Bioinformatics Core

Lang LiCenter for Computational Biology and BioinformaticsDivision of Biostatistics Department of Medicine

Bioinformatics Core Structure

Analyst 1

Analyst 2

Analyst N

Bioinformatics core (directed by Lang

Li)

Faculty 1

Faculty 2

Faculty N

CCBB faculty

Lab 1

Lab 2

Lab N

… … …Bioinformatics Leader

Microarray core(s)

Proteomics core

Sequencing core

…

Research area covered by CCBB and Bioinformatics core • Genetics– Population genetics– Pharmacogenetics

• Functional Genomics– Epigenetic regulation– Transcriptional regulation– Gene expression– Post-transcriptional regulation

• Proteomics/Metabolomics– Mass spectrometry data analysis– Protein structure prediction

• Drug screening• Pharmacometrics– Pharmacokinetics– Pharmacodynamics– Disease models

DNA

Protein

transcription

translation

mRNA

Drug

Lang LiTatiana Foroud Jeesun JungShen Li

Yunlong LiuLang Li Changyu Shen

Changyu Shen Jake ChenYaoqi Zhou Keith Dunker Vladimir UverskySamy Meroueh

Lang Li Robert Bies

http://compbio.iupui.edu/

http://compbio.iupui.edu/

Sequence Analysis pipeline

Primary analysis Secondary analysis Tertiary analysis

• Image acquisition and bead processing

• Quality metrics• Color calls

• Sequence alignment• Sequence stats• Consensus calling• Create QC files• Tag counting

Application-specific analysis•Re-sequencing•De novo sequencing•ChIP-seq•Whole transcriptome•DNA methylation•…

Sequencing Core Bioinformatics Core

High throughput data management

• caArray system is established at Bioinformatics core

• myTrack system for next generation sequencing data

Manage, compare, share and publish high throughput data produced using next generation sequencing technology

Our team!

• Genetics/Genomics– Lang Li, Tatiana Foroud, Jeesun Jung, Shen Li

• Functional Genomics– Yunlong Liu, Lang Li, Changyu Shen

• Proteomics/Metabolomics– Changyu Shen and Jake Chen (high throughput technology)– Yaoqi Zhou, Keith Dunker, Vladimir Uversky (protein

structure/disorder)

• Drug screening– Samy Meroueh

• Pharmacometrics– Lang Li, Robert Bies

Contact Info

• Lang Li, lali@iupui.edu• http://compbio.iupui.edu/core