ARBUDA - santhosh

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RASAOUSHADHIS AND BHASMAS IN THE MANAGEMENT OF ARBUDADR. SANTHOSH B DEPT. OF

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Rasoushadhis and bhasmas used in Arbuda

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Objectives To understand the samprapti of Arbuda To know different treatment modalities To know where we can use rasoushadhis30/07/09 Rasoushadhis and bhasmas used in Arbuda 3

Derivation Derived from the root Arb with suffix Ena and along with Nd Destroy particularly the Mamsa Dhatu. Denotes the fleshy out growths30/07/09 Rasoushadhis and bhasmas used in Arbuda 4

Cancer Dervied from Greek word Karkinosmeaning Crab. Appearance of large prominent veins surrounding the growth, encircled the mass like claws of a crab.

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Definition Large Glandular enlargement A growth of new cells which proliferate without relation to needs of body - Tumour Types - Benign - Malignant30/07/09 Rasoushadhis and bhasmas used in Arbuda 6

Mechanism of Carcinogen30/07/09 Rasoushadhis and bhasmas used in Arbuda 7

Initiation A single brief exposure to a carcinogen induces changes in the tissue The nature of the structural alterations in initiated cell is diverse Chemicals and ultra violet radiations directly alter DNA structure30/07/09 Rasoushadhis and bhasmas used in Arbuda 8

Promotion Ability of a compound to induce an area of proliferation in initiated tissue and stimulate tumour formation Dietary fat has been implicated as a tumour promoter in the development of colon cancer

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Progression Usually refers to the later stage of tumour cell evolution that are irreversible Once the tumour develops, individual traits such as hormone responsiveness, growth rate, histologic type and invasiveness, function as independent variables capable of progressionRasoushadhis and bhasmas used in Arbuda

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Metastasis Active process consisting of 3 stages attachment of cells to extra-cellular matrix local degradation of extra-cellular matrix locomotion through the locally degraded matrix

The spread of tumour from a primary lesion to a distant site is a major cause of morbidity and mortality Once the tumour cell has migrated to a metastatic site, additional metastatic foci may occur by repetition of these types30/07/09 Rasoushadhis and bhasmas used in Arbuda 11

Mechanism of Invasion & Metastasis Metastasis, the establishment of tumour cells at distant sites in the body, is the hallmark of cancer Tumour cells must acquire the ability to : Invade stroma

Stimulate neoangiogenesis Transgress stroma Invade vessel walls Extravasate into the extra vascular Rasoushadhis and bhasmas used 30/07/09 environment in Arbuda

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Initiation event Promotion event

Stem Cell Initiated Cell

Pre Cancer Cell Conversion event Cancer Cell Progression event30/07/09 Rasoushadhis and bhasmas used in Arbuda

Metastatic

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Charaka

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CLASSIFICATION OF ARBUDA

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AmM ? MTkMiu qSkMiu SwxjUiu ajl iw

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SAMPRAPTI OF ARBUDA30/07/09 Rasoushadhis and bhasmas used in Arbuda 24

Nija - Mamsahara Nidana sevana Agantuja - Mushtipraharad Dhatwagni mandya

Sanchaya Agnimandya Dosha prakopa

Prakopa

Prasara Rakta & mamsa dushti Sroto Dushti

Sthana Samshraya Khavaigunya Arbuda Mamsarbuda - Raktarbuda Vyakti Dwirarbuda - Adhyarbuda30/07/09 Rasoushadhis and bhasmas used in Arbuda

Bheda25

Dosha Dushya Srotas Sroto dushti Agni Rogamarga

SAMPRAPTI GHATAKA : Kapha and Vata predominant :Mamsa, Meda and Rakta :Mamsa, Meda and Raktavaha : Sanga and Sira granthi

: Jatharagni & Dhatwagni :Bahya

Udbhavsthana : Anywhere in the body Adhisthana : Sixth layer of the Skin - Rohini Pratyatma Linga: Mamso Pachaya Tu Shopham30/07/09 Rasoushadhis and bhasmas used in Arbuda 26

Lung CancerA coronal CT scan Showing malignant cancer of the lung.tumor central pleural effusion 1 & 3lungs 2spine 4ribs30/07/09

5aorta

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AETIOLOGY Genetics Changes in lifestyle especially in diet and regimen Highly polluted environment

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COMMON SITEST O P U B L I K30/07/09

THYROID ORAL PROSTATE UTERUS BREAST LUNGS GIT KIDNEYRasoushadhis and bhasmas used in Arbuda 30

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BENIGN MALIGNANT BOUNDARIES encapsulated or well circumscribed SIZEusually small Poorly circumscribed & irregular Often large More often Often poor resemblance32

SECONDARY CHANGES occurless often

tissue of origin Rasoushadhis and bhasmas used 30/07/09 in Arbuda closely

PATTERN usually resembles the

NUCLEOCYTOPLAS Increased MIC RATIOnormal FUNCTIONusually May be retained, well maintained lost or abnormal GROWTH RATE Rapid slow Usually infiltrates LOCAL INVASION the adjacent often compresses tissues the surrounding tissues without invading or infiltrating them Frequently present METASTASISRasoushadhis and bhasmas used 30/07/09 33 in Arbuda absent

STAGING IN CANCER TNM staging T tumour N lymph node involvement M metastasis30/07/09 Rasoushadhis and bhasmas used in Arbuda 34

TNM CLASSIFICATIONT1 T2 T3 T4 N130/07/09

< OR = to 2 cm > Than 2 & = to 4 cm > Than 4 cm Adjacent structures involved Unilateral single node > than 3 to 6 cm

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N2a N2b N2c N3 M0 M130/07/09

bilateral single node >than 3 to 6 cm unilateral multiple nodes < or = to 6 cm Bilateral or contralateral nodes < or = node (s) > than Any to 6cm 6cm No detectable distant metastasis Distant metastasis presentRasoushadhis and bhasmas used in Arbuda 36

Prognosis Susrutha

SadhyaVataja Pittaja Kaphaja Medoja30/07/09

AsadhyaMamsaja Adyarbuda Dvirarbuda RaktajaRasoushadhis and bhasmas used in Arbuda 37

Treatment of Cancer Specific Surgical Removal Radiation Therapy Chemotherapy Supportive Blood Product Transfusions Indwelling Central Catheters Enteral And Paraenteral Nutrition

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Liposarcoma Medo arbuda

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qk maR smr Rasoushadhis and bhasmas usedin Arbuda

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Frequently Used Rasoushadhis ApM pxq zZuw pxq iij pxq WUM pxq xuh pxq iq pxq US Ux AoSWU UxRasoushadhis and bhasmas used in Arbuda 43

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Rasendra sara sangraha UqohSMl rauWl mreri l

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Main Drugs mUS alkM uixlp

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Roudra Rasa References :

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