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Alkaloid ImidazolKelompok 10Dimas Agus P.H. (1306479873)

o!ia"i #ugia"$o (1306480061)

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Pe"da%ulua"

• Alkaloid imidazol me&upaka" alkaloid"o"'%e$e&osiklik.

• e&upaka" de&i!a$ da&i asam ami"o

%is$idi".• mum"*a alkaloid imidazol $e&dapa$

pada $a"ama" +e&,amili Rutaceae.

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• -o"$o% alkaloid *a"g $e&masuk golo"ga" imidazol

Piloka&pi"

Isopiloka&pi"

Pilosi"e

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/iosi"$esis

• P&eku&so& 'His$idi" memiliki 2i"2i" imidazole.

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PILOCARPUS MICROPHYLLUS

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 akso"omi

• Ki"gdomPla"$ae

• &do #api"dales

• 5amili u$a2eae• e"us

Pilo2a&pus

•

#pesiesPilocarpusmicrophyllus

• ama lai":

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-i&i'2i&i a"ama"

• /e&+e"$uk semak +eluka&

•  i"ggi 3'7 m

• /u"ga $e+al ke2il +e&:a&"a u"gu keme&a%a"

• Dau" +e&:a&"a %i;au kea+u'a+ua" memiliki +aua&oma$is da" &asa *a"g pa%i$

•  e&dapa$ 7 +ua% pu2uk dau"

• Pa";a"g pu2uk dau" <' 2m= le+a& pu2uk dau" 1'3 2m

• Kuli$ +a$a"g +e&:a&"a kea+u'a+ua"• /agia" *a"g digu"aka" u"$uk simplisia pu2uk

dau"

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Ka"du"ga"

• Pilocarpine

• Isopilo2a&pi"e

• Pilo2a&dipi"e

• Pilosi"e• Pseudopilo2a&pi"

e

•

Isopilosi"e o$al ka"du"ga"alkaloid"*a 0'1>

• Ka"du"ga"lai""*a

?ola$ile oil

o"o$e&pe"e

limo"e"e(dipe"$e"e)'pi"e"e sa+i"e"e

#es@ui$e&pe"e

 a""i2 a2id?ola$ile a2id

Po$assium 2%lo&ide

•  

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Pe"*e+a&a" da" K%asia$

Penyebaran

• e&dapa$ di /&azilu$a&a (-ea&a da"Pe&"am+u2o)

Khasiat

• A"$i glaukoma

• io$ik

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-a&a empe&ole%#implisia• Dau" di pa"e" da&i +a$a"g *a"g mi"imal $ela%

+e&+ua% sa$u kali da" +ua% $e&se+u$ $ela% masakdima"a 2a+a"g $e&se+u$ %a&us +e&ada di a$as02m da&i po%o" $e&se+u$

• Dipa"e" pada musim kema&au• Dike&i"gka" kemudia" disimpa"

•  Bika disimpa" le+i% da&i < $a%u" maka alkaloidaka" $e&u&ai

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-a&a Pem+ua$a" #implisia

• -ampu& se&+uk dau" de"ga" "a$&ium ka&+o"a$lalu disa&i de"ga" +e"ze"a

• Hasil pe"*a&ia" diko2ok de"ga" H-l e"2e& a$auH3

• a&u$a" $e&se+u$ dialkaliska" da" diko2ok de"ga"klo&o,o&m

• a&u$a" klo&o,o&m diko2ok lagi de"ga" la&u$a"asam maka ga&am alkaloid aka" $e&k&is$alisasi.

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PILOCARPUS !A"ORA#$I

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 akso"omi

• &do #api"dales

• 5amilia u$a2eae

• e"us Pilo2a&pus

•

#pesies Pilocarpus jaborani

• ama lai"

Pernambuco jaborani

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o&,ologi

• Dau" +e&+e"$uk elips la"se$a$au lo";o"g sampai la"se$pa";a"g"*a 6'1< 2m le+a& 1'4 2m

• /e&+e"$uk sepe&$i semak+eluka& %i"gga po%o" ke2il

•  i"ggi 3'7 me$e&

• Pu2uk dau" +e&;umla% 7+e&:a&"a %i;au kea+u'a+ua"

• Kuli$ +a$a"g"*a +e&:a&"a a+u'a+u da" memiliki $eks$u&lem+u$

• /u"ga"*a ke2il :a&"a"*a u"gukeme&a%a"

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Pe"*e+a&a" da" K%asia$

Pe"*e+a&a"

• e&dapa$ di /&azil

K%asia$

• A"$i glaukoma

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#implisia

• Didapa$ da&idau" *a"g $ela%dike&i"gka"

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Ka"du"ga" Kimia#implisia• -i"2i" imidazol (glioCali") adala% 2i"2i" u$ama

da&i piloka&pi" *a"g di%asilka" $a"ama"Pilo2a&pus ;a+o&a"di.

• Piloka&pi" adala% +asa $e&sie& *a"g me"ga"du"g

gugus lak$o" da" imidazol.• Di$i";au da&i s$&uk$u&"*a alkaloid i"i mu"gki"

di+e"$uk da&i %is$idi" a$au sua$u me$a+oli$ *a"geki!ale".

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-a&a empe&ole%#implisia• Dau" da" pu2uk (,olium) dikumpulka" pada saa$

,o$osi"$esis +e&la"gsu"g sa"ga$ ak$i, di$a"daide"ga" meli%a$ apaka% $a"ama" $e&se+u$ seda"g+e&+u"ga a$au +e&+ua% $e$api +ua% +elum

masak.• #e$ela% dipa"e" dau" dike&i"gka" u"$uk

kemudia" disimpa"

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Piloka&pi"

• Ka&ak$e&is$ik

• /e&+e"$uk k&is$al pada$ ;e&"i% $idak +e&:a&"a%ig&oskopis ,o$ose"si$i, = $idak +e&+au &asa pa%i$

•  i$ik didi% 39< 5 (<00 -)

• i$ik lele% 93 5

• #i,a$ muda% me"guap

• a&u$ alko%ol klo&o,o&m e$a"ol

• #a"ga$ sediki$ la&u$ +e"ze" e$e&

• P&ak$is $idak la&u$ dalam e$e& mi"*ak $a"a%

• i"gka&a" imidazol me&upaka" i"$i dasa& da&ipiloka&pi" da" Piloka&pus. Piloka&pi" adala% +asa$e&sie& +e&asam sa$u me"ga"du"g gugus lak$o"da" i"$i imidazol

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K%asia$

• a&am Piloka&pi" +e&gu"a dalam p&ak$ik o,$almik da"digu"aka" dalam o+a$ $e$es ma$a se+agai age"mio$ik da" u"$uk pe"go+a$a" glaukoma.

• e&upaka" age" koli"e&gik da" me&a"gsa"g &esep$o&

muska&i"ik pada ma$a me"*e+a+ka" pe"*empi$a"pupil da" pe"i"gka$a" a&us kelua& a@ueous %umo&

• /ioa!aila+ili$as okula& piloka&pi" &e"da% se%i"ggade"ga" 2epa$ me"galami kli&e"s *a"gme"gaki+a$ka" e,ek $e&api me";adi si"gka$

•A"$ago"is +ila di+e&ika" de"ga" a$&opi"

• em+e&ika" ma",aa$ $am+a%a" u"$uk keke&i"ga"pada mulu$ *a"g sa"ga$ umum pada pasie" *a"gme";ala"i &adio$e&api u"$uk mulu$ da" ka"ke&$e"ggo&oka"

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#ediaa"

• Piloka&pi" H-l Ha+lu& $idak +e&:a&"a agak$&a"spa&a" $idak +e&+au &asa agak pa%i$%ig&oskopis da" dipe"ga&u%i ole% 2a%a*a +e&eaksiasam $e&%adap ke&$as lakmus sa"ga$ muda% la&u$

dalam ai& muda% la&u$ dalam e$a"ol suka& la&u$dalam klo&o,o&m $idak la&u$ dalam e$e&.

• Piloka&pi" i$&a$ Ha+lu& pu$i% me"gkila$ s$a+ildiuda&a dipe"ga&u%i ole% 2a%a*a muda% la&u$dalam ai& agak suka& la&u$ dalam e$a"ol $idak

la&u$ dalam klo&o,o&m da" e$e&

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-o"$o% P&oduk

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e,e&e"si

• De:i2k P. (<009). Meicinal natural proucts.-%i2%es$e& Ees$ #usseC Eile*.

• F!a"s E. F!a"s D. a"d &ease . (<00<). %reasean &'ans( Pharmaco)nosy . Fdi"+u&g% E/

#au"de&s.• %$$pGG

:::.+o$a"i2al.2omG+o$a"i2alGmgm%G;G;a+o&a01.%$ml

• %$$psGG

+ooks.google.2o.idG+ooksidK:JIs*Dp4-pg#A13'PA73lpg#A13'PA73d@ma&a"%amL;a+o&a"disou&2e+lo$s8%;@&I03sig1E@CF$+&<0,:4"dzo<#!dP<g%lidsaMeiP$

I?2zCp-PuA/&I4DN!ed0-N6AF:DgO!o"epage@ma&a"%am><0;a+o&a"di,,alse