Author Index

Ullmann’s Industrial ToxicologyCopyright c© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimISBN: 3-527-31247-1

Author Index 1139

Author Index

Actor, Paul, Smith Kline & French Laboratories, Philadelphia, Pennsylvania 19101, United States (Chaps. 1, 3) Chemotherapeutics, 1013Allegra, Carmen J., National Cancer Institute, Bethesda, Maryland 20205, United States Cancer Chemotherapy, 839Aschenbrenner, Hans, Bayer AG, Leverkusen, Federal Republic of Germany (Section 6.4.2) Transport, Handling, and Storage, 487

Bartels, Klaus, Berufsgenossenschaft der chemischen Industrie, Heidelberg, Federal Republic of Germany (Section 4.1) Plant and ProcessSafety, 361

Bender, Herbert, BASF Aktiengesellschaft, Ludwigshafen, Federal Republic of Germany (Section 2.1) Plant and Process Safety, 361Berner, Sibylle, Boehringer Mannheim GmbH, Tutzing, Federal Republic of Germany (Chap. 7) Nucleic Acids, 739Berson, Emile, Ministere des Transports, Paris, France (Chap. 2) Transport, Handling, and Storage, 487Berson, Nadia, Paris, France (Chap. 2) Transport, Handling, and Storage, 487Berthold, Werner, BASF Aktiengesellschaft, Ludwigshafen, Federal Republic of Germany(Section 2.2.3) Plant and Process Safety, 361Binetti, Roberto, Istituto Superiore di Sanita, Rome, Italy (Chap. 3) Chemical Products: Safety Regulations, 553Bino, Goffredo Del, European Commission, Brussels, Belgium (Chap. 1) Chemical Products: Safety Regulations, 553Bosatra, Dan, Dow Europe S. A., Horgen, Switzerland (Section 3.1– 3.9) Occupational Health and Safety, 299Broecker, Bernard, formerly Hoechst Aktiengesellschaft, Frankfurt/Main, Federal Republic of Germany (Chaps. 2 and 4) Chemical Products:

Safety Regulations, 553Burtscher, Helmut, Boehringer Mannheim GmbH, Penzberg, Federal Republic of Germany (Chaps. 1–6) Nucleic Acids, 739

Chabner, Bruce A., National Cancer Institute, Bethesda, Maryland 20205, United States Cancer Chemotherapy, 839Chow, Alfred W., Smith Kline & French Laboratories, Philadelphia, Pennsylvania 19101, United States (Chaps. 1, 3) Chemotherapeutics, 1013Conrad, Dietrich, Berlin, Federal Republic of Germany (Section 2.2.2) Plant and Process Safety, 361Cross, Alan, Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington D.C. 20307-5100, United States (Chap.

5) Immunotherapy and Vaccines, 899Cryz, Stanley J. Jr., Swiss Serum and Vaccine Institute Berne, Switzerland (Chaps. 1 and 2) Immunotherapy and Vaccines, 899Curt, Gregory A., National Cancer Institute, Bethesda, Maryland 20205, United States Cancer Chemotherapy, 839

Dekant, Wolfgang, Institute of Toxicology, University of Wuerzburg, Germany Toxicology, 3Devos, Jean-Marie, CEFIC, Brussels, Belgium (Chaps. 1, 3) Legal Aspects, 585Dohrn, Klaus Jochem, Germanischer Lloyd, Hamburg, Federal Republic of Germany (Section 6.2.1.3 ) Transport, Handling, and Storage, 487Doktor, Kurt-Joseph, Bayer AG, Leverkusen, Federal Republic of Germany (Sections 6.2.1.1, 6.2.1.2, 6.3, 6.4) Transport, Handling, and

Storage, 487Dosch, Rainer, Bayer AG, Leverkusen, Federal Republic of Germany (Section 4.7) Occupational Health and Safety, 299Drauz, Karlheinz, Degussa-Huls AG, Hanau-Wolfgang, Germany Amino Acids, 777Drees, Stefan, Bayer AG, Leverkusen, Federal Republic of Germany (Section 3.5.1) Plant and Process Safety, 361Droste, Bernhard, Bundesanstalt fur Materialforschung und -prufung, Berlin, Federal Republic of Germany (Chap. 4) Transport, Handling,

and Storage, 487Dutko, Frank J., Sterling-Winthrop Research Institute, Rensselaer, New York 12144, United States (Chap. 4) Chemotherapeutics, 1013

Eberz, Albert, Bayer AG, Leverkusen, Federal Republic of Germany(Section 2.3) Plant and Process Safety, 361

Fine, Robert L., National Cancer Institute, Bethesda, Maryland 20205, United States Cancer Chemotherapy, 839Forster, Hans, Physikalisch-Technische Bundesanstalt, Braunschweig, Federal Republic of Germany (Section 3.5.3 in part) Plant and Process

Safety, 361Franzle, Otto, Christian-Albrechts-Universitat, Kiel, Federal Republic of Germany [(Sections1.1, 1.2, 2.1 (in part), 2.2, 2.3 (in part),

2.4, 3.1, 3.2 (in part)] Ecology and Ecotoxicology, 151

Geiger, Adrian, Sandoz, Basel, Switzerland (Section 4.2.1) Plant and Process Safety, 361Geschke, Frank-Ulrich, Bayer AG, Wuppertal, Federal Republic of Germany Antimycotics, 1075Glor, Martin, Ciba-Geigy AG, Basel, Switzerland (Section 2.2.3) Plant and Process Safety, 361Gottstein, Bruno, Institut fur Parasitologie, Universitat Zurich, Zurich, Switzerland (Section 4.1) Immunotherapy and Vaccines, 899Granstrom, Marta, Departments of Clinical Microbiology and of Vaccine Production, National Bacteriological Laboratory, Karolinska

Hospital, Stockholm, Sweden (Chap. 3) Immunotherapy and Vaccines, 899Grenner, Dieter, Bayer AG, Dormagen, Federal Republic of Germany (Sections 4.4, 4.5) Plant and Process Safety, 361Gruber, Joachim, Bayer AG, Leverkusen, Federal Republic of Germany (Section 4.4) Occupational Health and Safety, 299

Hagen, Hans, Bayer AG, Leverkusen, Federal Republic of Germany (Sections 3.4.1, Section 5.1 in part) Plant and Process Safety, 361Hahn, Klaus-Jurgen, Knoll AG, Ludwigshafen, Federal Republic of Germany (Section 4.2) Pharmaceuticals, General Survey and

Development, 981Harbordt, Jurgen, Bayer AG, Leverkusen, Federal Republic of Germany (Section 5.1 in part) Plant and Process Safety, 361Harke, Hans-P., Schulke & Mayr, Hamburg/Norderstedt, Federal Republic of Germany Disinfectants, 721Hasskarl, Horst, Ludwigshafen, Federal Republic of Germany (Chap. 3) Pharmaceuticals, General Survey and Development, 981Hawighorst, Josef, Bayer AG, Leverkusen, Federal Republic of Germany (Sections 6.2.1.1, 6.2.1.2) Transport, Handling, and Storage, 487Hesse, Gunter, Bayer AG, Brunsbuttel, Federal Republic of Germany (Section 3.5.2) Plant and Process Safety, 361

1140 Author Index

Hoppe, Bernd, Degussa-Huls AG, Frankfurt, Germany Amino Acids, 777Hubner, Heinz W., Bundesanstalt fur Materialforschung und -prufung, Berlin, Federal Republic of Germany (Section 6.1) Transport,

Handling, and Storage, 487

Itoda, Muneto, JCIA, Tokyo, Japan (Chap. 7) Legal Aspects, 585

Jørgensen, Sven Erik, Danmarks Farmaceutiske Højskole, Copenhagen, Denmark (Section 3.3) Ecology and Ecotoxicology, 151

Kiesselbach, Niko, Bayer AG, Leverkusen, Federal Republic of Germany (Section 4.3) Occupational Health and Safety, 299King, Norman, Department of the Environment, London, United Kingdom (Chaps. 5 and 6) Chemical Products: Safety Regulations, 553Kleemann, Axel, Hanau, Germany Amino Acids, 777Klemchuk, Peter P., CIBA-GEIGY Corporation, Ardsley, New York 10502, United States Antioxidants, 699Klusacek, Hans, Bayer AG, Dormagen, Federal Republic of Germany (Section 6.3) Transport, Handling, and Storage, 487Kolk, Jan J., Arnhem, The Netherlands (Sections 2.2, 2.3 in part, 4.1, 4.2, 4.5) Occupational Health and Safety, 299Kramer, Ludwig, Head of Legal Services, DG XI, European Commission, Brussels, Belgium (Chap. 2, Chap. 5 in part) Legal Aspects, 585Kretzschmar, Rolf, Knoll AG, Ludwigshafen, Federal Republic of Germany (Section 4.1) Pharmaceuticals, General Survey and

Development, 981Krimmer, Hans-Peter, Degussa-Huls AG, Hanau-Wolfgang, Germany Amino Acids, 777Kromarek, Pascale, Elf Aquitaine, Direction Environment, Paris-La-Defense, France (Chap. 5) Legal Aspects, 585Kutscher, Bernhard, ASTA Medica AG, Frankfurt am Main, Federal Republic of Germany Cancer Chemotherapy, 839

Lamb, Donald W., Miles Inc., Pittsburgh, United States (Sections 2.4, 3.10, 4.8) Occupational Health and Safety, 299Larrick, James, Genelabs Incorporated, Redwood City, California, United States (Chap. 6) Immunotherapy and Vaccines, 899Lersner, Heinrich Freiherr von, Umweltbundesamt, Berlin, Federal Republic of Germany (Chap. 8) Transport, Handling, and Storage, 487Leuchtenberger, Wolfgang, Degussa-Huls AG, Dusseldorf, Germany Amino Acids, 777Lipinski, Gert-Wolfhard von Rymon, formerly Hoechst Aktiengesellschaft, Frankfurt, Federal Republic of Germany Food Additives, 677Luck, Erich, formerly Hoechst Aktiengesellschaft, Frankfurt, Federal Republic of Germany Food Additives, 677Luhr, Hans-Peter, Technische Universitat, Institut fur wassergefahrdende Stoffe, Berlin, Federal Republic of Germany (Chap. 7) Transport,

Handling, and Storage, 487

McGuire, John L., Johnson & Johnson, New Brunswick, New Jersey 08933, United States (Chaps. 1 and 2) Pharmaceuticals, General Surveyand Development, 981

McKinlay, Mark A., Sterling-Winthrop Research Institute, Rensselaer, New York 12144, United States (Chap. 4) Chemotherapeutics, 1013Meyer, Gunter, IG-Chemie-Papier-Keramik, Hannover, Federal Republic of Germany (Section 2.1) Occupational Health and Safety, 299Miksche, Leopold W., Bayer AG, Leverkusen, Federal Republic of Germany (Chap. 1, Section 4.6) Occupational Health and Safety, 299Muhlegger, Klaus, Boehringer Mannheim GmbH, Tutzing, Federal Republic of Germany (Chap. 9) Nucleic Acids, 739Muller, Edmund, BASF Aktiengesellschaft, Ludwigshafen, Federal Republic of Germany (Section 4.3) Plant and Process Safety, 361Muller, Michael, Bayer AG, Leverkusen, Federal Republic of Germany (Section 2.2.1, Section 3.5.3 in part) Plant and Process Safety, 361Mix, Karl-Heinz, Bayer AG, Leverkusen, Federal Republic of Germany (Section 2.2.4) Plant and Process Safety, 361Mujagic, Hamza, National Cancer Institute, Bethesda, Maryland 20205, United States Cancer Chemotherapy, 839

Noha, Klaus, Hoechst Aktiengesellschaft, Frankfurt, Federal Republic of Germany (Section 4.2.2) Plant and Process Safety, 361Noordam, Philip, The Hague, The Netherlands (Sections 2.2, 2.3 in part) Occupational Health and Safety, 299

Perrin, Luc, Division d’Hematologie, Hopital Cantonal Universitaire, Geneve, Switzerland (Section 4.2) Immunotherapy and Vaccines, 899Pfau, Wolfgang, Department of Toxicology and Environmental Medicine of the Fraunhofer Society and Department of Toxicology, Hamburg

University Medical School, Hamburg, Germany Carcinogenic Agents, 651Pfau, Wolfgang, Umweltmedizin Hamburg e.V. and Institute of Toxicology, Hamburg University Medical School, Hamburg, Germany

Mutagenic Agents, 667Pilz, Volker, Bayer AG, Leverkusen, Federal Republic of Germany (Chap. 1, Sections 3.1–3.3) Plant and Process Safety, 361

Rennoch, Detlef, Bundesanstalt fur Materialforschung und -prufung, Berlin, Federal Republic of Germany (Chap. 3) Transport, Handling, andStorage, 487

Rolle, Annette, Bundesanstalt fur Materialforschung und -prufung, Berlin, Federal Republic of Germany (Section 6.2.2) Transport, Handling,and Storage, 487

Schacke, Helmut, Bayer AG, Leverkusen, Federal Republic of Germany (Section 3.4.2) Plant and Process Safety, 361Schmidt, Axel, Bayer AG, Wuppertal, Federal Republic of Germany Antimycotics, 1075Schrors, Bernd, Bayer AG, Leverkusen, Federal Republic of Germany (Section 3.4.3) Plant and Process Safety, 361Schulz, Nikolaus, Bayer AG, Dormagen, Federal Republic of Germany (Sections 4.4, 4.5) Plant and Process Safety, 361Seibl, Rudolf, Boehringer Mannheim GmbH, Penzberg, Federal Republic of Germany (Chap. 8) Nucleic Acids, 739Smith, Turner T. Jr., Hunton & Williams, Washington, D.C., United States (Chap. 6) Legal Aspects, 585Steinbach, Jorg, Schering AG, Berlin, Federal Republic of Germany(Section 2.3) Plant and Process Safety, 361Stoessel, Francis, Ciba-Geigy AG, Basel, Switzerland(Section 2.3) Plant and Process Safety, 361Straskraba, Milan, Akademie ved Ceske Republiky, Biomatematicka laborator, Entomologicky institut, Ceske Budejovice, Czech Republic

(Sections 2.1.4, 2.3.5, 3.2.3) Ecology and Ecotoxicology, 151Stroetmann, Clemens, Bad Honnef, Federal Republic of Germany (Chap. 1) Transport, Handling, and Storage, 487

Vamvakas, Spiridon, Institute of Toxicology, University of Wuerzburg, Germany Toxicology, 3Viard, Richard, Bayer AG, Leverkusen, Federal Republic of Germany (Section 3.4.2) Plant and Process Safety, 361Visser, Wieger Johannes, Nederlandse Spoorwegen, Utrecht, The Netherlands (Sections 5.1–5.2.1) Transport, Handling, and Storage, 487

Author Index 1141

Walper, Matthias, Bayer AG, Brunsbuttel, Federal Republic of Germany (Sections 5.2, 5.3) Plant and Process Safety, 361Walther, Claus-Diether, Bayer AG, Leverkusen, Federal Republic of Germany (Section 2.2.2) Plant and Process Safety, 361Wandrey, Peter-Andreas, Bundesanstalt fur Materialforschung und –prufung, Berlin, Federal Republic of Germany (Section 2.2.4) Plant and

Process Safety, 361Weckbecker, Christoph, Degussa-Huls AG, Hanau-Wolfgang, Germany Amino Acids, 777Weidlich, Stephan, Hoechst Aktiengesellschaft, Frankfurt, Federal Republic of Germany (Section 3.4.3) Plant and Process Safety, 361Whittaker, Victor P., Arbeitsgruppe Neurochemie, Max-Planck-Institut fur biophysikalische Chemie, Gottingen, Federal Republic of Germany

Johannes Gutenberg Universitat, Mainz, Federal Republic of Germany Neuropharmacology, 1115Widmer, Ulrich, Sandoz, Basel, Switzerland (Section 4.2.1) Plant and Process Safety, 361Williamson, Gabrielle H., LeBoeuf, Lamb, Greene & MacRae, Brussels, Belgium (Chap. 4) Legal Aspects, 585Wybenga, Frits, International Standards Coordinator, Office of Hazardous Materials Safety, Washington D.C. 20590, United States

(Section 5.2.2) Transport, Handling, and Storage, 487

Yasogawa, Yoshio, Nippon Kaiji Kentei Kyokai, Tokyo, Japan (Section 5.2.3) Transport, Handling, and Storage, 487Yeh, Grace Chao, National Cancer Institute, Bethesda, Maryland 20205, United States Cancer Chemotherapy, 839

Zahn, Manuel, Knoll AG, Ludwigshafen, Federal Republic of Germany (Section 4.3) Pharmaceuticals, General Survey and Development, 981Zimmermann, Jurgen, Bayer AG, Dormagen, Federal Republic of Germany (Sections 4.4, 4.5) Plant and Process Safety, 361

Subject Index

Ullmann’s Industrial ToxicologyCopyright c© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimISBN: 3-527-31247-1

Subject Index A-56620 – Aloid 1145

Subject Index

AA-56620 [98105-99-8] 1026A-76154 882Abfallartenkatalog 495Abfall-Transport-Berater 495Absorptiongastrointestinal 30of xenobiotics by the respiratory system 31of xenobiotics 28

Acacia gumas thickener 687

ACC 817Acceptable daily intake (ADI) 679of food additives 680

Accident Prevention Regulation 407, 507Acedapsone 1037Acemuc 817Acesulfame-Kacceptable daily intake value 679

Acetabs 817Acetein 817Acetic acidacidulant for foods 690as food preservative, concentration 684

Acetylcholinein synaptic transmission 1128, 1129

N-Acetylcysteine 817cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-

ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]pipera-zine

see Ketoconazole 1079Acetyst 817Acid Brilliant Green BSfor coloring of foods 689

Acidity regulatorsin food industry 693

Acidol 814Acidrine 815Acidulantsfor foods 690

Aciventral 814Aclacinomycin A 861Acrylonitrile–butadiene–styrene (ABS) polymersthermal stability testing 718

Acthiol 818Actinomycetes 1015Actinomycin Dfor cancer therapy 863

mechanism of action 863Activated charcoalin food industry 692, 693

Act on the Supervision of Labor Protection 314Acyclovir 766, 769, 1058Adenine 740Adenosine [58-61-7] 765as flavor enhancer 691

Adenosine monophosphate, cyclic (cAMP) 767Adenosine-5′-triphosphate (ATP) 768Adiclair 1097AD-Merkblatter 510ADN (European Agreement concerning the International

Transportation of Dangerous Goods by InlandWaterways) 518

ADNR (Regulations concerning the Transportation ofDangerous Goods on the Rhine) 518

Adozelesin 864

ADR (European Agreement concerning the InternationalTransportation of Dangerous Goods by Road) 517

ADR/RID classes 496, 497Adriamycin 859Aerosolin food industry 693

Aerosolstoxicology by absorption 32

Aflatoxin B1 660carcinogenicity of 51

Aflatoxinscarcinogenicity 660

Aflorix 1082Aftate 1104AG 331 843Agaras gelling agent in foods 687as thickener 687

Agency for Toxic Substances and Disease Registry (ATSDR)318

Agisten 1085Aglyconesbiotransformation enzyme 45

Agonists 1134, 1135Agrochemicalsamino acids in 820

Agupla 873AIDS3′-azidothymidine against 1065generation of humabs against 962HIV (Human Immunodeficiency Virus) infection 763HIV infection, therapeutic drug 765intravenous immunoglobulin, prophylaxis against bacterial

infections 954pneumocystis infection of patients with 1053virus 1055

Akneclor 1085Aktiferrin 816Aktivanad 816l-Alanine [56-41-7] 814Alanine as flavor enhancer 807β-Alanine 785d-Alanine 785d,l-Alanine 786l-Alanine 779, 783production 792

Alber-T 1104Albistat 1082Alcoban 1098Alcobon 1098Alcoholsdisinfectant properties 724

Aldehydesas carcinogenic agent 659

Alginateacceptable daily intake values 679

Alginatesas gelling agents in foods 687

Alginic acidas thickener 687

Al-Glycin 815Alhydex–Cidex 727Alkylating agentscarcinogenicity 659for cancer therapy 852

Aloid 1082

1146 α-Tocopherol – Aquilid A Subject Index

α-Tocopherollipophilic antioxidant 55

Altretamine 858Alzheimer’s disease 1122AM-715 1023AM-833 [79660-72-3] 1026Amantadinehydrochloride 1063

Amaranthacceptable daily intake values 679for coloring of foods 689

AmBisome 1094Amebas 1039Amebiasis 1039biology and chemotherapy 1053

Amecrin 863American Board of Industrial Hygiene (ABIH) 321American Conference of Government Industrial Hygienists

(ACGIH) 331American Industrial Health Council (AIHC) 357American Industrial Hygiene Association Journal 330American Occupational Hygiene Association (AIHA) 321Ames test 106, 670, 997Amicel 1087Amifloxacin 1025Amines, aromaticantioxidants 705as carcinogenic agent 658

Amines, hinderedantioxidants 710

Amino acidimbalance 827

Amino acid derivativesas pesticides 820as therapeutic agents 813

Amino acids 777biosynthesis 801economic significance 826essential and semiessential 802essential, food additives 680essential, requirements of humans 805esupplementation 805glucogenic 802ketogenic 802production by chemical synthesis 790production by extraction 790production by fermentation 791toxicology 827

4-Aminobenzenesulfonamide 10274-Aminobenzoic acid 1028γ-Aminobutyrate (GABA) 1129in synaptic transmission 1129

l-α-Aminobutyric acid 786γ-Aminobutyric acid (GABA) 7864-Amino-5-fluoro-2(1H)-pyrimidinonesee Flucytosine 1098

Aminoglutethimide 876α-Aminoisobutyric acid 7864-Aminosalicylic acid 1035, 1036Amithiozone 1036Ammonium nitrate and fuel oil (ANFO) 392Amodiaquine [86-42-0] 1049Amorolfine [78613-35-1] 1107hydrochlorid [78613-38-4] 1107

Ampho-Moronal 1094Amphotericin B [1397-89-3] 1094indications and efficacy of 1095MIC values for 1094

Amsacrine 863Amsidine 863Amudanesee Griseofulvin 1100

Amycor 1083Amylase (E.C. 2.4.1.1)use in food industry 694

4-tert-Amylphenol 729Anandron 878Anastrazole 876Ancotil 1098Andergin 1082Anetil 814Aneuploidyin genome mutations 669

Animal experimentsfor drug testing 993

Anorexiants 1126Anotit 1082Ansidyl 863Antagonists 1134Antarelix 882Anthocyaninsfor coloring of foods 689

Anthracyclinesfor cancer therapy 859

mechanism of action 860mechanism of resistance 861

Antiandrogensin cancer therapy 877

Antibiotic A 5283see Natamycin 1096

Antibioticsfor cancer therapy 858

Antibodiessee also Antibodies, monoclonal 901monoclonal 902monoclonal human (humabs) 906monoclonal, human, immunotherapeutic uses 960polyclonal 902

Antibodies, monoclonal (mAB)see also Antibodies 1131

Anticaking agentsas food additives 687

Antifoaming agentsin food industry 693

Antifungol 1085Antigens 901T-dependent and T-independent 903

Antihormonesin cancer therapy 874

Antimetabolitesin cancer therapys 841

Antimicotico 1085Antimony compoundsto treat leishmaniasis 1043

Antimutagenic agents 674Antimycotics 1075Antimyk Neu 1085Antioxidantssee also Oxidation inhibitors 699amino acids as, in foodstuffs 808as food additives 683

Antiozonants 700AntiRESA antibodies 945Anti-rheuma 815Antisense technology 759Antitubulin agentfor cancer therapy 866

Antrypol 1040Aplysia 1131Apocanda 1085β-Apo-8′-carotenalfor coloring of foods 689

Aquilid A 660

Subject Index 9-β-D-Arabinofuranosyladenine (Ara-A) – Bentonite 1147

9-β-d-Arabinofuranosyladenine (Ara-A)see also Vidarabin 769, 1059

Ara-C 847Ara-CTP 847Aralen hydrochloride and phosphate 1049Ardesyl 818Arensin 876Argiceto 814Argihepar 814l-Arginine [74-79-3] 779, 783, 8142-oxoglutarate 814as drug [16856-18-1] 814as drug [7675-83-4] 814as drug [4320-30-3] 814l-aspartate 814l-glutamate 814hydrochloride [1119-34-2] 814production 792l-pyroglutamate 814

Argivene 814Arildone [56219-57-9] 1065Arimedex 876Aristeromycin 765Aristolochic acid I 660Armitage-Doll modeltoxicologic risk estimation 136

Aroclor 1254 108Aromagrams 691Aromatase inhibitorsin cancer therapy 876mechanism of action 877

Arsenal 821Artemiatoxicity studies with 240

ARW value (Arbeitsplatzrichtwerte) 374Asbestoscarcinogenicity 661

Asbestos Act 316Ascending reticular activation system 1122Ascorbic acidantioxidant 55acceptable daily intake values 679as antioxidant for food 683, 684as dough conditioner 693

Asellustoxicity studies with 240

Aslos-C 818l-Asparagine [70-47-3] 814as drug 814monohydrate [5794-13-8] 814

l-Aspargine 783production 793

α-Aspartame 808acceptable daily intake values 679

l-Aspartatein synaptic transmission 1129

d,l-Aspartic acid [617-45-8] 786, 814as drug 814magnesium salt, tetrahydrate [52101-01-6] 814potassium salt, semihydrate [923-09-1] 814sodium salt, monohydrate 814

l-Aspartic acid [56-84-8] 783, 814as drug 814ferrous salt, tetrahydrate 814magnesium salt, dihydrate [2068-80-6] 814potassium salt, semihydrate [1115-63-5] 814production 792sodium salt, monohydrate [3792-50-5] 814

Aspisol 816Assert 821Association of German Electrical Engineers (VDE)occupational safety system control 304

Association of German Engineers (VDI)occupational safety system control 304

Astrocyte 1117AT-2266 1025Atamestane 876Athensa 816Autopharmacological agent 1127Autoradiographyfor investigation of neural activity 1127

Autotroph 175Avlosulfon 1037Axon 1116Axonal transport 11355-Azacytidine 846mechanism of action 846mechanism of resistance 846

Azaline B 881Azameno 10893′-Azidothymidine (AZT; Zidovudine) 765, 769, 1065Azlactones 782Azodicarbonamideas dough conditioner 693

Azolmen 1083Azo Rubineacceptable daily intake values 679for coloring of foods 689

Azotrex 1032Azubrondun 817Azutrimazol 1085

BBabesia 1052Babesiosis 1039Baccidal 1023Bacteriapathogenic bacteria 1014

Bacterial antigen targetgeneration of human monoclonal antibodies 961

Bacterial infectionschemotherapy 1018hospital-acquired, generation of humabs against 961hospital-acquired (nosocomial), vaccines against 915intravenous immunoglobulin against 954selection of antimicrobial agent for 1017

Bacterial vaccines 906Bactrim 1030Baked goodsadditives for 685

Baked productsemulsifiers in 685

Balantidiasis 1039BAM oven 387Barcroft–Warburg test 683Basta 820Batrafen 1102BAT value 339Bay 09867 1024Bay 5097see Clotrimazole 1085

Bayer 205 1040Bayer 2502 1042Bay h 4502see Bifonazole 1083

B cells 903BCNU 855Beetroot Redfor coloring of foods 689

Belganyl 1040Benalaxyl 823Benefluor 849Bentoniteas clarifying agent in food industry 692

1148 Benzalkonium chloride (BAK) – Calicheamicin Subject Index

Benzalkonium chloride (BAK) [8001-54-5] 730, 1108Benzeneas carcinogenic agent 658

Benzene Act 317Benznidazole 1042Benzoic acidacceptable daily intake values 679as food preservative, concentration 684metabolism 679

Benzoylprop 821Benzyl alcoholdisinfectant properties 727

2-Benzyl-4-chlorophenolas disinfectant 729

Berenil [908-54-3] 1041free bas [536-71-0] 1041

Berylliumcarcinogenicity 659

Betaine [107-43-7] 786, 814as drug 814citrate [17671-50-0] 814hydrochloride [590-46-5] 814monohydrate [17146-86-0] 814

Betaninfor coloring of foods 689

Beytout 1096B-GF 1100Bialofos 820Bicalutamide 878Bifonazole[60628-96-8] 1083MIC values for 1083

Bilanafos 820Bioassay 1128Bioconcentration 219Biodegradation 217Biofanal 1097Biological effect monitoring (BEM) 333for some chemicals 339

Biological exposure index (BEI) 341Biological monitoring (BM) 337interpretation of data 339

Biological occupational limit 339Biological oxygen demand (BOD) 236Biome 180Bioprotein-Holzinger 815Biotechnologysafety testing of biotechnological products 997

Biotransformation 217of xenobiotics 37

Biozolene 10771-([1,1′-Biphenyl]-4-ylphenylmethyl)-1H-imidazolesee Bifonazole 1083

Bisantrene hydrochloride 862Bisolvon 817Bixinfor coloring of foods 689

Bizelesin 865Black PNfor coloring of foods 689

Blasticidine [2079-00-7] 765Blauer Engel 581Bleaching agentin foods 689

Bleomycins 864for cancer therapy 863

Blooddistribution of xenobiotics 33

Botulinum toxin 1128Bowen ratio 173Box modelin ecotoxicology 222

Brachydanio rerioin toxicity tests 235, 240, 562

Brainhuman anatomy of 1121perfusion 1127weight 1119

Brandschacht test 378Brenazol 1082Brentan 1082Brilliant Black BNfor coloring of foods 689

Britane 1082British Examining and Registration Board in Occupational

Hygiene (BERBOH) 321Bromelain (E.C. 3.4.22.5)use in food industry 694

Bromovinyldeoxuridine [73110-56-2] 1060Bronchathiol 817Bronchocyt 817Bronchokod 817Broncloclar 817Broncoclar 817Broncorinol 817Bronkirex 817Broxyquinoline [521-74-4] 1054Brumixol 1102Brumoc 817Brunac 817Bryostatin 883Buciclovir 1062Buehler test 98Bulk containerfor solid bulk cargo 534

Bulking agentsas food additives 681

Bulk storage 537Bulk transport 526solid bulk cargo 533

Buraton 10F 726Burkitt’s lymphoma 661Bursting diskbrittle plates 439membrane-type 439shells of revolution 439

Buserelin 879, 880Butoconazole [64872-76-0] 1084nitrat [64872-77-1] 1084

Butylated hydroxyanisoleacceptable daily intake values 679as antioxidant for food 684

Butylated hydroxytoluene 704acceptable daily intake values 679as antioxidant for food 684

tert-Butylhydroquinoneas antioxidant for food 684

tert-Butylphenolsantioxidants 704

CCabagin 818Cadotussyl 817Cadre 821Calciumhomeostasis perturbation by xenobiotics 77

Calcium gluconateas food additive 684

Calcium polyphosphateas food additive 684

Calcium stearateas anticaking agent 688

Calicheamicin 865

Subject Index Calorimetry – 4-Chloro-3-methylphenol 1149

Calorimetryscreening method in process safety 401

Camoquin hydrochloride 1049Campto 869Camptothecin 868mechanism of action 869

Cancerby mutagenic agents 670causal link between mutation and 83

Candex 1097Candio-Hermal 1097Candoral 1080Canesten 1085Canifug 1085Canofite 1082Canstat 1097Canthaxanthinfor coloring of foods 689

Capsanthinfor coloring of foods 689

Capsorubinfor coloring of foods 689

Caramelacceptable daily intake values 679for coloring of foods 689

Carassius auratustoxicity studies with 235

4-Carbamoylimidazolium-5-olate 8525-Carbamoyl-1H-imidazol-4-yl piperonylate 852Carbocit 818Carbocysteine 817Carbon blackfor coloring of foods 689

Carbon cycle 178Carbon dioxidein food packaging 685

Carbon tetrachloridebiotransformation to trichloromethyl radical 53

Carboplat 873Carboplatin 873S-Carboxymethyl-l-cysteine [638-23-3] 817Carcinil 879Carcinogenesis 78, 651EU classification 560of chemical products 560mechanisms of 84transplacental 85

Carcinogenicityof chemicals in rodents 103

Carcinogens 651genotoxic mechanisms 652human 662identification of 655nongenotoxic mechanisms 654test in drugs 997

Carminic acidfor coloring of foods 689

Carmoisinfor coloring of foods 689

Carmustine 855Carnidazole [42116-76-7] 1045l-Carnitine 786Carob gumas thickener 687

Carotenefor coloring of foods 689

Carotenoidsfor coloring of foods 689

Carrageenanas gelling agent in foods 687as thickener 687

Carrier solventin food industry 692

Carzelesin 865Caseinas clarifying agent in food industry 692

Casodex 878CC-1065 864CCNU 855cDNAin situ hybridization 1122

Celluloseas filter aid in food industry 693

Cellulose ethersacceptable daily intake values 679as thickeners 687

Central nervous system (CNS)sensory neurons 1116

Centrifugationto measure molecular mass of DNA 751

Cestodesvaccines against 940

Cetonax 1080Cetrorelix 881Cetylpyridinium chloridedisinfectant properties 730

Chagas’ disease 1039Chalcone Ro 09-0410 [76554-66-0] 1064Cheeseemulsifying salts in cheese industry 693

Cheihepar 815Chemical oxygen demand (COD) 236Chemical ProductsSafety Regulations 553

Chemicals Act 314, 407Chemicals Hazard Information and Packaging (CHIP) 313Chemicals Law (Chemikaliengesetz) 306Chemical thermodynamic and hazard evaluation (CHETAH)

392Chemikaliengesetz 987Chemionazolo 1087Chemotherapeutics 1013based on antisense inhibition 757

Chewing gumbases 691

Chimassorb 944LD 710Chiniofon 1055Chinofungin 1104Chiral compounds 778Chlamydia 1015generation of humabs against 962

Chlorambucil 854Chlorellatoxicity studies with 240

Chlorella pyrenoidosatoxicity studies with 238

Chlorhexidinesee also 1,6-Bis(4′-chlorophenylbiguanide)hexane 730

Chlorinedisinfectant properties of aqueous solutions 733

Chlorisept 1104Chlormidazole [3689-76-7] 11081-[1-[2-(3-Chlorobenzyloxy)phenyl]vinyl]imidazolesee Croconazole 1086

4-Chloro-3,5-dimethylphenolsee also p-Chloro-m-xylenol 729

4-[Bis(2-chloroethyl)amino]-l-phenylalanine [148-82-3] 8531-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea 855N-(2-Chloroethyl)-N′-cyclohexyl-N-nitrosurea 855Chloroguanide [500-92-5] 1050hydrochloride [637-32-1] 1050

4-Chloro-3-methylphenolas disinfectant 729

1150 Chlorophene – Croconazole Subject Index

Chlorophenesee also 2-Benzyl-4-chlorophenol 729

(Z)-1-[2-[2-(4-Chlorophenoxy)ethoxy]-2-(2,4-dichlorophenyl)-1-methylethenyl]-1H-imidazole

see Omoconazole 10891-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazolesee Clotrimazole 1085

1-[2-[[(4-Chlorophenyl)methyl]thio]-2-(2,4-dichloro-phenyl)ethyl]-1H-imidazole

see Sulconazole 1091Chlorophyll, C.I. 75810for coloring of foods 689

Chloroquine [54-05-7] 1048Chloroquinaldol [72-80-0] 11081-[2-[(2-Chloro-3-thienyl)methyloxy]-2-(2,4-dichloro-

phenyl)ethyl]-1H-imidazolesee Tioconazole 1093

7-Chloro-4,6-trimethoxy-6′-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione

see Griseofulvin 1099Chloroxylenol 729Chlorozotocin 855, 8561-[2-[(4-Chlorphenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-

1H-imidazolesee Econazole 1086

Chlortritylimidazolesee Clotrimazole 1085

Chocolateadditives for 686

Choldestal 815Cholecystokinin (CCK) 1130Cholera vaccine 914Chromatin 80Chromiumcarcinogenicity 659

Chromosome, Philadelphia 764Chromosomes 745linear 743

CI-934 [91188-00-0] 1027CI-919 1025Cicatrex 814, 815Ciclochem 1102Ciclopirox [29342-05-0] 1101Ciclopirox olamin [41621-49-2] 1101Ciclopirox olamineMIC values for 1102

Ciliates 1039infections by, and chemotherapy 1053

Cinoxacin 1021Cinubac 1021Ciprofloxacin 1023Circular dichroism (CD) 780Circumsporozoite protein 943Cisplatin 871Citratesas food additives 684emulsifying salts in cheese industry 693

Citric acidacidulant for foods 690as food additive 684

Citrulline [372-75-8] 814d-Citrulline 786l-Citrulline 786CL 12625see Natamycin 1096

Cladribine 849Clarifying agentsin food industry 692

Clastogens 669Clazol 1085Clioquinol [130-26-7] 1054Clocim 1085

Clofazimine 1037Clofibratetoxicology 72

Clot-basan 1085Clotrifug 1085Clotrimaderm 1085Clotrimazole [23593-75-1] 1085MIC values for 1083

Clotrimix 1085clotri OPT 1085Clotrizol 1085Clouding agentsas food additives 687

Clozole 1085CM8282 (mononitrate)see Omoconazole 1089

Coating agentsas food additives 688

Cocci 1015Coccidiosis 1039Cochinealfor coloring of foods 689

Cochineal Red Afor coloring of foods 689

Cocol 1098Code on the Safe Handling of Bulk Cargoes 535Codon 746Codotussyl 817Coenzyme A[85-61-0] 768Coforin 849Cofrim 1030Collaborating Center of International Drug Monitoring (WHO)

1001Coloring agentsfor foods 688

Color stabilizerfor foods 689

Comet assay 672Committee of Dangerous Substances (AGS) 306, 506Comprehensive Environmental Response Compensation

Liability Act (CERCLA) 612Co-mutagens 674CONCAWE 545Conference for Environment and Development (UNCED) 546Conoderm 1082Conofite 1082Construction materialsclassification of flammability and test method for 378, 415

Contract Regarding Interim Supplement to Tanker Liability forOil Pollution (CHRISTAL) 612

Contrafungin 1085Controlled pore glass (CPG) 755Control of Substances Hazardous to Health (COSHH) 313Convention on the Limitation of Liability for Maritime Claims

(CLLMC) 608Copepodatoxicity studies with 240

Copperdeactivation of, in polyolefins 711

Cordycepin 765Corrosive substancestransport, handling, and storage 504

Corroverlan 814Corticotropin (adenocorticotropic hormone; ACTH) 1130Cotinazin 1034Cotton effect 780Council of State Decision on the Protection of Workers 315Crayfishinhibitory transmission in 1130

Creatine 786Croconazole [77175-51-0] 1086hydrochloride [77174-66-4] 1086

Subject Index Cryptosporidium – 4′,6-Dichloroflavan 1151

Cryptosporidium 1039, 1052Cryptoxanthinfor coloring of foods 689

Cuprimine 819Curare 1128Curcuminfor coloring of foods 689

Curling Factorsee Griseofulvin 1100

Cutistad 1085Cyabin 862Cyanox 1790 704Cyanox 2246 704Cyasorb UV 3346 710Cybis 1020Cyclamateacceptable daily intake values 679

Cyclaradine [69979-46-0] 1061d-Cyclohexylalanine 7866-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinonesee Ciclopirox 1101

6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone olaminesee Ciclopirox olamine 1101

Cyclophosphamide 854mechanism of action 854mechanism of resistance 854

Cymerin 856Cyprinus carpiotoxicity studies with 240used in toxicity tests 562

Cysteine as flavor enhancer 807l-Cysteine [52-90-4] 814Cysteine hydrochlorideas dough conditioner 693

l-Cysteine 779, 783as drug 815hydrochloride [52-89-1] 815hydrochloride monohydrate [7048-04-6] 815production 793

Cysticercosisvaccine against 940

Cystin “Brunner” 815l-Cystine 779, 783, 793Cytarabine 847Cytidine 765Cytochrome P450 39mechanism of enzyme induction 59oxidation catalyzed by 44

Cytochromes P450catalyst in the biotransformation of xenobiotics 40

Cytogenetic assaystests for 116

Cytomegalovirusgeneration of neutralizing humabs 962intravenous immunoglobulin against 953

Cytosine 740Cytosine arabinoside 847mechanism of action 847mechanism of resistance 847

Cytotoxicitymechanisms of 69

DDacarbazine 858mechanism of action 858

Dactinomycin 863Dafnegin 1102Daktar 1082Daktarin 1082Danger classificationvalues based on animal tests 568

Dangerous goodsdanger categories 568danger symbols for transport 565EU classification 567storage of 506symbols for danger categories 568transportation of 565transport classification 496

Dangerous goods regulationsinternational harmonization 546

Danger symbols 565Dantrirem 1038Daphnia magnatoxicity studies with 234

Dapsonesee also 4,4′-Diaminodiphenyl sulfone 1036

Daraprim 1028, 1050Daunomycin 859Daunorubicin 859(3S,4aS,8aS)-Decahydroisoquinolinecarboxylic acid 786Decapeptyl 879Declaration of Helsinki 989, 1001Decomposer 177Decomyc 1082Decree on Carcinogenic Substances and Processes 316Decree on Commercial and Noncommercial Services 316Decree on Industry and Workshops 316Decree on Specific Harmful Chemical Compounds 316Deep drainagemathematical treatment 171

Deflagration to detonation transition (DDT) 393Delgesic 816Delmofulvina 1100Dendrites 1116Deoxyadenosine [958-09-8] 765Deoxycytidine 765, 8482′-Deoxy-5-fluorouridine 8445′-Deoxy-5-fluorouridine 845Deoxyguanosine 765Depen 819Deralbine 1082Dermacure 1082Dermatitis 98Dermazol 1087Dermazole 1087Dermofix 1090Dermonistat 1082Dermoseptic 1090Dermo-Trosyd 1093Deronga 1096Design Institute of Emergency Relief Systems (DIERS) 440Deutsche Forschungsgemeinschaft (DFG) 326Deutsche Industrienorm (DIN)occupational safety system control 304

Dewar testscreening method for process safety 400

DHFR 841Diabeticsnutritive sweeteners for 689, 690

l-2,3-Diaminopropionic acid 787cis-Diamminedichloroplatinum 871Diasone sodium enterab 1037Diastatin 1097Dibenzthione [350-12-9] 11081,2-Dibromoethanemetabolization by glutathione 52

Dibromosalane [87-12-7] 11082,6-Di-tert-butyl-4-methylphenol (BHT) 7042,6-Di-tert-butylphenol 704Dichlorodiphenyltrichloroethanetoxicology 73

4′,6-Dichloroflavan 1064

1152 Dichlorophene – Drug Subject Index

Dichlorophene [97-23-4] 11081-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichloro-

phenyl)methoxy]ethyl]-1H-imidazolesee Miconazole 1081

1-[2-(2,4-Dichlorophenyl)-2-[(2,6-dichloro-phenyl)methoxy]ethyl]-1H-imidazole

see Isoconazole 1088(Z)-1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone

O-[(2,4-dichlorophenyl)methyl]oximesee Oxiconazole 1089

1-[2-(2,4-Dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole

see Fenticonazole 1087cis-1-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-

ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine

see Terconazole 10914-[4-[4-[4-[[2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-

ylmethyl)-1,3-dioxolan-4-yl]-methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

see Itraconazole 10782′,3′-Dideoxyadenosine (ddA) 7692′,3′-Dideoxycytidine (ddC) 7692′,3′-Dideoxyinosine (ddI) 769Dietetic productsamino acids in 806

2-(Diethylamino)ethyl-2,2-diphenylpentanoateinfluence on biotransformation enzymes 59

Diethylhexyl phthalatetoxicology 72

Diets, elemental 813Difloxacin 1026Diflucan 1077α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-

1,2,4-triazole-1-ethanolsee Fluconazole 1077

Dignotrimazol 1085Dihydro-5-azacytidine 8475,6-Dihydrodeoxycytidine 57Dihydrofolate reductase (DHFR)inhibition of, in cancer chemotherapy 841

l-3,4-Dihydroxyphenylalanine (l-DOPA) 787l-3,4-Dihydroxyphenylalanine (l-DOPA) 8189-(1,3-Dihydroxy-2-propoxymethyl)guanine (DHPG) 769,

10622,5-Diketopiperazines 782Dilauryl thiodipropionateas antioxidant 708as antioxidant for food 684

Diloxanide [579-38-4] 1055furoat [3736-81-0] 1055

(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine

see Terbinafine 1105Dimycon 1077Dinacrin 1034Dipeptides 778Diphenylas food preservative, concentration 684

Diphtheriaprophylaxis with hyperimmune globulin from horse blood

952Diphtheria toxoidgeneration of humabs against 961

Diphtheria vaccine 906Directive of Dangerous Substances 506Directorate General V 317Disinfectants 721toxicology 733, 734

Disoxaril [87495-31-6] 1065Dissection

investigating the nervous system by 1122Distamine 819DL-8280 1025DMDR 859A-DNA 741B-DNA 741C-DNA 741DNA·RNA hybrids 744, 749D-DNA 741DNA damagemethods to assess primary 120test systems providing indirect evidence 114

DNA (deoxyribonucleic acid)see also Nucleic acids 740see also Nucleic acids 739, 740bending 742breathing 740, 742chromosomal 750detection of human sequences 764methylation 749plasmid 750recombination 749repair 749repeats 742replication 745replication, lagging strand synthesis 745replication, leading strand synthesis 745sequencing techniques for 750supercoiling 742triple helix 743repair 81strand breaks 83structure and function 79transcription 81translation 81

DNA repairbase excision repair 669nucleotide excision repair 669

T-DNA 741Z-DNA 741Docetaxel 870Dolexalan 1085Dominant lethal test 114Domiphen bromide [13900-14-6] 1108Dopaflex 818Dopamine 1121in synaptic transmission 1129, 1130

Doparl 818Dopasol 818Dopaston 818Dose–response relationshipfactors influencing 19types of 14

Dose-response relationshipfor cumulative effects 18

Dough conditioners 693Down’s syndrome 669Doxorubicin 859Drill Expectorant 817Drogenil 878Droloxifene 875Drop testfor dangerous goods equipment 511

Drosophila melanogastermutation tests in 112

Drugdrug liability 991drug marketing 990legal requirements 985quality control 1002testing 992toxicology 995

Subject Index Drug development – EP certificate of suitability 1153

Drug development 987clinical trials 987, 997

Drug-resistant bacteria 1017DTIC 858Duchenne’s muscular dystrophy 764Dumicoat 1082Duocarmycin A 865durabronchal 817Durafungol 1085Dustexplosion indices of dust–air mixture 386ignition sensitivity of dust cloud 387

Dust explosibility 389Dyesfor foods 689

Dynemicin 865Dysentery, bacillaryvaccine against 913

EEastman Inhibitor OABH 713(E)-5-(2-Bromovinyl)-2′-deoxyuridine (BVDU) 769Ecalin 1087Eco-Cycle Waste Law 634Ecolabeling 581EC regulation 582EU official logo for 582EU scheme 582Nordic scheme 582

Ecology 151equilibrium constants for chemical distribution 210principles of 157risk assessment 259

Eco Mi 1087Econazole [27220-47-9] 1086MIC values for 1087nitrate [68797-31-9] 1086

Ecorex 1087Ecostatin 1087Ecosystembiplot analysis 161canonical correspondence analysis 161chi-square automatic interaction detection 163degradative, allogenetic, autogenic succession 163dominance-controlled community 166energy balance 171founder-controlled community 167gradient analysis 161, 163model of 158nutrient cycles and nutrient cycling in 174, 177ordination in 161primary and secondary production 186productivity of 180rank–abundance diagrams in 161sensitivity of 190, 200stability and resilience of 207water balance of 168

Ecosystem, aquaticimpact of xenobiotics 252

Ecosystem dynamicsessential processes of 180

Ecosystem evolutionmodel of long-term 209

Ecotoneslentic 190lotic 188sensitivity of 190, 206terestrial 188

Ecotoxicology 219acid-base reactions 277biomagnification 275

biotic PNEC estimates 244concentration factor 275dispersion in 222distribution of a chemical compound 276elimination in 222fugacity models 280models 266of chemical products 561PEC estimates in the air 224PEC estimates in waters 229photolysis 277PNEC estimates for soil 242release estimation in 220risk assessment 259test systems 234variogram analysis 224

Edatrexate 843Eisenia foetida 563Elazor 1077Electrodemicroelectrode 1124multibarrelled electrode 1124patch-clamp electrode 1124, 1125

Electron microscopyfor nucleic acid analyses 751investigating the nervous system by 1122

Electrophoresisof amino acids 825of DNA 752polyacrylamide gel, for oligonucleotide separation 757pulse-field, of DNA 752

Ellipticinefor DNA strand cleavage 743

EMBL 750Embryotoxicity 85, 100by chemical products 561patterns of dose–response in 86

Emergency Procedures for Ships carrying Dangerous Goods516

Emodin 660Empecid 1085Employers′ Liability Insurance Association of Chemical

Industries 367, 507Emulsifieras food additives 685in baked goods 685

Enantiomer 778, 780Enatone 879Encephalitisby tick bite, vaccine against 934japanese, vaccine against 934

Endocytosis 1123Endorphin 1128Endotoxins, gram-negativegeneration of humabs against 961

Engineering Code for Flammable Liquids (TRbF) 471, 507Enkephalin 1128Ennades 867Enocitabine 848Enoxacin 1024Environmental impact assessment laws 633Environmental legislationEuropean 631United States 631

Environmental Protection Agency (EPA) 318Enviroxime 1064Enzyme inhibitorsin cancer therapy 883

Enzymesuse in food industry 694in xenobiotics biotransformation 38

EP certificate of suitability 1011

1154 Epectan – Fenizolan Subject Index

Epectan 8184′-Epiadriamycin 859Epidermisabsorption of xenobiotics through 27

Epilepsy 1130Epi-Monistat 1082Epi-Pevaryl 1087Epirubicin 859Epitopes 901Epothilone A 871Epothilone B 871Epstein Barr virusgeneration of humabs against 962

Equipment Safety Act 304, 407Ergonomics 345assessment and testing criteria 346

Erythorbic acidas antioxidant for food 684

Erythrosin B, C.I. 45430acceptable daily intake values 679for coloring of foods 689

Escherichia coliDNA helix form 741DNA replication 746mRNA length 747species differentiation 764vaccine against 916, 919mutagenicity tests in 112

Esperamicin 865Estracyt 855Estramustine 855Estrimex 874Ethambutol hydrochloride 1034Ethanol (ethyl alcohol)disinfectant properties 724

Ethanox 330 704Ethionamide 1035Ethoxyquinas antioxidant for food 684

Ethylenediaminetetraacetic acid (EDTA)Ca or Na salt as food additive 684

2-Ethylhexanaldisinfectant properties 726

2-Ethyl-1-hexanoldisinfectant properties 724

Ethyl maltolacceptable daily intake values 679as flavor enhancer 691

2-Ethylthioisonicotinamide 1035Etoposide 868Etramon 1087Eu-5306 1025Eucaryotic cells 739Eucol 814Eugenol (2-methoxy-4-allylphenol) 729Eulerian modelin ecotoxicology 223

Eulexin 878Euploidyin genome mutations 669

Euronac 817European Committee on Legal Cooperation (CDCJ) 609European Community (EC) 593directives with regard to the transport of dangerous goods

518EC legislation 593measures 614

European Court of Justice (ECJ) 593European Economic Community (EEC) 593European legislationfor occupational health and safety 317

European Union (EU)

exports of waste from 621imports of waste into 621shipments of waste between member states 620transit of waste 622waste shipments in 613

European Waste Catalogue 635Eurosan 1085Excitatory postsynaptic potential (EPSP) 1125Exelderm 1091Exemestane 876Exocytosis 1123Exoderil 1105Exomuc 817Exon shuffling 747Expert Commission on Safety in the Swiss Chemical Industry

(ESCIS) 410Explosiondefinition 391mechanisms 392

Explosion barrier 442Explosion limit (EL) 390Explosion pressure 381as a function of time 390

Explosion prevention 425Explosion protection 425Explosion rangepressure dependence of 381

Explosion risk 419Explosion risk assessmentkeywords for 426

Explosion risk reduction 426Explosivesgrouping of 392

Explosives, desensitizedtransport, handling, and storage 501

Extractantsin food industry 692

Ezon-T 1104

FFadrozole 876Failure modes and effects analysis (FMEA) 397, 412Falvin 1088Fanasil 1032Fareston 874Farmorubicin 859Fasigyn 1045Faslodex 875Fatty acidssalts and other derivatives, as food additives 686

Fault tree analysis 413Fazol 1088FB b 5097see Clotrimazole 1085

5-FCsee Flucytosine 1098

FCE 24517 865Fc receptors 948-mediated clearance 956

Federal Institute forMaterials Research and Testing (BAM) 507Federal Institution of Industrial Medicine 307Federal Institution of Industrial Safety 307Federal Ministry of Labor 307Feedsformulation of feed mixes 810

Felacomp 814, 815Femcare 1085Femcosyn 1084Femeron 1082Femstat 1084Fenizolan 1088

Subject Index Fenticonazole – Funginazol 1155

Fenticonazole 1087nitrate [73151-29-8] 1087

Fentiderm 1088Fentigyn 1088FI-7045 (free base)see Sertaconazole 1090

FI-7056 (mononitrate)see Sertaconazole 1090

FIAC [69124-05-6] 848, 1060Ficin (E.C. 3.4.22.3)use in food industry 694

Filariasisdesign of vaccine against 939

Filter aidsin food industry 692

Fire protection 415design and construction of chemical plants 417equipment 417fire-fighting methods 418in transport, handling, and storage 511

Fischer–Helferich principle 767Fischer projection 780Fitonal 1080Fitonax 1087Flacar 814Flagellates 1039Flagyl 1038Flame arrester 442crimped-ribbon-type 442for dust–air mixture 444wet-type (siphon arrester) 442with temperature monitoring and steam injection 444

Flame detachment 379Flammability index test equipment 377Flammable liquidstransport, handling, and storage 499

Flammable solidstransport, handling, and storage 500

Flamprop-M 822Flash point test equipment 375Flavin-dependent monooxygenasesxenobiotic oxidation by 41

Flavine adenine dinucleotide (FAD) 768Flavor enhancer 691Flavoringartificial 691natural 691nature-identical 691

Flavorings 691Flavors and fragrancesamino acids as flavor and taste enhancers 806

Flavoxanthinfor coloring of foods 689

Florid 1082Flour improver 693Floxuridine 844Fluconazole [86386-73-4] 1077Flucytosine [2022-85-7] 1098MIC values for 1099

Fludara 849Fludarabinemechanism of action 849

Fludarabine phosphate 849Fluditec 817Fluifort 818Fluimucil 817Fluimucil Antibiotic 750 817Flumark 1025Flumequine 1026FluoconazoleMIC values for 1077

Fluorescent reagents

for analysis of amino acids 824Fluorocytosinesee Flucytosine 1098

2′-fluoro-5-iodo-1-β-d-arabinofuranosylcytosine 848Fluoropyrimidinesin cancer therapy 844

Fluoroquinolones 10225-Fluorouracil 844mechanism of action 844mechanism of resistance 845

5-Flurocytosinesee Flucytosine 1098

Flutamide 877tau-Fluvalinate 823Fluvic 817Foam stabilizersin foods 687

Focusan 1104Folic acidinhibition of synthesis by sulfonamides 1028

Fongamil 1089Fongarex 1089Fongaridl 823Foodaddition of amino acids 804amino acid content of some foodstuffs 804daily protein requirement 803protein quality of food and min. requirements 805,807stabilization with antioxidants 713, 716

Food additives 677Footwork 1104Forest diebackdynamic models of 249models with nonlinear dose–effect relationship 249static models of 248

Formaldehydedisinfectant properties 726

Formamidopyrimidine-deoxyguanosine 57Formestane 876Formic acidas food preservative, concentration 684

Formycin 765Foscarnet 1063Fotemustine 856Fotimin 1105Fourneau 309 1040Frank–Kamenetzkitemperature profiles 395

Freund’s complete adjuvant 98Ftorafur 845Fuchsin (basic violet) 11085-FUDR 844Fulcin 1100Fulcin S 1100Fulvicin 1100Fulvicina 1100Fulvicin P/G 1100Fumaric acidacceptable daily intake values 679acidulant for foods 690

Funganiline 1094Fungarest 1080Fungata 1077Fungibacid 1093Fungicidin 1097Fungicil 1080Fungiderm 1082, 1102Fungifos 1103Fungiframan 1085Fungilin 1094Fungi-med 1085Funginazol 1082

1156 Fungireduct – Griseostatin Subject Index

Fungireduct 1097Fungisdin 1082Fungistat 1092Fungivin 1100Fungizid-ratiopharm 1085Fungizone 1094Fungo-Hubber 1080Fungoral 1080Fungosten 1085Fungotox 1085Fungowas 1102Fungucit 1082Fungur 1082Furadantin 1038Furalaxyl 823Furazolidone [67-45-8] 1046Furnace test 378Furox 1047Furoxone 1046

GG4-DNA 743Galben 823Gallatesacceptable daily intake values 679as antioxidants 684

Gametocytes 941vaccines against 946

Gammarustoxicity studies with 240

Ganciclovir 766Ganirelix 882Gantrisin 1031Gasexplosion data for mixtures 378pressure limit of stability 383transport, handling, and storage 498

Gasolinestabilization with antioxidants 714

Gastripan-K 815Gefulvine 1100Gelatinas clarifying agent in food industry 692as gelling agent in foods 687

Gelling agentin foods 687

Gemcitabine 848monohydrochloride 848

Gemzar 848Genac 817GenBank 750Gene 746Gene expression 746General Agreement of Tariffs and Trade (GATT) 587Genetic engineering 759production of vaccines by 906

Genotoxic agentsseealso Mutagenic agents 667

Genotoxicityin vitro and in vivo short-term tests 105

German Federal Water Quality and Pollution Control Act(Wasserhaushaltsgesetz) 457

German Hazardous Materials Regulation (GefStoffV) 374Germanin 1040Gerontamin 815Giardiasisbiology and chemotherapy 1046

Gigasept/Gigasept FF 727Gilt 1085Gino-Canesten 1085Gino-Clotrimix 1085

Gino-Lotramina 1085Gino-Tralen 1093Glass milk 750Glia 1117γ-Globulinpreparations, adverse effects 958

Glucagon (GG) 1130Glucantime [133-51-7] 1044Glufosinate 820Glutamic acidas flavor enhancer 691in synaptic transmission 1129

d-Glutamic acid 787l-Glutamic acid 779, 783as drug 815calcium salt, dihydrate [5996-22-5] 815hydrochloride [138-15-8] 815magnesium salt, tetrahydrate [19238-50-7] 815monosodium salt, monohydrate [142-47-2] 815potassium salt, monohydrate [19473-49-5] 815production 793

Glutamineproduction 795

l-Glutamine [56-85-9] 779, 784, 815Glutaraldehydedisinfectant properties 726

Glutathioneconjugation of xenobiotics by 48detoxication of reactive oxygen metabolites and radicals 54

Glutergen 815Glycerol (propane-1,2,3-triol)as food additive 687

Bis(glycinato) copper(II) hydrate 781Glycinesee also Aminoacetic acid 779Aminoacetic acid 784in synaptic transmission 1129, 1130

Glycine as flavor enhancer 807Glyoxaldisinfectant properties 726

Glyphenarsine 1041Glyphosate 820Glyphosine 823Godbert–Greenwald furnace 387Golgi staining 1116Gonadotropin (gonadotropic hormone; GnTH) 1130Gonorrheavaccine against 921

Good Clinical Practice (GCP) 989Good Laboratory Practice (GLP) 987, 993, 1001Good Manufacturing Practice (GMP) 990, 1001Good-rite 3114 704Good-rite 3125 704Goserelin 879–881GRAS substances 696Green Sfor coloring of foods 689

Greosin 1100Grewer test apparatusfor testing spontaneous flammability of dusts 377

Gricin 1100Grifulin 1100Grifulvin V 1100Grisactin 1100Grisefuline 1100Griseo 1100Griseoderm 1100Griseofulvin 1099GriseofulvineMIC values for 1100

Griseomed 1100Griseostatin 1100

Subject Index Griseo von ct – Hurdle concept 1157

Griseo von ct 1100Grisfulvin 1100Grisol 1100Grisovin 1100Grisovina Fp 1100Grisovin-FP 1100Grivate 1100Gromazol 1085Grysio 1100Guanine 740Guanosine 765as flavor enhancer 691

Guar gumas thickener 687

Guidelines for Packing Cargo Transport Units 516Guinea pig maximisation test 97Gum arabicas thickener 687

Gyne-Lotremin 1085Gyno-Daktar 1082Gyno-Daktarin 1082Gyno-Monistat 1082Gyno-Myfungar 1090Gyno-Pevaryl 1087Gyno-Terazol 1092Gyno-Travogen 1088Gyno-Trosyd 1093

HHair preparationamino acids in 819

Halofantrine [69756-53-2] 1051β-glycerphosphate 1051hydrochloride [36167-63-2] 1051

2-Halopurinesin cancer therapy 849

Hartmann apparatus 388Hartmann apparatus, modified 389Hazardcauses and effects 364evaluation of 413in the chemical industry 301types and sources of 363

Hazard and operability study (HAZOP) 412Hazard assessmentin plant and process safety 397

Hazard characteristicsof exothermic processes 397

Hazard controlin plant and process safety 470

Hazard control planoff-battery 475plants and works 473

Hazard identification 419in health risk 351of chemical products 554of preparations 571

Hazardous Materials Regulation 407Hazardous substancessafety practices when working with 447symbols and letter codes 372

Hazard potentialfrom an explosion 369from release of a volatile substance 368magnitude 367mathematical treatment 368

Health and Safety at Work Act 313Health and Safety Executive (HSE) 332Heat flowdetermination of 171in soil 172

in the lower atmosphere 172Heavy-metal complexesfor cancer therapy 871

Heilmittelwerbegesetz 991Heliobacter pylori 661Helminthsvaccines against 936

Hemophilus influenzaegeneration of humabs against 961type b vaccines 922

Henderson–Hasselbalch equation 780Hepaderichol 814Hepa-Loges 814Hepa-Merz 816Hepatitisprophylaxis with hyperimmune globulin 952prophylaxis with immun serum globulin 950

Hepatitis B vaccine 928Hepatitis B virusgeneration of neutralizing humabs 962

Herniocid 1097Herpes simplexgeneration of humabs against 962

Heterotroph 175Hexachlorophene [70-30-4] 1108Hexamethylenetetramineas food preservative, concentration 684

Hexamethylmelamine 858Hi-Alarzin 1104High-performance liquid chromatography (HPLC)for oligonucleotide separation 757

Hilbert–Johnson method 766Histaminein synaptic transmission 1129

l-Histidine [71-00-1] 779, 784, 815hydrochloride monohydrate [5934-29-2] 815production 795

Histocompatibility locus (HLA)gene determination 764

Histones 745Histrelin 880HIV-1 661HIV-2 661HN2 852Hodgkin’s disease 661HOE 296bsee Ciclopirox 1101

Hoe-280 1025Hoechst 33258 plus Giemsa 115Holoxan 855l-Homocysteine 787Hoogsteen base pairing 740Hookwormsvaccines against 938

Hospital-acquired infectionsgeneration of humabs against 961vaccines against 915

Hostavin TMN 20 710HPA 23 1066HTLV-I 661Humabssee also Antibodies, monoclonal 906generation against bacterial infection 961immunotherapeutic use of 960tetanus-neutralizing 961

Human T cell leukemia virusgeneration of humabs against 962

Humectantsas food additives 687

Huntington’s chorea 1121Hurdle conceptfor food preservation 681

1158 Hybridization, sandwich – Intron Subject Index

Hybridization, sandwichof nucleic acids 760

Hydantoins 782Hydra 1131Hydrogen peroxidetoxicity of 53

Hydrolysisin environmental processes 213

Hydroperoxidesdecomposition by antioxidants 703forming in oxidation reactions 700

4-Hydroxybenzoic acid estersas food preservative, concentration 684

Hydroxychloroquine sulfate [747-36-4] 10498-Hydroxydeoxyguanosine 579-(2-Hydroxyethoxymethyl)guanine 769d-p-Hydroxyphenylglycine 787(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine 766l-Hydroxyproline 779, 784production 795

Hydroxyquinine 10498-Hydroxyquinolinesfor treating amebiasis 1054

5-Hydroxytryptaminein synaptic transmission 1129

l-5-Hydroxytryptophan 787(S)-5-Hydroxytryptophan 819Hyperimmune globulins 950prophylaxis with 952

Hypogammaglobulinemia 951Hypophysissource of neuropeptides 1130

Hypothalamusneuropeptide control in 1130

IIcaden 1088ICAO Technical Instructions 516Ice creamadditives for 685, 687thickeners for 687

Idamycin 859Idarubicin 859Idoxifene 875Idoxuidine [54-42-2] 1059Ifex 855Ifosfamide 855Ignition energy 385Ignition sensitivity 387Ignition temperatureapparatus for determining 385

IK 20 349see Tioconazole 1093

Ilmofosine 883Ilube 817Imazamethabenz 821Imazamox 821Imazapic 821Imazapyr 821Imazaquin 821Imazethaphyr 821IMDG-Code 496, 516α-Iminocarboxylic acids 782Imiprophin 823Immune response 903anamnestic response 904

Immune serum globulin 948prophylaxis with 950therapy with 953

Immunityvaccine-induced 904

Immunizationactive, by vaccines 905passive, by immunoglobulins from plasma of donors 905

Immunocytochemistry 1131Immunoglobulinavailable 900for intravenous use 949for passive immunization 905hyperimmune, from plasma of patients 950intravenous, against infections 953intravenous, against noninfections diseases 955on B cells 903preparation 948

Immunoglobulin A 903secretory IgA 903

Immunoglobulin D 903Immunoglobulin E 903Immunoglobulin G 902subclasses 948

Immunoglobulin M 902Immunotherapy 899Immunotoxicity 123Incident sequence analysis 413Indigo Carmine, C.I. 73015for coloring of foods 689

Indigotine, C.I. 73015for coloring of foods 689

Infectious substancestransport, handling, and storage 502

Infiltrationmathematical treatment 169

Influenza vaccine 931Infusion solutions 813INH 1034Inhibitory postsynaptic potential (IPSP) 1133Inosineas flavor enhancer 691

Institute of Occupational Hygiene (IOH) 321Institutional Review Board (IRB) 988Insulin 1130Intercalating anthracenesfor cancer therapy 862

Intergovernmental Organization for the International Carriage byRail (OTIF) 517

Interleukin-1 904Interleukin-2 904Intermediate bulk container (IBC) 511coding system and marking 522for piece goods transport 520types of 522

Internal market 615Internal pressure (hydraulic) testfor dangerous goods equipment 511

International Atomic Energy Agency (IAEA) 516International Bulk Chemical Code 529International Convention concerning the Carriage of Goods by

Rail (CIM) 517International Convention for the Prevention of Pollution from

Ships (MARPOL) 496, 505, 516International Convention for the Safety of Life at Sea (SOLAS)

496, 516International Gas Carrier Code (IGC) 529International Institute for the Unification of Private Law

(UNIDROIT) 599International Labour Office (ILO) 303International Maritime Organization (IMO)classes 497definition for dangerous goods 499

International Occupational Health Association (IOHA) 321International Program on Chemical Safety (IPCS) 358Intron 747

Subject Index Invertase (E.C. 3.2.1.26) – Lentaron 1159

Invertase (E.C. 3.2.1.26)use in food industry 694

Investigational new drug application (IND) 988Iodinedisinfectant properties 733

5-Iodo-2′-deoxyuridine, 5-bromovinyl-2′-deoxyuridine 7665-Iodo-2′-deoxyuridine (IDU) 769Iodoquinol [83-73-8] 1054Ion exchangein environmental processes 215

Ion-exchange chromatographyof amino acids 825

Ipec 1082Iprodione 823Iproplatin 873Irgafos P-EPQ 710Irganox 1010 704Irganox 1035 704Irganox 1076 704Irganox 1098 704Irganox 1330 704Irganox MD-1024 713Irinotecan 869Iron hydroxidefor coloring of foods 689

Iron oxidefor coloring of foods 689

Irradian 814Isoascorbic acidas antioxidant for food 684

Isoconazole [27523-40-6] 1088nitrat [24168-96-5] 1088

Isofosphamide 855Isogyn Ginecologico 1088d,l-Isoleucine 787l-Isoleucine [73-32-5] 779, 784, 815production 795

Isomaltfood additive 681

Isoniazid 1034biotransformation of 60

Isonicotinic acid hydrazide 1034Isosporiasis 1039, 1052Itraconazole [84625-61-6] 1078MIC values for 1078

Itrizole 1078

JJapanese encephalitis vaccine 934Jenamazol 1085Jestrosemin 816Jordanella floridaetoxicity studies with 235

Journal of Industrial Hygiene 330

KKadeFungin 1085Kalma 816Karman constant 173Karposi’s sarcoma 661KC 9147see Tolciclate 1103

Ketazol 1080Ketoconazole [65277-42-1] 1079MIC values for 1080

Ketoderm 1080Ketoisdin 1080Ketonan 1080Ketoral 1080Kieselguhr

as filter aid in food industry 693Kilmicen 1103Klartan 823Klebsiella spp.vaccine against 916

Korostatin 1097Krebs cycle 74Kwashiorkor 827

LLabor Protection Act 314Lactatesas food additives 684

Lactic acidacidulant for foods 690as food additive 684as food preservative, concentration 684

Laevil 814Lagrangian modelin ecotoxicology 223

Lambliasis 1039Lamisil 1105Lamoryl 1100Lampit 1042Lampren 1037Laristine 815Larodopa 818Lawsconcerning occupational health in FRG 303concerning occupational safety in Denmark 314concerning occupational safety in Finland 314concerning occupational safety in Spain 315concerning occupational safety in the Netherlands 316concerning occupational safety in UK 313concerning occupational safety in U.S. 317

Lead Act 317Leakproofness testfor dangerous goods equipment 511

Leberam 814Lecithin (phosphatidylcholin)as food additive 684–686as mold-release agents 693

Lederlind 1097Legal aspects 585carriage of dangerous substances by sea 608damage caused by dangerous activities 608EC packaging legislation 635EC Regulation 259/93, new 618EC Regulation 259/93 620environmental damage 611environmental protection 591in industrial chemistry 589insurance of the industrial risk 612Internal market, “1992” 614international harmonization for dangerous activities 600liability for damage caused during carriage 607liability for defective products 601liability for waste 605Maastricht Treaty 616on chemical installations 597polluter-pays principle 591precautionary principle 589product-oriented legislation 594Single European Act 615Treaty of Rome 617U.S. superfund 635

Leishmania 1039Leishmaniasis 1039biology and chemotherapy 1043

Lentaron 876

1160 Lepomis macrochirus – Medical First Aid Guide Subject Index

Lepomis macrochirustoxicity studies with 240, 562

Lepraegeneration of humabs against 962

Leprosy 1033antileprosy agents 1036

Leuchs anhydrides 782d,l-Leucine 787l-Leucine 779, 784production 796

l-tert-Leucine 787Leuciscus idustoxicity studies with 235, 562

Leukemiachronic myelogenous 764

Leuprorelin 879, 880Leustatin 849Levodopa 818Levothym 819Levotonine 819LHRH agonists 879in cancer therapy 879

LHRH analogsin cancer therapy 879

LHRH antagonists 879in cancer therapy 881

Light microscopyinvestigating the nervous system by 1122

Limbic system 1121Limiting oxygen concentration (LOC) 390β-Lipotropin 1130Lisil 818Lisomucil 818Lissamine Greenfor coloring of foods 689

List of Dangerous Goods Most Commonly Carried 494Lithol Rubine BKfor coloring of foods 689

Lobarthrose 819Localicid 1085Loceryl 1107Loceryl 1107Locust bean gumsee also Carob gum 687

Lomexin 1088Lomidine 1040Lomustine 855Loporox 1102Lotramina 1085Lotremin 1085Lotrimin 1085Lower explosion limit (LEL) 379Lowest observed adverse-effect level (LOAEL) 129Lowest observed effect level (LOEL) 129Lubricantsstabilization with antioxidants 714

Lupron 879Luteinfor coloring of foods 689

Lycopenefor coloring of foods 689

Lysergic acid diethylamide (LSD) 1128d,l-Lysineacetylsalicylate 816as drug 816monohydrochloride [34220-70-7] 816monohydrochloride [70-53-1] 816

d,l-Lysine hydrochloride 787l-Lysine [56-87-1] 784, 816acetate 816as drug 816l-aspartate 816

l-glutamate 816l-malate 816monohydrate 816monohydrochloride [27348-32-9] 816monohydrochloride [57282-49-2] 816monohydrochloride [657-27-2] 816monohydrochloride [71555-10-7] 816production 796

Lystin 1097

MMaastricht Treaty 616Macrodantin 1038Macronutrient 174Madopar 818Magnesiocard 814Magnesium stearateas anticaking agent 688

Magnesium Verla 814, 815Magnetic resonance imaging (MRI)investigation of nervous system with 1127

Magnussen test 997Maillard reactionflavors by 808

Major Hazards Directive 407MAK valueclassification of hazardous substances 373

Malaria 1039biology and chemotherapy 1047generation of humabs against 962life cycle of the malaria parasite 941

Malaria vaccine 941transmission blocking immunity 947

Malic acidacidulant for foods 690

Maltolas flavor enhancer 691

d-Mannitolin foods for diabetics 690

Mantel-Bryan modeltoxicologic risk estimation 136

Marasmus 827Marine tankerfor bulk transport of liquids and gases 529

Mark LA 55 710Matagen 758Mataven L 822Mavrik 823Maximum admissible concentration (MAC) 588Maximum allowable working pressure (MAWP) 510Maximum experimental safe gap (MESG) 385apparatus for determining 386

Maximum exposure limit (MEL) 314McIntosh index 158MCNU 856Mean effective dose 994Measlesprophylaxis with immun serum globulin 951vaccine 923virus, generation of humabs against 962

Measles–mumps–rubella vaccine, combined 926Meat productsadditives for 686

Mebrominsee also Mercurochrome 1108

Mechloroethamine 852Mecysteine hydrochloride 818Median effective dose 16Median lethal dose 16Medibronc 817Medical First Aid Guide 516

Subject Index Mefloquine – Monostat 7 (Ortho) 1161

Mefloquine [53230-10-7] 1051hydrochlorid [51773-92-3] 1051quinate 1051

Mel W [13355-00-5] 1041Melarsoprol 1040Melphalan 853mechanism of action 853mechanism of resistance 853

Melur 1089Membranesbiological 24diffusion of chemicals through 25penetration of, by chemicals 25transport of xenobiotics through 26

Memory cells 904Meningitisby tick bite, vaccine against 934vaccines against 917, 922

Meningitis, meningococcalvaccine against 917

Meningoencephalomyelitisby tick bite, vaccine against 934

6-Mercaptopurine 850mechanism of action 850mechanism of resistance 851

3-Mercapto-d-valine 819Mercurochrome [129-16-8] 1108see also Mebromin 1108

Merozoites 941surface antigens 945vaccines against 944

Mesitylene sulfonylnitrotriazole (MSNT) 755Metalaxyl 822Metalcaptase 819Metal chelatesfor DNA strand cleavage 743

Metal deactivatorstabilizers for polymers 703, 711

Metalothioneinbinding of metals 75

d,l-Methionine [59-51-8] 787, 816production 797

l-Methionine 779, 784production 797

Methiosulfonium chloride 818Methiosulfonium iodide [3493-11-6] 818Methotrexate 841cytotoxicity 843interaction with dihydrofolate reductase 842intracellular metabolism 842mechanism of action 841

methyl-CCNU 855Methyl cellulose (MC)as food additive 687

3-Methylcholanthreneinfluence on biotransformation enzymes 58

Methylcyclohexylchloroethylnitrosourea 855Methyl l-cysteine hydrochloride 818l-S-Methylmethionine 788l-Methylmethionine sulfonium chloride 8182-Methylnaphthoquinoneenzymatic redox cycling 53

(3-Methylphenyl)carbamothioic acidO-2-naphthalenylmethylester

see Tolnaftate 1103(E)-N-Methyl-N-(3-phenyl-2-propenyl)-1-

naphthalenemethenaminesee Naftifine 1104

Metoprine 843Metro I.V. 1038Metronid 1038Metronidazole 1037

Metryl 1038Micatin 1082Miclast 1102Micocert 1087Micoderm 1082Micoespec 1087Micofim 1082Micofun 1083Micofungal 1087Micogel 1082Micogin 1087Micogyn 1087Micomicen 1102Micomisan 1085Miconal 1082Miconazole [22916-47-8] 1081MIC values for 1082

Micoral 1080Micos 1087Micosten 1087Micostyl 1087Micotar 1082Micotef 1082Micotek 1080Micoter 1085Micoticum 1080Micoxolamin 1102Microbiological analysisof amino acids 825

Microcyte 1117Micronucleus assay 671Micronutrients (for plants) 174Microorganismcultures of, use in food industry 695infectious, identification by nucleic acid probe technology

763inhibition of microbial growth by CO2 atmosphere 685

Mikoderm 1104Mikostatin 1097Miloxacin 1022Miltefosine 883Miltex 884Mineralsas food additives 681

Minimum ignition energy (MIE) 388Minimum ignition temperature (MIT) 387Minimum shell thickness 510, 511Miproxifene phosphate 875Mirogastrin 815Mitekol 1087Mitochondria 1124Mitomycin-C 858Mitoxantrone hydrochloride 862mechanism of action 862

MK-0366 1023Modopar 818Modumate 814Moeslinger fining 692Mold-release agentsin food industry 693

Molecular rotation 780Moltanine 818Monistat 1082Monistat I.V. 1082Mono-Baycuten 1085Monomethylnitrosaminehydroxylation by cytochrome P450 51

Monoperoxyglutaric acid 727Monoperoxyphthalic acid 728Monoperoxysuccinic acid 727Monostat 7 (Ortho) 1082

1162 Moolgavkar-Venson-Knudson model – Nematodes Subject Index

Moolgavkar–Venson–Knudson modeltoxicologic risk estimation 136

MOPP 852Moranyl 1040Moronal 1097Motor fuelstabilization with antioxidants 714

Mouse somatic spot test 114Mouse specific locus test 114mRNA 744, 745in situ hybridization 1122

Muciclar 817Mucisol 817Muciteran 817Mucocedyl 817Mucocis 818Mucodyne 817, 818Mucofilin Sol. 817Mucojet 818Mucolase 818Mucolator 817Mucomyst 817Muco-Perasthman 817Mucopront 817Muco Sanigen 817Mucosit 817Mucosol 818Mucothiol 817Mucotreis 818Mucotrophir 817Mucret 817Multilind 1097Mumpsprophylaxis with hyperimmune globulin 952vaccine 924

Mupaten 1088Muphoran 857Murine local lymph node assay 98Muscular movementvoluntary 1121

MutagenesisEU classification 560of chemical products 560potential structural alerts for 656classification 667

Mutagenic agents 667–675chromatid-type aberrations 669chromosome-type aberrations 669direct genotoxins 675indirect genotoxins 675metabolic activation 673types of 674

MutagenicityAmes test 106eukaryotic tests for 111in vitro tests 112in vivo tests 114

Mutagenicity testin drugs 997cytogenetic assays 671eukaryotic 670indicator tests 672mammalian gene 670microbial 670micronucleus assay 671OECD Guidelines 670testing strategies 672transgenic animal assays 672in-vivo tests 671

Mutation 748causal link between cancer and 83forms of 81

Mutum 1077Myambutol 1035Mycelex 1085Mycelex-7 1085Mycelex-G 1085Myclo 1085Mycobacteria 1033Mycobacterium lepraegeneration of humabs against 961

Mycodermil 1088Mycofug 1085Myco-Hermal 1085Mycophyt 1096Mycoplasmas 1016MycoPosterine N 1097Mycoril 1085Mycospor 1083Mycosporin 1083, 1085Mycostatin 1097Mycoster 1102Mycotrim 1085Myfungar 1090MYK 1091MYK-1 1091Mykinac (NMC) 1097Myko Crdes 1085Mykofungin 1085Mykohaug 1085Mykopevaryl 1087Mykotral 1082Mykundex 1097Myprozine 1096Myxofat 817

NNAC 817N-Acetylamidofluoreneoxidation by cytochrome P450 51

Nacom 818Nadostine 1097Nafarelin 880Nafteryl 1105Naftifine [65472-88-0] 1104hydrochlorid [65473-14-5] 1104

Naftin 1105Naganol 1040Nagel Batrafen 1102Nalidixic acid 1019Naphthiomate-Tsee Tolnaftate 1103

d-3-(2′-Naphthyl)-alanine 788Naphthyridine 1019Naphuride 1040Naringinaseuse in food industry 694

Natacyn 1096Natafucin 1096Natamycin 1096National Institute for Occupational Safety and Health (NIOSH)

318National Toxicology Program (NTP) 318Naugard XL-1 713Navelbine 867Naxogin 1045Nedaplatin 873NegGram 1020Neisseria gonorrhoeae vaccine 921Neisseria meningitidesgeneration of humabs against 961

Nematodesvaccines against 938

Subject Index Neodopaston – Occupational health and safety 1163

Neodopaston 818Neplanocin A [72877-50-0] 765Nervous systemvertrebrate 1118

Neural cell 1116Neuroanatomy 1122Neurobiochemistry (Neurochemistry) 1125Neurons (nerve cells) 1116, 1118Neuropeptides 1130, 1131Neuropharmacology 1115, 1127Neurophysiology 1124Neurotoxicity 124Nickelcarcinogenicity 659

Nicotinamide adenine dinucleotide phosphate (NADP) 768Nicotinic acetylcholine receptor (nAChR) 1132Nifurtimox 1042Nilstat 1097Nilutamide 878Nimorazole [6506-37-2] 1045Ninhydrinreaction with amino acids 824

Nipent 849Nitracin 863Nitratesacceptable daily intake values 679as food preservative, concentration 684color stabilizers of meat 689

Nitritesacceptable daily intake values 679as food preservative, concentration 684color stabilizers of meat 689

Nitrofurantoinmonohydrate 1038

Nitrogenliquid, for direct cooling of foods 693

Nitrogen cycle 178Nitrogen mustard 852mechanism of action 852mechanism of resistance 853

N-Nitrosaminesas carcinogenic agent 656

N-Nitroso derivativesof amino acids 781

Nitrosomyoglobin 689Nitrosoureasin cancer therapy 855mechanism of action 856mechanism of resistance 856

Nivaquine 1049Nizoral 1080Nizshampoo 1080NKS-01 876N,N′-Bis(2-chloroethyl)-N-nitrosourea 855No-effect level (NEL) 559Nolvadex 874No-observed-adverse-effect level (NOAEL) 559No-observed-effect level (NOEL) 129, 559Noradrenalinein synaptic transmission 1128, 1129

Norbixinfor coloring of foods 689

Norfloxacin 1023Norofulvin 1100Noroxin 1023Nosocomial infectionsvaccines against 915

Notification of New Substances (NONS) 313Novanthrone 862NP-27 1104Nuclear magnetic resonance spectroscopy (NMR)for nucleic acid analysis 751

Nuclease, RNA (E.C. 3.1.27.5)RNase H 749RNase II 749RNase P 749, 750

Nucleic acidsee also DNA; RNA 739acid hydrolysis 745analysis 750catalytic activity 749degradation 749homopyrimidine–homopurine run 742hybridization 760interaction with proteins 745interaction with solenoids 745labeling; radioactive, nonradioactive, photolabeling 761structural elements 742translation 748

Nucleic acid probe technology 759nucleic acid sequence based amplification 763self-sustained sequence replication (3 SR) 763

Nucleosides 764Nucleotides 767Nucleus 1116Nyaderm 1097Nydrazid 1034Nysert 1097Nystacid 1097Nystaderm 1097Nysta-Dome 1097Nystan 1097Nystatin A1 1097Nystat-Rx 1097Nystavescent 1097Nystex 1097

OObytin 1102Occupational disease 352compensation for 354

Occupational environment 342Occupational epidemiology 341interpretation of data 335

Occupational exposure limit (OEL) 314, 324Occupational exposure standard (OES) 314Occupational health and safety 299anticipation of health hazards 321biological monitoring (BM) 337biological occupational limits 339communication and training 330company system 309dose/effect/polymorphism 350ergonomics 345European legislation 317evaluation of health risks 348exposure control methods 328first aid 355industrial hygiene in the U. S. 330laws and regulations in Germany 303legal requirements in Denmark 314legal requirements in Finland 314legal requirements in France 315legal requirements in Spain 315legal requirements in the Netherlands 316legal requirements in UK 313occupational diseases 352occupational epidemiology 341occupational exposure assessment 322occupational exposure limits 324occupational hygiene monitoring 325occupational medicine in the U.S. 357organization and staff management 320periodical medical examination 334

1164 Occupational Health Care Act – Peckle Subject Index

physical agents 329programs for industrial hygiene 320regulations for facilities 304sampling and analysis execution 327standards 320stress factors 346trade associations 308U.S. regulations 317

Occupational Health Care Act 315Occupational medicine 331, 357Occupational Safety and Health Administration (OSHA)

318,332Occupational safety committee 311Oceral 1090Octenidine 731Offshore Pollution Liability Agreement (OPOL) 612Ofloxacin 1025Okazaki fragments 746Oligodendrocyte 1117Oligo(dT) cellulose 750Oligodynamic effect 733Oligonucleotide, chemical synthesisH-phosphonate method 756phosphate triester method 755phosphoramidite (phosphite) method 755, 756

Oligonucleotidesnonradioactive labeling 758nuclease-resistant 757, 758sequence-specific artificial endonucleases 758

Oligonucleotides, chemical synthesisprotecting groups 754

Oligoribonucleotide, chemical synthesis 756Omnival 816Omoconazole [74512-12-2] 1089nitrat [83621-06-1] 1089

Oncogene 764recessive 764

Oncorhynchus mykisstoxicity studies with 235, 240

Oncovin 866Onkotrone 862Oocysts 941, 946Ookinetes 941, 946Opioid 1128Opsoninsagainst infections 957

Optically active compoundssee chiral compounds 778

Optical rotational dispersion (ORD) 780Optimax 816Orange Book 565Oranyst 1097Ordinance Concerning Safety and Health at Work 315Organic peroxidestransport, handling, and storage 502

Organoleptic substances 688Orimeten 876Ormaplatin 873Ornicetil 816Ornidazole [16773-42-5] 1045Ornitaine 816l-Ornithine 788, 8162-oxoglutarate 816acetate 816as drug 816l-aspartate 816monohydrochloride [5191-97-9] 816monohydrochloride [60259-81-6] 816

Oromycosal 1080Oronazol 1080Orthophosphoric acidacidulant for foods 690

Oryzias latipestoxicity studies with 235, 240used in toxicity tests 562

Over-the-counter (OTC) drugs 991Ovis Neu 1085O-V Statin 1097Oxaliplatin 8731,3-Oxazolidine-2,5-diones 7821,3-Oxazolin-5-ones 782Oxetanocin 765Oxiconazole [64211-45-6] 1089nitrat [64211-46-7] 1089

Oxidationin environmental processes 215of organic materials, mechanism 700

Oxistat 1090Oxitriptan 819Oxolinic acid 1020Oxyfan 819Oxytocin (OT) 1130

PPAAG methodsin plant and process safety 412

Pacitron 816Packagingof dangerous goods 511, 524

Packaging of foodin carbon dioxide atmosphere 685

Packing groupsfor dangerous goods 504

Paclitaxel 869mechanism of action 870

Paludrine 1051Panfungol 1080Panlomyc 1092Panomifene 875Pansan 815Panstabil 814Pantovipar 815Papain (E.C. 3.4.22.2)use in food industry 694

Parabenas food preservative, concentration 684

Paraoxone 50Paraplatin 873Parasitesvaccines against 936

Parathionoxidative desulfuration of 50

Pargin 1087Parkinson’s disease 1121Parkinsonian dementia 1122Parkinsonian rigidity 1135

Parvolex 817PAS-Heyl 1036Patent Blue V, C.I. 42051for coloring of foods 689

Pavlov’s dog 1125(±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorphenyl)thio]butyl]-

1H-imidazolesee Butoconazole 1084

PCPIMsee Clotrimazole 1085

PD-107779 1025(±)-1-[2,4-Dichloro-β-[(7-chlorobenzo[b]thien-3-

yl)methoxy]phenethyl]imidazolesee Sertaconazole 1090

(±)-cis-2,6-Dimethyl-4-[2-methyl-3(p-tert-pentylphenyl)pro-pyl]morpholine

see Amorolfine 1107Peckle 1085

Subject Index Pectasan – Plant and process safety 1165

Pectasan 817Pectinas gelling agent 687as thickener 687

Pectinasesin juice industry 694

Pedesal 1104Pediderm 1104Pedimycose 1104Pedisafe 1085Pefloxacin 1025Pemine 819Pendramine 819d-Penicillamine 788, 819l-Penicillamine 788Pentamethylmelamine 858Pentamidine 1040Pentamidine isethionate 1040Pentostam 1044Pentostatin 849mechanism of action 850

Peplomycin 864Pepsalara 815Pepticinnamin E 883Peptidomimeticsin cancer therapy 882

Perchloroethenerenal toxicity of 52

Perifosine 884Peripheral nervous system (PNS) 1118Peroxoacidsinorganic, disinfectant properties 727, 728

Peroxycarboxylic acidsdisinfectant properties 727

Pertussisprophylaxis with hyperimmune globulin 952vaccine 909

Pesimuriat 814Pevalip 1087Pevaryl 1087Pevaryl Lipogel 1087Pevaryl lotion 1087Pevaryl P.V. 1087Pharmaceutical inspection convention 1008Pharmaceutical inspection cooperation scheme 1009Pharmorubicin 859Phenethyl alcoholdisinfectant properties 727

Phenobarbitalinfluence on biotransformation enzymes 58

Phenolsdisinfectant properties 728sterically hindered, as antioxidants 704

Phenols, halogenatedas disinfectants 729

2-Phenoxyethanoldisinfectant properties 726

l-p-NO2-Phenylalanine 788d-Phenylalanine 788d,l-Phenylalanine 788d-p-Cl-Phenylalanine 788l-Phenylalanine 779, 785production 798

l-Phenylalanine mustard 853Phenylenediaminesantioxidants 705

d-Phenylglycine 788S-Phenyl-l-cysteine 7882-Phenylphenolas food preservative, concentration 684disinfectant properties 728

Phosgene

oxidation of chloroform to 51Phosphates (esters)acceptable daily intake values 679as food additives 684emulsifying salts in cheese industry 693

Phosphinothricine 820Phosphite 168 710Phosphitesantioxidants 709

Phosphonoacetic acid [4408-78-0] 1062Phosphonoformate [63585-09-1] 1063Phosphoric acidas food additive 684

Phosphoruscycle 179

Photolysisin environmental processes 214

Photosynthesisefficiency of 173

Phoxinus phoxinustoxicity studies with 235

Phytic acidas food additive 684

Pidorubicin 859Pigment Rubinefor coloring of foods 689

Pilzcin 1086Pima-Biciron 1096Pimafucin 1096Pimagyn 1096Pimaricinsee Natamycin 1096

Pimephales promelastoxicity studies with 240, 562

Pinorubicin 859Pipelaying and materials for 543

l-Pipecolic acid 789Pipelinedesign and construction 542types of 541

Pipeline systemsrequirements for 541

Pipemidic acid 1021l-Piperazinecarboxylic acid 789d-Piperidine-3-carboxylic acid 789Pirarubicin 859Piritrexim isothionate 843Piromidic acid 1021Pitrex 1104Placebo 999Plant and process safety 361assessment of criticality 404batch and continous processes 448checklists for preparation, production and termination 453chemical reactions 372definitions 366design 406explosion data for gas mixtures 378flammability ratings 375for exothermic reactions 394human aspect 451internal organization and policies 452legal aspects 428maintenance 459measures 406methodological aids 410methods of investigation 399modification of plants 468process control 429public awareness 475requirements for safety 365

1166 Plaquenil sulfate – Prontosil Subject Index

runaway scenario 403safe processing 415safety analysis methods 411sources of hazards 363special equipment 418technical inspection 457ventilation model 422

Plaquenil sulfate 1050Plasma (blood plasma)prophylaxis and therapy with 957

Plasmodia 1047Plasmodium falciparumlife cycle 941

Plasticssee also Foamed plastics; Polymers; Specialty plastics 716

cis-Platinum 871mechanism of action 872mechanism of resistance 872

Plexamine 815Plimycol 1085Pneumococcusgeneration of humabs against 961

Pneumocystis infection 1053Pneumocystosis 1039Pneumonia vaccine 912Podophyllotoxin 868Poecilia reticulatatoxicity studies with 235, 240, 562

Polaris 823Polilevo 814, 816Polimucil 818Polioprophylaxis with immun serum globulin 951vaccine 926

Polyacetalthermal stability testing 718

Polyamides (PA)stabilization by antioxidants 716thermal stability testing 718

Polybutadienethermal stability testing 718

Polycain 1087Polycarbonate (PC)thermal stability testing 718

Polycyclic aromatic hydrocarbonsas carcinogenic agent 658

Polydextrosefood additive 681

Polyestersthermal stability testing 718

Polyethylene, high-density (HDPE)thermal stability testing 718

Polyethylene, low-density (LDPE)thermal stability testing 718

Polyfungin A1see Nystatin A1 1097

Polygris 1100Poly(hexamethylenebiguanide) hydrochloridesee also Polyaminopropyl biguanide hydrochloride 730, 731

Polymerase chain reaction (PCR) 762Polymerase, DNADNA polymerase III 746

Polymerase, RNAQ β replicase 763

Polymersantioxidants for 699stabilization by antioxidants 714thermal stability testing 717

Polyolefinsstabilization by antioxidants 715

Polyoxymethylene (POM)stabilization by antioxidants 716

polypropylene (PP)thermal stability testing 718

Polystyrene (PS)stabilization by antioxidants 715thermal stability testing 718

Poly(vinyl chloride) (PVC)thermal stability testing 718

Polyvinylpyrrolidoneas clarifying agent in food industry 692

Ponceau 4Rfor coloring of foods 689

Positron-emission tomography (PET)for detection of cerebral blood flow 1127

Potassium hexacyanoferrate(III)as food additive 684for removing traces of iron from wine 692

Potentiator 814Predicted environmental concentration (PEC) 220, 575Predicted no-effect concentration (PNEC) 220, 575Preservativesfor foods 681, 682

Pressuremaximum explosion 381

Pressure design criteriafor gas tanks 511

Pressure limitof stability for unstable gases 383

Prilagin 1082Primaquine [90-34-6] 1050Primaquine phosphate 1050Primase 746Priorin 815Procarbazine 857mechanism of action 857mechanism of resistance 858

Process control engineering (PCE)damage minimizing systems 431monitoring system 430operating systems 430requirements for plant safety 429safety system 431system functions 430

Process hazard assessment and safety evaluation (PHASE) 397Processing aidsin food 691

Product Register at the Danish Working Environment Service314

Productsecolabeling 581ecotoxicological properties 561EU classification 565EU ecolabeling scheme 582hazard classification based on chemical effects 572hazard classification based on physical effects 572hydrosolubility 564labeling requirements 579liposolubility 564oxidizing power 564physicochemical properties 555risk management 578toxicological properties 557

Profact 879Programmable electronic systems (PES) 434Proguanil 1050Proklar 1032Prolactin (PRL) 1130d-Proline 789d,l-Proline 789l-Proline [147-85-3] 779, 785, 816production 799

Proloprim 1030Prontosil 1027

Subject Index 1,2-Propanediol alginate – Rinofluimucil 1167

1,2-Propanediol alginateas thickener 687

Propane Sultone Act 3162-Propanol (IPA) (isopropyl alcohol)disinfectant properties 724

1-Propanol (propyl alcohol) (NPA)disinfectant properties 724

Propellantsin food industry 693

Propionic acidas food preservative, concentration 684

Prostaglandinsbiotransformation of xenobiotics by 42

Proteinogenic amino acids 783Proteins 777biologic value 805daily requirement 805deficiency symptoms 827viral 1055

Protein synthesisRNA involvement in 748

Protosib 1044Protozoan infections 1038Pseudomonas aeruginosageneration of humabs against 961vaccine against 916

Psicosoma 815Psychoverlan 815Pulmicret 817Pursuit 821Push–pull cannulae 1127Pyrazinamide 1035Pyrazinecarboxamide 1035Pyridoglutethimide 876d-3-(3′-Pyridyl)-alanine 789Pyrimethamine [58-14-0] 1028, 1050Pyrindamycin 865Pyrrolizidine 660

QQueuosine [57072-36-3] 765Quinacrine hydrochloride [6151-30-0] 1046Quinineas additive for tonic 690for treating malaria 1048

Quinoline Yellowacceptable daily intake values 679for coloring of foods 689

4-Quinolone 1019Quinolonesantibacterial 1018

Quinone methides 705

RR07-1051 1043R 14827 (mononitrate)see Econazole 1087

R 14889 (mononitrate)see Miconazole 1081

R 15454 (mononitrate)see Isoconazole 1088

R 18134see Miconazole 1081

R 41400see Ketoconazole 1079

R 42470see Terconazole 1092

R 51211see Itraconazole 1078

Rabiesgeneration of humabs against 962prophylaxis with hyperimmune globulin 952

vaccine 929Radanil 1043Radcol 818Radiationcarcinogenesis 662

Radioactive substancestransport, handling, and storage 504

Radioimmunoassay (RIA) 1131Railroad tank carsfor bulk transport of liquids and gases 529

Rainmeasurement 168

Raloxifene 875Raltitrexed 843Ramorelix 882Rana 240Ranimustine 856Rapid eye movement (REM)sleep 1122

Raptor 821Rasbora heteromorphatoxicity studies with 235

1589-RB 1025Reaction, chemicaladiabatic temperature increase 403heats of reaction for common processes 395overpressure-inducing exothermic reactions 396probability and kinetics of a runaway 404runaway potential 394

Rec 15/1476 (mononitrate)see Fenticonazole 1087

Recommended exposure limit (REL) 331Reducdyn 814Reductionin environmental processes 215

Reflex 1119Reichsversicherungsordnung (RVO) 308Release agentsin food industry 693

Renkonen index 161Renoquid 1032Reomucil 818Resochin 1049Restatin 1097Restriction fragment length polymorphism (RFLP) 764Secretin (SEC) 1130Retrovirus 748, 1055R-Gene 814Rheaform 1054Rheumatoid arthritisintravenous immunoglobulin against 956

Rhinathiol 817Rhinofluimucil 817Rho(D) immune globulin 952Rhodoxanthinfor coloring of foods 689

Rhoptry antigens 945Riboflavinfor coloring of foods 689

1-β-d-Ribofuranosyl-1H-1,2,4-triazole-3-carboxyamide[36791-04-5] 1061

1-β-d-Ribofuranosyl-1,2,4-triazole-3-carboxyamide 769Ribozymes 749Rickettsias 1015RID (International Convention concerning the Transportation of

Dangerous Goods by Rail) 517Ridomil 822Rift valley fever vaccine 935Rimantadine [13392-28-4] 1063hydrochloride 1063

Ring-infected erythrocyte surface antigen 945Rinofluimucil 817

1168 Risk – Seveso directive Subject Index

Riskin transport, handling, and storage 490lethal to humans 367

Risk, acceptabledefinition of 576

Risk assessmentdefinitions 554dose–response assessment 575exposure assessment 575general methodology 574hazard identification 575

Risk–benefit considerations 576Risk characterization 576Risk chart 367Risk estimationin occupational health and safety 352

Risk evaluationin occupational health and safety 352

Risk limitationin occupational health and safety 352

Risk managementcodes of practice 579control of supply and use 579monitoring effectiveness 581pollution and chemicals control 580product standards 579risk communication 578voluntary agreements 580

Rivostatin 1097RNA Antisense 746RNA (ribonucleic acid) 739, 743nuclear 744sequencing techniques for 751

Ro 2-9915see Flucytosine 1098

Ro 13-8996/000 (free base)see Oxiconazole 1089

Ro 13-8996/001see Oxiconazole 1089

Rochagan 1043Rods (bacteria) 1015Rofenid 1080Rogletimide 876Rosoxacin 1022Roundup 820Rovral 823Roxadyl 10222168-RP 1044RP 17774see Amphotericin B 1094

rRNA 744RS-44872see Sulconazole 1091

Ru-43-280 1025Rubberantioxidants for 715

Rubellageneration of humabs against 962prophylaxis with immune serum globulin 951vaccine 925

Rubixanthinfor coloring of foods 689

Rules for the Storage of Explosives 507

SSaccharinacceptable daily intake values 679

Saccharomyces cerevisiaemutagenicity tests 112

l-Saccharopine 789S-Adenosyl methionine

in xenobiotic biotransformation 47Safety coefficientfor ductile metals 510

Safety label 304Safety measuresin transport, handling, and storage 508

Safety ratings 371Safety valve 437controlled 438full-lift 438proportional 438sizing of 439standard 438supplementary loaded 438weight-loaded and spring-loaded 438

Salmo gairdneriused in toxicity tests 562

Salmonellabacterial identification 764

Salmonella typhimuriumused in the Ames test 106

Saltatory conduction 1117Sampling devicesafe design of 446

Sandostab P-EPQ 710Sanger method 750Santonox R 704Santowhite powder 704Sargenor 814Satric 1038Sausage binders 686Saxitoxintoxicology 72

Scanning tunneling microscopy (STM)for nucleic acid analysis 751

Scenedesmustoxicity studies with 240

Scenedesmus quadricaudatoxicity studies with 238

Scenedesmus subspicatustoxicity studies with 238

Scepter 821Schistosomiasis 661Schistosomiasis infectionvaccines against 936

Schizonts 941vaccines against 944

Schwann cells 1117SD-Hermal 1085Secnidazole [3366-95-8] 1045Sedotussin 817Sekinin 818Selenastrumtoxicity studies with 240

Self-accelerating decomposition temperature (SADT) 394Semenov temperature profiles 395Sempera 1078Sensorsilicon, for DNA analysis 752

Separin 1104Septa 1030Septic shockplasma infusion against 957

Sequestering agentsas food additives 684

d-Serine 789d,l-Serine 789l-Serine 779, 785production 799

Sertaconazole [99592-32-2] 1090nitrate [99592-39-9] 1090

Seveso directive 627

Subject Index Sgd 301-76 (mononitrate) – Sulfoxone 1169

Sgd 301-76 (mononitrate)see Oxiconazole 1089

Shannon’s diversity index 158Shigella vaccine 913Sickle-cell anemia 764Sideryl 814Sigamucil 817Silicon dioxideas anticaking agent 688

Silveroligodynamic effect 734

Silver compoundsdisinfectant properties 734

Simplotan 1045Simpson index 158Sinefungin 765Sinemet 818Single European Act 615Siran 817Siros 1078Sister-chromatid exchange assay 671Sister-chromatid exchange test 115Skilar 1087Skinabsorption of chemicals 27sensitization testing 97

Skin cosmeticsamino acids in 819

SK-Metronidazol 1038SK-Soxazole 1031Sleeping sickness 1039Small burner test 378Smallpoxprophylaxis with hyperimmune globulin 952vaccine 935

S-Methyl-l-cysteine 787snRNA 748Sodium chloridesubstitutes for use as table salt 690

Solfomucil 818Solmucol 817Solubilityin environmental processes 212

Solucis 818Somatostatin (somatotropin release inhibiting hormone; SRIH)

1131Somatotropin (somatotropic hormone;STH;

growth hormone; GH) 1131Sorbenor 814Sorbic acid (2,4-hexadienoic acid)acceptable daily intake values 679as food preservative, concentration 684effect as food additive 681

Sorbitolas food additive 687in foods for diabetics 690

Sorgoa 1104Sorptionin environmental processes 215

Soybean formula 806Spartocine 814Spectazole 1087Spinal cordrelationship to the peripheral nervous system 1118

Spinuvex A-36 710Spirochetes 1016Spliceosome 749Sporanox 1078Sporiderm 1104Sporiline 1104Sporozoans 1039, 1047Sporozoite vaccines 942

Stacking testfor dangerous goods equipment 511

Stainingfor nucleic acid quantification 751

Standard immune serum globulin 948Standard operating procedure (SOP) 451Staphylococcus aureusvaccine against 916

Starchand derivatives, as thickeners 687as anticaking agent 688

Stark–Einstein law 277stas-akut 817Statistical modelin ecotoxicology 223

Stearic acidas mold-release agent 693

Stearoyl-2-lactylatesas food additives 686

Stearyl tartrateas food additive 686

Stereomycin 1097Stibogluconate, sodium salt [16037-91-5] 1043Stiemazol 1085Stilbenequinones 704Stirred-tank reactorsafety analysis methods applied to 413

Storage safety 492Stoxil 1059Strand displacementin nucleic and hybridization 761

Strecker degradationflavors by 808

Streptococcus pneumoniae vaccine 912Streptozotocin 855Strychnine 1121as spinal inhibition blocker 1133

Succinaldehydedisinfectant properties 726

Succinic acidacidulant for foods 690

Sucroglyceridesas food additives 686

Suffix 821Suffix BW 822Suladyne 1031, 1032Sulconazole [61318-90-9] 1091nitrate [61318-91-0] 1091

Sulcosyn 1091Suldicyn 1091Sulfacytine 1031Sulfadiazine 1031Sulfadoxine 1032Sulfa drugs 1027Sulfafurazole 1030Sulfaguanidine 1033Sulfamethizole 1032Sulfamethoxazole 1029Sulfasalazine 1032Sulfasuxidine 1033Sulfathalidine 1033Sulfisoxazole 1030Sulfiteas antoxidants 684as food preservative, concentration 683

Sulfolitruw 816Sulfonamides 10274,4′-Sulfonylbis(acetanilide) 10374,4′-Sulfonyldianiline 1036Sulfosate 820Sulfoxonedisodium salt 1037

1170 Sulfur compounds, organic – Thymine Subject Index

Sulfur compounds, organicantioxidants 705

Sulfur dioxideas antioxidant for food 684as food preservative, concentration 683

Sulvina 1100Sunset Yellow FCFfor coloring of foods 689

Superfund legislation 635Superthiol 818Suprecur 879Suramin 1040, 1065Surfactants, amphotericas disinfectants 732

Surfactants, cationicas disinfectants 730

Surolan 1082Sverdrup–Albrecht methodheat flow determination 173

Sweeteners, intenseas food additives 689

Sweeteners, nutritiveas food additives 690

Swift test 683Sydnones 781Symmetrel 1063Synapse 1117Synaptic transmission 1128ionotropic action 1132metabolotropic action 1133receptors in drug action 1134

Synaptic vesicles 1123Synaptosomes 1126Synergistssequestrants in combination with antioxidants 684

Synogil 1096

TTable saltsubstitutes for sodium chloride 690

Talcas anticaking agent 688as coating agent 688

Tamoxifen 874Tamoxifen and toremifenemechanism of action 874

Tamuc 817Tankfor bulk storage 540for dangerous goods 510

Tank containersfor bulk transport of liquids and gases 527

Tankers Owners Voluntary Agreement Concerning Liability forOil Pollution (TOVALOP) 612

Tank trucksfor bulk transport of liquids and gases 528

Tanninas clarifying agent in food industry 692

TapewormTaenia solium infection, vaccine against 940

Tarivid 1025Tartaric acidacidulant for foods 690as food additive 684

Tartratesas food additives 684

Tartrazinefor coloring of foods 689

Taurine (2-Aminoethanesulfonic acid)in synaptic transmission 1129

Taxoids 869

Taxol 870Taxotere 870T-cell growth factor 904T cells 903cytotoxic 904

Technical Control Board (TUV) 457occupational safety system control 304

Technical Regulations for Dangerous Substances (TRGS)306,506

Tego 732Telomerases 743, 748Telomerestelomere addition during DNA replication 743

Teniposide 868Tennecetinsee Natamycin 1096

Teratogenesis 85maternal toxicity 102patterns of dose–response in 86

Teratogenicity 100Teratogensrisk assessment for 145

Terazol 1092Terbinafine [91161-71-6] 1105hydrochlorid [78628-80-4] 1105

Terconal 1092Terconazole [67915-31-5] 1091Tercospor 1092Terzolin 1080Tetanusprophylaxis with hyperimmune globulin 952vaccine 908

2,3,7,8-Tetrachlorodibenzodioxininfluence on biotransformation enzymes 59

Tetradecanoyl phorbol acetate (TPA) 660Tetrahymena 749Tetrodotoxintoxicology 72

Thalassemia 764Thalidomidedisaster 996

Thaumatinas flavor enhancer 691

Theoretical oxygen demand (TOD) 236Thermal analysis, differential (DTA)screening method in process safety 399

Thermoplastic elastomers (TPE)stabilization by antioxidants 715thermal stability testing 718

Thermoplasticsstabilization by antioxidants 715

Thiabendazoleas food preservative, concentration 684

Thiacetazone 1036l-Thiazolidine-4-carboxylic acid 789Thickenerin foods 686

Thimerosal [54-64-8] 1108Thiobarbituric acid testfor antioxidants 683

3,3′-Thiodipropionic acidas antioxidant for food 684

6-Thioguanine 850Thiohydantoins 782Thiosnifil-A 1032Thio-TEPA 854d,l-Threonine 789l-Threonine 785production 799

Threshold limit value (TLV) 331, 374Thymidine 765Thymine 740, 741

Subject Index Thymol (6-isopropyl-3-methylphenol) – L-Tryosine 1171

Thymol (6-isopropyl-3-methylphenol) 729Thyrotropin (thyroid stimulating hormone; TSH) 1130Thyroxine (T4)see also Levothyroxine 789

Tick-borne encephalitis vaccine 934Tierschutzgesetz 987Tinacidin 1104Tinactin 1104Tinatox 1104Tinavet 1104Tineafax 1104Ting 1104Tinidazole [19387-91-8] 1045Tinuvin 622LD 710Tinuvin 144 710Tinuvin 770 710TIOsee Tioconazole 1093

Tioconazole [65899-73-2] 1093Tissue fractionation technique 1126Titanium dioxide, C.I. 77891for coloring of foods 689

Tixair 817TNPP 710Tocopherolsas antioxidants 684

Tolciclate [50838-36-3] 1103Tolmicen 1103Tolmicol 1103Tolnaftate [2398-96-1] 1103Tonoftal 1104Topanol CA 704Topotecan 869Topotecin 869Toremifene 874Torpedoelectric organ 1132

Touchdown 820Toxic effectsevaluation of 126levels of risk 127risk assessment process 129terminology of 11types of 13

Toxicityacute 88of chemical products 557repeated-dose 95subacute 88subchronic 89

Toxicity, acutefixed-dose method 91LD50 test 90mechanisms of 70testing for, by inhalation 94testing for dermal 92

Toxicity, developmentalmechanisms of chemically induced 84tests 99in vitro tests for 102

Toxicokinetics 19models 66species-specific differences in 21

Toxicology 3–150absorption by respiratory system 30biochemical basis of 69biotransformation of xenobiotics 36dose–response relationship 13dosimetry 139extrapolation between species 138extrapolation from experiment to human situations 139extrapolation from high to low dose 138

fields of 6general reproductive performance 100lethal concentration) (LC) 16mathematical models 136median effective dose (ED50) 16ophtalmic 96peri- and postnatal 101phototoxicity and photosensitization testing 99testing methods 87

Toxic substancestransport, handling, and storage 502

Toxic Substances Control Act (TSCA) 318Toxoplasmosis 1039, 1052Trace elementsas food additives 681

Tragacanthas food additive 687as thickener 687

Tralen 1093Transbronchin 817Transcription 747splicing 747

Transport, handling, and storage 487bulk storage 537bulk transport 526cargo storage 535in Europe 517in Japan 519in United States 518quality assurance measures 513safety 490

Travogen 1088Travogyn 1088Treaty of Rome 616, 617Trecator-SC 1036Triaconazolesee Terconazole 1092

Triasporin 1078Trichomonas vaginalisbiology and chemotherapy 1044

Trichomoniasis 1039Triclosansee also 5-Chloro-2-(2,4-dichloro)-phenoxyphenol 729

Tricosten 1085Triethylenethiophosphoramide 854Triflucan 10775-Trifluoromethyl-2′-deoxyuridine 769Trifluridinesee also 2′-Deoxy-5-(trifluoromethyl)uridine 1059

Trifonazolesee Bifonazole 1083

Trihydroxybutyrophenoneas antioxidant for food 684

Trimethoprim 1028, 1030Trimetrexate 843Trimpex 1030Trimysten 1085Tript-OH 819Triptorelin 879, 880Tris(nonylphenyl)phosphite 709Trisomy 21see Down’s syndrome 669

Trisorcin 819TRK value 374tRNA 744, 745Trolovol 819Trommcardin 814Trophicard-Kohler 814Trosid 1093Trosyd 1093Trosyl 1093l-Tryosine 785

1172 Trypanosomes – Wetlands Subject Index

Trypanosomes 1039Trypanosomiasis, africanbiology and chemotherapy 1039

Trypanosomiasis, americanbiology and chemotherapy 1042

Tryparsam 1041Tryparsamide 1041Tryparsamidium 1041Tryparsone 1041d,l-Tryptophan 789l-Tryptophan 785, 816syntheses 800

Tubercidin 765Tuberculosistreatment of 1033vaccine 918

Tubulinantitubuline agents 866

Tumor diagnosisnucleic acid probe technology 764

Tumor formationmolecular mechanisms of 81

Tunicamycin A 765Tunicamycin B 765Tunicamycin C 765Tunicamycin D 765Tussiverlan 817Typhoid fever vaccine 910d,l-Tyrosine 790l-Tyrosine [60-18-4] 799, 816production 801

UUK49858see Fluconazole 1077

Ultragris 1100Ultranox 626 710Umami substances 691UNCETDG 494UN classesof dangerous goods 496

Undecylenic acid [112-38-9] 1108Unscheduled DNA synthesis (UDS) 672Upper explosion limit (UEL) 379Uracil 740Ureidocarboxylic acid 782Uridine 765Uridine diphosphate glucuronic acidbiotransformation enzyme 45

Uromykol 1085Utibid 1021

VVaccine 899active immunization by 905adjuvants for 905available 900parenteral and oral 905production by genetic engineering 906

Vagistat 1093d-Valine 790d,l-Valine 790l-Valine 779, 785production 801

Van Slyke methodfor analysis of amino acids 781

Varicellaprophylaxis with hyperimmune globulin 952vaccine 932

Varicella zoster infection

generation of neutralizing humabs 962Variogram analysis 224mathematical concept 224

Vasoactive intestinal peptide (VIP) 1130Vasopressin (VP) 1130Velban 866Verordnung uber brennbare Flussigkeiten (VbF) 507Vidarabin 765Vinblastine 866Vinca alkaloidsfor cancer therapy 866

mechanism of action 867mechanism of resistance 867

Vincaleukoblastine 866Vincristine 866Vindesine 867Vinegaracidulant for foods 690

Vinorelbine 867Vinyl chloridecarcinogenicity of 51

Vinyl Chloride Act 317Vioform 1054Violaxanthinfor coloring of foods 689

Vira-A 1060Viral antigen targetsfor generation of humabs 962

Viral infectionintravenous immunoglobulin against 953laboratory diagnosis 1056

Viral vaccines 923Virazole 1061Viroid 746Viroptic 1059Virusbiological characteristics and chemotherapy 1055carcinogenicity 661DNA and RNA 661families and human pathogens 1057Hepatitis B virus (HBV) 661Hepatitis C 661Herpes 661retrovirus 661

Visclair 818Vitaminas food additives 680

Vitaminization 680Vitaminsas food additives 680as food additives, fortification 680as food additives, revitaminization 680

Vitemur 817Vivacalcium 815Vivioptal 816VM-26 868Vodol 1082Vogel–Bonner plates 109Vorozole 876VP-16 868

WWalden inversion 45Wallonian waste decree 623Water pollutantstransport, handling, and storage 505

Weibull modeltoxicologic risk estimation 136

Weston 618 710Wetlandsinland and tidal 190

Subject Index WIN 49375 – Zovirax 1173

WIN 49375 1026WIN 51711 1065Wintomylon 1020Working Environment Act (Arbeidsomstandighedenwet) 316World Health Organization (WHO) 354World Medical Association 989Wyosine [52662-10-9] 765

XX 31 influenza virusgeneration of humabs against 962

Xanthan gumas thickener 687

Xenobioticsbinding of, to biomolecules 74bioactivation of 49disposition of 23elimination of 62storage in organs and tissues 36

Xenopus 240Xeroderma pigmentosum 662X-ray analysisof nucleic acids 751

Xylitolin foods for diabetics 690

YYellow fever vaccine 933Yodoxin 1054

ZZalain 1090Zantrene 862Zeasorb-AF 1104Zostervaccine against 932

Zovirax 1059