trophic systems, benthos

UNIT II MARINE MICROORGANISMS 10 hrs.Marine biodiversity, Marine microbial habitats – Microbial distribution in the oceans, Symbiosis with invertebrates,

Screening for new metabolites from marine microorganisms, The secondary metabolites and biosynthetic gene clustersof marine cyanobacteria, marine actinomycetes and fungi

UNIT III MARINE FLORA AND BIOACTIVE PRODUCTS 10 hrs.Culture techniques of Seaweeds and microalgae. Byproduct- Agar and agarose, Algin and Alginates, Carrageenan

UNIT IV MARINE FAUNA AND THEIR BIOACTIVE PRODUCTS 10 hrs.Culture practices of sea bass, tiger shrimp, lobsters, edible oyster, pearl oyster and mussel. Fish Genetics-

gynogenesis, androgensis, polyploidy, control of sex, artificial insemination, eye stalk ablation. transgenesis andcryopreservation. Byproduct- Chitin and Chitosan, Heparin

UNIT V THREAT TO MARINE ENVIRONMENT 10 hrs.Human impacts on marine microbial diversity – Critical microbially-mediated equilibria that impact environmental

and human health – Using marine microbes to ameliorate environmental deterioration. Control of oil spills andbioremediation. Environmental issues: Effects of bio-fouling and bio-deterioration on marine structures. Protectionmethods against corrosion and fouling. Red tides: Causative factors and effects on the organisms of marine environment.

TEXT BOOKS: 1. Milton Fingerman and Rachakonda Nagabhushanam, Recent Advances in Marine Biotechnology (Series) Biomaterials and

Bioprocessing, Science Publishers, 2009. 2. Proksch and Werner E.G.Muller, Frontiers in Marine Biotechnology. Horizon Bioscience, 2006.

REFERENCES: 1. Le Gal, Y., Ulber, R, Marine Biotechnology I: Advances in Biochemical Engineering/Biotechnology (Series editor: T. Scheper)

Springer-Verlag Berlin Heidelberg. Vol. 96, 2005. 2. Le Gal, Y., Ulber, R Marine Biotechnology II: Advances in Biochemical Engineering/Biotechnology (Series editor: T. Scheper)

Springer-Verlag Berlin Heidelberg. Vol. 97, 2005.







SBTX4008BIOPROCESS ENGINEERING LAB - 2 (DOWN STREAM PROCESSING LAB)


0 0 4 2 100

1. Isolation and identification

(a) Isolation and identification of commercially important enzyme producing microorganisms

2. Extraction

(a) Extraction of Extracellular Enzyme

(b) Extraction of Intracellular Enzyme

3. Purification

(a) Salting in and salting out

(b) Dialysis

(c) Ultrafiltration

(d) Gel chromatography

(e) Lyophilization

4. Activity

(a) Enzyme activity – effect of temperature and pH

5. Preservation

(a) Crystallization of citric acid

SBTX4009 PLANT TISSUE CULTURE LABL T P Credits Total Marks

0 0 4 2 100

1. Plant Tissue Culture Nutrient Media Preparation

2. Micropropagation of Plants

3. Cell and Callus Culture

4. Anther/ Pollen culture

5. Embryo Culture

6. Somatic Embryogenesis

7. Synthetic Seed Production

8. Isolation, Culture and Fusion of Protoplast

S23XPROJ PROJECT WORK & VIVA VOCEL T P Credits Total Marks

0 0 30 15 100

The objective of the project work is to make use of the knowledge gained by the student at various stages ofthe degree course. Students, will also be permitted to undertake industrial/consultancy project work, outside thedepartment, in industries/Research labs.

There shall be three assessments during the semester by a review committee. The student shall make threepresentations on the progress made before the committee at various stages of the Project work. The Head of theDepartment shall constitute the review committee for each branch of study. The total marks obtained in the threereviews, shall be taken in to account. There will be a viva-voce examination at the end of the Project work, conductedby one internal examiner and one external examiner. The total marks secured will be the sum of marks secured inthe Project reviews and Viva Voce Examination.

Each student is required to submit a Project report on the project assigned to him by the department. Thereport should be based on the information available in the literature or data obtained by the student by way ofexperiments conducted in the laboratory/industry.



SBTX1021 NEURO SCIENCEL T P Credits Total Marks

3 0 0 3 100


An overview of neuroscience and Biotechnology - Neurons and Neuroglia – Neuronal membrane at rest, ActionPotential – Synaptic transmission- neurotransmitter system

UNIT II NERVOUS SYSTEM IN HEALTH 10 hrs.

The structure of nervous system – gross anatomy – Brain spinal cord and peripheral nerves.

UNIT III PATHOLOGY OF THE NERVOUS SYSTEM 10 hrs.

Molecular and cellular mechanisms – pathological features of genetics of multiple sclerosis-Parkinson’s Diseases-Huntington’s Diseases – Alzheimer’s disease.

UNIT IV NEUROSCIENCE METHODS AND TECHNIQUES 10 hrs.

Techniques to understand the functions of nervous system: Patch clamp techniques, intracellular recording, extracellular recording, mass unit recording, Evoked potentials and electro encephalographic (EEG),

Techniques to understand the chemistry of nervous system: Brain Imaging, CT scan, PET, MRI, FMRI,Angiography.

UNIT V BIOTECHNOLOGY AND DISEASES OF NERVOUS SYSTEM 10 hrs.

Gene therapy and development of transgenic mice- ethical concern.

REFERENCES:1. Eric R. Kandel, James H.S. Chwarts and Thomas M. Jessel, Principles of Neural Science 4th Edition, 2006.2. Gupta, Basic Neuro anatomy, McGraw Hill, 5th Edition, 2006.







SBTX1022 CANCER BIOLOGYL T P Credits Total Marks

3 0 0 3 100

UNIT I THE BASICS OF CANCER BIOLOGY 10 hrs.Nomenclature, Historical perspective, Oncogenesis, Cell cycle & check points, cancer mechanism, Receptors,

Signal molecules, Signal transduction – Modulation study, oncogenesis, Diagnostic tools for detection of cancer gene,treatment and prevention of cancer.

UNIT II CAUSE, TYPES AND DETECTION OF CANCER 10 hrs.Incidence of cancer, Factors related to transformation- environment, Geography,Genetic modification – telomerase

study, Types of carcinogenesis – physical, chemical and Biological carcinogenesis. Detection of cancer, Identificationof cancer using-signal targets- gene therapy – New techniques of early detection of cancers and early detectedcancer-curative methodologies.

UNIT III BIOLOGY OF CANCER 10 hrs.Differentiation, rate of growth, local invasion, Metastasis, Pathways of spread. Tumor progression, theory of

invasion – tumor cell invasion – invasion of extracellular matrix – Vascular dissemination and homing of tumor cells.

UNIT IV ONCOGENES AND ONCOPROTEINS 10 hrs.Conditions of cancer, protooncogenes,oncogenes and oncoprotein,Tumor suppressor genes – p53

genes,activation-study. Evasion of apoptosis – DNA repair defects and instability of genes in cancer cells.Stromal andmicroenvironment and carcinogenesis. Dysregulation of cancer, Chromosomal changes,amplication of genes, Molecularprofile of cancer cells.

UNIT V CANCER THERAPY 10 hrs.Cancer therapy: different types of cancer therapy-physical, chemical, biological and conventional method of cancer

therapy.

TEXT BOOKS:1. Maly B.W.J . Virology:APractical approach IRC press,Oxford, 19872. Dunmock N.J and Primrose S.B;Introduction to Modern virology,Blackwell Scientific publication,oxford, 1988

REFERENCES:1. Margaret A. Knowles and Peter T. Selvo, An introduction to cellular and molecular biology of cancer, Oxford Medical publication,

1991


Max Marks: 80 Exam duration: 3hrs





SBTX1023 MICROBIAL PATHOGENESISL T P Credits Total Marks

3 0 0 3 100


Introduction to microbial pathogenesis, prion, virus, bacteria and fungi, epidemiology, microbial pathogen geneticdiversity in nature.

UNIT II HOST PATHOGEN INTERACTION 10 hrs.

Host defences against pathogens, clinical importance of understanding of host defences, components of the hostsurface defences systems like mucosa and defences systems of the eye, mouth, respiratory tract etc., componentsof the systemic defence like the tissues and blood.

UNIT III DETECTION 10 hrs.

Detection of pathogen by biochemical, microbial culture and microscopy and molecular diagnostic tools for bacterialinfection like typhoid, tuberculosis, leprosy, parasitic infections like amoebiasis, hydaid disease, malaria, filariasis, Viraldisease: herpes, measles, influenza mononucleosis, HIV. Fungal infections: mycetoma, rhinosporidiosis, candidiasis,Aspergillosis.

UNIT IV PRIONS AND CANCER 10 hrs.

Molecular pathogenesis of prions- humanprion disease, diagnostic criterion of human prion’s disease. Molecularmechanisms for inflammation-promoted pathogenesis of cancer- topical inflammation caused by cancer causing agents

UNIT V PREVENTION AND TREATMENT 10 hrs.

Prevention: modulation of immune response by vaccines, properties of vaccines, other immuno modulators. Treatmentby conventional and recombinant method.

TEXT BOOKS:1. Iglewski B.H. and Clark V.L. Molecular basis of Bacterial pathogenesis, Academic press, 1990.2. Janeway C.A. Jr, and Travers P. T. Immunobiology. Blackwell J Scientific Publishers, 1994.

REFERENCES:1. Talaro K. and Talaro A. Foundations in Microbiology, W.C. Brown Publishers, 1993.2. Roitt I. Essentials of Immunology, 8th Edition, Blackwell Scientific Publishers, 1994.3. Austyn J.M. and Wood K.J. Principles Cellular and Molecular Immunology, OxfordUniversityPress,1993.







SMEX1017RESOURCE MANAGEMENT TECHNIQUES



3 0 0 3 100

UNIT I INTRODUCTION AND LINEAR PROGRAMMING 10 hrs.

Operations Research(OR)-Nature-Characteristics-Phases.-Role of OR in Decision making- Outline of OR ModelsLinear Programming – Formulation of L.P.problems –Solution by graphical method, simplex method, and big M methods– Applications of O.R. in production management

UNIT II TRANSPORTATION AND ASSIGNMENT MODEL 10 hrs.

Transportation problem – Initial feasible solution- Northwest corner method, Least Cost method, Vogel’sapproximation method – Test for optimality-MODI method

Assignment problems- Hungarian assignment models- Travelling salesman problems

UNIT III RESOURCE SCHEDULING AND NETWORK ANALYSIS 10 hrs.

Problem of Sequencing – Problem with N jobs and 2 machines, 3 jobs and M machines. Project Management– Basic concepts – Case studies – Network construction and scheduling, Program evaluation and resource levelingby network techniques, time – Cost trade off.

UNIT IV INVENTORY CONTROL AND SIMULATION 10 hrs.

Inventory Control – Various Types of inventory models – deterministic inventory models – Production model,Purchase model– with and without shortage- EOQ – Buffer stock – Shortage quantity, Probabilistic inventory models– Quantity Discount and Price Breaks Simulation – Use, advantages & limitations, Monte –Carlo simulation, applicationto queuing, inventory & other problems

UNIT V QUEUEING THEORY, GAME THEORY AND REPLACEMENT MODELS 10 hrs.

Queuing theory – Poisson arrivals and exponential service times, Single channel models only. Game theory-Payoff matrix, competitive games with pure strategy, minimax criterion, principles of dominance &mixed strategiesReplacement policy for items whose maintenance cost increases with time- Consideration of money value- Replacementpolicy- Individual, Group replacement of items that fail completely

TEXT BOOK:1. Kanti Swarup, P.K.Gupta, & Manmohan., Operations Research – S. Chand & Sons, 11th Edition, 1978.

REFERENCES:1. K.V.Mital and C.Mohan,” Optimization Methods in O.R and System Analysis “, New Age International Publishers.2. S.D.Sharma,”Operations Research”, Kedarnath Ramnath& Co, 2002.3. Hamdy A. Taha,” Operations Research”, 5th Edition, PHI, 19954. Hiller & Liberman,”Introduction to operation research”, 5th Edition, McGraw Hill, 2001.5. Ravindran,Phillips&Solberg, “Operations Research: principles and practice”, 2nd Edition, Wiley India Lts, 2007







SCHX1020 HEAT AND FLUID DYNAMICSL T P Credits Total Marks

3 0 0 3 100

UNIT I FLUID FLOW PHENOMENA 10 hrs.

Nature of fluids: incompressible and compressible, hydrostatic equilibrium, manometers, potential flow, boundarylayer, the velocity field, laminar flow, Newtonian and non-Newtonian fluids, Newton’s-law of viscosity, turbulence,Reynolds number and transition from laminar to turbulent flow.

UNIT II TURBO MACHINERY & FLOW MEASUREMENT 10 hrs.

Streamlines and stream tubes, equation of continuity, Bernoulli equation, and pump work in Bernoulli equation.Classification of pumps - Positive Displacement Pumps, Centrifugal pumps, Constant and variable headmeters – Venturi,Orifice and Rota meter

UNIT III HEAT CONDUCTION 10 hrs.

Introduction to various modes of heat transfer, Fourier’s law of heat conduction, effect of temperature on thermalconductivity, steady-state conduction, compound resistances in series, heat flow through a cylinder.

UNIT IV CONVECTION & RADIATION 10 hrs.

Concept of heat transfer by convection - Natural and forced convection - Application of dimensional analysisfor convection - Equations for forced convection under laminar, transition and turbulent conditions - Equations fornatural convection - Concept of thermal radiations - Black body concept - Stefan Boltsman’s law.

UNIT V HEAT TRANSFER EQUIPMENTS 10 hrs.

Parallel and counter flow heat exchangers - Log mean temperature difference - Single pass and multipass heatexchangers; Shell & Tube Heat Exchanger, Double pipe heat exchanger – Applications.

REFERENCES: 1. Warren L. Mccabe, Julian C. Smith and peter Harriott, “Unit Operations of Chemical Engineering”, 6th Edition, McGraw Hill International

Edition, NewYork 2001 2. Coulson J.M., Richardson J.F., Backhurst J.R. and Harker J.M., “Coulson & Richardson’s Chemical Engineering”, Vol. I, 6th Edition,

Butter worth Heinemann, Oxford, 1999. 3. Coulson J.M., Richardson J.F., Backhurst J.R. and Harker J.M., “Coulson & Richardson’s Chemical Engineering”, Vol. II, 4th Edition,

Butter worth Heinemann, Oxford, 1996.







SCHX1021 INDUSTRIAL SAFETYL T P Credits Total Marks

3 0 0 3 100

UNIT I INDUSTRIAL SAFETY PRINCIPLES 10 hrs.

Site selection, plant layout- design for ventilation - basic rules and requirements which govern the chemicalindustries – social environmental setup – tolerance limit of the society.

UNIT II HAZARD 10 hrs.

Chemical hazards classification – hazards due to fire and explosion – safety analysis – chemical and job safety– safe handling and operation of materials and machineries.

UNIT III HAZARD ANALYSIS 10 hrs.

Types of hazard analysis – hazard identification – HAZOP – hazard survey – Fault tree analysis - event treeanalysis.

UNIT IV APPRAISAL 10 hrs.

Effective steps to implement safety procedure – periodic advice and constant maintenance – personal protectiveequipments- types – fire fighting equipments.

UNIT V BIOSAFETY 10 hrs.

Introduction – biosafety issues in Biotechnology – Historical background – primary contaminents for biohazards-biosafet guidelines and regulations (National and International) – operation of Biosafety guidelines and regulation ofGovernment of India – Risk analysis – risk assessment – risk management.

REFERENCES:1. Fawcett H.H. and Wood W.S. Safety and Hazard prevention in chemical operation, Intersciences, 1965.2. Blake R.P. Industrial safety Prentice Hall Inc. New Jersey, 2nd Edition, 1963.







SCHX1022 FOOD BIOTECHNOLOGYL T P Credits Total Marks

3 0 0 3 100


Microbiology of different types of food – vegetables and fruits, meat and fish, milk and milk products- intrinsicand extrinsic parameters of food that affect microbial growth – microbiological quality testing of foods – enumerationand detection of food borne organisms.

UNIT II PRODUCTION OF FOOD STUFFS 10 hrs.

Yeast based products – beer, wine and distill spirits – defects and correction- production of bacteria basedproducts- dairy, meat, fish, vinegar, polysaccharides – food additives.

UNIT III NEW PROTEIN FOODS 10 hrs.

SCP, mushrooms, food yeast, spirullina - production of sweeteners, flavors – amino acids, vitamins, cocoa, tea,coffee fermentations- emerging processes – genetically modified foods and consumer preference – prebiotic andprobiotic foods.

UNIT IV APPLICATION OF ENZYMES IN FOOD PROCESSING 10 hrs.

De-oxygenating and de-sugaring by glucose oxidase, beer mashing, chill proofing- cheese making by proteases– operations, unit clarification of juices.

UNIT V PROCESS WASTES 10 hrs.

Whey, molasses, starch substrates Unit processes and food wastes for bioconversions. Food borne pathogensand toxins and outbreak of diseases.

REFERENCES:1. James. M. Jay, Martin J. Loessner and David A.Golden, Food Microbiology, Springer Publication, 7th Edition, 2005.2. Frazier, Food Microbiology, McGraw Hill Publication, 4th Edition, 20013. Shetty K., G. Paliyath et al. – Food Biotechnlogy – 2nd Edition- Taylor and francis, 2006.4. Keshav Trehan, Biotechnology, New Age International (P) Ltd. Publishers, 2002.







SCHX1023 FOOD BIOCHEMISTRY AND NUTRITIONL T P Credits Total Marks

3 0 0 3 100

UNIT I ENERGY VALUE OF FOODS 10 hrs.

Thermal equivalent of oxgen, respiratory quotient, calorigenic action of the foods ,basal metabolic ratedefinitionnd its measurement, factors affecting BMR, energy requirements of the human beings.- Direct and indirect calorimetry

UNIT II NUTRITIONAL ASPECTS OF CARBOHYDRATES 10 hrs.

Different dietary types, requirements,utilization and functions. Special role of the non starchpolysaccharides.Nutritional aspects of the lipids - Different dietary types, requirements, utilization andfunctions. Essentialfatty acids.

UNIT III NUTRITIONAL ASPECTS OF PROTEINS 10 hrs.

Classification of amino acids and proteins,essential amino acids, nutritive value of proteins and the methods forits determination, amino acid imbalance, protein requirements, utilization and functions.Nutritional aspects of the vitaminsand minerals

UNIT IV INTERMEDIARY METABOLISM 10 hrs.

Metabolism of Carbohydrates, Lipids, Proteins, and Aminoacids, Nucleic acids,Hemoglobin, metabolic control,energy production & regulation.Metabolic interrelationships & regulatory mechanismsMetabolic changes during starvation

UNIT V BALANCED DIET 10 hrs.

Recommended dietary allowances for different categories of the human beings. Disorders related to the nutrition-Protein energy malnutrition -kwashirkor and marasmus Starvation, Obesity.

REFERENCES:1. James. M. Jay, Martin J. Loessner and David A.Golden, Food Microbiology, Springer Publication, 7th Edition, 2005.2. Frazier, Food Microbiology, McGraw Hill Publication, 4th Edition, 20013. Shetty K., G. Paliyath et al. – Food Biotechnlogy, Taylor and francis 2nd Edition, 2006.4. Keshav Trehan – Biotechnology, New Age Publishers, 2002.







SCHX1024 FOOD PROCESSING AND PRESERVATIONL T P Credits Total Marks

3 0 0 3 100

UNIT I NECESSITY FOR PRESERVATION 10 hrs.

History – spoilage due to environment – microbial spoilage of different foods – traditional methods of foodpreservation- picking, salting, sun drying.

UNIT II FOOD PRESERVATION BY DEHYDRATION 10 hrs.

Osmotic dehydration- high temperature and low temperature and cryopreservation – food preservation by additives-equipments used in food preservation.

UNIT III PRINCIPLES OF PRESERVATION BY FERMENTATION 10 hrs.

Fruit, vegetables, meat and milk based products – production of jams and jellies.

UNIT IV MODERN METHODS OF FOOD PRESERVATION 10 hrs.

High pressure, drying by microwave, radio frequency and gamma irradiation methods- quality control, HACCP-food toxins.

UNIT V PACKAGING OF FOODS 10 hrs.

Solid, liquid, modified atmosphere packing- labeling of foods- materials of packing- food grade- retort pouch.

REFERENCES:

1. Fennema R., Principles of Food Sciences, Technology and Engineering, 1978. 2. Sivashakar B., Food processing preservation, Prentice Hall of India, Pvt, Ltd, 2002.







SBTX1024 STEM CELL BIOLOGYL T P Credits Total Marks

3 0 0 3 100


Terminology, Types and Source, Embryonic development, Evolution of stem cell, Stem cell niche, cell cycleregulation of stem cell, Genetic regulation of stem cell fate. Potential applications for stem cell research. Origin andcharacterization of human stem cells, plasticity of human somatic stem cell research novel stem cell based therapies,scientific and technical obstacles to overcome before realising the potential clinical use of novel human stem cellbased therapy, cord blood, stem cell marker.

UNIT II HUMAN EMBROYONIC STEM CELL RESEARCH 10 hrs.

Possible sources for human embryonic stem cell, Growing human ESC in laboratory, Current advantages andlimitations of hESC and human somatic cells, Examination the need for new cell lines, Developments regardingestablishment of human stem cell banks and registries. Government of hESC research, Ethical issues at stake,regulation in European member states regarding human ESC research, Regulation in some Non European countriesregarding hESC research.

UNIT III HUMAN ADULT STEM CELL STUDY 10 hrs.

Isolation of haemopoietic stem cell, muscle and cardiac stem cell, and its applications. Molecular mechanismsof self-renewal, pluri/multipotency and lineage differentiation

UNIT IV PRESERVATION 10 hrs.

Isolation, identification and preservation of stem cells : isolation of neurosphere, mesenchymal cell, inner cellmass of embryo, identification by immuno labeling procedure using specific marker.

UNIT V APPLICATION OF STEM CELL AND REGENERATION 10 hrs.

Gene therapy: Possibilities to overcome immuno – rejection in stem cell therapy, Haematopoietic stem celltransplantation-A new therapy for autoimmune disease, Hematopoietic stem cell mobilization, Prenatal diagnosis ofgenetic abnormalities using fetal CD34+ stem cells. Stem cells in treatment for major disease and reparative medicine,Germ – line therapy.

TEXT BOOKS: 1. Kursad and Turksen, Embryonic Stem cells, Humana Press, 2002. 2. By Committee on the Biological and Biomedical applications of Stem cell Research, Stem cell and future of regenerative medicine,

National Academic press, 2002.

REFERENCES: 1. J. Odorico, et al., Human Embryonic stem cell, Garland/ BIOS Scientific, 2005, 2. Human Embryonic stem cells –The practical handbook –Stephan Sullivan Chad.A Cowan, kevinn Eggan, John Wiely & Sons Ltd.

2007







SBTX1025 TISSUE ENGINEERINGL T P Credits Total Marks

3 0 0 3 100

UNIT I INTRODUCTION TO TISSUE ENGINEERING 10 hrs.

Origin of Tissue Engineering – Tissue Engineering Triad, History and scope of tissue engineering – Challengeof imitating nature.

UNIT II BASIS OF GROWTH AND DIFFERENTIATION 10 hrs.

Organization of cells into higher ordered structures – Dynamics of Cell-ECM interactions – Composition anddiversity of ECM – Receptors for ECM molecules – Apoptosis – Wound healing process. Tissue engineering andmorphology – BMP and growth factors.

UNIT III CONTROL OF TISSUE DEVELOPMENT 10 hrs.

Mechanical and chemical determinants of Tissue development – Pattern formation through ECM remodeling –Mechanochemical switching between growth and differentiation – Animal cell culture.

UNIT IV SYNTHESIS OF TISSUES AND ORGANS 10 hrs.

Tissue engineering bioreactors – bioreactor technologies. Tissue assembly in microgravity – vascularization – Invitro embryology – In vivo synthesis of tissues and organs – basic parameters and fundamental design principles.

UNIT V: APPLICATIONS OF TISSUE ENGINEERING 10 hrs.

Gene therapy – Breast reconstruction – Cardiovascular system tissue engineering – Cornea – Bioartificial pancreas– Liver and hematopoietic system components.

TEXT BOOK:1. Robert Lanza, Robert Langer and Joseph Vacanti, Principles of Tissue Engineering – Elsevier Academic press (2007) 3rd Edition.

REFERENCES:1. Ulrich Meyer, Jörg Handschel, Thomas Meyer and Hans Peter Wiesmann, Fundamentals of Tissue Engineering and regenerative

medicine – Springer Verlag Publications, 2009.2. Anthony Atala and Robert Paul Lanza, Methods of Tissue engineering – Academic Press, 2002.







SBTX1026 METABOLITES AND MECHANISML T P Credits Total Marks

3 0 0 3 100


Basic concepts of Metabolic Engineering – Overview of cellular metabolism – Different models for cellularreactions, induction – Jacob Monod model and its regulation, Differential regulation by isoenzymes, Feed back regulation.

UNIT II BIOSYNTHESIS OF PRIMARY METABOLITES 10 hrs.

Amino acid synthesis pathways and its regulation at enzyme level and whole cell level, Alteration of feed backregulation, Limiting accumulation of end products.

UNIT III BIOSYNTHESIS OF SECONDARY METABOLITES 10 hrs.

Regulation of secondary metabolite pathways, precursor effects, prophase, idiophase relationship, Cataboliteregulation by passing control of secondary metabolism, producers of secondary metabolites, applications of secondarymetabolites.

UNIT IV BIOCONVERSIONS 10 hrs.

Applications of Bioconversions, Factors affecting bioconversions, Specificity, Yields, Co-metabolism, Productinhibition, mixed or sequential bioconversions, Conversion of insoluble substances.

UNIT V REGULATION OF ENZYME PRODUCTION AND METABOLIC FLUX 10 hrs.

Feed back repression, Catabolite Repression, optimization and control of metabolic activities. The modificationof existing – or the introduction of entirely new – metabolic pathways. Integration of anabolism and catabolism, metabolicflux distribution analysis bioprocess, material balance, kinetic types, equilibrium reaction. Experimental determinationmethod of flux distribution, Metabolic flux analysis and its applications.

TEXT BOOK: 1. Wang.D.I.C, Cooney C.L., Demain A.L., Dunnil.P. Humphrey A.E. and Lilly M.D., Fermentation and Enzyme Technology – John

Wiley and Sons, 1980.

REFERENCES: 1. Stanbury P.F., and Whitaker A., Principles of Fermentation Technology – Pergamon Press, 1984. 2. Zubay G., Biochemistry – Macmillan Publishers, 1989.







SBTX1027 BIOETHICS, BIOSAFETY AND IPRL T P Credits Total Marks

3 0 0 3 100

UNIT I BIOETHICS 10 hrs.

The legal and socioeconomic impact of biotechnology, public education of the process of biotechnology involvedin generating new forms of life for informed decision making, biosafety regulation and national and internationalguidelines, r-DNA guidelines, experimental protocol approvals, levels of containment,

UNIT II BIOSAFETY 10 hrs.

Environmental aspect of biotech applications, use of genetically modified organism and their release inenvironment Special procedures for r-DNA based product production,

UNIT III IPR 10 hrs.

Intellectual property rights, TRIPS, International conventions patents and methods of application of patents.

UNIT IV PATENTING 10 hrs.

Legal implications, biodiversity and farmers right. Beneficial application and development of research focus tothe need of the poor, identification of directions for yield effect in agriculture, aquaculture etc.., Bioremediation.

UNIT V PATENT SYSTEM 10 hrs.

Objectives of the patent system - Basic principles and general requirements of patent law-biotechnologicalinventions and patent law-Legal development-Patentable subjects and protection in biotechnology.

REFERENCES:1. Sasson A., Biotechnologies and Development, UNESCO Publications, 1988.2. Sasson A., Biotechnologies in developing countries present and future, UNESCO Publishers, 19933. Singh K., Intellectual Property Rights on Biotechnology, Kalyani Publication, 2nd Edition, 2008







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