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Aperio [email protected] (760) 539-1100 www.aperio.com Applied Spectral Imaging Dror Armon [email protected] +97246547567 www.spectral-imaging.com ScanScope digital slide scanners, Spectrum information management software, and SlideAnalysis image analysis tools The system is used to scan high-quality digital slides, manage associated case and project information, and improve accuracy of results with image analysis tools. Our ScanScope scanners use line-scanning technol- ogy, which create seamless, true-color, entire-slide digital images in minutes, which can then be viewed from anywhere in the world. High Intermediate or variable Low 25 slides per hour Dedicated phone, e-mail, online, and field support for all products Contact company Has the largest installed base of systems in the world, and are the patent- holder of line-scanning tech- nology. Offers the only com- prehensive DP solution on the market that allows users to scan, manage, analyze, and share pathology data. PathEx product line Tissue pathologies, IHC over expression, DNA sequence amplification, deletion, translocation, break apart, cytology IHC and dysplasia, TB bacilli presence, antibody co-expression scoring. A combined system of hardware and software for all acquisition mode and image analysis modules all aimed at specific applications and indication in pathology diagnosis. High Intermediate or variable Low Depends heavily on the application type: May vary between 60 samples per hour to 10 samples per hour. Full support $15,000 to $100,000 Accommodates different HW, methods/samples/antibod- ies; compatibility to existing laboratory workflow and equipment (microscopes); modularity; accommodates control; combines cytogenet- ics and pathology applica- tions; and user-defined/ changeable parameters. intelliPATH FLX™ immuno- histochemistry system intelliPATH FLX is a flexible, fully open instrument that automates immunohisto- chemistry testing of patient slides in anatomic pathology and research laboratories. The intelliPATH FLX is an open system, continuous random access IHC instrument that is capable of simultaneous multiplex IHC staining. It features onboard chromogen dilution and 1 hour STAT capability. High Intermediate or variable Low Slide capacity of 50 slides, with 10 slides on each of five trays. Slide capacity per shift: 150 single-stain IHC and up to 450 reimbursable multiplex IHC tests per shift. 24-hour tech support; 24- to 48-hour service engineer response time, and help with methods development is available. List price is $99,500. Alternate financing such as reagent rentals and lease agreements is available. Fully open platform; continu- ous random access capabil- ity adjusts to any workflow; industry-leading throughput: 150 slides per shift (450 reimbursable tests with multiplex IHC); simultaneous multiplex IHC reduces labor and reagent costs by >50%. Lung Multiplex IHC:Lung Squamous-2™ and Lung Adeno-2™ multiplex IHC products The Lung Multiplex IHC products are designed to allow differentiation between adenocarcinoma and squamous cell carcinoma of the lung in NSCLC (non small cell lung carcinoma) patients. Lung Multiplex IHC tests use proprietary and patent- pending simultaneous Multiplex IHC technology to differentiate lung adenocar- cinoma versus squamous cell carcinoma in FFPE tissue. High Intermediate or variable Low Multiplex IHC technology allows for multiple antibod- ies to be stained in just a lit- tle over the time required for IHC with single antibodies. multiplex IHC staining of 20 slides can be completed in just under 3 hours (manual or semiautomated protocol) using the intelliPATH FLX instrument. STAT samples complete in about 2 hours using the intelliPATH FLX™ automated slide stainer. 24-hour technical support. Application specialists are available for product training. Contact company Rapidly differentiate adeno- carcinoma from squamous cell carcinoma in NSCLC patients with high sensitivity and specificity; eliminates harmful side affects of EGFR and VEGF inhibitors or Avastin ® that may be inappropriate based on the diagnosis. Biocare Medical Mark Cross [email protected] (925) 603-8014 www.biocare.net Biocare Medical Mark Cross [email protected] (925) 603-8014 www.biocare.net 1) What is the name of your company’s anatomic or digital pathology product or product line? 2) What is this system designed to detect? 3) Briefly describe the technology on which this product is based. 4) Intended volume use: 5) Throughput (samples per hour), under ideal conditions: 6) What type of support is offered for this product? 7) Price range: 8) What differentiates this product from others on the market? 20 May 2010 | clpmag.com www.clpmag.com Anatomic and Digital Pathology Systems Survey ’10

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[email protected](760) 539-1100www.aperio.com

Applied Spectral ImagingDror [email protected]+97246547567www.spectral-imaging.com

ScanScope digital slide scanners, Spectrum information management software, and SlideAnalysis image analysis tools

The system is used to scan high-quality digital slides, manage associated case and project information, and improve accuracy of results with image analysis tools.

Our ScanScope scanners use line-scanning technol-ogy, which create seamless, true-color, entire-slide digital images in minutes, which can then be viewed from anywhere in the world.

■ High■ Intermediate or variable■ Low

25 slides per hour

Dedicated phone, e-mail, online, and field support for all products

Contact company

Has the largest installed base of systems in the world, and are the patent-holder of line-scanning tech-nology. Offers the only com-prehensive DP solution on the market that allows users to scan, manage, analyze, and share pathology data.

PathEx product line

Tissue pathologies, IHC over expression, DNA sequence amplification, deletion, translocation, break apart, cytology IHC and dysplasia, TB bacilli presence, antibody co-expression scoring.

A combined system of hardware and software for all acquisition mode and image analysis modules all aimed at specific applications and indication in pathology diagnosis.

❏ High■ Intermediate or variable■ Low

Depends heavily on the application type: May vary between 60 samples per hour to 10 samples per hour.

Full support

$15,000 to $100,000

Accommodates different HW, methods/samples/antibod-ies; compatibility to existing laboratory workflow and equipment (microscopes); modularity; accommodates control; combines cytogenet-ics and pathology applica-tions; and user-defined/changeable parameters.

intelliPATH FLX™ immuno-histochemistry system

intelliPATH FLX is a flexible, fully open instrument that automates immunohisto-chemistry testing of patient slides in anatomic pathology and research laboratories.

The intelliPATH FLX is an open system, continuous random access IHC instrument that is capable of simultaneous multiplex IHC staining. It features onboard chromogen dilution and 1 hour STAT capability.

■ High■ Intermediate or variable■ Low

Slide capacity of 50 slides, with 10 slides on each of five trays. Slide capacity per shift: 150 single-stain IHC and up to 450 reimbursable multiplex IHC tests per shift.

24-hour tech support; 24- to 48-hour service engineer response time, and help with methods development is available.

List price is $99,500. Alternate financing such as reagent rentals and lease agreements is available.

Fully open platform; continu-ous random access capabil-ity adjusts to any workflow; industry-leading throughput: 150 slides per shift (450 reimbursable tests with multiplex IHC); simultaneous multiplex IHC reduces labor and reagent costs by >50%.

Lung Multiplex IHC:Lung Squamous-2™ and Lung Adeno-2™ multiplex IHC products

The Lung Multiplex IHC products are designed to allow differentiation between adenocarcinoma and squamous cell carcinoma of the lung in NSCLC (non small cell lung carcinoma) patients.

Lung Multiplex IHC tests use proprietary and patent- pending simultaneous Multiplex IHC technology to differentiate lung adenocar-cinoma versus squamous cell carcinoma in FFPE tissue.

■ High■ Intermediate or variable■ Low

Multiplex IHC technology allows for multiple antibod-ies to be stained in just a lit-tle over the time required for IHC with single antibodies. multiplex IHC staining of 20 slides can be completed in just under 3 hours (manual or semiautomated protocol) using the intelliPATH FLX instrument. STAT samples complete in about 2 hours using the intelliPATH FLX™ automated slide stainer.

24-hour technical support. Application specialists are available for product training.

Contact company

Rapidly differentiate adeno-carcinoma from squamous cell carcinoma in NSCLC patients with high sensitivity and specificity; eliminates harmful side affects of EGFR and VEGF inhibitors or Avastin® that may be inappropriate based on the diagnosis.

Biocare MedicalMark [email protected](925) 603-8014www.biocare.net

Biocare MedicalMark [email protected](925) 603-8014www.biocare.net

1) What is the name of your company’s anatomic or digital pathology product or product line?

2) What is this system designed to detect?

3) Briefly describe the technology on which this

product is based.

4) Intended volume use:

5) Throughput (samples per hour), under ideal conditions:

6) What type of support is

offered for this product?

7) Price range:

8) What differentiates this product from others on

the market?

20 May 2010 | clpmag.com

www.clpmag.com

Anatomic and Digital Pathology SystemsSurvey ’10

CLP_20_23.indd 20 5/7/10 10:45:23 AM

clpmag.com | May 2010 21

www.clpmag.com

BioImagene IncSuchi [email protected](408) 207-4200www.bioimagene.com

Biocare MedicalMark [email protected](925) 603-8014www.biocare.net

BioImagene IncSuchi [email protected](408) 207-4200www.bioimagene.com

iScan Coreo Au™

iScan Coreo Au is a high-throughput, high-slide-capacity brightfield scanning system designed to digitize glass microscope slides and create high-resolution digital images.

The iScan Coreo Au is a brightfield whole-slide imag-ing system with the ability to scan up to 160 glass slides. An LED light source is used to support the imaging.

■ High❏ Intermediate or variable❏ Low

40 slides/hour (at 20X magnification)

Training and installation services, as well as online and call support

Contact company; pay-per-click pricing is available

Automated turret with support for four objectives (4X, 10X, 20X, and 40X), autoloader for walkaway scanning, laser-based slide detector, volume scanned (Z-stacked) images with multiple focus planes, automatic tissue region identification.

SPOT-Light® HER2 CISH kit

The SPOT-Light® HER2 CISH kit quantitatively determines HER2 gene amplification sta-tus in formalin fixed (FFPE) tissues using chromogenic in situ hybridization (CISH) and brightfield microscopy.

The HER2 CISH kit is based on proprietary subtrac-tion probe technology and utilizes chromogenic in situ hybridization technology for a quantitative assessment of HER2/neu gene copy number.

■ High■ Intermediate or variable■ Low

Patient results are avail-able in as little as 17 hours (includes incubation times and an overnight probe hybridization). Throughtput can vary according to the laboratory’s needs from a few tests to more than 100 tests in this time period.

24-hour technical support. Web-based and live tutorial; on-site product training is available.

List price: $2,500 per 20 test/kit

The only FDA-approved CISH kit available in the US; 99% concordance with an FDA-approved HER2 FISH method; no fluorescent microscope required; and simultaneously view overall morphology, tumoral heterogeneity, and HER2 amplification.

iSlide™ input device

The iSlide is designed for users to comfortably and ergonomically view digital images of glass tissue slides on a computer monitor.

The iSlide incorporates a proprietary slide emula-tor mechanism for smooth on-screen viewing. It allows users to mimic the motion of a glass slide on a micro-scope to view digital images of the slide.

■ High❏ Intermediate or variable❏ Low

N/A

Training and installation services, as well as online and call support

Contact company

Integrated keyboard, mouse, speakers and microphone, microscope-like viewing of digital images, knobs to control focus and magnifica-tion, ergonomic design to support both left- and right-handed users.

Virtuoso™ digital pathology application software

Virtuoso is a Web-based digital pathology software application designed for users to view, manage, archive, and analyze digital images of tissues, produce reports, and collaborate in real time.

Virtuoso has been devel-oped using state-of-the-art Web technologies, and is designed to work with all major Web browsers; BioImagene supports both thick- and thin-client versions of Virtuoso.

■ High❏ Intermediate or variable❏ Low

N/A

Training and installation services, as well as online and call support

Contact company; pay-per-click pricing is available

Fast image viewing; role-based features; intuitive case browsing; accurate image analysis; quality control module; LIS workflow integration; and customized reporting capabilities.

LigoLab station

LigoLab Station is a compre-hensive and scalable labo-ratory information system designed to accommodate a wide array of laboratory environments with a spe-cial emphasis on anatomic pathology workflow.

Java-based product that is operating system indepen-dent and automatically creates a secure VPN tunnel via the Internet, allowing for geographical independence.

■ High■ Intermediate or variable■ Low

The system is completely scalable and can handle anywhere from 30 cases per day to 3,000 cases per day on basic hardware.

General support is open from 8 am to 8 pm, and there is 24-hour support for emergencies.

$50,000 to $600,000, depending on modules

Fully integrated system (document scanning, specimen tracking, interface to slide/cassette printers, stainers, EMR/HIS inter-faces, rule-based dynamic workflow), very intuitive, and utilizes the latest technology advancements.

BioImagene IncSuchi [email protected](408) 207-4200www.bioimagene.com

LigoLabSuren [email protected](440) 544-6522www.ligolab.com

CLP_20_23.indd 21 5/7/10 10:45:24 AM

NovovisionRichard [email protected](732) 329-3209www.novopath.com

OmnyxTony [email protected] (412) 894-2104www.omnyx.com

NovoPath™

NovoPath is used to manage patient informa-tion and specimens, and enables quick and accu-rate resulting of suspected diseased tissues.

The software’s program-ming language platform is Microsoft Visual Studio.

■ High■ Intermediate or variable■ Low

N/A

Support varies depending on needs, from 8 hours per day 5 days a week, to 24 hours per day, 365 days a year.

Modular, so labs may cus-tomize the system to their needs and budgets

NovoPath is easy to use even for the “computer challenged” individuals. There are several unique features in NovoPath that streamline the workflow in the departments while enhancing the users’ experiences relative to speed and accuracy.

Omnyx Scanners

The Omnyx scanner products are designed to scan H&E, IHC, and special stain tissue-based ana-tomic pathology specimens affixed to glass. Not yet FDA cleared.

Uses patented independent dual-sensor technology. This technology allows focusing very similar to the pathologist: fine focusing on every field of view inde-pendently.

■ High■ Intermediate or variable❏ Low

60 samples per hour (15- x 15-mm sample at 20x)

Product is not yet commer-cially available. However, contracts for maintaining and servicing the scanner products will be offered.

Contact company

Image quality: The scanner focuses optimally on every field of view and every tile; speed and throughput: the scanner generates an image to the pathologist every 60 seconds; usability and automation: The scan-ner fits into lab environ-ments, has all computing on board and is designed for walk-away, fully auto-mated operation.

Omnyx Pathologist Cockpit

Provides a complete digital case sign-out environment with all images organized into cases and presented in a worklist layout. Trays and paperwork are all organized digitally. Not yet cleared by the FDA for diagnostic use.

The Omnyx software plat-form is based on the most current Microsoft tech-nologies including .NET, SQL Server, and Microsoft Servers. It offers enterprise scalability, supportability, and stability.

■ High■ Intermediate or variable❏ Low

Unlimited—at pathologist speed

The product is not yet commercially available. However, implementation and call center support, and software maintenance upgrades will be offered.

Contact company

Complete digital workflow: The Omnyx Pathologist Cockpit is the only digital pathology system enabling total digital control of pathologist workflow; efficiency: The Omnyx Pathologist Cockpit improves the efficiency of the pathologist by linking all images and clinical con-tent into a complete case.

OmnyxTony [email protected] (412) 894-2104www.omnyx.com

OmnyxTony [email protected] (412) 894-2104www.omnyx.com

1) What is the name of your company’s anatomic or digital pathology product or product line?

2) What is this system designed to detect?

3) Briefly describe the technology on which this

product is based.

4) Intended volume use:

5) Throughput (samples per hour), under ideal conditions:

6) What type of support is

offered for this product?

7) Price range:

8) What differentiates this product from others on

the market?

22 May 2010 | clpmag.com

www.clpmag.com

Sakura Finetek USA IncTheresa [email protected](310) 972-7800www.sakura-americas.com

Tissue-Tek® Xpress® x series rapid tissue proces-sors and the Tissue-Tek® AutoTEC® automated embedding system

The Tissue-Tek products are utilized in histology for tissue preparation from grossing to coverslipping. The product line includes consumables and high-tech instrumentation.

Tissue-Tek products utilize either conventional methods or a unique application of blended technologies for the Xpress x series rapid tissue processors. Linked systems and robotics are key.

■ High■ Intermediate or variable■ Low

Processes tissue continu-ously at a rate of 120 sam-ples per hour. The Tissue-Tek AutoTEC Automated Embedding System keeps the same pace of 120 samples per hour. Almost 1,000 per 8-hour shift.

Service and Support is available for all custom-ers, via the 800 number, Monday through Friday, 6 am to 5 pm PST.

The products include consumables and instru-ments. Prices vary; contact company.

The Tissue-Tek brand is recognized for quality, reliability, and innovation.

Omnyx Diagnostic Archive

Designed to acquire, dis-tribute, and store whole slide pathology images and scales to manage petabytes of image data. It offers high-speed streaming of images to the pathologist anywhere in the enterprise and over their existing network resources.

Based on a combination standard Microsoft technolo-gies and pathology-specific image compression and streaming. It has been designed to scale from a single server, to a multinode federated storage network. Standard storage hardware technologies are used.

■ High■ Intermediate or variable❏ Low

Scales from single servers to a multinode federated enterprise deployment. A single diagnostic archive can support multiple scanners and many pathologists.

The product is not yet commercially available. However, implementation and call center support, and software maintenance upgrades will be offered.

Contact company

Distributed: Multiple labs can appear as one to the patholo-gist without the need to move large images over the net-work; scalability: The Omnyx Diagnostic Archive can scale from a single-tower server to a full rack managing peta-bytes of images; speed: The Omnyx Diagnostic Archive allows streaming of pathol-ogy images from any lab to the pathologist anywhere in the enterprise.

Anatomic and Digital Pathology SystemsSurvey ’10

CLP_20_23.indd 22 5/7/10 10:45:25 AM