BioSignalling Oke

7/24/2019 BioSignalling Oke

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MUSYARRAFAH

BAGIAN BIOKIMIAFAKULTAS KEDOKTERAN

UNIVERSITAS ISLAM AL-AZHAR

BIOSIGNALING(Pengsinyalan Biologi)


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SIGNAL IN OUR LIFE

SIGNAL Connecting

Commnic!tion


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Bio"ign!#ing in Ce##Commnic!tion


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Bio"ign!#ing in Ce##Commnic!tion

The cells communicatethrough secretion ofc$emic!# me""enge%" thatcarry ! "ign!# to anothercell.

In human, &i'e%ent ce##t()e" carry out &i'e%ent*nction"+

Signals c$!nge !ction" of

intracellular proteins(metabolic enzymes, generegulatory proteins, ionchannels, or cytoskeletalproteins) in t!%get ce##".


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E,!m)#e o* Sign!# Mo#ec#e

Loc!# Me&i!to%: Epidermalgrowth factor (!"),Platellet-derived growthfactor (PDGF), Nervegrowth factor (NGF),

Histamine, Nitric oxide (N)

Ho%mone": #$renaline,%ortisol, !lucagon,Insulin, Testosteronean$ Thyroi$

Ne%ot%!n"mitte%:#cetylcholine& !#B#


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Ho to "en& t$e "ign!#mo#ec#e to t$e t!%get ce##".


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T$e /%o)e%tie" o* "ign!#mo#ec#e"0 'y$rophobic an$ hy$rophilic

signal molecules

eseptornyabera$a $i

$alam sel

eseptornyabera$a $ipermukaanmembran

sel


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Gene%!# *e!t%e

o* "ign!#mo#ec#e"0Transmit messages

beteen cells


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Sign!# T%!n"&ction

eceptors contain

a bin$ing site speci*c for a singlechemical messengeranother bin$ing site in+ol+e$ in

transmitting message.

Bin$ing site may interact ithanother protein or ith -#:either plasma membrane receptors

or intracellular bin$ing proteins("ig.).

/hen a chemical messengerbin$s to a receptor:Signal is con+erte$ into an

intracellular response.This con+ersion is calle$ "ign!#

t%!n"&ction+


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Secon&me""enge%" are

non proteingenerate$ insi$e cellin response tohormone bin$ing thatcontinuetransmission ofmessage


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Sign!# Te%min!tion

Sign!#


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Sign!#Te%min!tion

Sites of signal termination.Processes that terminate

signals are shon in 1#e.

/ithin each pathay of signal

trans$uction, signal may beturne$ o0 at speci*c steps:.receptor might be $esensitize$ tomessenger by phosphorylation.1.! proteins automatically terminate

messages as they hy$rolyze !TP.2.$egra$ation of secon$ messenger(e.g., phospho$iesterase clea+age ofc#3P).4.remo+ing phosphate groups fromproteins by phosphatases.


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Re*e%ence"

. #lbert, 3olecular %ell an$ Biology 5the$ition

1. ssensial %ell an$ Biology2. 'arper Biochemistry, 16the$ition


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BioSignalling Oke