'Alpha Molecular Imprints'- Issue Of Potencies Finally Resolved

Chandran K C

http://dialecticalhomeopathy.com. Email: similimum@gmail.com

Once similimum is selected for a case through a process of exhaustive case taking, repertorization and material medica study, the next issue that bothers a young homeopath the most is the selection of potency, dosage and repetitions. A lot of confusions, controversies and phobias exist regarding the selection of potencies. Each homeopath has his own ways, and believes that only he is right. Young homeopaths get confused due to totally contradicting advice they get from their different teachers.

I am trying to resolve the issue of potencies in the light of scientifically viable working hypothesis regarding homeopathic therapeutics and potentization.

The word 'drug potency' and 'drug potentization' is associated with the concept of 'dynamic drug energy'. As per this view, every drug substance has its 'inherent qualities', which exist as specific 'energy' of dynamic in form, and act up on the 'vital force' of organism by a dynamic way. This dynamic drug energy can exist free from 'material drug, substance and transferred into rectified spirit or sugar of milk through a process called 'potentization'. By this process, the 'dynamic drug energy' gettin freed from the drug substance moves to the potentizing medium and 'energizes' it. By the process of serial dilution and succussion, this dynamic energy could be 'raised' to new energy levels, and as such, it is believed that 'higher' dilutions are more 'potentized' and more powerful. This 'dynamic drug energy' carried by the 'potentized drugs' act upon the vital force and induces a 'healing process'.

According to the MIT concept I propose, I am explaining the process involved in potentization in terms of 'molecular imprinting'. It is not the 'dynamic drug energy' that is transferred into the medium during so-called process of potentization, but the three dimensional configuration of constituent drug molecules getting imprinted into the supra-molecular matrix of potentizing medium in the form of nanocavities, through a process of forming hydration shells. These nanocavities act as artificial binding sites or artificial 'key holes' for pathogenic molecules having configurational similarity to imprinted

molecules. This concept scientifically explains the molecular dynamics of homeopathic therapeutics involved in 'similia similibus curentur' in a way fitting to the concepts of modern biochemistry, molecular pathology and therapeutics.

Obviously, the term 'potentization' reflects the vitalistic philosophy behind it. It would be ideal to use the term 'molecular imprinting' to explain the exact process in scientific terms.

Once you understand and accept 'molecular imprinting' as the real process involved in potentization, and perceive 'potentized' drugs in terms of constituent molecular imprints, all confusions regarding selection of potencies will be scientifically resolved.

My inquiry for a more reliable and perfect way of preparing molecular imprinted drugs have finally resulted in presenting a new method called ‘Alpha Molecular Imprints’.

ALPHA MOLECULAR IMPRINTS will provide a most perfect method of preparing molecular imprints of drug substances, on the basis of MIT concepts

It is prepared by adding mother tincture of drug substance to equal quantity of rectified spirit, and serially diluting it in 1:1 ratio up to 80 steps, so as to cross the avogadro limit. During each step, 300 succussions are given at a rate of 1 succussion per second (5 minutes). During each step,the solution is given 10 minutes rest at a temperature of 5-10 celsius before succussion. That means, each step takes 15 minutes. Solution gets total 24000 succussion during 80 dilution steps. During succussion, bottles should not be filled more than half, to enable free movement of contents while shaking. If you are using 50 ml bottle, use only 10ml drug and 10ml diluent. If 100ml bottle is used, you can add 20ml drug and 20ml diluent. Whole process will take 20 working hours to get the finished product.

By this process, drug molecules get maximum exposure and interaction with vehicle molecules, enabling perfect molecular imprinting of all individual constituent molecules. By 80th step, all drug molecules will be removed from the medium, and only the molecular imprints representing diverse types of constituent molecules remain. Molecular imprints will be more saturated, perfect and stable than those we get from conventional ways of potentization. If used as similimum, this preparation will be acting as most effective therapeutic agent.

Since we use 1:1 dilution ratio, this product may be called ALPHA MOLECULAR IMPRINTS, to differentiate from other potency scales. May be labelled as Nux Vomica α. A drug will have only a 'single' potency in this scheme. If we use ALPHA MOLECULAR IMPRINTS, all confusions associated with selection of potencies will be resolved once and for all.

Exactly, I am not trying to find a new potency. I am searching for ways to get molecular imprinting done more perfectly and accurately, on the basis of MIT concepts. Better to say, I am trying to find a way of molecular imprinting, more perfect and scientific than 'potentization'.

I am not introducing a new 'potency scale'. In ALPHA MOLECULAR IMPRINTING, there is only one end product, not a series of potencies.

In ALPHA method, the procedure is stopped once avogadro limit is crossed. By that time, all constituent molecules will be removed, after imprinting into the medium as supramolecular clusters. We do not subscribe to the idea of 'potency increasing' by going to higher dilutions, which is an idea related with 'dynamic energy' concept.

In decimal scale of potentization, avogadro limit is crossed at 23x. In centecimal scale it happens by 12c. In ALPHA method I propose, avogadro limit is crossed by 80th step of dilution, which gives maximum exposure of drug molecules, enabling them to interact with imprinting medium very long time. Dilution is done through 80 steps, subjecting them to 24000 succussions by that time. That ensures a much higher perfection and accuracy of of molecular imprinting.

According to my view of potentization as a process of molecular imprinting, I wanted to do it in a way most appropriate to happen molecular imprinting. According to this view, dilution has to be done up to avogadro limit only, same time giving maximum exposure of drug molecules to interact with vehicle. So I selected 1:1 ratio for dilution. As per calculations, dilution would cross avogadro limit by 80th dilution step. By that time, all drug molecules will be removed. Regarding succussions, I consider it a way to break hydration shells and make them free molecular imprints. I wanted to give alternate succussions and resting period to allow formation of new hydration shells and then break them open. So i decided to give a 10 minute rest after each dilution, followed by 5 minutes succussion. When succussion was done by hand, I could do it at a rate of 1 per second. Hence, 300 succussions could be dobne by 5 minutes. Actually, it would be

better if we give maximimu number of succussions during each dilution steps. I decided 5 minutes succussion from a practical point of view. In this way, we can prepare a molecular imprinted drug by 20 working hours

1:1 is the most appropriate ratio we can practically do. Maximum dilution steps within avogadro limit-that was my objective

If dilution does not cross avogadro limit, the product will contain 'drug molecules' also, which would act on biological molecules. I want only 'molecular imprints' only, which act on pathogenic molecules only. Drug molecules act exactly similar to allopathic drug action. That is why I insist to cross avogadro limit.

If we continue diluting even after crossing avogadro limit, there will be no drug molecules in them for 'imprinting'. Just crossing avogadro limit, the product will be saturated with molecular imprints, same time without any crude drug molecules. That will be the ideal product to be used as per similia similibus curentur

Since we stop potentization at 80th step, we can do it by hand itself. If we can use a machine acting exactly similar to our hands in actions, there will not be any harm

Number of succussions, intermediary rest period and number of dilutions are all very important. They should be maximum as possible, but all should be limited below avogadro limit. There is no meaning in diluting and succussing after all molecules are removed. Because, according to me, molecular imprinting is what we want to happen

Shaking helps in mixing the drug molecules with vehicle well. Rest period facilitates formation of hydration shells around drug molecules. By keeping in low temperatures above freezing point, movements of molecules are restricted, which help in formation of hydrogen bonded shells. Succussions facilitates breaking of hydration shells and freeing of drug molecules. Serial dilutions facilitates systematic removal of drug molecules. Hence, I think all three steps are very important in effective molecular imprinting. I limited succussions to 300 per step out of practical considerations. There is no harm if you do it a bit longer. But everything should be limited below avogadro limit

I would request all my scientific-minded friends to make ALPHA MOLECULAR IMPRINTS of one or two drugs commonly used, and verify their effectiveness. I hope,

this may lead to a great revolution in homeopathy. Be a part of history by participating this experiment.

GUIDELINES TO PREPARE ALPHA MOLECULAR IMPRINTS:

To start working, we should first decide the drug we intend to work up on. Before making this decision, discuss with the group and ensure other members are not doing it, so as to avoid duplication of work.

Procure a good sample of mother tincture of selected drug from a most reliable source. Only sealed bottles should be purchased. 30ml is enough.

Collect 10 high quality amber colored glass bottles of 100 ml capacity. Emplty bottles of german potentized drugs can be used, after rinsing and washing for long time in hot water, and drying well in sunlight. Well graduated stickers should be then affixed on the bottles. Keep them well corked in a dust free place.

Procure 4 pounds of high quality rectified spirit from trusted pharmacy.

Arrange a clean, dust and moisture free room. and work table.

Now we can start work:

Add 20ml mother tincture into one 100ml bottle. Then add 20ml rectified spirit into the bottle. Since bottles are graduated, no measuring utensils are required.

Cork the bottle well, Label the bottle as ALPHA 1,shake for 2-3 minutes. Keep the bottle still for 10 minutes. It will be good it it is kept at 5-10 celsius, in the lower part of refrigerator.

Then take the bottle out, and start succussing using hand using right hand, and hitting the bottle on left palm strongly, with right elbow fully abducted and making anti-clockwise motions. A rubber padding on right palm will be useful. One succussion per second (approximate), do it for 5 minutes without stopping(300 succussions approximate).

Stop succussing and immediately pour away 20 ml from the bottle. (You can discard it or keep it for later use, in a separate bottle labeling the dilution step on the bottle)

Add 20ml rectified spirit into the original bottle, cork well, label as ALPHA 2, shake well for 2-3 minutes and keep 10 minutes at 5-10 celsius. Then take the bottle out and give 300 succussions (5 minutes). Immediately pour away 20ml from the bottle, add 20ml rectified spirit to the bottle, cork it, label ALPHA 3, shake for 2-3 minutes, rest for 10 minutes, give 300 succussions, immediately pour away 20 ml.

Repeat this process continuously up to 80 steps of dilution and succussion. Final product is now ready. Affix the label a s 'DRUG NAME+ A', and keep for use.

Be careful to save the discarded portion of final 10 or 20 steps, labeling well in separate bottles, for future use as back potencies below avogadro limit.

I HAVE ALREADY PREPARED A STOCK OF ALPHA POTENCIES IS OF ABOUT 15 COMMONLY USED DRUGS, AND I AM GETTING EXCELLENT RESULTS BY THEIR USE.

One of the major criticism raised by a good friend of mine against my suggestion for 'Alpha Molecular Imprints is: “we have already large stock of potencies,why to waste time on this? Do other works to make homeopathy scientific".

I am bound to answer this question, as it is asked by a person who genuinely believe we have to 'work homeopathy scientific'. There may be many other friends who think that working for 'alpha molecular imprints' is unnecessary, and a waste of time.

By saying 'we should work to make homeopathy', it is obvious that my friend believes homeopathy as it exist today is 'not scientific'.

'Making homeopathy scientific' means, to identify the 'unscientific' parts of homeopathy, and replace them with 'scientific' ideas and practices.

Does my friend consider the 'large stock of potencies' already available today are 'scientific', and there is no changes or advancements required in the potentization methods and potentizations scales while we 'work to make homeopathy scientific'?

I would like to bring to the notice of my friend the fact that all those 'large stock of potencies' now available were prepared through processes based on the concepts of 'dynamic medicinal energy', which we consider unscientific and want to rectify. The basis of 'dynamic energy' concept is that drug substances have some 'inherent' 'medicinal energy' that act on the 'vital force' of organism 'dynamically', without the involvement of any material particle and effects a cure. This 'dynamic drug energy' could be 'liberated' from the material drugs, and 'transferred' to sugar of milk or rectified spirit, abandoning the material drug molecules. According to this concept, potentization involves the process of 'liberating' the 'dynamic medicinal energy' from drug substances and 'transfering' it to the potentizing medium. More higher the potentization level, more powerful and dynamic the 'drug energy' becomes- that is the belief.

All the existing potentization 'scales' and 'methods' are based on this 'dynamization' concept. Even the term 'potentization' indicates this 'dynamization concept. All the 'large stock of ptencies' available to us now are the products of this 'dynamic' concept.

When we perceive potentization as a process of molecular imprinting, we will have to rethink our existing 'potentization scales' as a whole.

From a scientific perspective, there is no such a thing called 'drug energy' that can be liberated from drug substances and 'transferred' to another medium abandoning the drug substances. Medicinal properties of substances come from the 'structure' of individual constituent molecules contained in drug substances. In the absence of 'drug molecules', there cannot be any 'drug energy'. During potentization, through the process of molecular imprinting, the supramolecular structure of water is changed, and it is this 'changed water' or molecular imprints that act as therapeutic agents. It has nothing to do with 'liberation' or 'transfer' of drug energy. Only molecular imprinting.

When we perceive potentization in terms of molecular imprinting, and molecular imprints as the active principles of potentized drugs, we will have to inquire whether the existing potentization methods are ideal for producing perfect molecular imprints. We will have inquire whether we can modify the existing methods or evolve entirely new methods that would ensure better molecular imprinting.

According to the concept of molecular imprinting, potentization involves two stages. Breaking of intermolecular bonds between constituent molecules and making them free molecules and ions is the first stage, which is effected through the process called

'trituration'. Trituations will break the intermolecular bonds in the drug substances, and they would be divided maximum up to the level of constituent molecules and ions. Further division to atomic level will not happen, since the mechanical energy of triturations cannot break the very strong chemical bonds between atoms inside molecules. Medicinal properties of a substance id decided by the structure and chemical properties of constituent molecules of drug substance.

Second stage involves actual molecular imprinting. When the drug substance is mixed with rectified spirit (water-alcohol mixture), constituent drug molecules undergoes a process of 'hydration', thereby forming 'guest-host' complexes of drug molecules and water-alcohol molecules. These 'guest-host' complexes are broken my the process of succussion, thereby generating free 'hydration shells'. Through a process of serial dilution and succussion, the drug molecules are progressively removed from the medium, and increasing the number of free hydration shells. Once the dilution crosses avogadro limit, all drug molecules will be removed. Calculations show that this crossing limit is 12c in centesimal scale, and 23x in decimal scale. That means, above 12c or 23x, the will be no drug molecules present for further imprinting, and hence, continuing potentization beyond that stage is meaningless or futile act. Since presently existing potentization methods do not understand the molecular imprinting involved, they go on diluting and succussing infinitely, thinking that it will make the drugs more powerful and dynamic.

According to scientific view of molecular imprinting, we should stop diluting and succussing once the avogadro limit is crossed. Same time, we have to ensure that the process allows maximum molecular imprinting to happen within this limit. By increasing the number of dilution steps within avogadro limit will give maximum exposure to drug molecules in the medium, thereby making imprinting more perfect.

My method of 'alpha molecular imprinting' is designed based on this idea. By diluting in 1:1 ratio instead of 1:10 or 1:100 of classical methods, we get 80 dilution steps before crossing avogadro limit. This is much higher than 12 steps of C scale, or 23 steps of X scale. This by itself more effective molecular imprinting, far better than centesimal or decimal scale potentization. More over, the dilutions are given a cooling and resting stage before succussions during each step, which will allow the stabilization of 'guest-host' complexes. 5 minutes strong succussion for each stage will help breaking 'guest-host' complexes and generating free molecular imprints.

Another point to be considered is that many of the individual drug molecules may get removed from the medium before getting properly imprinted, when we cross the avogadro limit very fast. Due to this reason, chances of some or other molecular imprints being absent in potentized drugs are more in classical potentization scales. The phenomenon of 'perfectly simililimum does not act' arises from this cause. Alpha Molecular Imprinting ensures perfect imprinting of all constituent molecules by giving 80 steps of dilution before crossing avogadro limit. Hence 'alpha' products will be therapeutically more effective, and the issue of 'similimum not acting properly' never happens. This is a great achievement of Alpha Molecular Imprinting.

Another point to be noticed is that 'alpha molecular imprinting' resolves all confusions regarding potency selection. There will be only one 'potency' for one drug.

Obviously, the concept and technique of 'alpha' method is more perfect and more scientific than classical methods of potentization, and hence, is expected to produce perfect molecular imprints.

Regarding the term 'alpha molecular imprinting'. Many friends ask why this name 'alpha'. It only indicates that this is only the first step in the evolution of new scientific molecular imprinting techniques. We will have to work for developing novel molecular imprinting media and imprinting techniques in future. ALPHA is only a first step in this direction.

Regarding the first question my friend asked: "why waste time for this- do other works to make homeopathy scientific". Finding a better way of producing perfect molecular imprints is an essential part of 'making homeopathy scientific'. We need reliable and genuine products for using in our research works.