Bioprocess Engineering

Dimaano, Jezza B.ChE- 5201

What is Bioprocess Engineering? A specialization of chemical engineering that

deals with the design and development of equipment and process for the manufacturing of products from biological materials

It is the discipline that puts biotechnology into work

Biotechnology Is the use of living systems and organisms to

develop or make products, or “any technological application that uses biological systems, living organisms or derivatives thereof, to make or modify products or processes for specific use” (UN Convention on biological Diversity, Art. 2)

Karl Ereky Hungarian agricultural engineer Coined the term “biotechnology” in 1919

Steps in development of a complete bioprocess for commercial manufacture of a new recombinant-DNA-derived product

Microbiology It is the study of microscopic organisms, such as viruses,

bacteria, archaea, fungi and protozoa

Viruses-depend on the host cells that they infect to reproduce. When found outside of host cells, viruses exist as protein coat or capsid, sometimes enclosed within a membrane.

Capsid- protein shell of a virus. It encloses the genetic material of the virus

1898Friedrich Loeffler and Paul Frosch fround

evidence that the cause of foot-and-mouth disease in livestock was an infectious particle smaller than any bacteria.

Bacteria and archaea-fall into a category of life called

prokaryotes- are the only prokaryotes- earliest forms of life on earth

Notable Bacteria Bacillus anthracis

Causes anthrax, a deadly disease in cattle and a potential bioweapon against humans

Brucella abortus Causes breeding losses in livestock

Cyanobacteria (formerly known as blue green algae) Live in water, where they produce large amounts

of the oxygen we breathe

Escherichia coli (E. coli) Lives in the gut, where it helps digest food

and produces vitamin K. The bad strain of E. coli O157:H7 causes severe food borne sickness.

Deinococcus radiodurans Can withstand blasts of radiation 1, 000 times

greater than would kill a human being

Unit Operations Basic step in a process. It involves a physical change or

chemical transformation

Bioprocess A specific process that uses complete living cells or

their components to obtain desired products

Bioproducts Materials, chemicals and energy derived from

renewable biological resources

Bioproducts engineering engineering of bioproducts from renewable bioresources

Bioproducts engineers  play a major role in the design and development of

“green” products including biofuels, bioenergy, biodegradable plastics, biocomposites, building materials, paper and chemicals.

develop energy efficient, environmentally friendly manufacturing processes for these products as well as effective end-use applications.

Emerging bioproducts  biofuels, bioenergy, starch- based and cellulose- based

ethanol, bio- based adhesives, biochemicals, biodegradable plastics, etc.

Biosystems Engineering In USA

A field of engineering which integrates science and design with applied biological, environmental and agricultural sciences.

Represents an evolution of the Agricultural Engineering discipline to all living organisms but generally not including biomedical applications, which is the realm of biomedical engineering

In Europe A field of engineering which integrates engineering science

and design with applied biological and environmental sciences.

Represents an evolution of Engineering disciplines applied to all living organisms not including biomedical applications

references Bioprocess Engineering Principles by Pauline M

. Doran Extinction and viruses. Biosystems

31: 155-159 by Emiliani C. 1993 http://www.nature.com/subjects/microbiology http://

www.microbeworld.org/types-of-microbes/bacteria