16
PARTICIPANT STATISTICS Chemistry Q3 2017 Basic Chemistry Specimen 1 Specimen 2 Specimen 3 Specimen 4 Specimen 5 Name Line No. Range & Type Mean SD Range & Type Mean SD Range & Type Mean SD Range & Type Mean SD Range & Type Mean SD No. of Labs Alanine Aminotransferase (ALT or SGPT) Initial Grouping by Reagent and Instrument Abbott & Abbott Architect c, ci, i 1 151 - 227 P 189.0 4.6 196 - 295 P 245.5 6.1 60 - 90 P 75.2 2.0 37 - 55 P 46.0 1.6 128 - 192 P 160.3 3.7 21 Alfa Wassermann & Alfa Wasser Axcel/Alera 2 124 - 186 P 154.7 3.5 162 - 243 P 202.3 4.4 49 - 74 P 61.3 2.2 29 - 44 P 36.5 2.2 105 - 158 P 131.6 3.0 19 Beckman Coulter & Beck Coult Unicel DXC 3 149 - 223 P 185.8 2.6 191 - 286 P 238.3 2.3 64 - 96 P 79.9 1.5 42 - 63 P 52.9 1.3 128 - 192 P 159.9 3.0 17 Beckman Coulter & Beck Olym AU 400/600/5400 4 132 - 198 P 164.6 11.3 170 - 255 P 212.8 13.3 55 - 83 P 68.8 5.6 35 - 52 P 43.4 4.6 114 - 172 P 143.0 8.5 5 Beckman Coulter & Beckman AU 480 5 136 - 205 P 170.6 12.7 176 - 264 P 219.8 15.5 55 - 82 P 68.3 5.2 34 - 52 P 43.0 3.6 116 - 174 P 145.0 10.1 6 Beckman Olympus & Beck Olym AU 400/600/5400 6 129 - 194 P 161.8 7.1 167 - 251 P 208.8 8.0 52 - 77 P 64.4 2.7 32 - 48 P 39.9 1.5 110 - 165 P 137.2 5.0 28 Beckman Olympus & Beck Olympus AU 2700 7 129 - 193 P 160.8 3.5 166 - 249 P 207.8 5.0 51 - 77 P 64.0 1.9 32 - 48 P 40.3 0.4 110 - 165 P 137.3 4.4 4 Beckman Olympus & Beckman AU 480 8 131 - 196 P 163.4 4.6 169 - 254 P 211.7 5.1 52 - 79 P 65.6 1.9 33 - 49 P 41.0 0.9 111 - 167 P 139.0 3.6 21 Carolina & Beck Olym AU 400/600/5400 9 139 - 209 P 173.8 9.3 179 - 269 P 223.8 14.2 56 - 84 P 70.4 4.4 36 - 55 P 45.6 4.1 116 - 174 P 144.8 10.4 5 Carolina & Beckman Synchron CX3/7/9/L 10 148 - 222 P 185.2 11.4 189 - 283 P 236.0 16.8 63 - 94 P 78.6 4.4 41 - 61 P 51.0 3.5 127 - 191 P 159.0 10.5 5 Horiba ABX & Horiba ABX 400 11 161 - 241 P 201.1 5.4 208 - 312 P 259.6 6.5 66 - 98 P 82.0 2.3 41 - 62 P 51.6 2.5 138 - 207 P 172.6 4.9 7 Ortho Vitros & Ortho Vitros 3600, 5600 12 150 - 226 P 188.1 5.0 192 - 288 P 240.2 3.5 67 - 100 P 83.2 4.2 45 - 67 P 55.9 4.5 130 - 195 P 162.6 4.2 18 Ortho Vitros & Ortho Vitros 5,1 FS 13 149 - 224 P 186.5 6.0 190 - 284 P 237.0 8.2 67 - 101 P 84.3 5.9 47 - 70 P 58.3 2.4 130 - 194 P 162.0 5.3 4 Ortho Vitros & Ortho Vitros not DT or ECi 14 150 - 226 P 188.0 5.5 190 - 286 P 238.1 6.0 67 - 101 P 84.2 4.4 46 - 69 P 57.3 3.8 131 - 196 P 163.2 4.8 27 Pointe Scientific & Beck Olym AU 400/600/5400 15 146 - 219 P 182.8 7.6 188 - 282 P 235.3 8.6 59 - 88 P 73.5 3.2 37 - 55 P 45.8 2.5 125 - 187 P 155.8 5.8 4 Roche Cobas & Roche Cobas 6000 16 141 - 212 P 176.8 2.0 183 - 275 P 228.9 3.2 57 - 85 P 70.9 0.9 35 - 53 P 44.2 0.6 120 - 180 P 150.4 1.9 9 Roche Cobas & Roche Cobas Integra 17 144 - 217 P 180.5 4.4 186 - 279 P 232.9 5.0 58 - 87 P 72.7 2.1 36 - 54 P 45.0 1.5 123 - 185 P 153.9 3.4 14 Roche Cobas & Roche e/c, 1XX, X000, Elec series 18 142 - 213 P 177.2 3.3 183 - 275 P 228.9 4.5 57 - 85 P 71.2 1.6 36 - 53 P 44.4 1.0 120 - 181 P 150.5 2.7 19 SDI Biomed & SDI CA-240, 480 19 123 - 184 P 153.3 1.1 169 - 254 P 211.7 5.8 52 - 78 P 64.7 0.7 34 - 52 P 43.0 1.9 105 - 157 P 131.0 3.0 6 Sekisui & Beck Olym AU 400/600/5400 20 137 - 206 P 171.6 6.9 178 - 267 P 222.4 8.6 55 - 82 P 68.2 2.1 33 - 50 P 41.8 1.5 116 - 175 P 145.6 6.0 5 Siemens ALTI & Siemens Dimension EXL 21 153 - 229 P 191.2 3.0 198 - 297 P 247.2 4.0 63 - 94 P 78.6 1.7 40 - 60 P 49.9 1.9 131 - 196 P 163.4 2.6 45 Siemens ALTI & Siemens Dimension Xpand 22 155 - 232 P 193.3 3.0 199 - 299 P 249.3 5.4 63 - 95 P 79.2 2.3 41 - 61 P 50.7 2.0 133 - 199 P 166.0 3.8 15 Siemens Dimension & Siemens Dimension EXL 23 154 - 231 P 192.6 5.0 199 - 299 P 248.9 3.9 64 - 95 P 79.4 2.5 41 - 61 P 51.0 2.8 132 - 198 P 165.4 3.5 14 Siemens Dimension & Siemens Dimension Xpand 24 154 - 231 P 192.6 2.8 199 - 299 P 249.3 2.3 63 - 95 P 78.8 1.2 40 - 60 P 50.4 0.7 132 - 198 P 165.1 1.9 8 Siemens no P5P & Siemens Advia 25 148 - 222 P 185.3 5.8 191 - 287 P 239.3 7.1 60 - 90 P 75.3 3.0 38 - 58 P 48.0 2.1 126 - 189 P 157.5 6.3 4 Synermed & Synermed IR500 26 156 - 234 P 194.8 12.6 207 - 310 P 258.3 15.7 65 - 98 P 81.8 8.8 44 - 66 P 55.4 8.4 142 - 213 P 177.6 16.2 5 Initial Grouping by Reagent Abbott 27 151 - 227 P 189.0 4.6 196 - 295 P 245.5 6.1 60 - 90 P 75.2 2.0 37 - 55 P 46.0 1.6 128 - 192 P 160.3 3.7 21 Alfa Wassermann 28 124 - 186 P 154.7 3.5 162 - 243 P 202.3 4.4 49 - 74 P 61.3 2.2 29 - 44 P 36.5 2.2 105 - 158 P 131.6 3.0 19 Beckman Coulter 29 143 - 215 P 179.0 11.7 184 - 276 P 229.8 14.2 60 - 91 P 75.5 6.6 39 - 59 P 49.1 5.5 123 - 184 P 153.7 10.0 28 Beckman Olympus 30 130 - 195 P 162.3 6.1 168 - 252 P 209.8 7.0 52 - 78 P 64.8 2.4 32 - 48 P 40.4 1.4 110 - 165 P 137.9 4.6 53 Carolina 31 143 - 214 P 178.5 16.2 184 - 275 P 229.5 22.0 59 - 89 P 74.0 7.2 38 - 57 P 47.5 5.1 121 - 181 P 151.1 14.7 15 Horiba ABX 32 161 - 241 P 201.1 5.4 208 - 312 P 259.6 6.5 66 - 98 P 82.0 2.3 41 - 62 P 51.6 2.5 138 - 207 P 172.6 4.9 7 Ortho Vitros 33 150 - 225 P 187.9 5.4 191 - 286 P 238.7 5.7 67 - 101 P 83.9 4.4 46 - 68 P 56.9 4.1 130 - 195 P 162.8 4.7 51 Pointe Scientific 34 150 - 226 P 188.0 9.6 194 - 291 P 242.3 12.9 61 - 92 P 76.7 4.5 38 - 57 P 47.7 3.4 124 - 186 P 154.8 11.8 9 Roche Cobas 35 143 - 214 P 178.2 3.9 184 - 276 P 230.2 4.8 57 - 86 P 71.6 1.8 36 - 54 P 44.6 1.2 121 - 182 P 151.6 3.2 42 SDI Biomed 36 123 - 184 P 153.3 1.1 169 - 254 P 211.7 5.8 52 - 78 P 64.7 0.7 34 - 52 P 43.0 1.9 105 - 157 P 131.0 3.0 6 Sekisui 37 139 - 209 P 174.1 10.9 180 - 270 P 225.3 15.3 56 - 84 P 69.6 4.1 35 - 53 P 44.1 4.8 118 - 177 P 147.8 8.3 8 Siemens ALTI 38 154 - 230 P 191.9 3.5 198 - 298 P 248.0 4.6 63 - 95 P 78.8 2.0 40 - 60 P 50.1 1.9 131 - 197 P 164.1 3.3 65 Siemens Dimension 39 154 - 231 P 192.5 4.7 199 - 298 P 248.7 4.9 63 - 95 P 79.1 2.2 41 - 61 P 50.8 2.5 132 - 198 P 165.2 3.5 24 Siemens no P5P 40 148 - 222 P 185.3 5.8 191 - 287 P 239.3 7.1 60 - 90 P 75.3 3.0 38 - 58 P 48.0 2.1 126 - 189 P 157.5 6.3 4 Synermed 41 160 - 240 P 200.2 15.7 211 - 317 P 264.0 18.2 66 - 99 P 82.6 8.1 44 - 66 P 54.7 7.9 143 - 215 P 178.8 15.0 6 Initial Grouping by Sensitivity or Principle Other no P5P 42 131 - 197 P 164.0 15.4 172 - 257 P 214.4 19.0 54 - 80 P 67.0 7.3 34 - 51 P 42.1 6.0 112 - 168 P 139.7 13.4 45 Standardized methods 43 140 - 210 P 175.1 15.0 181 - 272 P 226.4 18.6 57 - 85 P 71.2 6.7 36 - 54 P 44.9 4.9 119 - 179 P 149.1 12.7 142 Other P5P 44 155 - 233 P 194.3 19.4 204 - 306 P 255.0 26.1 65 - 98 P 81.3 7.9 43 - 65 P 53.9 7.5 140 - 210 P 174.7 17.2 7 Vitros and related methods 45 150 - 225 P 187.9 5.4 191 - 286 P 238.7 5.7 67 - 101 P 83.9 4.4 46 - 68 P 56.9 4.1 130 - 195 P 162.8 4.7 51 Roche and related 46 143 - 214 P 178.2 3.9 184 - 276 P 230.2 4.8 57 - 86 P 71.6 1.8 36 - 54 P 44.6 1.2 121 - 182 P 151.6 3.2 42

Alanine Aminotransferase (ALT or SGPT) Basic Chemistry... · PARTICIPANT STATISTICS Chemistry Q3 2017 Basic Chemistry Specimen 1 Specimen 2 Specimen 3 Specimen 4 Specimen 5 Name Line

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PARTICIPANT STATISTICS Chemistry Q3 2017

Basic Chemistry

Specimen 1 Specimen 2 Specimen 3 Specimen 4 Specimen 5

Name Line No. Range &Type Mean SD Range &

Type Mean SD Range &Type Mean SD Range &

Type Mean SD Range &Type Mean SD No. of Labs

Alanine Aminotransferase (ALT or SGPT)Initial Grouping by Reagent and InstrumentAbbott & Abbott Architect c, ci, i 1 151 - 227 P 189.0 4.6 196 - 295 P 245.5 6.1 60 - 90 P 75.2 2.0 37 - 55 P 46.0 1.6 128 - 192 P 160.3 3.7 21Alfa Wassermann & Alfa Wasser Axcel/Alera 2 124 - 186 P 154.7 3.5 162 - 243 P 202.3 4.4 49 - 74 P 61.3 2.2 29 - 44 P 36.5 2.2 105 - 158 P 131.6 3.0 19Beckman Coulter & Beck Coult Unicel DXC 3 149 - 223 P 185.8 2.6 191 - 286 P 238.3 2.3 64 - 96 P 79.9 1.5 42 - 63 P 52.9 1.3 128 - 192 P 159.9 3.0 17Beckman Coulter & Beck Olym AU 400/600/5400 4 132 - 198 P 164.6 11.3 170 - 255 P 212.8 13.3 55 - 83 P 68.8 5.6 35 - 52 P 43.4 4.6 114 - 172 P 143.0 8.5 5Beckman Coulter & Beckman AU 480 5 136 - 205 P 170.6 12.7 176 - 264 P 219.8 15.5 55 - 82 P 68.3 5.2 34 - 52 P 43.0 3.6 116 - 174 P 145.0 10.1 6Beckman Olympus & Beck Olym AU 400/600/5400 6 129 - 194 P 161.8 7.1 167 - 251 P 208.8 8.0 52 - 77 P 64.4 2.7 32 - 48 P 39.9 1.5 110 - 165 P 137.2 5.0 28Beckman Olympus & Beck Olympus AU 2700 7 129 - 193 P 160.8 3.5 166 - 249 P 207.8 5.0 51 - 77 P 64.0 1.9 32 - 48 P 40.3 0.4 110 - 165 P 137.3 4.4 4Beckman Olympus & Beckman AU 480 8 131 - 196 P 163.4 4.6 169 - 254 P 211.7 5.1 52 - 79 P 65.6 1.9 33 - 49 P 41.0 0.9 111 - 167 P 139.0 3.6 21Carolina & Beck Olym AU 400/600/5400 9 139 - 209 P 173.8 9.3 179 - 269 P 223.8 14.2 56 - 84 P 70.4 4.4 36 - 55 P 45.6 4.1 116 - 174 P 144.8 10.4 5Carolina & Beckman Synchron CX3/7/9/L 10 148 - 222 P 185.2 11.4 189 - 283 P 236.0 16.8 63 - 94 P 78.6 4.4 41 - 61 P 51.0 3.5 127 - 191 P 159.0 10.5 5Horiba ABX & Horiba ABX 400 11 161 - 241 P 201.1 5.4 208 - 312 P 259.6 6.5 66 - 98 P 82.0 2.3 41 - 62 P 51.6 2.5 138 - 207 P 172.6 4.9 7Ortho Vitros & Ortho Vitros 3600, 5600 12 150 - 226 P 188.1 5.0 192 - 288 P 240.2 3.5 67 - 100 P 83.2 4.2 45 - 67 P 55.9 4.5 130 - 195 P 162.6 4.2 18Ortho Vitros & Ortho Vitros 5,1 FS 13 149 - 224 P 186.5 6.0 190 - 284 P 237.0 8.2 67 - 101 P 84.3 5.9 47 - 70 P 58.3 2.4 130 - 194 P 162.0 5.3 4Ortho Vitros & Ortho Vitros not DT or ECi 14 150 - 226 P 188.0 5.5 190 - 286 P 238.1 6.0 67 - 101 P 84.2 4.4 46 - 69 P 57.3 3.8 131 - 196 P 163.2 4.8 27Pointe Scientific & Beck Olym AU 400/600/5400 15 146 - 219 P 182.8 7.6 188 - 282 P 235.3 8.6 59 - 88 P 73.5 3.2 37 - 55 P 45.8 2.5 125 - 187 P 155.8 5.8 4Roche Cobas & Roche Cobas 6000 16 141 - 212 P 176.8 2.0 183 - 275 P 228.9 3.2 57 - 85 P 70.9 0.9 35 - 53 P 44.2 0.6 120 - 180 P 150.4 1.9 9Roche Cobas & Roche Cobas Integra 17 144 - 217 P 180.5 4.4 186 - 279 P 232.9 5.0 58 - 87 P 72.7 2.1 36 - 54 P 45.0 1.5 123 - 185 P 153.9 3.4 14Roche Cobas & Roche e/c, 1XX, X000, Elec series 18 142 - 213 P 177.2 3.3 183 - 275 P 228.9 4.5 57 - 85 P 71.2 1.6 36 - 53 P 44.4 1.0 120 - 181 P 150.5 2.7 19SDI Biomed & SDI CA-240, 480 19 123 - 184 P 153.3 1.1 169 - 254 P 211.7 5.8 52 - 78 P 64.7 0.7 34 - 52 P 43.0 1.9 105 - 157 P 131.0 3.0 6Sekisui & Beck Olym AU 400/600/5400 20 137 - 206 P 171.6 6.9 178 - 267 P 222.4 8.6 55 - 82 P 68.2 2.1 33 - 50 P 41.8 1.5 116 - 175 P 145.6 6.0 5Siemens ALTI & Siemens Dimension EXL 21 153 - 229 P 191.2 3.0 198 - 297 P 247.2 4.0 63 - 94 P 78.6 1.7 40 - 60 P 49.9 1.9 131 - 196 P 163.4 2.6 45Siemens ALTI & Siemens Dimension Xpand 22 155 - 232 P 193.3 3.0 199 - 299 P 249.3 5.4 63 - 95 P 79.2 2.3 41 - 61 P 50.7 2.0 133 - 199 P 166.0 3.8 15Siemens Dimension & Siemens Dimension EXL 23 154 - 231 P 192.6 5.0 199 - 299 P 248.9 3.9 64 - 95 P 79.4 2.5 41 - 61 P 51.0 2.8 132 - 198 P 165.4 3.5 14Siemens Dimension & Siemens Dimension Xpand 24 154 - 231 P 192.6 2.8 199 - 299 P 249.3 2.3 63 - 95 P 78.8 1.2 40 - 60 P 50.4 0.7 132 - 198 P 165.1 1.9 8Siemens no P5P & Siemens Advia 25 148 - 222 P 185.3 5.8 191 - 287 P 239.3 7.1 60 - 90 P 75.3 3.0 38 - 58 P 48.0 2.1 126 - 189 P 157.5 6.3 4Synermed & Synermed IR500 26 156 - 234 P 194.8 12.6 207 - 310 P 258.3 15.7 65 - 98 P 81.8 8.8 44 - 66 P 55.4 8.4 142 - 213 P 177.6 16.2 5Initial Grouping by ReagentAbbott 27 151 - 227 P 189.0 4.6 196 - 295 P 245.5 6.1 60 - 90 P 75.2 2.0 37 - 55 P 46.0 1.6 128 - 192 P 160.3 3.7 21Alfa Wassermann 28 124 - 186 P 154.7 3.5 162 - 243 P 202.3 4.4 49 - 74 P 61.3 2.2 29 - 44 P 36.5 2.2 105 - 158 P 131.6 3.0 19Beckman Coulter 29 143 - 215 P 179.0 11.7 184 - 276 P 229.8 14.2 60 - 91 P 75.5 6.6 39 - 59 P 49.1 5.5 123 - 184 P 153.7 10.0 28Beckman Olympus 30 130 - 195 P 162.3 6.1 168 - 252 P 209.8 7.0 52 - 78 P 64.8 2.4 32 - 48 P 40.4 1.4 110 - 165 P 137.9 4.6 53Carolina 31 143 - 214 P 178.5 16.2 184 - 275 P 229.5 22.0 59 - 89 P 74.0 7.2 38 - 57 P 47.5 5.1 121 - 181 P 151.1 14.7 15Horiba ABX 32 161 - 241 P 201.1 5.4 208 - 312 P 259.6 6.5 66 - 98 P 82.0 2.3 41 - 62 P 51.6 2.5 138 - 207 P 172.6 4.9 7Ortho Vitros 33 150 - 225 P 187.9 5.4 191 - 286 P 238.7 5.7 67 - 101 P 83.9 4.4 46 - 68 P 56.9 4.1 130 - 195 P 162.8 4.7 51Pointe Scientific 34 150 - 226 P 188.0 9.6 194 - 291 P 242.3 12.9 61 - 92 P 76.7 4.5 38 - 57 P 47.7 3.4 124 - 186 P 154.8 11.8 9Roche Cobas 35 143 - 214 P 178.2 3.9 184 - 276 P 230.2 4.8 57 - 86 P 71.6 1.8 36 - 54 P 44.6 1.2 121 - 182 P 151.6 3.2 42SDI Biomed 36 123 - 184 P 153.3 1.1 169 - 254 P 211.7 5.8 52 - 78 P 64.7 0.7 34 - 52 P 43.0 1.9 105 - 157 P 131.0 3.0 6Sekisui 37 139 - 209 P 174.1 10.9 180 - 270 P 225.3 15.3 56 - 84 P 69.6 4.1 35 - 53 P 44.1 4.8 118 - 177 P 147.8 8.3 8Siemens ALTI 38 154 - 230 P 191.9 3.5 198 - 298 P 248.0 4.6 63 - 95 P 78.8 2.0 40 - 60 P 50.1 1.9 131 - 197 P 164.1 3.3 65Siemens Dimension 39 154 - 231 P 192.5 4.7 199 - 298 P 248.7 4.9 63 - 95 P 79.1 2.2 41 - 61 P 50.8 2.5 132 - 198 P 165.2 3.5 24Siemens no P5P 40 148 - 222 P 185.3 5.8 191 - 287 P 239.3 7.1 60 - 90 P 75.3 3.0 38 - 58 P 48.0 2.1 126 - 189 P 157.5 6.3 4Synermed 41 160 - 240 P 200.2 15.7 211 - 317 P 264.0 18.2 66 - 99 P 82.6 8.1 44 - 66 P 54.7 7.9 143 - 215 P 178.8 15.0 6Initial Grouping by Sensitivity or PrincipleOther no P5P 42 131 - 197 P 164.0 15.4 172 - 257 P 214.4 19.0 54 - 80 P 67.0 7.3 34 - 51 P 42.1 6.0 112 - 168 P 139.7 13.4 45Standardized methods 43 140 - 210 P 175.1 15.0 181 - 272 P 226.4 18.6 57 - 85 P 71.2 6.7 36 - 54 P 44.9 4.9 119 - 179 P 149.1 12.7 142Other P5P 44 155 - 233 P 194.3 19.4 204 - 306 P 255.0 26.1 65 - 98 P 81.3 7.9 43 - 65 P 53.9 7.5 140 - 210 P 174.7 17.2 7Vitros and related methods 45 150 - 225 P 187.9 5.4 191 - 286 P 238.7 5.7 67 - 101 P 83.9 4.4 46 - 68 P 56.9 4.1 130 - 195 P 162.8 4.7 51Roche and related 46 143 - 214 P 178.2 3.9 184 - 276 P 230.2 4.8 57 - 86 P 71.6 1.8 36 - 54 P 44.6 1.2 121 - 182 P 151.6 3.2 42

Siemens and related 47 153 - 230 P 191.7 4.2 198 - 297 P 247.8 5.2 63 - 94 P 78.7 2.2 40 - 60 P 50.2 2.2 131 - 197 P 164.1 3.8 93Total PopulationWhole Population 48 144 - 216 P 180.3 15.2 186 - 279 P 232.8 18.8 60 - 90 P 74.6 7.7 38 - 57 P 47.5 6.4 124 - 185 P 154.5 13.6 380

AlbuminInitial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 3.1 - 3.8 P 3.46 0.05 3.6 - 4.3 P 3.95 0.05 2.2 - 2.7 P 2.47 0.05 2.0 - 2.4 P 2.2 0.04 2.9 - 3.5 P 3.22 0.06 13Abbott BCG & Abbott Architect c, ci, i 2 3.1 - 3.8 P 3.48 0.07 3.6 - 4.4 P 3.98 0.07 2.2 - 2.7 P 2.46 0.05 2.0 - 2.4 P 2.22 0.07 2.9 - 3.6 P 3.26 0.05 5Alfa Wassermann & Alfa Wasser Axcel/Alera 3 3.2 - 3.9 P 3.57 0.07 3.6 - 4.4 P 4.02 0.07 2.3 - 2.8 P 2.59 0.05 2.1 - 2.6 P 2.32 0.05 3.0 - 3.7 P 3.33 0.07 18Beckman BCG & Beck Olym AU 400/600/5400 4 3.3 - 4.0 P 3.62 0.07 3.7 - 4.5 P 4.08 0.07 2.3 - 2.8 P 2.54 0.1 2.0 - 2.5 P 2.26 0.08 3.0 - 3.7 P 3.32 0.07 5Beckman BCP & Beck Coult Unicel DXC 5 2.7 - 3.3 P 2.96 0.07 3.0 - 3.6 P 3.29 0.08 2.0 - 2.5 P 2.26 0.05 1.9 - 2.3 P 2.07 0.05 2.5 - 3.1 P 2.79 0.06 17Beckman Olympus & Beck Olym AU 400/600/5400 6 3.2 - 3.9 P 3.56 0.1 3.6 - 4.4 P 4.03 0.19 2.2 - 2.7 P 2.49 0.06 2.0 - 2.4 P 2.21 0.08 3.0 - 3.6 P 3.29 0.1 29Beckman Olympus & Beck Olympus AU 2700 7 3.2 - 3.9 P 3.55 0.05 3.6 - 4.4 P 4.0 0.0 2.2 - 2.7 P 2.48 0.04 2.0 - 2.4 P 2.2 0.0 2.9 - 3.6 P 3.25 0.05 4Beckman Olympus & Beckman AU 480 8 3.2 - 3.9 P 3.59 0.12 3.7 - 4.5 P 4.08 0.13 2.3 - 2.8 P 2.52 0.08 2.0 - 2.5 P 2.23 0.07 3.0 - 3.7 P 3.34 0.11 22Carolina BCG & Beck Olym AU 400/600/5400 9 3.1 - 3.8 P 3.45 0.27 3.4 - 4.2 P 3.8 0.29 2.3 - 2.9 P 2.6 0.07 2.1 - 2.6 P 2.33 0.15 2.9 - 3.6 P 3.23 0.27 4Carolina BCP & Beckman Synchron CX3/7/9/L 10 2.5 - 3.1 P 2.8 0.0 2.8 - 3.4 P 3.13 0.04 1.9 - 2.3 P 2.13 0.04 1.8 - 2.2 P 2.0 0.07 2.4 - 3.0 P 2.7 0.07 4Horiba ABX & Horiba ABX 400 11 3.2 - 3.9 P 3.56 0.09 3.6 - 4.4 P 3.96 0.1 2.3 - 2.9 P 2.6 0.05 2.1 - 2.6 P 2.36 0.07 3.0 - 3.6 P 3.3 0.05 7Ortho Vitros & Ortho Vitros 3600, 5600 12 3.2 - 3.9 P 3.51 0.11 3.7 - 4.5 P 4.11 0.12 2.1 - 2.6 P 2.35 0.05 1.9 - 2.3 P 2.09 0.07 2.9 - 3.6 P 3.25 0.13 18Ortho Vitros & Ortho Vitros 5,1 FS 13 3.2 - 3.9 P 3.53 0.04 3.7 - 4.5 P 4.13 0.11 2.1 - 2.6 P 2.38 0.04 1.9 - 2.3 P 2.1 0.0 3.0 - 3.6 P 3.3 0.07 4Ortho Vitros & Ortho Vitros not DT or ECi 14 3.1 - 3.8 P 3.48 0.14 3.7 - 4.5 P 4.07 0.18 2.1 - 2.6 P 2.34 0.1 1.9 - 2.3 P 2.08 0.07 2.9 - 3.6 P 3.25 0.11 26Roche Cobas & Roche Cobas Integra 15 3.5 - 4.3 P 3.87 0.07 4.0 - 4.8 P 4.4 0.1 2.5 - 3.0 P 2.73 0.07 2.2 - 2.7 P 2.43 0.07 3.3 - 4.0 P 3.62 0.09 6Roche Cobas & Roche e/c, 1XX, X000, Elec series 16 3.5 - 4.2 P 3.85 0.14 3.9 - 4.8 P 4.35 0.13 2.5 - 3.0 P 2.73 0.11 2.2 - 2.7 P 2.41 0.1 3.2 - 3.9 P 3.58 0.12 10Roche Cobas BCG, gen II & Roche Cobas 6000 17 3.5 - 4.3 P 3.9 0.08 3.9 - 4.8 P 4.38 0.09 2.5 - 3.0 P 2.77 0.07 2.2 - 2.7 P 2.45 0.05 3.2 - 4.0 P 3.6 0.08 6Roche Cobas BCG, gen II & Roche Cobas Integra 18 3.5 - 4.3 P 3.87 0.09 3.9 - 4.8 P 4.36 0.09 2.5 - 3.0 P 2.73 0.07 2.2 - 2.6 P 2.4 0.05 3.2 - 3.9 P 3.59 0.1 7Roche Cobas BCG, gen II & Roche e/c, 1XX, X000,Elec series 19 3.5 - 4.2 P 3.84 0.1 3.9 - 4.8 P 4.36 0.11 2.4 - 3.0 P 2.72 0.07 2.2 - 2.6 P 2.4 0.09 3.2 - 3.9 P 3.53 0.09 9

SDI Biomed & SDI CA-240, 480 20 3.6 - 4.4 P 3.97 0.09 3.8 - 4.7 P 4.25 0.08 2.4 - 3.0 P 2.7 0.08 2.1 - 2.6 P 2.38 0.04 3.3 - 4.0 P 3.63 0.05 6Sekisui & Beck Olym AU 400/600/5400 21 3.3 - 4.0 P 3.65 0.11 3.8 - 4.6 P 4.2 0.07 2.4 - 2.9 P 2.68 0.08 2.1 - 2.6 P 2.35 0.05 3.1 - 3.8 P 3.45 0.05 4Siemens Advia & Siemens Advia 22 3.4 - 4.2 P 3.78 0.08 3.9 - 4.8 P 4.33 0.08 2.4 - 2.9 P 2.63 0.04 2.1 - 2.6 P 2.33 0.04 3.2 - 3.9 P 3.5 0.07 4Siemens BCP & Siemens Dim RxL, RxL Max 23 2.5 - 3.1 P 2.8 0.0 2.8 - 3.4 P 3.13 0.04 1.9 - 2.3 P 2.1 0.07 1.8 - 2.1 P 1.95 0.05 2.4 - 2.9 P 2.63 0.04 4Siemens BCP & Siemens Dimension EXL 24 2.5 - 3.1 P 2.78 0.06 2.8 - 3.4 P 3.11 0.06 1.9 - 2.3 P 2.09 0.05 1.7 - 2.1 P 1.93 0.05 2.4 - 2.9 P 2.62 0.06 59Siemens BCP & Siemens Dimension Xpand 25 2.5 - 3.0 P 2.76 0.06 2.8 - 3.4 P 3.07 0.07 1.9 - 2.3 P 2.08 0.06 1.7 - 2.1 P 1.93 0.06 2.3 - 2.8 P 2.59 0.06 23Synermed & Synermed IR500 26 3.2 - 3.9 P 3.55 0.18 3.6 - 4.5 P 4.05 0.11 2.3 - 2.8 P 2.5 0.12 2.1 - 2.5 P 2.3 0.07 3.0 - 3.7 P 3.33 0.08 4Initial Grouping by ReagentAbaxis Piccolo 27 2.5 - 3.0 P 2.75 0.05 2.7 - 3.3 P 2.98 0.04 1.9 - 2.3 P 2.1 0.07 1.8 - 2.1 P 1.95 0.05 2.3 - 2.8 P 2.53 0.04 4Abbott Architect 28 3.1 - 3.8 P 3.46 0.05 3.6 - 4.3 P 3.95 0.05 2.2 - 2.7 P 2.47 0.05 2.0 - 2.4 P 2.2 0.04 2.9 - 3.5 P 3.22 0.06 13Abbott BCG 29 3.1 - 3.8 P 3.48 0.07 3.6 - 4.4 P 3.98 0.07 2.2 - 2.7 P 2.46 0.05 2.0 - 2.4 P 2.22 0.07 2.9 - 3.6 P 3.26 0.05 5Alfa Wassermann 30 3.2 - 3.9 P 3.57 0.07 3.6 - 4.4 P 4.02 0.07 2.3 - 2.8 P 2.59 0.05 2.1 - 2.6 P 2.32 0.05 3.0 - 3.7 P 3.33 0.07 18Beckman BCG 31 3.3 - 4.1 P 3.69 0.17 3.7 - 4.6 P 4.16 0.22 2.3 - 2.8 P 2.58 0.12 2.1 - 2.5 P 2.29 0.11 3.1 - 3.7 P 3.39 0.17 8Beckman BCP 32 2.7 - 3.3 P 2.96 0.07 3.0 - 3.6 P 3.29 0.08 2.0 - 2.5 P 2.26 0.05 1.9 - 2.3 P 2.07 0.04 2.5 - 3.1 P 2.79 0.06 18Beckman Olympus 33 3.2 - 3.9 P 3.57 0.11 3.6 - 4.5 P 4.05 0.16 2.2 - 2.8 P 2.5 0.07 2.0 - 2.4 P 2.22 0.08 3.0 - 3.6 P 3.31 0.11 55Carolina BCG 34 3.2 - 3.9 P 3.51 0.22 3.5 - 4.3 P 3.9 0.25 2.3 - 2.9 P 2.61 0.06 2.1 - 2.6 P 2.34 0.12 3.0 - 3.6 P 3.3 0.22 7Carolina BCP 35 2.7 - 3.3 P 2.99 0.28 3.0 - 3.6 P 3.3 0.3 2.0 - 2.5 P 2.23 0.2 1.8 - 2.2 P 2.03 0.17 2.6 - 3.1 P 2.84 0.26 7Horiba ABX 36 3.2 - 3.9 P 3.56 0.09 3.6 - 4.4 P 3.96 0.1 2.3 - 2.9 P 2.6 0.05 2.1 - 2.6 P 2.36 0.07 3.0 - 3.6 P 3.3 0.05 7Ortho Vitros 37 3.1 - 3.8 P 3.49 0.13 3.7 - 4.5 P 4.08 0.15 2.1 - 2.6 P 2.34 0.08 1.9 - 2.3 P 2.08 0.07 2.9 - 3.6 P 3.25 0.12 50Pointe Scientific 38 3.4 - 4.1 P 3.77 0.24 3.9 - 4.7 P 4.29 0.2 2.4 - 2.9 P 2.65 0.16 2.1 - 2.6 P 2.36 0.13 3.2 - 3.9 P 3.51 0.21 10Roche Cobas 39 3.5 - 4.2 P 3.86 0.11 3.9 - 4.8 P 4.36 0.11 2.5 - 3.0 P 2.75 0.11 2.2 - 2.7 P 2.42 0.09 3.3 - 4.0 P 3.62 0.13 19Roche Cobas BCG, gen II 40 3.5 - 4.3 P 3.87 0.09 3.9 - 4.8 P 4.36 0.1 2.5 - 3.0 P 2.74 0.07 2.2 - 2.7 P 2.41 0.08 3.2 - 3.9 P 3.57 0.1 22SDI Biomed 41 3.6 - 4.4 P 3.97 0.09 3.8 - 4.7 P 4.25 0.08 2.4 - 3.0 P 2.7 0.08 2.1 - 2.6 P 2.38 0.04 3.3 - 4.0 P 3.63 0.05 6Sekisui 42 3.3 - 4.0 P 3.66 0.12 3.8 - 4.7 P 4.25 0.1 2.4 - 3.0 P 2.69 0.08 2.2 - 2.6 P 2.4 0.07 3.1 - 3.8 P 3.46 0.09 8Siemens Advia 43 3.4 - 4.2 P 3.78 0.08 3.9 - 4.8 P 4.33 0.08 2.4 - 2.9 P 2.63 0.04 2.1 - 2.6 P 2.33 0.04 3.2 - 3.9 P 3.5 0.07 4Siemens BCP 44 2.5 - 3.1 P 2.78 0.06 2.8 - 3.4 P 3.11 0.07 1.9 - 2.3 P 2.09 0.06 1.7 - 2.1 P 1.93 0.05 2.3 - 2.9 P 2.61 0.06 89Synermed 45 3.2 - 3.9 P 3.56 0.16 3.7 - 4.5 P 4.08 0.12 2.3 - 2.8 P 2.5 0.11 2.1 - 2.5 P 2.3 0.06 3.0 - 3.7 P 3.34 0.08 5Initial Grouping by Sensitivity or PrincipleBCP-bromcresol purple 46 2.5 - 3.1 P 2.82 0.12 2.8 - 3.5 P 3.14 0.13 1.9 - 2.3 P 2.13 0.1 1.8 - 2.2 P 1.96 0.08 2.4 - 2.9 P 2.65 0.12 119BCG-rapid (60 sec or less) 47 3.2 - 3.9 P 3.54 0.14 3.7 - 4.5 P 4.07 0.17 2.2 - 2.7 P 2.45 0.11 2.0 - 2.4 P 2.17 0.11 3.0 - 3.6 P 3.29 0.12 130BCG-bromcresol green 48 3.3 - 4.1 P 3.72 0.19 3.8 - 4.6 P 4.19 0.21 2.4 - 2.9 P 2.66 0.12 2.1 - 2.6 P 2.37 0.1 3.1 - 3.8 P 3.47 0.17 121Total PopulationWhole Population 49 3.0 - 3.7 P 3.37 0.41 3.4 - 4.2 P 3.81 0.5 2.2 - 2.7 P 2.42 0.24 2.0 - 2.4 P 2.17 0.19 2.8 - 3.5 P 3.14 0.37 371

Alkaline PhosphataseInitial Grouping by Reagent and Instrument

Abbott & Abbott Architect c, ci, i 1 172 - 320 P 246.1 13.1 214 - 397 P 305.2 15.2 78 - 145 P 111.4 5.9 53 - 99 P 76.1 4.6 147 - 274 P 210.4 11.5 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 170 - 316 P 242.7 15.0 211 - 391 P 301.0 19.6 78 - 145 P 111.6 6.8 53 - 99 P 75.8 5.1 147 - 272 P 209.5 12.8 19Beckman Coulter & Beck Coult Unicel DXC 3 150 - 279 P 214.8 8.5 186 - 345 P 265.1 10.4 68 - 126 P 97.2 4.1 47 - 87 P 66.9 3.2 129 - 240 P 184.5 7.4 17Beckman Coulter & Beck Olym AU 400/600/5400 4 144 - 267 P 205.4 17.2 179 - 333 P 256.4 20.7 64 - 119 P 91.6 7.2 44 - 82 P 63.0 5.2 121 - 225 P 173.4 13.1 5Beckman Coulter & Beckman AU 480 5 161 - 299 P 230.2 16.4 200 - 371 P 285.0 22.3 74 - 138 P 106.0 7.1 51 - 95 P 72.8 4.8 141 - 262 P 201.4 13.1 5Beckman Olympus & Beck Olym AU 400/600/5400 6 155 - 289 P 222.1 23.7 193 - 358 P 275.5 28.1 70 - 130 P 99.8 9.8 48 - 89 P 68.7 7.1 133 - 247 P 190.2 19.1 24Beckman Olympus & Beckman AU 480 7 151 - 281 P 216.0 12.1 187 - 347 P 266.7 14.4 68 - 126 P 97.0 5.6 46 - 86 P 66.3 3.8 129 - 240 P 184.5 10.3 21Beckman Olympus no DEA & Beck Olym AU400/600/5400 8 152 - 283 P 217.8 6.6 190 - 353 P 271.3 6.8 69 - 127 P 98.0 2.0 47 - 88 P 67.8 1.5 130 - 242 P 185.8 4.1 4

Carolina & Beck Olym AU 400/600/5400 9 139 - 258 P 198.8 5.6 169 - 314 P 241.8 8.6 63 - 118 P 90.6 3.6 44 - 82 P 63.0 3.0 120 - 223 P 171.6 7.5 5Carolina & Beckman Synchron CX3/7/9/L 10 138 - 257 P 197.4 18.8 172 - 320 P 246.4 21.6 63 - 117 P 90.2 7.6 44 - 82 P 63.2 5.2 122 - 227 P 174.6 14.9 5Horiba ABX & Horiba ABX 400 11 183 - 341 P 262.1 6.2 225 - 418 P 321.7 6.9 84 - 156 P 119.9 3.3 59 - 109 P 84.1 4.4 158 - 293 P 225.1 4.3 7Ortho Vitros & Ortho Vitros 3600, 5600 12 130 - 242 P 185.8 10.6 148 - 274 P 210.8 12.4 69 - 128 P 98.8 4.8 50 - 93 P 71.7 3.8 117 - 217 P 167.1 8.8 18Ortho Vitros & Ortho Vitros 5,1 FS 13 134 - 248 P 191.0 7.1 151 - 281 P 216.0 6.7 66 - 122 P 94.0 9.9 52 - 96 P 73.8 1.8 120 - 222 P 171.0 5.2 4Ortho Vitros & Ortho Vitros not DT or ECi 14 131 - 244 P 187.4 8.5 146 - 271 P 208.8 10.1 71 - 133 P 102.0 4.1 52 - 97 P 74.8 2.8 119 - 221 P 170.3 7.6 27Roche IFCC Gen. 2 & Roche Cobas 6000 15 163 - 303 P 232.8 9.2 201 - 373 P 287.0 10.1 74 - 137 P 105.2 4.7 51 - 94 P 72.6 3.6 140 - 259 P 199.4 7.2 5Roche IFCC Gen. 2 & Roche Cobas Integra 16 171 - 317 P 243.8 9.7 212 - 394 P 303.2 14.0 78 - 144 P 110.9 4.7 54 - 99 P 76.5 3.5 147 - 272 P 209.5 9.6 13Roche IFCC Gen. 2 & Roche e/c, 1XX, X000, Elecseries 17 164 - 304 P 234.2 12.7 204 - 379 P 291.5 14.0 75 - 139 P 106.6 5.2 51 - 96 P 73.5 3.7 141 - 263 P 202.1 9.0 15

Roche/Hitachi & Roche Cobas 6000 18 161 - 299 P 230.0 14.0 200 - 371 P 285.3 15.1 73 - 136 P 104.8 5.8 51 - 94 P 72.3 3.6 138 - 256 P 196.8 8.6 4SDI Biomed & SDI CA-240, 480 19 179 - 333 P 256.2 2.3 217 - 402 P 309.5 12.6 85 - 157 P 120.7 2.2 60 - 111 P 85.2 3.1 158 - 293 P 225.2 2.9 6Sekisui & Beck Olym AU 400/600/5400 20 187 - 347 P 266.8 20.4 228 - 423 P 325.6 25.0 84 - 157 P 120.4 10.3 58 - 108 P 83.2 5.8 159 - 295 P 226.8 19.8 5Siemens Dimension & Siemens Dimension EXL 21 185 - 344 P 264.3 8.8 230 - 427 P 328.6 10.6 83 - 154 P 118.1 3.8 57 - 105 P 80.9 3.1 159 - 295 P 226.6 7.6 38Siemens Dimension & Siemens Dimension Xpand 22 187 - 347 P 266.9 8.2 232 - 431 P 331.3 10.6 84 - 155 P 119.4 4.8 57 - 105 P 80.9 3.5 160 - 297 P 228.8 8.0 14Siemens Dimension IFCC & Siemens Dimension EXL 23 186 - 346 P 266.3 10.4 232 - 431 P 331.4 11.4 83 - 154 P 118.6 3.9 57 - 105 P 80.8 2.8 160 - 297 P 228.5 8.0 19Siemens Dimension IFCC & Siemens DimensionXpand 24 183 - 340 P 261.9 8.0 227 - 422 P 324.7 8.8 81 - 150 P 115.7 4.4 55 - 102 P 78.3 4.0 157 - 291 P 224.2 6.8 9

Synermed & Synermed IR500 25 180 - 334 P 256.8 24.4 218 - 405 P 311.5 27.5 82 - 152 P 117.0 10.4 56 - 105 P 80.5 7.8 152 - 281 P 216.5 20.0 4Initial Grouping by ReagentAbaxis Piccolo 26 143 - 265 P 204.0 41.7 178 - 331 P 254.8 47.0 66 - 122 P 94.0 14.7 47 - 87 P 67.3 8.0 126 - 233 P 179.5 29.0 4Abbott 27 172 - 320 P 246.1 13.1 214 - 397 P 305.2 15.2 78 - 145 P 111.4 5.9 53 - 99 P 76.1 4.6 147 - 274 P 210.4 11.5 19Alfa Wassermann 28 170 - 316 P 242.7 15.0 211 - 391 P 301.0 19.6 78 - 145 P 111.6 6.8 53 - 99 P 75.8 5.1 147 - 272 P 209.5 12.8 19Beckman Coulter 29 151 - 281 P 215.9 14.5 187 - 347 P 267.2 18.0 68 - 127 P 97.8 7.0 47 - 87 P 67.3 5.0 130 - 241 P 185.6 13.1 27Beckman Olympus 30 154 - 285 P 219.5 19.1 190 - 353 P 271.9 22.6 69 - 128 P 98.8 8.0 47 - 88 P 67.8 5.8 132 - 244 P 187.9 15.6 48Beckman Olympus no DEA 31 154 - 286 P 219.8 7.2 191 - 355 P 273.2 7.2 69 - 128 P 98.8 2.4 48 - 89 P 68.2 1.6 132 - 244 P 188.0 5.8 5Carolina 32 141 - 262 P 201.3 20.2 170 - 316 P 243.4 27.8 64 - 119 P 91.7 8.8 46 - 85 P 65.0 8.3 125 - 232 P 178.7 23.3 15Horiba ABX 33 183 - 341 P 262.1 6.2 225 - 418 P 321.7 6.9 84 - 156 P 119.9 3.3 59 - 109 P 84.1 4.4 158 - 293 P 225.1 4.3 7Ortho Vitros 34 131 - 243 P 186.9 9.2 147 - 273 P 210.1 10.8 70 - 130 P 100.2 5.5 51 - 96 P 73.5 3.4 118 - 220 P 168.9 8.0 51Pointe Scientific 35 165 - 306 P 235.2 39.4 205 - 381 P 293.0 53.0 75 - 140 P 107.4 19.7 52 - 97 P 74.8 13.9 142 - 264 P 202.9 37.2 11Roche IFCC Gen. 2 36 166 - 309 P 237.8 12.1 207 - 384 P 295.4 14.9 76 - 141 P 108.1 5.5 52 - 97 P 74.6 3.9 143 - 266 P 204.6 9.9 33Roche/Hitachi 37 161 - 300 P 230.6 18.5 203 - 376 P 289.4 18.6 74 - 138 P 106.0 6.7 51 - 95 P 73.3 3.7 140 - 261 P 200.6 12.0 7SDI Biomed 38 179 - 333 P 256.2 2.3 217 - 402 P 309.5 12.6 85 - 157 P 120.7 2.2 60 - 111 P 85.2 3.1 158 - 293 P 225.2 2.9 6Sekisui 39 177 - 329 P 252.9 27.9 217 - 404 P 310.6 31.9 80 - 149 P 114.8 12.1 55 - 103 P 79.1 7.8 151 - 281 P 216.4 22.7 8Siemens Dimension 40 186 - 345 P 265.5 8.5 231 - 429 P 330.2 10.7 83 - 154 P 118.7 4.0 57 - 105 P 81.0 3.0 160 - 296 P 228.0 7.9 58Siemens Dimension IFCC 41 185 - 344 P 264.9 9.7 230 - 428 P 329.1 10.9 82 - 153 P 117.7 4.2 56 - 104 P 80.1 3.4 159 - 295 P 227.1 7.7 29Synermed 42 180 - 334 P 256.8 24.4 218 - 405 P 311.5 27.5 82 - 152 P 117.0 10.4 56 - 105 P 80.5 7.8 152 - 281 P 216.5 20.0 4Initial Grouping by Sensitivity or PrincipleIFCC Standardized 43 159 - 295 P 227.1 25.9 196 - 365 P 280.5 32.4 72 - 134 P 103.3 12.0 50 - 93 P 71.3 8.5 137 - 254 P 195.7 22.3 190Vitros and related methods 44 131 - 243 P 186.9 9.2 147 - 273 P 210.1 10.8 70 - 130 P 100.2 5.5 51 - 96 P 73.5 3.4 118 - 220 P 168.9 8.0 51IFCC Gen 2 45 175 - 326 P 250.4 17.5 218 - 405 P 311.2 21.4 79 - 146 P 112.6 6.9 54 - 100 P 77.2 4.6 151 - 280 P 215.1 14.4 62Siemens and related 46 185 - 344 P 264.9 8.6 231 - 428 P 329.4 10.8 83 - 154 P 118.5 4.0 57 - 105 P 80.8 3.1 159 - 296 P 227.4 8.1 62Other P5P 47 180 - 334 P 256.8 24.4 218 - 405 P 311.5 27.5 82 - 152 P 117.0 10.4 56 - 105 P 80.5 7.8 152 - 281 P 216.5 20.0 4Total PopulationWhole Population 48 163 - 302 P 232.5 31.7 200 - 372 P 285.9 50.5 75 - 140 P 107.6 15.0 52 - 97 P 74.7 10.3 141 - 262 P 201.6 30.9 372

Aspartate Aminotransferase (AST or SGOT)Initial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 156 - 234 P 194.7 3.1 202 - 302 P 251.9 5.0 62 - 93 P 77.9 1.5 38 - 57 P 47.7 1.3 132 - 198 P 165.0 2.9 17Alfa Wassermann & Alfa Wasser Axcel/Alera 2 141 - 211 P 176.0 4.6 182 - 273 P 227.6 5.6 56 - 84 P 69.9 2.4 32 - 48 P 40.3 2.1 120 - 180 P 150.1 4.3 19Beckman Coulter & Beck Coult Unicel DXC 3 154 - 230 P 192.0 3.3 197 - 296 P 246.8 4.8 64 - 96 P 80.4 2.1 42 - 63 P 52.6 1.3 132 - 197 P 164.5 3.6 17Beckman Coulter & Beck Olym AU 400/600/5400 4 133 - 199 P 166.0 2.7 171 - 256 P 213.6 4.8 53 - 80 P 66.6 1.0 33 - 50 P 41.6 1.0 113 - 169 P 141.0 3.0 5Beckman Coulter & Beckman AU 480 5 136 - 204 P 169.8 30.0 183 - 274 P 228.5 24.6 57 - 85 P 71.0 5.9 35 - 53 P 44.0 2.8 121 - 182 P 151.3 12.4 6

Beckman Olympus & Beck Olym AU 400/600/5400 6 135 - 203 P 169.3 6.7 174 - 261 P 217.4 8.6 54 - 81 P 67.6 3.1 34 - 50 P 41.9 1.9 114 - 171 P 142.7 5.7 28Beckman Olympus & Beck Olympus AU 2700 7 140 - 209 P 174.5 8.2 179 - 269 P 224.3 11.1 56 - 84 P 69.8 3.8 35 - 52 P 43.5 2.2 118 - 177 P 147.3 7.5 4Beckman Olympus & Beckman AU 480 8 136 - 204 P 170.1 5.3 176 - 264 P 220.0 7.7 55 - 82 P 68.2 2.2 34 - 51 P 42.4 1.3 115 - 173 P 144.3 4.2 21Carolina & Beck Olym AU 400/600/5400 9 163 - 244 P 203.3 10.0 207 - 311 P 259.2 16.6 66 - 98 P 82.0 4.4 41 - 61 P 50.7 3.3 136 - 205 P 170.5 9.9 6Carolina & Beckman Synchron CX3/7/9/L 10 160 - 240 P 200.2 7.8 203 - 305 P 253.8 11.4 67 - 100 P 83.2 3.3 43 - 64 P 53.6 1.9 138 - 206 P 172.0 5.5 5Horiba ABX & Horiba ABX 400 11 159 - 238 P 198.3 4.1 204 - 307 P 255.6 5.3 64 - 96 P 80.0 1.2 40 - 59 P 49.4 1.7 135 - 203 P 169.0 3.0 7Ortho Vitros & Ortho Vitros 3600, 5600 12 173 - 259 P 216.1 5.4 234 - 351 P 292.4 9.5 64 - 96 P 80.4 2.2 39 - 59 P 48.9 0.9 144 - 216 P 179.8 5.5 18Ortho Vitros & Ortho Vitros 5,1 FS 13 176 - 263 P 219.5 5.5 238 - 358 P 298.0 6.7 66 - 100 P 83.0 2.9 40 - 60 P 50.3 1.3 148 - 221 P 184.5 5.4 4Ortho Vitros & Ortho Vitros not DT or ECi 14 173 - 259 P 215.8 6.5 233 - 349 P 290.7 10.2 64 - 97 P 80.5 2.4 39 - 59 P 49.1 1.8 146 - 218 P 181.9 6.2 27Pointe Scientific & Beck Olym AU 400/600/5400 15 161 - 242 P 201.5 7.6 206 - 309 P 257.8 9.5 65 - 98 P 81.5 4.5 40 - 60 P 50.3 1.9 136 - 203 P 169.5 6.2 4Roche Cobas & Roche Cobas 6000 16 155 - 232 P 193.6 6.9 198 - 298 P 248.1 8.0 62 - 92 P 76.9 3.1 38 - 57 P 47.6 1.8 131 - 196 P 163.2 5.6 9Roche Cobas & Roche Cobas Integra 17 156 - 235 P 195.6 5.9 202 - 302 P 252.0 7.7 63 - 94 P 78.5 2.3 38 - 58 P 48.1 1.5 133 - 199 P 166.2 4.5 14Roche Cobas & Roche e/c, 1XX, X000, Elec series 18 154 - 231 P 192.7 6.7 198 - 298 P 248.0 8.0 62 - 92 P 77.0 2.6 38 - 57 P 47.4 1.9 131 - 196 P 163.5 5.4 19SDI Biomed & SDI CA-240, 480 19 142 - 213 P 177.3 1.7 181 - 271 P 226.0 5.1 58 - 87 P 72.3 1.2 37 - 55 P 45.8 0.9 121 - 181 P 150.7 2.7 6Sekisui & Beck Olym AU 400/600/5400 20 144 - 216 P 179.8 4.9 185 - 277 P 231.0 6.1 57 - 85 P 71.0 1.2 35 - 52 P 43.5 1.1 122 - 182 P 152.0 4.2 4Siemens Dimension & Siemens Dimension EXL 21 158 - 237 P 197.7 5.3 205 - 307 P 256.2 5.5 62 - 93 P 77.3 2.3 38 - 57 P 47.2 1.9 134 - 201 P 167.8 3.9 50Siemens Dimension & Siemens Dimension Xpand 22 161 - 241 P 200.8 3.2 208 - 313 P 260.5 4.9 63 - 94 P 78.7 2.4 39 - 58 P 48.5 2.7 137 - 205 P 170.9 3.4 20Siemens P5P & Siemens Dimension EXL 23 156 - 234 P 195.4 3.4 204 - 305 P 254.4 4.8 62 - 92 P 77.0 0.8 37 - 56 P 46.4 1.0 134 - 201 P 167.3 4.3 7Siemens no P5P & Siemens Advia 24 159 - 239 P 198.8 7.0 205 - 307 P 255.8 9.7 64 - 97 P 80.5 4.0 40 - 60 P 50.3 2.8 135 - 203 P 169.3 6.1 4Sterling Diagnostic & Other spectrophotometers 25 126 - 188 P 157.0 10.6 151 - 226 P 188.5 8.4 59 - 89 P 74.0 3.8 38 - 57 P 47.8 2.3 119 - 178 P 148.5 1.5 4Sterling Diagnostic & Pointe Sci 180/Sterl 2000 26 128 - 193 P 160.5 13.9 154 - 232 P 193.0 14.6 61 - 91 P 75.8 6.6 38 - 57 P 47.3 5.9 114 - 171 P 142.3 11.9 4Synermed & Synermed IR500 27 175 - 262 P 218.4 7.7 225 - 338 P 281.4 12.8 76 - 114 P 95.0 0.0 56 - 84 P 69.8 6.4 150 - 224 P 187.0 9.5 5Vital Diagnostics Envoy & Vital Diagnostic Envoy 28 158 - 237 P 197.8 7.4 201 - 301 P 251.0 9.9 63 - 95 P 79.0 2.4 40 - 60 P 49.8 2.7 135 - 203 P 168.8 7.6 4Initial Grouping by ReagentAbbott Architect 29 156 - 234 P 194.7 3.1 202 - 302 P 251.9 5.0 62 - 93 P 77.9 1.5 38 - 57 P 47.7 1.3 132 - 198 P 165.0 2.9 17Alfa Wassermann 30 141 - 211 P 176.0 4.6 182 - 273 P 227.6 5.6 56 - 84 P 69.9 2.4 32 - 48 P 40.3 2.1 120 - 180 P 150.1 4.3 19Beckman Coulter 31 146 - 219 P 182.6 18.4 190 - 284 P 236.9 17.9 61 - 91 P 75.9 6.6 39 - 59 P 48.8 5.1 126 - 189 P 157.5 11.4 28Beckman Olympus 32 136 - 204 P 170.0 6.5 175 - 263 P 218.9 8.7 54 - 82 P 68.0 2.9 34 - 51 P 42.2 1.8 115 - 172 P 143.7 5.5 53Carolina 33 164 - 245 P 204.5 13.2 206 - 309 P 257.8 16.2 66 - 99 P 82.4 4.6 41 - 62 P 51.3 3.6 137 - 205 P 170.9 10.3 16Horiba ABX 34 159 - 238 P 198.3 4.1 204 - 307 P 255.6 5.3 64 - 96 P 80.0 1.2 40 - 59 P 49.4 1.7 135 - 203 P 169.0 3.0 7Ortho Vitros 35 173 - 260 P 216.4 6.2 234 - 350 P 292.0 9.7 65 - 97 P 80.7 2.5 39 - 59 P 49.2 1.6 145 - 218 P 181.3 5.9 51Pointe Scientific 36 160 - 239 P 199.4 6.1 205 - 307 P 256.1 7.7 63 - 95 P 79.0 7.5 41 - 61 P 51.1 2.2 133 - 199 P 166.1 9.7 9Roche Cobas 37 155 - 233 P 193.8 6.6 200 - 299 P 249.4 8.1 62 - 93 P 77.5 2.7 38 - 57 P 47.6 1.8 132 - 197 P 164.4 5.3 42SDI Biomed 38 142 - 213 P 177.3 1.7 181 - 271 P 226.0 5.1 58 - 87 P 72.3 1.2 37 - 55 P 45.8 0.9 121 - 181 P 150.7 2.7 6Sekisui 39 145 - 218 P 181.4 9.6 185 - 278 P 231.6 12.3 58 - 87 P 72.3 3.7 36 - 54 P 44.6 2.3 122 - 182 P 152.0 7.5 8Siemens Dimension 40 159 - 238 P 198.7 4.9 206 - 309 P 257.8 5.6 62 - 93 P 77.8 2.3 38 - 57 P 47.6 2.1 135 - 203 P 168.9 4.0 77Siemens P5P 41 159 - 238 P 198.4 6.0 206 - 309 P 257.7 7.0 63 - 94 P 78.7 3.7 38 - 58 P 48.0 3.3 136 - 204 P 169.9 6.1 10Siemens no P5P 42 159 - 239 P 199.0 6.3 206 - 309 P 257.4 9.3 64 - 96 P 80.2 3.7 40 - 60 P 49.8 2.6 136 - 204 P 169.6 5.5 5Sterling Diagnostic 43 127 - 191 P 158.8 12.5 153 - 229 P 190.8 12.2 60 - 90 P 74.9 5.5 38 - 57 P 47.5 4.5 116 - 174 P 144.8 9.7 8Synermed 44 176 - 264 P 220.4 15.4 226 - 340 P 283.0 19.1 69 - 104 P 86.5 8.5 44 - 66 P 55.0 5.0 147 - 220 P 183.7 11.5 7Vital Diagnostics Envoy 45 158 - 237 P 197.8 7.4 201 - 301 P 251.0 9.9 63 - 95 P 79.0 2.4 40 - 60 P 49.8 2.7 135 - 203 P 168.8 7.6 4Initial Grouping by Sensitivity or PrincipleOther no P5P 46 151 - 226 P 188.5 16.3 192 - 288 P 240.4 19.3 60 - 91 P 75.6 7.0 37 - 55 P 46.0 5.8 127 - 191 P 158.9 12.7 48Standardized methods 47 144 - 216 P 180.2 15.7 185 - 278 P 231.5 20.3 59 - 88 P 73.3 6.2 37 - 55 P 46.0 4.4 123 - 184 P 153.7 12.1 142Vitros and related 48 173 - 260 P 216.4 6.2 234 - 350 P 292.0 9.7 65 - 97 P 80.7 2.5 39 - 59 P 49.2 1.6 145 - 218 P 181.3 5.9 51Roche and related 49 155 - 233 P 193.8 6.6 200 - 299 P 249.4 8.1 62 - 93 P 77.5 2.7 38 - 57 P 47.6 1.8 132 - 197 P 164.4 5.3 42Siemens and related 50 159 - 238 P 198.7 5.1 206 - 309 P 257.7 6.0 62 - 94 P 78.0 2.7 38 - 57 P 47.8 2.4 135 - 203 P 169.1 4.4 92Other P5P 51 174 - 261 P 217.4 16.5 222 - 333 P 277.9 22.4 68 - 102 P 84.7 7.4 42 - 64 P 53.0 5.0 145 - 217 P 181.0 12.5 8Total PopulationWhole Population 52 156 - 234 P 194.8 44.7 200 - 300 P 249.7 25.5 61 - 92 P 76.7 6.5 38 - 57 P 47.4 4.7 131 - 196 P 163.2 14.7 384

Bicarbonate (Total CO2)Initial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 19 - 28 P 23.2 2.1 22 - 33 P 27.6 2.3 12 - 20 C 15.7 1.8 10 - 18 C 13.7 1.7 17 - 26 P 21.3 2.1 18Alfa Wassermann & Alfa Wasser Axcel/Alera 2 22 - 33 P 27.8 3.0 25 - 38 P 31.6 3.7 14 - 22 C 18.4 2.7 12 - 20 C 16.3 1.7 20 - 31 P 25.6 3.0 18Beckman Coulter & Beck Coult Unicel DXC 3 20 - 30 P 24.8 2.0 24 - 35 P 29.4 2.0 14 - 22 C 17.8 1.0 12 - 20 C 15.5 1.0 19 - 28 P 23.4 1.7 17Beckman Coulter & Beck Olym AU 400/600/5400 4 20 - 30 P 24.6 3.7 24 - 35 P 29.4 4.1 13 - 21 C 16.8 2.6 10 - 18 C 14.4 2.6 18 - 27 P 22.6 3.7 5Beckman Coulter & Beckman AU 480 5 19 - 28 P 23.6 3.3 23 - 34 P 28.2 3.7 12 - 20 C 16.0 2.5 10 - 18 C 13.8 1.9 17 - 26 P 21.6 3.1 5Beckman Olympus & Beck Olym AU 400/600/5400 6 21 - 31 P 26.1 2.2 25 - 37 P 31.0 2.1 13 - 21 C 17.4 1.3 11 - 19 C 15.4 1.1 19 - 29 P 24.1 1.6 28Beckman Olympus & Beck Olympus AU 2700 7 21 - 32 P 26.5 1.5 25 - 37 P 31.0 1.6 14 - 22 C 18.0 1.6 12 - 20 C 15.5 1.7 20 - 30 P 25.0 2.1 4Beckman Olympus & Beckman AU 480 8 21 - 32 P 26.7 1.2 25 - 37 P 31.2 1.3 14 - 22 C 18.0 1.2 11 - 19 C 14.9 1.6 19 - 28 P 23.6 1.3 21Carolina & Beck Olym AU 400/600/5400 9 22 - 32 P 27.0 2.1 24 - 37 P 30.6 1.9 15 - 23 C 18.6 1.5 12 - 20 C 16.3 1.6 20 - 30 P 24.6 2.5 7

Carolina & Beckman Synchron CX3/7/9/L 10 20 - 30 P 25.2 2.1 24 - 36 P 29.8 1.8 15 - 23 C 19.2 1.0 13 - 21 C 17.4 1.0 19 - 29 P 24.0 1.1 5Horiba ABX & Horiba ABX 400 11 21 - 31 P 25.7 1.2 24 - 36 P 29.6 1.2 14 - 22 C 18.1 1.4 11 - 19 C 15.4 1.7 18 - 27 P 22.9 1.1 7Medica & Medica Easy RA 12 22 - 32 P 27.0 1.7 24 - 37 P 30.5 2.2 13 - 21 C 17.1 2.6 11 - 19 C 14.6 2.2 18 - 27 P 22.3 2.6 8Ortho Vitros & Ortho Vitros 3600, 5600 13 20 - 30 P 24.7 1.9 23 - 35 P 29.3 1.8 12 - 20 C 16.4 1.3 10 - 18 C 14.1 1.0 18 - 26 P 21.9 1.2 17Ortho Vitros & Ortho Vitros not DT or ECi 14 20 - 30 P 25.0 1.5 23 - 35 P 28.8 1.8 12 - 20 C 15.9 1.0 9 - 17 C 13.4 1.0 17 - 25 P 21.1 1.2 23Ortho Vitros UV/unc & Ortho Vitros not DT or ECi 15 21 - 31 P 25.8 1.1 24 - 36 P 30.0 1.4 13 - 21 C 17.0 0.7 10 - 18 C 14.3 0.4 18 - 26 P 22.0 0.7 4Roche Cobas & Roche Cobas 6000 16 20 - 30 P 25.0 1.1 23 - 35 P 29.3 1.2 13 - 21 C 16.6 1.1 11 - 19 C 14.6 1.0 18 - 27 P 22.3 1.2 8Roche Cobas & Roche Cobas Integra 17 20 - 30 P 24.7 1.1 23 - 34 P 28.5 1.1 13 - 21 C 16.5 0.8 10 - 18 C 14.4 1.1 17 - 26 P 21.6 1.2 10Roche Cobas & Roche e/c, 1XX, X000, Elec series 18 19 - 28 P 23.5 1.9 22 - 33 P 27.4 2.2 12 - 20 C 15.5 1.5 9 - 17 C 13.3 1.6 16 - 25 P 20.5 2.0 16SDI Biomed & SDI CA-240, 480 19 21 - 32 P 26.6 1.6 26 - 38 P 32.0 1.1 15 - 23 C 18.6 0.5 14 - 22 C 17.6 0.8 20 - 30 P 25.2 1.2 5Siemens ECO2 & Siemens Dim RxL, RxL Max 20 22 - 32 P 27.0 2.9 24 - 36 P 30.0 0.7 14 - 22 C 18.0 0.7 12 - 20 C 15.8 1.1 19 - 28 P 23.3 1.5 4Siemens ECO2 & Siemens Dimension EXL 21 22 - 34 P 28.1 2.0 26 - 39 P 32.3 2.3 15 - 23 C 19.3 1.6 13 - 21 C 17.2 1.2 20 - 31 P 25.6 2.0 57Siemens ECO2 & Siemens Dimension Xpand 22 23 - 34 P 28.2 1.6 26 - 39 P 32.5 1.9 16 - 24 C 19.6 1.7 14 - 22 C 17.6 1.3 21 - 31 P 26.0 1.6 22Synermed & Synermed IR500 23 23 - 35 P 28.8 2.4 27 - 41 P 34.3 2.3 16 - 24 C 19.5 2.3 13 - 21 C 16.8 2.4 22 - 33 P 27.3 2.5 4Vital Diagnostics Envoy & Vital Diagnostic Envoy 24 20 - 31 P 25.5 1.7 24 - 36 P 29.8 2.4 12 - 20 C 15.5 1.7 10 - 18 C 13.5 1.1 18 - 27 P 22.5 2.6 4Initial Grouping by ReagentAbaxis Piccolo 25 21 - 32 P 26.5 0.9 24 - 36 P 29.8 1.9 12 - 20 C 15.8 0.4 9 - 17 C 13.0 0.0 19 - 28 P 23.5 1.1 4Abbott Architect 26 19 - 28 P 23.2 2.1 22 - 33 P 27.6 2.3 12 - 20 C 15.7 1.8 10 - 18 C 13.7 1.7 17 - 26 P 21.3 2.1 18Alfa Wassermann 27 22 - 33 P 27.8 3.0 25 - 38 P 31.6 3.7 14 - 22 C 18.4 2.7 12 - 20 C 16.3 1.7 20 - 31 P 25.6 3.0 18Beckman Coulter 28 20 - 30 P 24.6 2.7 23 - 35 P 29.1 2.9 13 - 21 C 17.3 1.9 11 - 19 C 15.0 1.8 18 - 27 P 22.9 2.6 27Beckman Olympus 29 21 - 32 P 26.4 1.9 25 - 37 P 31.1 1.8 14 - 22 C 17.7 1.3 11 - 19 C 15.2 1.4 19 - 29 P 24.0 1.6 53Carolina 30 21 - 31 P 25.9 2.7 24 - 36 P 30.0 2.7 14 - 22 C 18.4 2.0 12 - 20 C 16.4 2.0 19 - 29 P 24.0 2.6 17Horiba ABX 31 21 - 31 P 25.7 1.2 24 - 36 P 29.6 1.2 14 - 22 C 18.1 1.4 11 - 19 C 15.4 1.7 18 - 27 P 22.9 1.1 7Medica 32 22 - 32 P 27.0 1.7 24 - 37 P 30.5 2.2 13 - 21 C 17.1 2.6 11 - 19 C 14.6 2.2 18 - 27 P 22.3 2.6 8Ortho Vitros 33 20 - 30 P 25.0 1.7 23 - 35 P 29.1 1.8 12 - 20 C 16.3 1.3 10 - 18 C 13.9 1.3 17 - 26 P 21.6 1.4 45Ortho Vitros UV/unc 34 20 - 29 P 24.5 2.3 23 - 35 P 29.2 1.9 13 - 21 C 16.5 1.0 10 - 18 C 13.8 0.9 17 - 26 P 21.5 1.3 6Pointe Scientific 35 20 - 30 P 25.4 2.6 23 - 35 P 29.0 3.0 14 - 22 C 17.9 2.0 11 - 19 C 15.4 2.1 18 - 27 P 22.6 2.9 7Roche Cobas 36 19 - 29 P 24.2 1.7 23 - 34 P 28.2 1.8 12 - 20 C 16.1 1.3 10 - 18 C 13.9 1.5 17 - 26 P 21.3 1.7 34SDI Biomed 37 21 - 32 P 26.6 1.6 26 - 38 P 32.0 1.1 15 - 23 C 18.6 0.5 14 - 22 C 17.6 0.8 20 - 30 P 25.2 1.2 5Sekisui 38 19 - 29 P 24.0 1.8 22 - 33 P 27.8 2.5 12 - 20 C 15.5 1.8 10 - 18 C 13.5 2.4 17 - 26 P 21.4 1.2 8Siemens ECO2 39 22 - 34 P 28.0 1.9 26 - 39 P 32.2 2.3 15 - 23 C 19.3 1.6 13 - 21 C 17.3 1.3 20 - 31 P 25.6 2.0 87Synermed 40 23 - 35 P 28.8 2.4 27 - 41 P 34.3 2.3 16 - 24 C 19.5 2.3 13 - 21 C 16.8 2.4 22 - 33 P 27.3 2.5 4Vital Diagnostics Envoy 41 20 - 31 P 25.5 1.7 24 - 36 P 29.8 2.4 12 - 20 C 15.5 1.7 10 - 18 C 13.5 1.1 18 - 27 P 22.5 2.6 4Initial Grouping by Sensitivity or PrincipleUV/kinetic (rate) methods 42 20 - 30 P 24.7 1.9 23 - 35 P 28.8 2.2 12 - 20 C 16.4 1.5 10 - 18 C 14.3 1.8 18 - 26 P 22.0 2.1 43Diluted ISE results 43 20 - 29 P 24.4 2.7 23 - 35 P 28.8 2.8 13 - 21 C 16.8 2.1 11 - 19 C 14.6 1.9 18 - 27 P 22.3 2.7 55UV/bichromatic methods 44 21 - 32 P 26.6 2.2 25 - 37 P 31.1 2.4 14 - 22 C 17.9 1.8 12 - 20 C 15.5 1.6 19 - 29 P 24.2 2.1 78UV/uncorrected methods 45 21 - 31 P 25.8 2.8 24 - 36 P 29.8 3.1 14 - 22 C 17.6 2.3 11 - 19 C 15.2 2.5 18 - 28 P 23.1 3.2 57Undiluted ISE results 46 20 - 30 P 25.0 1.7 23 - 35 P 29.1 1.8 12 - 20 C 16.3 1.3 10 - 18 C 13.9 1.3 17 - 26 P 21.6 1.4 45All other methods 47 22 - 34 P 28.0 1.9 26 - 39 P 32.2 2.3 15 - 23 C 19.3 1.6 13 - 21 C 17.3 1.3 20 - 31 P 25.6 2.0 87Total PopulationWhole Population 48 21 - 31 P 25.9 2.9 24 - 36 P 30.1 3.2 14 - 22 C 17.6 2.3 11 - 19 C 15.3 2.2 19 - 28 P 23.4 2.9 368

Bilirubin, TotalInitial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 2.2 - 3.3 P 2.72 0.25 2.8 - 4.2 P 3.46 0.3 0.8 - 1.6 C 1.18 0.15 0.3 - 1.1 C 0.72 0.09 1.8 - 2.7 P 2.27 0.12 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 2.4 - 3.6 P 3.03 0.24 3.1 - 4.7 P 3.92 0.26 1.0 - 1.8 C 1.36 0.1 0.5 - 1.3 C 0.89 0.1 2.1 - 3.2 P 2.65 0.18 20Beckman Coulter & Beck Coult Unicel DXC 3 2.5 - 3.8 P 3.14 0.25 3.2 - 4.8 P 3.96 0.31 1.0 - 1.9 C 1.45 0.13 0.6 - 1.4 C 0.97 0.12 2.1 - 3.2 P 2.66 0.21 17Beckman Coulter & Beck Olym AU 400/600/5400 4 2.3 - 3.4 P 2.84 0.1 2.8 - 4.3 P 3.56 0.16 0.8 - 1.6 C 1.24 0.05 0.4 - 1.2 C 0.84 0.05 1.9 - 2.9 P 2.42 0.13 5Beckman Coulter & Beckman AU 480 5 2.2 - 3.3 P 2.74 0.08 2.8 - 4.1 P 3.44 0.15 0.8 - 1.6 C 1.22 0.04 0.4 - 1.2 C 0.8 0.0 1.9 - 2.9 P 2.38 0.07 5Beckman Olympus & Beck Olym AU 400/600/5400 6 2.3 - 3.4 P 2.86 0.15 2.9 - 4.3 P 3.59 0.19 0.8 - 1.6 C 1.24 0.07 0.4 - 1.2 C 0.84 0.07 2.0 - 2.9 P 2.44 0.14 28Beckman Olympus & Beck Olympus AU 2700 7 2.2 - 3.3 P 2.78 0.15 2.8 - 4.2 P 3.53 0.22 0.8 - 1.6 C 1.2 0.07 0.4 - 1.2 C 0.8 0.07 1.9 - 2.9 P 2.38 0.15 4Beckman Olympus & Beckman AU 480 8 2.3 - 3.5 P 2.89 0.15 2.9 - 4.4 P 3.67 0.18 0.9 - 1.7 C 1.27 0.08 0.5 - 1.3 C 0.85 0.07 2.0 - 3.0 P 2.48 0.12 21Carolina & Beck Olym AU 400/600/5400 9 2.6 - 3.8 P 3.2 0.45 3.0 - 4.5 P 3.77 0.26 1.0 - 1.8 C 1.4 0.24 0.6 - 1.4 C 1.0 0.08 2.0 - 3.0 P 2.5 0.37 4Carolina & Beckman Synchron CX3/7/9/L 10 2.2 - 3.3 P 2.78 0.12 2.9 - 4.3 P 3.62 0.07 1.0 - 1.8 C 1.36 0.2 0.5 - 1.3 C 0.94 0.1 2.0 - 3.0 P 2.46 0.08 5Horiba ABX & Horiba ABX 400 11 2.2 - 3.2 P 2.7 0.19 2.8 - 4.2 P 3.47 0.2 0.7 - 1.5 C 1.11 0.1 0.3 - 1.1 C 0.7 0.08 1.8 - 2.7 P 2.29 0.1 7Ortho Vitros & Ortho Vitros 3600, 5600 12 2.4 - 3.6 P 2.97 0.22 3.1 - 4.6 P 3.84 0.27 0.8 - 1.6 C 1.21 0.08 0.4 - 1.2 C 0.78 0.06 2.0 - 3.0 P 2.54 0.2 18Ortho Vitros & Ortho Vitros 5,1 FS 13 2.3 - 3.4 P 2.83 0.23 2.9 - 4.4 P 3.65 0.27 0.8 - 1.6 C 1.18 0.13 0.4 - 1.2 C 0.75 0.09 2.0 - 2.9 P 2.45 0.21 4Ortho Vitros & Ortho Vitros not DT or ECi 14 2.3 - 3.5 P 2.92 0.16 3.0 - 4.5 P 3.73 0.19 0.9 - 1.7 C 1.25 0.09 0.4 - 1.2 C 0.83 0.09 2.0 - 3.0 P 2.5 0.12 27Roche Cobas & Roche Cobas 6000 15 2.0 - 3.1 P 2.56 0.13 2.6 - 3.9 P 3.26 0.18 0.7 - 1.5 C 1.07 0.07 0.3 - 1.1 C 0.74 0.12 1.7 - 2.6 P 2.17 0.13 7Roche Cobas & Roche Cobas Integra 16 1.9 - 2.8 P 2.36 0.13 2.4 - 3.6 P 3.04 0.2 0.6 - 1.4 C 1.01 0.09 0.3 - 1.1 C 0.66 0.05 1.6 - 2.4 P 2.04 0.1 9Roche Cobas & Roche e/c, 1XX, X000, Elec series 17 2.0 - 3.0 P 2.52 0.2 2.6 - 3.9 P 3.26 0.26 0.6 - 1.4 C 1.04 0.11 0.3 - 1.1 C 0.67 0.08 1.7 - 2.6 P 2.17 0.18 9

Roche Cobas BILTS & Roche Cobas Integra 18 1.9 - 2.8 P 2.34 0.14 2.5 - 3.7 P 3.12 0.21 0.6 - 1.4 C 1.02 0.07 0.3 - 1.1 C 0.66 0.05 1.6 - 2.5 P 2.06 0.1 5Roche Cobas BILTS & Roche e/c, 1XX, X000, Elecseries 19 2.0 - 3.0 P 2.53 0.09 2.6 - 3.9 P 3.23 0.12 0.6 - 1.4 C 1.03 0.05 0.3 - 1.1 C 0.67 0.05 1.7 - 2.6 P 2.15 0.08 10

SDI Biomed & SDI CA-240, 480 20 2.2 - 3.3 P 2.78 0.04 2.8 - 4.3 P 3.55 0.05 0.9 - 1.7 C 1.33 0.05 0.4 - 1.2 C 0.83 0.05 1.9 - 2.9 P 2.4 0.08 6Sekisui & Beck Olym AU 400/600/5400 21 1.8 - 2.7 P 2.25 0.11 2.4 - 3.5 P 2.95 0.14 0.5 - 1.3 C 0.93 0.07 0.2 - 1.0 C 0.62 0.04 1.5 - 2.3 C 1.93 0.11 6Siemens Dimension & Siemens Dim RxL, RxL Max 22 2.1 - 3.1 P 2.6 0.25 2.7 - 4.0 P 3.35 0.34 0.7 - 1.5 C 1.05 0.11 0.3 - 1.1 C 0.7 0.1 1.8 - 2.6 P 2.2 0.19 4Siemens Dimension & Siemens Dimension EXL 23 2.1 - 3.2 P 2.65 0.14 2.7 - 4.1 P 3.42 0.18 0.7 - 1.5 C 1.1 0.07 0.3 - 1.1 C 0.71 0.05 1.8 - 2.7 P 2.28 0.12 56Siemens Dimension & Siemens Dimension Xpand 24 2.1 - 3.2 P 2.63 0.19 2.7 - 4.1 P 3.41 0.22 0.7 - 1.5 C 1.11 0.09 0.3 - 1.1 C 0.71 0.08 1.8 - 2.7 P 2.27 0.15 23Synermed & Synermed IR500 25 2.7 - 4.1 P 3.4 0.27 3.4 - 5.1 P 4.22 0.39 1.1 - 1.9 C 1.48 0.16 0.6 - 1.4 C 0.98 0.11 2.2 - 3.4 P 2.8 0.28 4Initial Grouping by ReagentAbbott Architect 26 2.2 - 3.3 P 2.72 0.25 2.8 - 4.2 P 3.46 0.3 0.8 - 1.6 C 1.18 0.15 0.3 - 1.1 C 0.72 0.09 1.8 - 2.7 P 2.27 0.12 19Alfa Wassermann 27 2.4 - 3.6 P 3.03 0.24 3.1 - 4.7 P 3.92 0.26 1.0 - 1.8 C 1.36 0.1 0.5 - 1.3 C 0.89 0.1 2.1 - 3.2 P 2.65 0.18 20Beckman Coulter 28 2.4 - 3.6 P 3.01 0.27 3.0 - 4.5 P 3.79 0.35 1.0 - 1.8 C 1.37 0.15 0.5 - 1.3 C 0.91 0.12 2.0 - 3.1 P 2.56 0.22 27Beckman Olympus 29 2.3 - 3.4 P 2.87 0.15 2.9 - 4.3 P 3.62 0.2 0.9 - 1.7 C 1.25 0.08 0.4 - 1.2 C 0.84 0.07 2.0 - 2.9 P 2.45 0.14 53Carolina 30 2.4 - 3.6 P 2.97 0.31 3.0 - 4.5 P 3.71 0.17 1.0 - 1.8 C 1.4 0.2 0.5 - 1.3 C 0.94 0.14 2.0 - 3.0 P 2.53 0.22 14Horiba ABX 31 2.2 - 3.2 P 2.7 0.19 2.8 - 4.2 P 3.47 0.2 0.7 - 1.5 C 1.11 0.1 0.3 - 1.1 C 0.7 0.08 1.8 - 2.7 P 2.29 0.1 7Ortho Vitros 32 2.3 - 3.5 P 2.92 0.19 3.0 - 4.5 P 3.75 0.24 0.8 - 1.6 C 1.23 0.09 0.4 - 1.2 C 0.8 0.08 2.0 - 3.0 P 2.5 0.16 51Pointe Scientific 33 2.3 - 3.5 P 2.9 0.3 2.9 - 4.3 P 3.61 0.28 0.8 - 1.6 C 1.18 0.15 0.4 - 1.2 C 0.8 0.12 2.0 - 3.1 P 2.55 0.26 11Roche Cobas 34 2.0 - 3.0 P 2.47 0.18 2.5 - 3.8 P 3.18 0.24 0.6 - 1.4 C 1.04 0.09 0.3 - 1.1 C 0.68 0.09 1.7 - 2.5 P 2.12 0.15 25Roche Cobas BILTS 35 2.0 - 3.0 P 2.5 0.16 2.6 - 3.9 P 3.22 0.18 0.6 - 1.4 C 1.04 0.07 0.3 - 1.1 C 0.68 0.05 1.7 - 2.6 P 2.14 0.11 17SDI Biomed 36 2.2 - 3.3 P 2.78 0.04 2.8 - 4.3 P 3.55 0.05 0.9 - 1.7 C 1.33 0.05 0.4 - 1.2 C 0.83 0.05 1.9 - 2.9 P 2.4 0.08 6Sekisui 37 1.9 - 2.8 P 2.33 0.29 2.4 - 3.6 P 3.01 0.3 0.6 - 1.4 C 0.99 0.16 0.2 - 1.0 C 0.64 0.11 1.6 - 2.4 P 2.0 0.22 9Siemens Dimension 38 2.1 - 3.2 P 2.65 0.16 2.7 - 4.1 P 3.42 0.2 0.7 - 1.5 C 1.11 0.08 0.3 - 1.1 C 0.71 0.06 1.8 - 2.7 P 2.27 0.13 87Siemens caffeine 39 2.2 - 3.3 P 2.75 0.21 2.8 - 4.2 P 3.48 0.24 0.7 - 1.5 C 1.15 0.05 0.4 - 1.2 C 0.75 0.05 1.9 - 2.8 P 2.35 0.11 4Synermed 40 2.7 - 4.0 P 3.34 0.27 3.3 - 5.0 P 4.14 0.39 1.0 - 1.8 C 1.44 0.16 0.6 - 1.4 C 0.96 0.1 2.2 - 3.3 P 2.75 0.26 5Initial Grouping by Sensitivity or PrincipleOxidation 41 2.4 - 3.6 P 3.0 0.4 3.0 - 4.5 P 3.74 0.51 0.9 - 1.7 C 1.31 0.18 0.5 - 1.3 C 0.91 0.1 2.0 - 3.0 P 2.49 0.32 10Diazonium ion 42 2.3 - 3.4 P 2.86 0.23 2.9 - 4.4 P 3.63 0.26 0.8 - 1.6 C 1.24 0.13 0.4 - 1.2 C 0.81 0.1 2.0 - 2.9 P 2.44 0.18 147Diazo/DMSO 43 2.4 - 3.6 P 2.97 0.3 3.0 - 4.5 P 3.78 0.3 0.9 - 1.7 C 1.27 0.15 0.5 - 1.3 C 0.85 0.12 2.1 - 3.1 P 2.57 0.23 37Diazo/caffeine-benzoate 44 2.2 - 3.3 P 2.71 0.27 2.8 - 4.2 P 3.47 0.32 0.7 - 1.5 C 1.15 0.16 0.4 - 1.2 C 0.75 0.12 1.8 - 2.8 P 2.31 0.22 127Diazo/surfactant 45 2.0 - 3.1 P 2.55 0.22 2.6 - 3.9 P 3.27 0.26 0.7 - 1.5 C 1.08 0.14 0.3 - 1.1 C 0.7 0.1 1.8 - 2.6 P 2.19 0.19 53Direct spectrophotometric 46 2.3 - 3.4 P 2.84 0.29 2.9 - 4.4 P 3.66 0.19 0.6 - 1.4 C 1.02 0.26 0.3 - 1.1 C 0.67 0.05 1.9 - 2.8 P 2.32 0.23 5Total PopulationWhole Population 47 2.2 - 3.3 P 2.78 0.36 2.8 - 4.2 P 3.54 0.39 0.8 - 1.6 C 1.19 0.17 0.4 - 1.2 C 0.78 0.14 1.9 - 2.8 P 2.37 0.27 379

CalciumInitial Grouping by Reagent and InstrumentAbbott & Abbott Architect c, ci, i 1 10.1 - 12.1 C 11.1 0.16 11.4 - 13.4 C 12.44 0.13 7.3 - 9.3 C 8.31 0.1 6.7 - 8.7 C 7.67 0.09 9.4 - 11.4 C 10.39 0.13 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 9.9 - 11.9 C 10.94 0.21 11.3 - 13.3 C 12.26 0.23 7.7 - 9.7 C 8.65 0.16 7.0 - 9.0 C 8.02 0.17 9.6 - 11.6 C 10.62 0.2 20Beckman Coulter & Beck Coult Unicel DXC 3 9.9 - 11.9 C 10.9 0.23 11.2 - 13.2 C 12.15 0.21 7.5 - 9.5 C 8.52 0.18 6.9 - 8.9 C 7.92 0.13 9.3 - 11.3 C 10.33 0.12 6Beckman Coulter & Beck Olym AU 400/600/5400 4 10.0 - 12.0 C 11.0 0.17 11.2 - 13.2 C 12.23 0.25 7.3 - 9.3 C 8.3 0.24 6.8 - 8.8 C 7.75 0.21 9.3 - 11.3 C 10.3 0.24 6Beckman Coulter & Beckman AU 480 5 9.8 - 11.8 C 10.83 0.2 11.1 - 13.1 C 12.08 0.2 7.3 - 9.3 C 8.27 0.15 6.7 - 8.7 C 7.67 0.17 9.2 - 11.2 C 10.2 0.14 6Beckman ISE & Beck Coult Unicel DXC 6 9.9 - 11.9 C 10.88 0.18 11.1 - 13.1 C 12.06 0.16 7.6 - 9.6 C 8.55 0.15 6.9 - 8.9 C 7.93 0.11 9.3 - 11.3 C 10.3 0.13 11Beckman Olympus Arsenazo & Beck Olym AU400/600/5400 7 9.9 - 11.9 C 10.85 0.3 11.1 - 13.1 C 12.1 0.34 7.3 - 9.3 C 8.25 0.24 6.6 - 8.6 C 7.63 0.21 9.2 - 11.2 C 10.22 0.28 26

Beckman Olympus Arsenazo & Beckman AU 480 8 9.9 - 11.9 C 10.88 0.23 11.2 - 13.2 C 12.16 0.25 7.4 - 9.4 C 8.36 0.24 6.7 - 8.7 C 7.72 0.22 9.3 - 11.3 C 10.34 0.32 20Carolina & Beck Olym AU 400/600/5400 9 10.1 - 12.1 C 11.13 0.13 11.0 - 13.0 C 11.97 0.35 7.2 - 9.2 C 8.23 0.18 6.5 - 8.5 C 7.48 0.29 9.2 - 11.2 C 10.18 0.2 4Carolina & Beckman Synchron CX3/7/9/L 10 9.7 - 11.7 C 10.72 0.41 10.9 - 12.9 C 11.92 0.42 7.5 - 9.5 C 8.46 0.29 6.8 - 8.8 C 7.82 0.15 9.5 - 11.5 C 10.46 0.24 5Horiba ABX & Horiba ABX 400 11 10.1 - 12.1 C 11.09 0.2 11.3 - 13.3 C 12.26 0.32 7.3 - 9.3 C 8.33 0.15 6.6 - 8.6 C 7.57 0.12 9.3 - 11.3 C 10.34 0.2 7Medica Easy RA & Medica Easy RA 12 9.8 - 11.8 C 10.79 0.29 10.9 - 12.9 C 11.94 0.25 7.2 - 9.2 C 8.2 0.33 6.5 - 8.5 C 7.51 0.17 9.2 - 11.2 C 10.15 0.22 8Ortho Vitros & Ortho Vitros 3600, 5600 13 10.2 - 12.2 C 11.17 0.17 11.3 - 13.3 C 12.32 0.22 7.5 - 9.5 C 8.52 0.16 6.8 - 8.8 C 7.83 0.17 9.5 - 11.5 C 10.52 0.17 18Ortho Vitros & Ortho Vitros 5,1 FS 14 10.2 - 12.2 C 11.17 0.05 11.4 - 13.4 C 12.37 0.24 7.6 - 9.6 C 8.6 0.0 7.0 - 9.0 C 7.97 0.05 9.6 - 11.6 C 10.6 0.0 4Ortho Vitros & Ortho Vitros not DT or ECi 15 10.2 - 12.2 C 11.2 0.23 11.4 - 13.4 C 12.37 0.21 7.5 - 9.5 C 8.54 0.17 6.9 - 8.9 C 7.87 0.18 9.6 - 11.6 C 10.58 0.18 27Roche Cobas & Roche Cobas 6000 16 10.2 - 12.2 C 11.16 0.24 11.5 - 13.5 C 12.48 0.26 7.5 - 9.5 C 8.53 0.25 6.8 - 8.8 C 7.84 0.2 9.5 - 11.5 C 10.51 0.31 8Roche Cobas & Roche Cobas Integra 17 10.3 - 12.3 C 11.31 0.25 11.6 - 13.6 C 12.59 0.22 7.6 - 9.6 C 8.59 0.21 6.9 - 8.9 C 7.88 0.18 9.6 - 11.6 C 10.63 0.21 14Roche Cobas & Roche e/c, 1XX, X000, Elec series 18 10.2 - 12.2 C 11.16 0.21 11.5 - 13.5 C 12.5 0.25 7.5 - 9.5 C 8.47 0.17 6.8 - 8.8 C 7.83 0.19 9.5 - 11.5 C 10.53 0.22 19SDI Biomed & SDI CA-240, 480 19 10.1 - 12.1 C 11.1 0.14 11.4 - 13.4 C 12.38 0.12 7.6 - 9.6 C 8.6 0.06 7.0 - 9.0 C 8.04 0.14 9.3 - 11.3 C 10.32 0.04 5Sekisui & Beck Olym AU 400/600/5400 20 9.8 - 11.8 C 10.78 0.33 10.8 - 12.8 C 11.8 0.24 7.3 - 9.3 C 8.3 0.13 6.6 - 8.6 C 7.63 0.05 9.1 - 11.1 C 10.1 0.24 6Siemens OCPC & Siemens Dim RxL, RxL Max 21 9.9 - 11.9 C 10.85 0.27 11.2 - 13.2 C 12.18 0.35 7.2 - 9.2 C 8.2 0.23 6.6 - 8.6 C 7.57 0.28 9.1 - 11.1 C 10.1 0.27 4Siemens OCPC & Siemens Dimension EXL 22 9.9 - 11.9 C 10.92 0.27 11.3 - 13.3 C 12.25 0.3 7.3 - 9.3 C 8.28 0.18 6.6 - 8.6 C 7.62 0.18 9.2 - 11.2 C 10.24 0.23 58Siemens OCPC & Siemens Dimension Xpand 23 9.8 - 11.8 C 10.83 0.14 11.1 - 13.1 C 12.14 0.21 7.3 - 9.3 C 8.26 0.17 6.6 - 8.6 C 7.62 0.19 9.2 - 11.2 C 10.2 0.18 23Synermed & Synermed IR500 24 10.1 - 12.1 C 11.07 0.33 11.2 - 13.2 C 12.23 0.53 7.5 - 9.5 C 8.45 0.45 7.0 - 9.0 C 8.0 0.29 9.2 - 11.2 C 10.23 0.38 4

Initial Grouping by ReagentAbaxis Piccolo 25 9.7 - 11.7 C 10.73 0.15 11.0 - 13.0 C 11.95 0.35 7.5 - 9.5 C 8.45 0.05 6.9 - 8.9 C 7.85 0.34 9.3 - 11.3 C 10.33 0.26 4Abbott 26 10.1 - 12.1 C 11.1 0.16 11.4 - 13.4 C 12.44 0.13 7.3 - 9.3 C 8.31 0.1 6.7 - 8.7 C 7.67 0.09 9.4 - 11.4 C 10.39 0.13 19Alfa Wassermann 27 9.9 - 11.9 C 10.94 0.21 11.3 - 13.3 C 12.26 0.23 7.7 - 9.7 C 8.65 0.16 7.0 - 9.0 C 8.02 0.17 9.6 - 11.6 C 10.62 0.2 20Beckman Coulter 28 9.9 - 11.9 C 10.91 0.21 11.2 - 13.2 C 12.16 0.23 7.4 - 9.4 C 8.36 0.22 6.8 - 8.8 C 7.78 0.2 9.3 - 11.3 C 10.28 0.19 18Beckman ISE 29 9.9 - 11.9 C 10.88 0.18 11.1 - 13.1 C 12.06 0.16 7.6 - 9.6 C 8.55 0.15 6.9 - 8.9 C 7.93 0.11 9.3 - 11.3 C 10.3 0.13 11Beckman Olympus Arsenazo 30 9.9 - 11.9 C 10.87 0.27 11.1 - 13.1 C 12.13 0.3 7.3 - 9.3 C 8.31 0.24 6.7 - 8.7 C 7.66 0.21 9.3 - 11.3 C 10.28 0.3 49Carolina 31 9.9 - 11.9 C 10.87 0.34 11.0 - 13.0 C 11.97 0.46 7.3 - 9.3 C 8.32 0.27 6.6 - 8.6 C 7.59 0.3 9.3 - 11.3 C 10.25 0.34 14Horiba ABX 32 10.1 - 12.1 C 11.09 0.2 11.3 - 13.3 C 12.26 0.32 7.3 - 9.3 C 8.33 0.15 6.6 - 8.6 C 7.57 0.12 9.3 - 11.3 C 10.34 0.2 7Medica Easy RA 33 9.8 - 11.8 C 10.79 0.29 10.9 - 12.9 C 11.94 0.25 7.2 - 9.2 C 8.2 0.33 6.5 - 8.5 C 7.51 0.17 9.2 - 11.2 C 10.15 0.22 8Ortho Vitros 34 10.2 - 12.2 C 11.18 0.2 11.4 - 13.4 C 12.35 0.22 7.5 - 9.5 C 8.53 0.16 6.9 - 8.9 C 7.86 0.17 9.6 - 11.6 C 10.55 0.17 51Pointe Sci Arsenazo 35 9.8 - 11.8 C 10.83 0.41 11.0 - 13.0 C 11.97 0.47 7.4 - 9.4 C 8.43 0.39 6.8 - 8.8 C 7.76 0.23 9.5 - 11.5 C 10.5 0.51 6Pointe Sci OCPC 36 9.8 - 11.8 C 10.84 0.49 11.2 - 13.2 C 12.24 0.3 7.2 - 9.2 C 8.24 0.27 6.5 - 8.5 C 7.52 0.31 9.1 - 11.1 C 10.14 0.48 5Roche Cobas 37 10.2 - 12.2 C 11.21 0.24 11.5 - 13.5 C 12.52 0.25 7.5 - 9.5 C 8.52 0.21 6.9 - 8.9 C 7.85 0.19 9.6 - 11.6 C 10.56 0.24 41SDI Biomed 38 10.1 - 12.1 C 11.1 0.14 11.4 - 13.4 C 12.38 0.12 7.6 - 9.6 C 8.6 0.06 7.0 - 9.0 C 8.04 0.14 9.3 - 11.3 C 10.32 0.04 5Sekisui 39 9.9 - 11.9 C 10.85 0.35 10.9 - 12.9 C 11.86 0.29 7.4 - 9.4 C 8.38 0.27 6.7 - 8.7 C 7.73 0.26 9.2 - 11.2 C 10.17 0.39 9Siemens OCPC 40 9.9 - 11.9 C 10.9 0.25 11.2 - 13.2 C 12.22 0.29 7.3 - 9.3 C 8.28 0.2 6.6 - 8.6 C 7.62 0.2 9.2 - 11.2 C 10.23 0.23 90Synermed 41 10.1 - 12.1 C 11.05 0.29 11.3 - 13.3 C 12.25 0.46 7.5 - 9.5 C 8.46 0.4 7.0 - 9.0 C 7.95 0.27 9.3 - 11.3 C 10.27 0.33 5Initial Grouping by Sensitivity or PrincipleAll estimated total Ca's 42 9.7 - 11.7 C 10.73 0.15 11.0 - 13.0 C 11.95 0.35 7.5 - 9.5 C 8.45 0.05 6.9 - 8.9 C 7.85 0.34 9.3 - 11.3 C 10.33 0.26 4Arsenazo-based 43 10.0 - 12.0 C 10.98 0.29 11.2 - 13.2 C 12.2 0.33 7.4 - 9.4 C 8.41 0.26 6.8 - 8.8 C 7.76 0.24 9.4 - 11.4 C 10.38 0.29 223Other, electrochemical 44 9.9 - 11.9 C 10.88 0.18 11.1 - 13.1 C 12.06 0.16 7.6 - 9.6 C 8.55 0.15 6.9 - 8.9 C 7.93 0.11 9.3 - 11.3 C 10.3 0.13 11OCPC (o-cresolphth complex) 45 10.0 - 12.0 C 10.98 0.31 11.3 - 13.3 C 12.3 0.32 7.4 - 9.4 C 8.35 0.23 6.7 - 8.7 C 7.68 0.23 9.3 - 11.3 C 10.32 0.29 145Total PopulationWhole Population 46 10.0 - 12.0 C 10.98 0.34 11.2 - 13.2 C 12.23 0.37 7.4 - 9.4 C 8.4 0.3 6.7 - 8.7 C 7.74 0.31 9.4 - 11.4 C 10.36 0.35 384

ChlorideInitial Grouping by Reagent and InstrumentAbbott & Abbott Architect c, ci, i 1 98 - 109 P 103.4 0.7 101 - 112 P 106.4 0.7 91 - 101 P 96.3 0.6 90 - 99 P 94.7 0.5 97 - 107 P 101.8 0.6 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 101 - 111 P 106.1 1.0 106 - 117 P 111.1 0.7 90 - 99 P 94.3 1.0 87 - 96 P 91.4 1.2 97 - 108 P 102.4 0.8 18Beckman Coulter & Beck Coult Unicel DXC 3 97 - 107 P 102.1 1.2 100 - 111 P 105.7 1.5 91 - 101 P 95.8 1.1 89 - 99 P 93.9 1.1 96 - 106 P 101.1 1.3 17Beckman Coulter & Beck Olym AU 400/600/5400 4 96 - 106 P 101.3 0.9 100 - 110 P 104.8 1.5 89 - 99 P 94.2 0.9 87 - 97 P 92.0 0.6 95 - 105 P 100.2 1.5 6Beckman Coulter & Beckman AU 480 5 97 - 107 P 101.9 0.6 100 - 111 P 105.6 1.2 90 - 100 P 94.9 0.8 88 - 98 P 92.9 0.6 95 - 105 P 100.3 1.0 7Beckman Olympus & Beck Olym AU 400/600/5400 6 97 - 107 P 102.2 1.0 101 - 111 P 105.9 1.4 90 - 100 P 94.8 1.0 88 - 98 P 93.0 1.0 96 - 106 P 100.6 1.1 34Beckman Olympus & Beck Olympus AU 2700 7 98 - 108 P 102.8 0.8 101 - 112 P 106.3 1.1 90 - 100 P 95.0 0.0 88 - 97 P 92.8 0.4 96 - 106 P 100.8 0.4 4Beckman Olympus & Beckman AU 480 8 97 - 107 P 102.2 1.5 101 - 111 P 106.0 1.4 90 - 100 P 95.0 0.9 88 - 98 P 93.1 0.7 95 - 105 P 100.3 1.4 21Carolina & Beckman Synchron CX3/7/9/L 9 100 - 111 P 105.4 2.3 103 - 114 P 108.2 2.5 93 - 102 P 97.5 2.1 92 - 101 P 96.4 2.4 97 - 107 P 102.2 2.8 5Diamond Diagnostics & Beck Olym AU 400/600/5400 10 99 - 109 P 103.8 0.7 101 - 112 P 106.8 1.2 91 - 101 P 96.2 0.4 89 - 99 P 94.2 1.2 96 - 106 P 101.4 0.8 5Horiba ABX & Horiba ABX 400 11 100 - 111 P 105.3 1.8 105 - 117 P 111.0 2.3 89 - 99 P 93.9 1.2 86 - 95 P 90.4 1.0 97 - 108 P 102.6 1.7 7Medica Easy RA & Medica Easy RA 12 100 - 111 P 105.4 1.6 106 - 117 P 111.7 1.7 89 - 98 P 93.3 1.3 86 - 95 P 90.6 1.0 98 - 108 P 102.9 1.2 10Ortho Vitros & Ortho Vitros 3600, 5600 13 99 - 109 P 103.9 1.6 103 - 113 P 107.9 1.8 91 - 101 P 95.9 1.5 89 - 99 P 94.1 1.4 97 - 107 P 101.8 1.7 17Ortho Vitros & Ortho Vitros 5,1 FS 14 99 - 109 P 103.8 2.6 103 - 113 P 108.0 2.2 91 - 100 P 95.3 1.9 89 - 98 P 93.3 1.3 97 - 107 P 102.3 1.9 4Ortho Vitros & Ortho Vitros not DT or ECi 15 97 - 108 P 102.4 1.2 101 - 112 P 106.6 1.6 90 - 99 P 94.7 1.3 88 - 98 P 93.0 1.3 96 - 106 P 101.0 1.3 27Roche Cobas dil ISE & Roche Cobas 6000 16 95 - 105 P 99.8 1.6 100 - 110 P 104.9 1.1 86 - 95 P 90.3 0.9 84 - 93 P 88.1 1.0 92 - 102 P 97.3 1.0 8Roche Cobas dil ISE & Roche Cobas Integra 17 99 - 110 P 104.3 1.2 104 - 115 P 109.3 1.7 90 - 100 P 94.8 1.1 88 - 97 P 92.4 1.0 97 - 107 P 102.0 1.2 12Roche Cobas dil ISE & Roche e/c, 1XX, X000, Elecseries 18 95 - 105 P 99.6 1.6 100 - 110 P 104.8 1.4 86 - 95 P 90.8 1.6 84 - 93 P 88.4 1.8 93 - 103 P 98.1 1.4 14

SDI Biomed & SDI CA-240, 480 19 99 - 110 P 104.5 0.9 101 - 112 P 106.8 0.8 90 - 100 P 95.0 0.7 85 - 94 P 89.3 2.7 95 - 105 P 100.3 0.4 4Siemens Advia & Siemens Advia 20 99 - 109 P 104.0 1.0 101 - 111 P 106.0 3.7 92 - 101 P 96.5 1.1 89 - 99 P 94.0 0.8 98 - 108 P 103.0 1.4 4Siemens QuickLYTE IMT & Siemens Dim RxL, RxLMax 21 99 - 110 P 104.3 0.8 104 - 115 P 109.8 1.3 87 - 96 P 91.8 1.6 84 - 93 P 88.5 1.5 96 - 106 P 100.8 1.3 4

Siemens QuickLYTE IMT & Siemens Dimension EXL 22 100 - 110 P 104.9 1.0 105 - 116 P 110.3 1.4 89 - 99 P 93.9 0.7 86 - 96 P 91.0 0.9 97 - 107 P 102.2 1.0 59Siemens QuickLYTE IMT & Siemens DimensionXpand 23 100 - 110 P 104.9 1.0 105 - 116 P 110.5 1.4 89 - 98 P 93.6 0.7 86 - 95 P 90.8 0.6 97 - 107 P 101.9 1.0 23

Vital Diagnostics Envoy & Vital Diagnostic Envoy 24 101 - 112 P 106.7 1.7 107 - 118 P 112.3 1.8 91 - 101 P 95.8 0.4 88 - 97 P 92.8 0.4 99 - 110 P 104.3 0.4 4Initial Grouping by ReagentAbaxis Piccolo 25 101 - 111 P 105.8 2.9 102 - 113 P 107.8 1.1 91 - 101 P 96.3 1.2 91 - 100 P 95.5 2.7 98 - 109 P 103.5 1.5 4Abbott 26 98 - 109 P 103.4 0.7 101 - 112 P 106.4 0.7 91 - 101 P 96.3 0.6 90 - 99 P 94.7 0.5 97 - 107 P 101.8 0.6 19Alfa Wassermann 27 101 - 111 P 106.1 1.0 106 - 117 P 111.1 0.7 90 - 99 P 94.3 1.0 87 - 96 P 91.4 1.2 97 - 108 P 102.4 0.8 18Beckman Coulter 28 97 - 107 P 101.9 1.1 100 - 111 P 105.5 1.5 91 - 100 P 95.3 1.2 89 - 98 P 93.3 1.2 96 - 106 P 100.7 1.4 30Beckman Olympus 29 97 - 107 P 102.2 1.2 101 - 111 P 105.9 1.4 90 - 100 P 94.8 0.9 88 - 98 P 93.0 0.9 95 - 106 P 100.5 1.2 60Carolina 30 99 - 109 P 103.9 3.3 102 - 113 P 107.6 3.4 90 - 100 P 94.9 3.2 89 - 98 P 93.2 4.0 97 - 107 P 102.1 2.5 11Diamond Diagnostics 31 98 - 108 P 103.0 1.5 101 - 111 P 106.1 1.6 91 - 101 P 96.1 1.6 89 - 99 P 94.1 1.9 96 - 106 P 101.4 1.5 7

Horiba ABX 32 100 - 111 P 105.3 1.8 105 - 117 P 111.0 2.3 89 - 99 P 93.9 1.2 86 - 95 P 90.4 1.0 97 - 108 P 102.6 1.7 7Medica Easy RA 33 100 - 111 P 105.4 1.6 106 - 117 P 111.7 1.7 89 - 98 P 93.3 1.3 86 - 95 P 90.6 1.0 98 - 108 P 102.9 1.2 10Medica EasyLyte 34 101 - 112 P 106.3 2.0 108 - 119 P 113.8 2.9 90 - 100 P 95.0 2.2 88 - 97 P 92.3 2.3 99 - 109 P 104.0 1.2 4Ortho Vitros 35 98 - 108 P 103.0 1.7 102 - 112 P 107.1 1.9 90 - 100 P 95.1 1.5 89 - 98 P 93.3 1.5 96 - 106 P 101.3 1.6 50Pointe Scientific 36 101 - 112 P 106.5 2.2 108 - 119 P 113.5 0.9 90 - 99 P 94.5 0.5 87 - 97 P 92.0 0.7 99 - 110 P 104.3 0.8 4Roche Cobas dil ISE 37 96 - 106 P 101.3 2.6 101 - 112 P 106.4 2.6 88 - 97 P 92.3 2.4 85 - 94 P 89.8 2.4 94 - 104 P 99.4 2.4 34Roche Cobas und ISE 38 96 - 106 P 101.3 0.9 101 - 112 P 106.3 0.7 87 - 96 P 91.6 1.7 84 - 93 P 88.2 2.1 94 - 104 P 98.7 0.9 6SDI Biomed 39 99 - 110 P 104.4 0.8 102 - 112 P 107.0 0.9 90 - 100 P 95.0 0.6 85 - 94 P 89.6 2.5 95 - 105 P 100.2 0.4 5Siemens Advia 40 99 - 109 P 104.0 1.0 101 - 111 P 106.0 3.7 92 - 101 P 96.5 1.1 89 - 99 P 94.0 0.8 98 - 108 P 103.0 1.4 4Siemens QuickLYTE IMT 41 100 - 110 P 104.9 1.1 105 - 116 P 110.3 1.5 89 - 98 P 93.7 1.0 86 - 95 P 90.8 1.1 97 - 107 P 102.1 1.1 89Vital Diagnostics Envoy 42 101 - 112 P 106.7 1.7 107 - 118 P 112.3 1.8 91 - 101 P 95.8 0.4 88 - 97 P 92.8 0.4 99 - 110 P 104.3 0.4 4Initial Grouping by Sensitivity or PrincipleUndiluted ISE 43 99 - 109 P 104.0 2.2 103 - 114 P 108.8 2.9 90 - 99 P 94.6 1.8 88 - 97 P 92.2 2.2 97 - 107 P 101.7 1.8 106Colorimetric 44 100 - 111 P 105.4 2.2 104 - 115 P 109.1 3.0 91 - 100 P 95.5 1.6 88 - 97 P 92.6 3.6 97 - 108 P 102.5 2.0 14Diluted ISE 45 98 - 108 P 103.3 2.2 102 - 113 P 107.8 2.8 90 - 99 P 94.3 1.8 87 - 97 P 92.0 2.2 96 - 106 P 101.2 1.8 260Total PopulationWhole Population 46 98 - 109 P 103.6 2.4 103 - 114 P 108.1 3.0 90 - 99 P 94.4 2.1 87 - 97 P 92.0 2.4 96 - 106 P 101.3 2.1 381

Cholesterol, TotalInitial Grouping by Reagent and InstrumentAbbott & Abbott Architect c, ci, i 1 162 - 197 P 179.5 1.4 183 - 223 P 203.1 0.9 119 - 146 P 132.4 1.0 108 - 132 P 120.3 0.9 151 - 184 P 167.7 1.2 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 165 - 202 P 183.8 5.0 185 - 226 P 205.1 3.9 122 - 149 P 135.2 3.6 110 - 134 P 122.1 7.0 153 - 187 P 170.3 3.0 16Beckman Coulter & Beck Coult Unicel DXC 3 165 - 201 P 182.8 4.4 187 - 228 P 207.3 2.3 120 - 147 P 133.4 3.0 109 - 133 P 120.9 1.4 154 - 188 P 170.9 2.2 16Beckman Coulter & Beck Olym AU 400/600/5400 4 157 - 192 P 174.8 4.2 177 - 216 P 196.8 4.1 114 - 140 P 127.0 3.7 105 - 128 P 116.3 3.5 146 - 179 P 162.5 3.5 4Beckman Coulter & Beckman AU 480 5 157 - 191 P 174.0 4.7 181 - 221 P 201.2 14.3 111 - 135 P 123.0 10.7 105 - 129 P 117.2 3.8 148 - 181 P 164.5 4.3 6Beckman Olympus & Beck Olym AU 400/600/5400 6 155 - 189 P 172.0 5.6 175 - 214 P 194.3 5.7 113 - 139 P 126.1 4.7 103 - 126 P 114.7 3.9 145 - 177 P 160.8 5.4 24Beckman Olympus & Beck Olympus AU 2700 7 153 - 187 P 170.3 1.1 173 - 212 P 192.3 1.3 115 - 141 P 127.8 3.6 101 - 124 P 112.5 3.0 141 - 173 P 157.0 3.7 4Beckman Olympus & Beckman AU 480 8 158 - 193 P 175.4 4.8 178 - 218 P 198.0 5.1 116 - 142 P 129.3 3.2 106 - 130 P 118.1 3.5 147 - 180 P 163.8 4.4 19Carolina & Beck Olym AU 400/600/5400 9 169 - 206 P 187.3 7.0 191 - 233 P 212.2 7.6 124 - 152 P 137.8 6.3 114 - 140 P 127.0 5.5 159 - 194 P 176.8 7.8 6Carolina & Beckman Synchron CX3/7/9/L 10 157 - 192 P 174.4 7.6 175 - 214 P 194.2 6.8 115 - 141 P 128.2 4.5 105 - 129 P 117.0 4.6 150 - 183 P 166.2 9.8 5Horiba ABX & Horiba ABX 400 11 159 - 194 P 176.3 4.4 179 - 219 P 199.0 5.7 117 - 143 P 130.0 2.7 106 - 129 P 117.3 2.9 147 - 180 P 163.8 3.3 5Ortho Vitros & Ortho Vitros 3600, 5600 12 156 - 191 P 173.5 5.9 178 - 217 P 197.6 4.3 110 - 134 P 121.8 4.0 98 - 120 P 109.3 3.5 144 - 175 P 159.5 4.6 18Ortho Vitros & Ortho Vitros 5,1 FS 13 158 - 194 P 176.0 4.6 180 - 220 P 199.8 5.8 111 - 135 P 123.0 3.1 100 - 122 P 111.0 3.1 147 - 179 P 163.0 2.8 4Ortho Vitros & Ortho Vitros not DT or ECi 14 155 - 189 P 171.9 6.5 178 - 217 P 197.4 8.3 111 - 136 P 123.4 3.8 100 - 122 P 111.3 3.9 146 - 178 P 162.1 5.3 25Pointe Scientific & Other spectrophotometers 15 168 - 205 P 186.4 4.1 183 - 223 P 203.0 5.3 120 - 147 P 133.2 2.3 110 - 134 P 122.2 3.7 153 - 187 P 169.6 4.8 5Pointe Scientific & Pointe Sci 180/Sterl 2000 16 161 - 197 P 178.8 4.3 184 - 225 P 204.3 4.6 120 - 147 P 133.8 2.6 111 - 135 P 123.0 3.9 152 - 185 P 168.5 6.1 4Roche Cobas & Roche Cobas 6000 17 162 - 198 P 179.6 3.3 183 - 224 P 203.7 4.8 120 - 147 P 133.3 3.1 109 - 133 P 121.0 3.0 152 - 185 P 168.4 4.9 8Roche Cobas & Roche Cobas Integra 18 160 - 196 P 177.8 3.4 182 - 222 P 201.9 4.5 119 - 145 P 132.2 3.1 108 - 132 P 120.1 2.3 150 - 184 P 167.2 3.3 13Roche Cobas & Roche e/c, 1XX, X000, Elec series 19 160 - 196 P 177.8 4.5 180 - 221 P 200.5 4.2 118 - 145 P 131.6 4.0 107 - 131 P 118.8 3.4 150 - 183 P 166.2 3.9 18SDI Biomed & SDI CA-240, 480 20 163 - 199 P 180.8 3.1 183 - 223 P 202.8 4.8 120 - 147 P 133.8 0.8 111 - 136 P 123.5 1.1 151 - 185 P 168.0 2.1 4Sekisui & Beck Olym AU 400/600/5400 21 162 - 198 P 180.0 4.5 179 - 219 P 199.3 4.8 118 - 144 P 130.8 3.1 106 - 129 P 117.3 4.3 150 - 183 P 166.3 6.9 4Siemens Dimension & Siemens Dim RxL, RxL Max 22 160 - 196 P 178.3 3.3 181 - 222 P 201.5 3.2 118 - 144 P 131.0 1.6 108 - 133 P 120.5 1.7 149 - 183 P 166.0 2.9 4Siemens Dimension & Siemens Dimension EXL 23 159 - 194 P 176.3 4.0 179 - 218 P 198.5 4.5 118 - 144 P 130.6 3.3 107 - 131 P 118.9 3.0 148 - 181 P 164.7 4.0 56Siemens Dimension & Siemens Dimension Xpand 24 158 - 194 P 176.1 5.4 178 - 217 P 197.3 5.2 117 - 143 P 130.0 4.5 106 - 130 P 118.0 4.1 148 - 181 P 164.2 5.1 23Stering Diagnostic & Other spectrophotometers 25 168 - 205 P 186.3 6.7 182 - 223 P 202.6 5.4 121 - 148 P 134.4 2.9 113 - 138 P 125.2 4.6 154 - 189 P 171.4 4.9 9Stering Diagnostic & Pointe Sci 180/Sterl 2000 26 163 - 199 P 181.0 3.2 183 - 224 P 203.3 3.7 121 - 148 P 134.1 3.3 110 - 135 P 122.3 3.1 154 - 188 P 171.3 3.2 7Vital Diagnostics Envoy & Vital Diagnostic Envoy 27 166 - 202 P 184.0 3.6 187 - 228 P 207.3 4.5 122 - 149 P 135.7 3.3 112 - 137 P 124.3 2.5 152 - 186 P 168.7 0.5 4Initial Grouping by ReagentAbbott 28 162 - 197 P 179.5 1.4 183 - 223 P 203.1 0.9 119 - 146 P 132.4 1.0 108 - 132 P 120.3 0.9 151 - 184 P 167.7 1.2 19Alfa Wassermann 29 165 - 202 P 183.8 5.0 185 - 226 P 205.1 3.9 122 - 149 P 135.2 3.6 110 - 134 P 122.1 7.0 153 - 187 P 170.3 3.0 16Beckman Coulter 30 162 - 197 P 179.5 6.0 184 - 225 P 204.1 8.4 117 - 143 P 130.0 7.3 107 - 131 P 119.3 3.2 151 - 185 P 168.0 4.7 26Beckman Olympus 31 156 - 191 P 173.2 5.4 176 - 215 P 195.6 5.6 115 - 140 P 127.5 4.4 104 - 127 P 115.9 4.1 146 - 178 P 161.7 5.3 47Carolina 32 164 - 200 P 182.0 10.5 185 - 226 P 205.2 12.0 121 - 148 P 134.4 7.7 111 - 135 P 122.9 7.2 155 - 189 P 172.1 10.1 15Horiba ABX 33 159 - 194 P 176.3 4.4 179 - 219 P 199.0 5.7 117 - 143 P 130.0 2.7 106 - 129 P 117.3 2.9 147 - 180 P 163.8 3.3 5Ortho Vitros 34 155 - 190 P 172.7 6.1 178 - 217 P 197.5 6.8 110 - 135 P 122.7 3.8 99 - 122 P 110.5 3.7 145 - 177 P 161.0 5.0 49Pointe Scientific 35 165 - 202 P 183.2 6.0 185 - 226 P 205.2 6.7 121 - 148 P 134.4 4.3 111 - 136 P 123.4 4.1 154 - 188 P 170.9 6.0 17Roche Cobas 36 160 - 196 P 178.2 4.0 181 - 222 P 201.6 4.5 119 - 145 P 132.1 3.6 108 - 132 P 119.7 3.1 150 - 184 P 167.1 4.0 40SDI Biomed 37 163 - 199 P 180.8 3.1 183 - 223 P 202.8 4.8 120 - 147 P 133.8 0.8 111 - 136 P 123.5 1.1 151 - 185 P 168.0 2.1 4Sekisui 38 163 - 199 P 181.3 8.7 181 - 221 P 200.6 8.7 119 - 145 P 131.7 5.8 106 - 130 P 118.3 4.9 150 - 183 P 166.7 7.3 7Siemens Dimension 39 159 - 194 P 176.8 4.9 179 - 219 P 198.8 5.4 118 - 144 P 130.6 3.7 107 - 131 P 118.9 3.4 149 - 182 P 165.0 4.7 87Stering Diagnostic 40 166 - 202 P 184.0 6.1 183 - 223 P 202.9 4.8 121 - 148 P 134.3 3.1 112 - 136 P 123.9 4.3 154 - 189 P 171.4 4.3 16Synermed 41 177 - 216 P 196.8 7.7 198 - 242 P 219.8 7.8 132 - 161 P 146.5 5.1 117 - 143 P 130.0 7.4 163 - 200 P 181.5 7.4 4

Vital Diagnostics Envoy 42 166 - 202 P 184.0 3.6 187 - 228 P 207.3 4.5 122 - 149 P 135.7 3.3 112 - 137 P 124.3 2.5 152 - 186 P 168.7 0.5 4Initial Grouping by Sensitivity or PrincipleAll enzymatic cholesterol 43 160 - 196 P 177.8 7.0 181 - 221 P 200.6 7.4 117 - 144 P 130.5 6.0 107 - 130 P 118.6 5.7 149 - 183 P 166.1 6.4 376Total PopulationWhole Population 44 159 - 194 P 176.3 14.3 180 - 220 P 199.6 11.9 116 - 142 P 129.4 11.6 106 - 130 P 117.8 9.4 150 - 183 P 166.3 9.9 376

CreatinineInitial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 3.0 - 4.0 P 3.49 0.08 3.8 - 5.1 P 4.47 0.1 1.2 - 1.8 C 1.48 0.05 0.7 - 1.3 C 0.96 0.05 2.5 - 3.4 P 2.98 0.08 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 2.7 - 3.7 P 3.22 0.12 3.4 - 4.6 P 4.01 0.15 1.3 - 1.9 C 1.6 0.07 0.9 - 1.5 C 1.16 0.07 2.4 - 3.3 P 2.86 0.13 20Beckman Coulter & Beck Coult Unicel DXC 3 2.9 - 3.9 P 3.36 0.09 3.6 - 4.9 P 4.22 0.12 1.3 - 1.9 C 1.55 0.08 0.8 - 1.4 C 1.07 0.09 2.5 - 3.4 P 2.93 0.13 10Beckman Coulter & Beck Olym AU 400/600/5400 4 2.8 - 3.8 P 3.34 0.1 3.6 - 4.8 P 4.18 0.07 1.2 - 1.8 C 1.52 0.04 0.7 - 1.3 C 1.04 0.05 2.5 - 3.3 P 2.9 0.06 5Beckman Coulter & Beckman AU 480 5 2.7 - 3.6 P 3.14 0.08 3.4 - 4.6 P 4.0 0.14 1.1 - 1.7 C 1.44 0.05 0.7 - 1.3 C 0.98 0.04 2.3 - 3.2 P 2.74 0.1 5Beckman Olympus & Beck Olym AU 400/600/5400 6 2.8 - 3.7 P 3.26 0.11 3.5 - 4.7 P 4.09 0.15 1.2 - 1.8 C 1.48 0.05 0.7 - 1.3 C 1.04 0.06 2.4 - 3.2 P 2.81 0.09 30Beckman Olympus & Beck Olympus AU 2700 7 2.7 - 3.7 P 3.22 0.04 3.5 - 4.8 P 4.15 0.05 1.2 - 1.8 C 1.48 0.08 0.8 - 1.4 C 1.05 0.05 2.4 - 3.2 P 2.8 0.07 4Beckman Olympus & Beckman AU 480 8 2.8 - 3.8 P 3.29 0.12 3.5 - 4.7 P 4.12 0.12 1.2 - 1.8 C 1.49 0.06 0.7 - 1.3 C 1.04 0.05 2.4 - 3.3 P 2.85 0.08 22Beckman Synchron IDMS trace & Beck Coult UnicelDXC 9 2.8 - 3.8 P 3.3 0.08 3.5 - 4.8 P 4.14 0.13 1.2 - 1.8 C 1.5 0.0 0.8 - 1.4 C 1.09 0.06 2.4 - 3.3 P 2.83 0.05 7

Carolina & Beck Olym AU 400/600/5400 10 2.8 - 3.8 P 3.28 0.2 3.4 - 4.6 P 4.02 0.22 1.3 - 1.9 C 1.63 0.09 0.9 - 1.5 C 1.22 0.07 2.4 - 3.3 P 2.88 0.22 6Carolina & Beckman Synchron CX3/7/9/L 11 2.8 - 3.8 P 3.32 0.13 3.5 - 4.7 P 4.08 0.26 1.3 - 2.0 C 1.65 0.13 0.9 - 1.5 C 1.22 0.07 2.5 - 3.4 P 2.92 0.23 6Horiba ABX & Horiba ABX 400 12 2.7 - 3.7 P 3.19 0.1 3.4 - 4.6 P 4.01 0.12 1.2 - 1.8 C 1.47 0.07 0.7 - 1.3 C 1.01 0.06 2.4 - 3.2 P 2.81 0.1 7Medica & Medica Easy RA 13 2.9 - 3.9 P 3.38 0.06 3.6 - 4.9 P 4.29 0.1 1.3 - 1.9 C 1.57 0.05 0.8 - 1.4 C 1.1 0.0 2.5 - 3.4 P 2.92 0.06 9Ortho Vitros 1-slide enz & Ortho Vitros 3600, 5600 14 2.6 - 3.5 P 3.06 0.07 3.3 - 4.5 P 3.87 0.09 1.1 - 1.7 C 1.4 0.0 0.7 - 1.3 C 1.0 0.0 2.3 - 3.1 P 2.66 0.07 9Ortho Vitros 1-slide enz & Ortho Vitros not DT or ECi 15 2.7 - 3.6 P 3.17 0.09 3.4 - 4.6 P 4.0 0.09 1.1 - 1.7 C 1.41 0.05 0.7 - 1.3 C 1.0 0.0 2.3 - 3.2 P 2.74 0.08 10Roche Cobas & Roche Cobas 6000 16 2.7 - 3.7 P 3.21 0.16 3.4 - 4.6 P 4.03 0.21 1.2 - 1.8 C 1.54 0.09 0.8 - 1.4 C 1.07 0.1 2.4 - 3.3 P 2.83 0.12 7Roche Cobas & Roche Cobas Integra 17 2.7 - 3.6 P 3.16 0.13 3.3 - 4.5 P 3.94 0.17 1.2 - 1.8 C 1.49 0.06 0.7 - 1.3 C 1.04 0.07 2.3 - 3.2 P 2.75 0.14 14Roche Cobas & Roche e/c, 1XX, X000, Elec series 18 2.7 - 3.7 P 3.18 0.13 3.4 - 4.6 P 3.96 0.17 1.2 - 1.8 C 1.46 0.06 0.7 - 1.3 C 1.02 0.05 2.4 - 3.2 P 2.77 0.12 18SDI Biomed & SDI CA-240, 480 19 2.8 - 3.7 P 3.25 0.05 3.4 - 4.6 P 3.98 0.07 1.3 - 1.9 C 1.58 0.07 0.8 - 1.5 C 1.15 0.05 2.4 - 3.3 P 2.88 0.04 6Sekisui & Beck Olym AU 400/600/5400 20 2.8 - 3.8 P 3.28 0.15 3.4 - 4.6 P 4.0 0.12 1.3 - 1.9 C 1.6 0.07 0.8 - 1.5 C 1.15 0.05 2.4 - 3.3 P 2.85 0.05 4Siemens Advia & Siemens Advia 21 2.7 - 3.7 P 3.22 0.08 3.5 - 4.7 P 4.1 0.07 1.2 - 1.8 C 1.45 0.05 0.7 - 1.3 C 0.98 0.04 2.4 - 3.3 P 2.83 0.08 4Siemens Dimension & Siemens Dimension EXL 22 2.9 - 3.9 P 3.42 0.09 3.7 - 5.0 P 4.34 0.1 1.3 - 1.9 C 1.61 0.06 0.8 - 1.5 C 1.15 0.06 2.5 - 3.4 P 2.95 0.09 42Siemens Dimension & Siemens Dimension Xpand 23 2.9 - 3.9 P 3.39 0.07 3.7 - 5.0 P 4.31 0.09 1.3 - 1.9 C 1.59 0.04 0.8 - 1.4 C 1.13 0.05 2.5 - 3.4 P 2.94 0.05 16Sterling Diagnostic & Other spectrophotometers 24 2.7 - 3.6 P 3.15 0.09 3.3 - 4.4 P 3.83 0.04 1.3 - 1.9 C 1.6 0.07 0.9 - 1.5 C 1.18 0.04 2.4 - 3.2 P 2.8 0.25 4Synermed & Synermed IR500 25 2.6 - 3.6 P 3.1 0.19 3.3 - 4.5 P 3.92 0.31 1.4 - 2.0 C 1.7 0.12 1.0 - 1.6 C 1.25 0.05 2.4 - 3.2 P 2.77 0.22 6Initial Grouping by ReagentAbaxis Piccolo 26 2.9 - 3.9 P 3.4 0.08 3.6 - 4.9 P 4.25 0.15 1.4 - 2.0 C 1.7 0.1 0.9 - 1.5 C 1.17 0.04 2.5 - 3.4 P 2.95 0.11 4Abbott Architect 27 3.0 - 4.0 P 3.49 0.08 3.8 - 5.1 P 4.47 0.1 1.2 - 1.8 C 1.48 0.05 0.7 - 1.3 C 0.96 0.05 2.5 - 3.4 P 2.98 0.08 19Alfa Wassermann 28 2.7 - 3.7 P 3.22 0.12 3.4 - 4.6 P 4.01 0.15 1.3 - 1.9 C 1.6 0.07 0.9 - 1.5 C 1.16 0.07 2.4 - 3.3 P 2.86 0.13 20Beckman Coulter 29 2.8 - 3.8 P 3.3 0.13 3.5 - 4.8 P 4.15 0.15 1.2 - 1.8 C 1.52 0.08 0.7 - 1.3 C 1.04 0.08 2.4 - 3.3 P 2.87 0.14 20Beckman Olympus 30 2.8 - 3.8 P 3.27 0.11 3.5 - 4.7 P 4.11 0.13 1.2 - 1.8 C 1.48 0.06 0.7 - 1.3 C 1.04 0.06 2.4 - 3.3 P 2.83 0.09 56Beckman Synchron IDMS trace 31 2.8 - 3.8 P 3.28 0.1 3.5 - 4.7 P 4.11 0.15 1.2 - 1.8 C 1.5 0.0 0.8 - 1.4 C 1.08 0.07 2.4 - 3.2 P 2.81 0.06 8Carolina 32 2.8 - 3.8 P 3.34 0.17 3.5 - 4.7 P 4.08 0.22 1.3 - 1.9 C 1.64 0.1 0.9 - 1.5 C 1.19 0.09 2.5 - 3.3 P 2.91 0.19 17Horiba ABX 33 2.7 - 3.7 P 3.19 0.1 3.4 - 4.6 P 4.01 0.12 1.2 - 1.8 C 1.47 0.07 0.7 - 1.3 C 1.01 0.06 2.4 - 3.2 P 2.81 0.1 7Medica 34 2.9 - 3.9 P 3.38 0.06 3.6 - 4.9 P 4.29 0.1 1.3 - 1.9 C 1.57 0.05 0.8 - 1.4 C 1.1 0.0 2.5 - 3.4 P 2.92 0.06 9Ortho Vitros 1-slide enz 35 2.6 - 3.6 P 3.11 0.09 3.3 - 4.5 P 3.93 0.11 1.1 - 1.7 C 1.4 0.04 0.7 - 1.3 C 1.0 0.0 2.3 - 3.1 P 2.7 0.08 23Ortho Vitros IDMS traceable 36 2.7 - 3.6 P 3.12 0.12 3.4 - 4.5 P 3.95 0.12 1.1 - 1.7 C 1.4 0.05 0.7 - 1.3 C 1.0 0.04 2.3 - 3.1 P 2.7 0.1 23Pointe Scientific 37 2.8 - 3.9 P 3.35 0.1 3.5 - 4.8 P 4.14 0.16 1.3 - 1.9 C 1.63 0.04 0.8 - 1.5 C 1.15 0.07 2.4 - 3.3 P 2.86 0.08 11Roche Cobas 38 2.7 - 3.7 P 3.18 0.14 3.4 - 4.6 P 3.96 0.18 1.2 - 1.8 C 1.49 0.07 0.7 - 1.3 C 1.04 0.07 2.4 - 3.2 P 2.77 0.13 39SDI Biomed 39 2.8 - 3.7 P 3.25 0.05 3.4 - 4.6 P 3.98 0.07 1.3 - 1.9 C 1.58 0.07 0.8 - 1.5 C 1.15 0.05 2.4 - 3.3 P 2.88 0.04 6Sekisui 40 2.8 - 3.7 P 3.25 0.17 3.4 - 4.6 P 4.02 0.18 1.3 - 1.9 C 1.58 0.07 0.8 - 1.4 C 1.13 0.07 2.4 - 3.3 P 2.85 0.15 6Siemens Advia 41 2.7 - 3.7 P 3.22 0.08 3.5 - 4.7 P 4.1 0.07 1.2 - 1.8 C 1.45 0.05 0.7 - 1.3 C 0.98 0.04 2.4 - 3.3 P 2.83 0.08 4Siemens Dimension 42 2.9 - 3.9 P 3.41 0.08 3.7 - 5.0 P 4.33 0.1 1.3 - 1.9 C 1.6 0.06 0.8 - 1.5 C 1.15 0.06 2.5 - 3.4 P 2.95 0.08 63Siemens ECRE IDMS 43 2.8 - 3.8 P 3.34 0.05 3.7 - 4.9 P 4.3 0.06 1.3 - 1.9 C 1.58 0.04 0.8 - 1.4 C 1.14 0.05 2.5 - 3.3 P 2.9 0.0 5Siemens EZCR/IDMS Traceable 44 2.8 - 3.8 P 3.31 0.08 3.6 - 4.8 P 4.18 0.11 1.3 - 1.9 C 1.55 0.06 0.8 - 1.4 C 1.12 0.06 2.4 - 3.3 P 2.88 0.06 12Siemens nonenz rate 45 2.8 - 3.9 P 3.35 0.12 3.6 - 4.9 P 4.26 0.15 1.3 - 1.9 C 1.59 0.08 0.8 - 1.4 C 1.12 0.06 2.5 - 3.3 P 2.89 0.09 11Sterling Diagnostic 46 2.7 - 3.6 P 3.16 0.18 3.3 - 4.5 P 3.9 0.25 1.3 - 1.9 C 1.6 0.11 0.8 - 1.4 C 1.14 0.07 2.4 - 3.2 P 2.79 0.28 7Synermed 47 2.6 - 3.5 P 3.06 0.19 3.3 - 4.5 P 3.87 0.3 1.3 - 1.9 C 1.64 0.16 0.9 - 1.5 C 1.17 0.12 2.3 - 3.2 P 2.76 0.21 7Vital Diagnostic 48 2.6 - 3.6 P 3.1 0.19 3.3 - 4.5 P 3.93 0.08 1.2 - 1.8 C 1.45 0.15 0.7 - 1.3 C 0.98 0.04 2.3 - 3.1 P 2.72 0.11 4Initial Grouping by Sensitivity or PrincipleEnzymatic methods 49 2.8 - 3.8 P 3.34 0.15 3.6 - 4.9 P 4.23 0.2 1.3 - 1.9 C 1.56 0.1 0.8 - 1.4 C 1.11 0.08 2.5 - 3.3 P 2.89 0.13 99Nonenzymatic rate 50 2.8 - 3.8 P 3.27 0.16 3.5 - 4.7 P 4.1 0.21 1.2 - 1.8 C 1.53 0.1 0.8 - 1.4 C 1.07 0.1 2.4 - 3.3 P 2.85 0.13 232IDMS traceable 51 2.7 - 3.7 P 3.21 0.14 3.4 - 4.7 P 4.05 0.19 1.2 - 1.8 C 1.49 0.1 0.8 - 1.4 C 1.07 0.08 2.4 - 3.2 P 2.79 0.14 55

Nonenzymatic endpoint 52 2.8 - 3.7 P 3.25 0.05 3.4 - 4.6 P 3.98 0.07 1.3 - 1.9 C 1.58 0.07 0.8 - 1.5 C 1.15 0.05 2.4 - 3.3 P 2.88 0.04 6Total PopulationWhole Population 53 2.8 - 3.8 P 3.28 0.17 3.5 - 4.7 P 4.12 0.23 1.2 - 1.8 C 1.54 0.11 0.8 - 1.4 C 1.09 0.1 2.4 - 3.3 P 2.85 0.14 398

GlucoseInitial Grouping by Reagent and InstrumentAbbott & Abbott Architect c, ci, i 1 165 - 202 P 183.4 2.6 205 - 251 P 228.1 3.2 88 - 107 P 97.6 1.1 68 - 83 P 75.1 0.9 145 - 177 P 161.3 2.4 20Alfa Wassermann & Alfa Wasser Axcel/Alera 2 175 - 214 P 194.9 4.7 215 - 263 P 238.7 6.2 95 - 116 P 105.7 2.1 74 - 90 P 82.2 2.1 156 - 191 P 173.3 3.6 20Beckman HK & Beck Coult Unicel DXC 3 167 - 204 P 185.5 3.1 205 - 251 P 227.9 4.4 88 - 107 P 97.7 2.1 68 - 83 P 75.8 1.8 148 - 180 P 163.9 3.6 10Beckman O2 electrode & Beck Coult Unicel DXC 4 163 - 200 P 181.6 2.7 203 - 249 P 226.0 2.5 86 - 105 P 95.8 1.6 67 - 81 P 74.0 1.7 145 - 178 P 161.6 2.4 5Beckman Olympus & Beck Olym AU 400/600/5400 5 167 - 204 P 185.1 5.7 205 - 251 P 227.9 6.5 89 - 108 P 98.4 2.9 69 - 84 P 76.3 2.5 148 - 180 P 164.0 5.5 27Beckman Olympus & Beck Olympus AU 2700 6 169 - 207 P 188.0 2.7 206 - 252 P 229.0 3.2 89 - 109 P 98.8 1.3 69 - 84 P 76.4 0.8 147 - 180 P 163.2 2.7 5Beckman Olympus & Beckman AU 480 7 168 - 206 P 187.2 2.9 208 - 254 P 230.9 4.8 90 - 110 P 99.7 2.1 69 - 85 P 77.2 1.8 149 - 182 P 165.7 2.9 23Carolina HK & Beck Olym AU 400/600/5400 8 173 - 211 P 192.0 5.6 211 - 258 P 234.3 4.7 95 - 116 P 105.0 2.4 73 - 89 P 80.8 2.3 152 - 186 P 169.3 4.4 4Horiba ABX & Horiba ABX 400 9 169 - 207 P 188.0 6.7 206 - 252 P 229.4 7.3 90 - 110 P 99.9 2.9 68 - 84 P 76.1 2.2 148 - 180 P 163.9 4.5 7Medica & Medica Easy RA 10 183 - 223 P 202.9 3.6 222 - 271 P 246.8 2.8 98 - 119 P 108.4 2.8 76 - 93 P 84.1 2.1 161 - 197 P 179.3 4.3 9Ortho Vitros & Ortho Vitros 3600, 5600 11 161 - 197 P 179.3 4.1 202 - 246 P 224.0 3.9 83 - 102 P 92.3 2.0 65 - 79 P 72.2 1.8 141 - 172 P 156.7 3.3 18Ortho Vitros & Ortho Vitros 5,1 FS 12 162 - 198 P 180.3 1.5 202 - 247 P 224.8 1.9 84 - 102 P 93.0 1.2 65 - 79 P 72.0 1.7 142 - 173 P 157.5 1.5 4Ortho Vitros & Ortho Vitros not DT or ECi 13 162 - 198 P 180.1 4.2 201 - 246 P 223.7 3.2 85 - 103 P 93.9 2.5 66 - 81 P 73.2 1.9 142 - 173 P 157.7 3.3 27Roche Cobas & Roche Cobas 6000 14 170 - 208 P 189.0 3.3 209 - 255 P 231.9 4.6 89 - 109 P 99.4 1.7 70 - 85 P 77.4 1.3 150 - 184 P 167.2 3.6 9Roche Cobas & Roche Cobas Integra 15 170 - 207 P 188.4 2.6 208 - 254 P 231.3 4.0 90 - 110 P 100.2 2.0 70 - 85 P 77.6 1.1 150 - 184 P 167.2 3.3 13Roche Cobas & Roche e/c, 1XX, X000, Elec series 16 168 - 206 P 187.1 4.1 208 - 255 P 231.5 5.3 89 - 109 P 99.4 2.2 69 - 84 P 76.8 1.9 149 - 182 P 165.4 3.9 19SDI Biomed & SDI CA-240, 480 17 170 - 207 P 188.4 1.6 216 - 264 P 239.6 3.9 93 - 114 P 103.8 2.8 72 - 88 P 80.4 3.0 155 - 190 P 172.4 2.1 5Sekisui & Beck Olym AU 400/600/5400 18 167 - 204 P 185.8 6.5 206 - 252 P 229.2 10.6 93 - 113 P 103.0 5.1 71 - 87 P 79.2 3.1 149 - 182 P 165.5 4.8 6Siemens HK & Siemens Advia 19 168 - 206 P 187.0 2.0 207 - 253 P 230.0 1.9 89 - 108 P 98.5 0.9 69 - 84 P 76.3 0.4 149 - 182 P 165.0 1.9 4Siemens HK & Siemens Dimension EXL 20 171 - 209 P 190.1 4.1 210 - 256 P 233.1 4.1 92 - 112 P 102.0 2.1 72 - 87 P 79.5 1.6 151 - 185 P 167.9 3.1 29Siemens HK & Siemens Dimension Xpand 21 171 - 209 P 190.0 2.2 209 - 256 P 232.6 2.4 91 - 111 P 101.3 1.8 71 - 87 P 79.0 1.5 151 - 185 P 168.0 1.4 12Siemens HK, GLUC & Siemens Dimension EXL 22 171 - 209 P 190.1 3.8 211 - 258 P 234.6 4.7 92 - 112 P 102.0 2.3 71 - 87 P 79.3 1.9 152 - 185 P 168.6 4.1 30Siemens HK, GLUC & Siemens Dimension Xpand 23 169 - 207 P 188.3 3.8 209 - 256 P 232.4 4.9 91 - 111 P 101.0 2.4 71 - 87 P 78.8 1.9 150 - 184 P 167.2 4.1 10Sterling Diagnostic & Other spectrophotometers 24 170 - 208 P 189.3 2.8 209 - 255 P 232.0 4.1 92 - 112 P 102.0 2.1 72 - 88 P 80.3 2.1 150 - 184 P 167.2 2.5 6Sterling Diagnostic & Pointe Sci 180/Sterl 2000 25 167 - 204 P 185.6 3.9 206 - 252 P 229.0 5.5 91 - 112 P 101.4 1.8 71 - 87 P 79.0 1.4 149 - 182 P 165.4 3.5 7Synermed & Synermed IR500 26 175 - 214 P 194.8 7.0 213 - 261 P 237.0 7.2 92 - 113 P 102.5 3.3 71 - 87 P 79.0 2.4 154 - 188 P 170.8 5.2 4Vital Diagnostics Envoy & Vital Diagnostic Envoy 27 180 - 221 P 200.5 0.5 223 - 273 P 248.0 0.0 97 - 119 P 108.0 0.0 76 - 93 P 84.7 1.2 166 - 202 P 184.0 6.0 4Initial Grouping by ReagentAbaxis Piccolo 28 165 - 201 P 183.0 3.2 203 - 248 P 225.4 3.8 88 - 108 P 97.8 1.3 69 - 85 P 77.0 0.6 146 - 179 P 162.6 3.1 5Abbott 29 165 - 202 P 183.4 2.6 205 - 251 P 228.1 3.2 88 - 107 P 97.6 1.1 68 - 83 P 75.1 0.9 145 - 177 P 161.3 2.4 20Alfa Wassermann 30 175 - 214 P 194.9 4.7 215 - 263 P 238.7 6.2 95 - 116 P 105.7 2.1 74 - 90 P 82.2 2.1 156 - 191 P 173.3 3.6 20Beckman GO 31 169 - 207 P 188.3 2.2 209 - 256 P 232.3 1.3 90 - 110 P 100.3 1.1 70 - 85 P 77.5 0.5 152 - 186 P 168.8 3.0 4Beckman HK 32 169 - 206 P 187.6 4.5 209 - 255 P 231.8 8.1 89 - 109 P 98.9 2.5 69 - 85 P 76.9 2.2 149 - 182 P 165.6 4.5 16Beckman O2 electrode 33 163 - 200 P 181.6 2.7 203 - 249 P 226.0 2.5 86 - 105 P 95.8 1.6 67 - 81 P 74.0 1.7 145 - 178 P 161.6 2.4 5Beckman Olympus 34 168 - 205 P 186.2 4.6 206 - 252 P 229.2 5.8 89 - 109 P 99.0 2.6 69 - 84 P 76.7 2.1 148 - 181 P 164.6 4.5 55Carolina HK 35 175 - 214 P 194.1 6.7 211 - 258 P 234.6 4.9 94 - 114 P 104.0 3.0 73 - 89 P 80.6 2.3 153 - 187 P 169.6 4.9 12Horiba ABX 36 169 - 207 P 188.0 6.7 206 - 252 P 229.4 7.3 90 - 110 P 99.9 2.9 68 - 84 P 76.1 2.2 148 - 180 P 163.9 4.5 7Medica 37 183 - 223 P 202.9 3.6 222 - 271 P 246.8 2.8 98 - 119 P 108.4 2.8 76 - 93 P 84.1 2.1 161 - 197 P 179.3 4.3 9Ortho Vitros 38 162 - 198 P 179.9 4.0 202 - 246 P 224.0 3.4 84 - 103 P 93.3 2.4 66 - 80 P 72.8 1.9 142 - 173 P 157.4 3.2 51Pointe Sci HK 39 168 - 205 P 186.8 5.3 209 - 255 P 231.9 10.2 91 - 112 P 101.4 4.0 72 - 88 P 80.4 3.5 152 - 186 P 169.4 7.4 9Roche Cobas 40 169 - 207 P 187.9 3.6 208 - 255 P 231.5 4.8 90 - 110 P 99.7 2.1 69 - 85 P 77.2 1.6 150 - 183 P 166.4 3.8 41SDI Biomed 41 170 - 207 P 188.4 1.6 216 - 264 P 239.6 3.9 93 - 114 P 103.8 2.8 72 - 88 P 80.4 3.0 155 - 190 P 172.4 2.1 5Sekisui 42 168 - 206 P 186.9 5.7 207 - 253 P 230.0 9.3 92 - 113 P 102.5 4.4 71 - 87 P 79.4 2.6 150 - 184 P 167.1 4.5 10Siemens HK 43 171 - 209 P 189.9 3.6 210 - 256 P 233.0 3.9 92 - 112 P 101.7 2.2 71 - 87 P 79.2 1.8 151 - 185 P 167.9 2.9 52Siemens HK, GLUC 44 171 - 209 P 189.7 3.9 211 - 258 P 234.1 4.8 92 - 112 P 101.8 2.4 71 - 87 P 79.2 1.9 151 - 185 P 168.3 4.1 41Sterling Diagnostic 45 169 - 206 P 187.3 3.9 207 - 253 P 230.4 5.1 92 - 112 P 101.7 1.9 72 - 88 P 79.6 1.9 150 - 183 P 166.2 3.2 13Synermed 46 177 - 216 P 196.4 7.1 215 - 263 P 239.2 7.8 93 - 113 P 103.0 3.1 71 - 87 P 79.2 2.2 155 - 189 P 172.2 5.5 5Vital Diagnostics Envoy 47 180 - 221 P 200.5 0.5 223 - 273 P 248.0 0.0 97 - 119 P 108.0 0.0 76 - 93 P 84.7 1.2 166 - 202 P 184.0 6.0 4Initial Grouping by Sensitivity or PrincipleHexoKinase (HK) 48 169 - 207 P 187.9 5.0 208 - 255 P 231.5 6.3 90 - 111 P 100.5 3.1 70 - 86 P 78.0 2.6 150 - 183 P 166.4 4.7 279HexoKinase Alfa Wasserman and related 49 175 - 214 P 194.9 4.7 215 - 263 P 238.7 6.2 95 - 116 P 105.7 2.1 74 - 90 P 82.2 2.1 156 - 191 P 173.3 3.6 20Glucose Oxidase (GO) 50 167 - 204 P 185.1 8.6 206 - 252 P 228.8 8.3 88 - 107 P 97.4 5.9 68 - 83 P 75.9 4.5 147 - 179 P 162.9 8.2 87Oxygen electrode 51 163 - 200 P 181.6 2.7 203 - 249 P 226.0 2.5 86 - 105 P 95.8 1.6 67 - 81 P 74.0 1.7 145 - 178 P 161.6 2.4 5Vital Diagnostic and related 52 182 - 222 P 201.8 3.1 224 - 274 P 249.0 1.7 97 - 119 P 108.2 2.6 76 - 93 P 84.7 1.7 165 - 202 P 183.7 5.2 7Total PopulationWhole Population 53 169 - 207 P 188.0 6.9 209 - 255 P 231.7 7.9 90 - 110 P 100.2 4.5 70 - 86 P 77.9 3.6 149 - 182 P 165.9 9.5 401

PhosphorusInitial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 3.2 - 4.4 P 3.81 0.1 3.9 - 5.2 P 4.53 0.07 2.0 - 2.8 C 2.36 0.05 1.6 - 2.4 C 1.99 0.05 2.9 - 4.0 P 3.46 0.1 15Alfa Wassermann & Alfa Wasser Axcel/Alera 2 3.3 - 4.5 P 3.93 0.15 3.9 - 5.2 P 4.53 0.15 2.1 - 2.9 C 2.53 0.1 1.8 - 2.6 C 2.16 0.12 3.0 - 4.0 P 3.5 0.11 7Beckman Olympus blanked & Beck Olym AU400/600/5400 3 3.2 - 4.4 P 3.81 0.11 3.8 - 5.2 P 4.48 0.13 2.0 - 2.8 C 2.35 0.08 1.5 - 2.4 C 1.95 0.07 2.9 - 4.0 P 3.45 0.11 11

Beckman Olympus blanked & Beckman AU 480 4 3.3 - 4.5 P 3.88 0.2 3.9 - 5.3 P 4.6 0.27 2.0 - 2.8 C 2.44 0.13 1.6 - 2.4 C 2.04 0.13 3.0 - 4.1 P 3.53 0.21 8Beckman Olympus no blank & Beck Olym AU400/600/5400 5 3.2 - 4.4 P 3.8 0.18 3.9 - 5.2 P 4.55 0.18 2.0 - 2.8 C 2.39 0.14 1.7 - 2.4 C 2.05 0.12 3.0 - 4.0 P 3.5 0.18 11

Beckman Olympus no blank & Beckman AU 480 6 3.3 - 4.5 P 3.88 0.17 3.9 - 5.3 P 4.58 0.21 2.0 - 2.8 C 2.42 0.21 1.6 - 2.4 C 2.03 0.08 3.0 - 4.1 P 3.54 0.2 13Beckman Synchron PHS & Beck Coult Unicel DXC 7 3.5 - 4.7 P 4.09 0.1 4.1 - 5.5 P 4.79 0.12 2.1 - 2.9 C 2.49 0.05 1.7 - 2.5 C 2.06 0.07 3.1 - 4.2 P 3.69 0.09 10Carolina & Beck Olym AU 400/600/5400 8 3.4 - 4.7 P 4.05 0.15 4.0 - 5.4 P 4.7 0.22 2.2 - 3.0 C 2.63 0.11 1.9 - 2.7 C 2.25 0.15 3.1 - 4.2 P 3.63 0.19 4Carolina & Beckman Synchron CX3/7/9/L 9 3.4 - 4.7 P 4.05 0.32 4.1 - 5.6 P 4.83 0.24 2.2 - 2.9 C 2.55 0.21 1.7 - 2.5 C 2.13 0.15 3.1 - 4.2 P 3.68 0.29 4Horiba ABX & Horiba ABX 400 10 3.6 - 4.8 P 4.18 0.08 4.2 - 5.7 P 4.93 0.08 2.3 - 3.1 C 2.65 0.05 1.8 - 2.6 C 2.2 0.07 3.2 - 4.3 P 3.78 0.08 4Ortho Vitros & Ortho Vitros 3600, 5600 11 3.3 - 4.5 P 3.91 0.1 3.9 - 5.3 P 4.61 0.13 2.2 - 3.0 C 2.58 0.1 1.8 - 2.6 C 2.22 0.1 3.0 - 4.1 P 3.58 0.12 16Ortho Vitros & Ortho Vitros 5,1 FS 12 3.5 - 4.7 P 4.08 0.08 4.0 - 5.4 P 4.72 0.04 2.3 - 3.1 P 2.68 0.08 1.9 - 2.7 C 2.3 0.07 3.1 - 4.3 P 3.7 0.07 4Ortho Vitros & Ortho Vitros not DT or ECi 13 3.4 - 4.6 P 3.98 0.16 4.0 - 5.4 P 4.71 0.18 2.2 - 3.0 C 2.64 0.12 1.9 - 2.7 C 2.27 0.11 3.1 - 4.2 P 3.68 0.12 17Roche Cobas & Roche Cobas 6000 14 3.3 - 4.5 P 3.89 0.1 3.9 - 5.3 P 4.64 0.07 2.0 - 2.8 C 2.41 0.06 1.6 - 2.4 C 2.01 0.06 3.0 - 4.0 P 3.5 0.11 7Roche Cobas & Roche e/c, 1XX, X000, Elec series 15 3.3 - 4.5 P 3.91 0.12 3.9 - 5.3 P 4.62 0.14 2.0 - 2.8 C 2.42 0.09 1.6 - 2.4 C 2.03 0.07 3.0 - 4.1 P 3.54 0.13 12Roche Cobas Integra & Roche Cobas Integra 16 3.3 - 4.5 P 3.93 0.15 4.0 - 5.4 P 4.67 0.15 2.0 - 2.8 C 2.43 0.11 1.7 - 2.5 C 2.07 0.07 3.0 - 4.1 P 3.55 0.1 6SDI Biomed & SDI CA-240, 480 17 3.0 - 4.0 P 3.5 0.0 3.6 - 4.9 P 4.23 0.05 1.9 - 2.7 C 2.25 0.05 1.5 - 2.3 C 1.9 0.07 2.8 - 3.7 P 3.25 0.11 4Sekisui & Beck Olym AU 400/600/5400 18 3.3 - 4.5 P 3.88 0.19 3.8 - 5.2 P 4.52 0.23 2.0 - 2.8 C 2.38 0.12 1.6 - 2.4 C 2.02 0.15 2.9 - 4.0 P 3.46 0.19 5Siemens Dimension & Siemens Dim RxL, RxL Max 19 3.5 - 4.7 P 4.08 0.08 4.0 - 5.5 P 4.75 0.15 2.2 - 3.0 C 2.63 0.08 1.8 - 2.6 C 2.2 0.07 3.2 - 4.3 P 3.75 0.05 4Siemens Dimension & Siemens Dimension EXL 20 3.5 - 4.7 P 4.08 0.09 4.1 - 5.5 P 4.77 0.11 2.2 - 3.0 C 2.6 0.09 1.8 - 2.6 C 2.21 0.08 3.2 - 4.3 P 3.71 0.08 53Siemens Dimension & Siemens Dimension Xpand 21 3.5 - 4.7 P 4.09 0.08 4.0 - 5.5 P 4.75 0.07 2.2 - 3.0 C 2.6 0.08 1.8 - 2.6 C 2.22 0.07 3.1 - 4.2 P 3.69 0.07 13Initial Grouping by ReagentAbbott Architect 22 3.2 - 4.4 P 3.81 0.1 3.9 - 5.2 P 4.53 0.07 2.0 - 2.8 C 2.37 0.06 1.6 - 2.4 C 1.99 0.04 3.0 - 4.0 P 3.47 0.09 16Alfa Wassermann 23 3.3 - 4.5 P 3.93 0.15 3.9 - 5.2 P 4.53 0.15 2.1 - 2.9 C 2.53 0.1 1.8 - 2.6 C 2.16 0.12 3.0 - 4.0 P 3.5 0.11 7Beckman Olympus blanked 24 3.3 - 4.4 P 3.84 0.16 3.9 - 5.2 P 4.54 0.21 2.0 - 2.8 C 2.39 0.11 1.6 - 2.4 C 1.99 0.1 3.0 - 4.0 P 3.49 0.16 21Beckman Olympus no blank 25 3.3 - 4.4 P 3.84 0.17 3.9 - 5.2 P 4.56 0.19 2.0 - 2.8 C 2.41 0.17 1.6 - 2.4 C 2.03 0.1 3.0 - 4.0 P 3.52 0.19 26Beckman Synchron PHS 26 3.5 - 4.7 P 4.08 0.1 4.1 - 5.5 P 4.77 0.13 2.1 - 2.9 C 2.49 0.05 1.7 - 2.5 C 2.07 0.07 3.1 - 4.2 P 3.69 0.09 11Carolina 27 3.4 - 4.6 P 3.99 0.26 4.0 - 5.4 P 4.68 0.3 2.2 - 2.9 C 2.55 0.17 1.8 - 2.6 C 2.15 0.15 3.1 - 4.2 P 3.61 0.24 11Horiba ABX 28 3.6 - 4.8 P 4.18 0.08 4.2 - 5.7 P 4.93 0.08 2.3 - 3.1 C 2.65 0.05 1.8 - 2.6 C 2.2 0.07 3.2 - 4.3 P 3.78 0.08 4Ortho Vitros 29 3.4 - 4.6 P 3.96 0.14 4.0 - 5.4 P 4.67 0.16 2.2 - 3.0 C 2.62 0.12 1.9 - 2.7 C 2.25 0.11 3.1 - 4.2 P 3.64 0.13 37Pointe Scientific 30 3.4 - 4.6 P 4.03 0.04 4.0 - 5.5 P 4.75 0.11 2.1 - 2.9 C 2.5 0.07 1.7 - 2.5 C 2.1 0.0 3.1 - 4.2 P 3.65 0.09 5Roche Cobas 31 3.3 - 4.5 P 3.9 0.11 3.9 - 5.3 P 4.62 0.12 2.0 - 2.8 C 2.42 0.08 1.6 - 2.4 C 2.02 0.07 3.0 - 4.0 P 3.52 0.12 21Roche Cobas Integra 32 3.3 - 4.5 P 3.94 0.15 4.0 - 5.4 P 4.66 0.15 2.1 - 2.9 C 2.45 0.11 1.7 - 2.5 C 2.07 0.08 3.0 - 4.1 P 3.55 0.11 8SDI Biomed 33 3.0 - 4.0 P 3.5 0.0 3.6 - 4.9 P 4.23 0.05 1.9 - 2.7 C 2.25 0.05 1.5 - 2.3 C 1.9 0.07 2.8 - 3.7 P 3.25 0.11 4Sekisui 34 3.3 - 4.5 P 3.87 0.18 3.8 - 5.2 P 4.52 0.21 2.0 - 2.8 C 2.38 0.11 1.6 - 2.4 C 2.0 0.14 2.9 - 4.0 P 3.45 0.17 6Siemens Dimension 35 3.5 - 4.7 P 4.07 0.11 4.0 - 5.5 P 4.76 0.11 2.2 - 3.0 C 2.59 0.1 1.8 - 2.6 C 2.2 0.09 3.1 - 4.3 P 3.7 0.09 73Synermed 36 3.5 - 4.7 P 4.07 0.09 4.1 - 5.6 P 4.87 0.05 2.2 - 3.0 C 2.57 0.17 1.9 - 2.7 C 2.25 0.21 3.2 - 4.3 P 3.73 0.12 4Initial Grouping by Sensitivity or PrincipleUV-uncorrected 37 3.3 - 4.5 P 3.93 0.15 3.9 - 5.3 P 4.64 0.23 2.1 - 2.9 C 2.45 0.13 1.7 - 2.5 C 2.06 0.14 3.0 - 4.1 P 3.57 0.19 19UV-bichromatic-sam blanked 38 3.4 - 4.6 P 3.98 0.17 4.0 - 5.4 P 4.68 0.18 2.1 - 2.9 C 2.51 0.14 1.7 - 2.5 C 2.12 0.13 3.1 - 4.2 P 3.61 0.16 143UV-bichromatic-no sam blks 39 3.3 - 4.4 P 3.83 0.19 3.9 - 5.2 P 4.53 0.2 2.0 - 2.8 C 2.41 0.17 1.6 - 2.4 C 2.04 0.12 3.0 - 4.0 P 3.48 0.19 37UV-just sample blanked 40 3.5 - 4.7 P 4.08 0.1 4.1 - 5.5 P 4.77 0.12 2.1 - 2.9 C 2.5 0.06 1.7 - 2.5 C 2.07 0.07 3.1 - 4.2 P 3.69 0.09 12UV-rate 41 3.5 - 4.7 P 4.06 0.17 4.1 - 5.5 P 4.78 0.18 2.1 - 2.9 C 2.53 0.13 1.7 - 2.5 C 2.13 0.09 3.1 - 4.2 P 3.67 0.15 16Visible 42 3.4 - 4.6 P 3.96 0.14 4.0 - 5.4 P 4.68 0.16 2.2 - 3.0 C 2.62 0.12 1.9 - 2.7 C 2.25 0.12 3.1 - 4.2 P 3.65 0.13 40Total PopulationWhole Population 43 3.4 - 4.6 P 3.97 0.19 4.0 - 5.4 P 4.67 0.21 2.1 - 2.9 C 2.52 0.17 1.7 - 2.5 C 2.13 0.17 3.1 - 4.2 P 3.61 0.18 268

PotassiumInitial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 5.1 - 6.1 C 5.64 0.05 6.1 - 7.1 C 6.59 0.04 3.2 - 4.2 C 3.68 0.04 2.7 - 3.7 C 3.19 0.03 4.7 - 5.7 C 5.15 0.06 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 5.3 - 6.3 C 5.76 0.13 6.2 - 7.2 C 6.74 0.1 3.2 - 4.2 C 3.7 0.08 2.7 - 3.7 C 3.16 0.07 4.7 - 5.7 C 5.19 0.05 17Beckman Coulter & Beck Coult Unicel DXC 3 5.1 - 6.1 C 5.57 0.06 6.0 - 7.0 C 6.54 0.07 3.1 - 4.1 C 3.62 0.05 2.6 - 3.6 C 3.13 0.05 4.6 - 5.6 C 5.1 0.07 17Beckman Coulter & Beck Olym AU 400/600/5400 4 5.0 - 6.0 C 5.48 0.07 5.9 - 6.9 C 6.4 0.15 3.1 - 4.1 C 3.62 0.04 2.6 - 3.6 C 3.13 0.05 4.5 - 5.5 C 5.02 0.07 6Beckman Coulter & Beckman AU 480 5 5.0 - 6.0 C 5.54 0.05 6.0 - 7.0 C 6.49 0.12 3.2 - 4.2 C 3.73 0.05 2.7 - 3.7 C 3.21 0.03 4.5 - 5.5 C 5.04 0.09 7Beckman Olympus & Beck Olym AU 400/600/5400 6 5.0 - 6.0 C 5.5 0.07 5.9 - 6.9 C 6.44 0.09 3.1 - 4.1 C 3.63 0.04 2.7 - 3.7 C 3.16 0.05 4.5 - 5.5 C 5.04 0.06 34Beckman Olympus & Beck Olympus AU 2700 7 5.0 - 6.0 C 5.53 0.08 6.0 - 7.0 C 6.5 0.07 3.1 - 4.1 C 3.63 0.04 2.7 - 3.7 C 3.18 0.04 4.6 - 5.6 C 5.05 0.05 4Beckman Olympus & Beckman AU 480 8 5.0 - 6.0 C 5.48 0.09 5.9 - 6.9 C 6.42 0.1 3.1 - 4.1 C 3.62 0.05 2.7 - 3.7 C 3.16 0.05 4.5 - 5.5 C 5.01 0.06 21

Carolina & Beckman Synchron CX3/7/9/L 9 5.2 - 6.2 C 5.7 0.06 6.1 - 7.1 C 6.62 0.13 3.2 - 4.2 C 3.72 0.07 2.7 - 3.7 C 3.22 0.07 4.6 - 5.6 C 5.14 0.05 5Diamond Diagnostics & Beck Olym AU 400/600/5400 10 5.0 - 6.0 C 5.54 0.05 6.0 - 7.0 C 6.48 0.07 3.1 - 4.1 C 3.64 0.05 2.7 - 3.7 C 3.16 0.05 4.6 - 5.6 C 5.06 0.05 5Horiba ABX & Horiba ABX 400 11 5.0 - 6.0 C 5.49 0.12 5.9 - 6.9 C 6.4 0.15 3.1 - 4.1 C 3.63 0.05 2.7 - 3.7 C 3.19 0.03 4.5 - 5.5 C 5.03 0.07 7Medica Easy RA & Medica Easy RA 12 5.0 - 6.0 C 5.49 0.09 5.9 - 6.9 C 6.39 0.12 3.1 - 4.1 C 3.56 0.05 2.6 - 3.6 C 3.13 0.05 4.5 - 5.5 C 5.0 0.09 10Ortho Vitros & Ortho Vitros 3600, 5600 13 5.2 - 6.2 C 5.71 0.09 6.2 - 7.2 C 6.69 0.1 3.2 - 4.2 C 3.74 0.07 2.8 - 3.8 C 3.25 0.07 4.7 - 5.7 C 5.22 0.07 17Ortho Vitros & Ortho Vitros 5,1 FS 14 5.2 - 6.2 C 5.7 0.1 6.1 - 7.1 C 6.63 0.19 3.2 - 4.2 C 3.7 0.1 2.7 - 3.7 C 3.22 0.08 4.7 - 5.7 C 5.18 0.08 4Ortho Vitros & Ortho Vitros not DT or ECi 15 5.2 - 6.2 C 5.72 0.07 6.2 - 7.2 C 6.71 0.08 3.3 - 4.3 C 3.75 0.05 2.8 - 3.8 C 3.26 0.05 4.7 - 5.7 C 5.24 0.07 27Roche Cobas dil ISE & Roche Cobas 6000 16 5.2 - 6.2 C 5.66 0.16 6.1 - 7.1 C 6.6 0.2 3.2 - 4.2 C 3.71 0.11 2.7 - 3.7 C 3.19 0.13 4.6 - 5.6 C 5.13 0.12 8Roche Cobas dil ISE & Roche Cobas Integra 17 5.1 - 6.1 C 5.63 0.04 6.1 - 7.1 C 6.55 0.05 3.2 - 4.2 C 3.68 0.04 2.7 - 3.7 C 3.2 0.0 4.6 - 5.6 C 5.13 0.05 12Roche Cobas dil ISE & Roche e/c, 1XX, X000, Elecseries 18 5.2 - 6.2 C 5.68 0.07 6.2 - 7.2 C 6.66 0.09 3.2 - 4.2 C 3.73 0.09 2.7 - 3.7 C 3.24 0.08 4.7 - 5.7 C 5.19 0.09 14

SDI Biomed & SDI CA-240, 480 19 5.0 - 6.0 C 5.54 0.1 6.0 - 7.0 C 6.46 0.2 3.2 - 4.2 C 3.66 0.14 2.7 - 3.7 C 3.24 0.1 4.6 - 5.6 C 5.12 0.04 5Siemens QuickLYTE IMT & Siemens Dim RxL, RxLMax 20 5.0 - 6.0 C 5.53 0.04 6.0 - 7.0 C 6.45 0.05 3.1 - 4.1 C 3.63 0.08 2.7 - 3.7 C 3.18 0.04 4.6 - 5.6 C 5.05 0.05 4

Siemens QuickLYTE IMT & Siemens Dimension EXL 21 5.1 - 6.1 C 5.63 0.05 6.1 - 7.1 C 6.56 0.06 3.2 - 4.2 C 3.66 0.05 2.7 - 3.7 C 3.18 0.05 4.6 - 5.6 C 5.13 0.06 59Siemens QuickLYTE IMT & Siemens DimensionXpand 22 5.1 - 6.1 C 5.62 0.07 6.1 - 7.1 C 6.6 0.09 3.2 - 4.2 C 3.65 0.06 2.7 - 3.7 C 3.17 0.06 4.7 - 5.7 C 5.15 0.08 23

Siemens dil ISE & Siemens Advia 23 5.1 - 6.1 C 5.55 0.05 5.9 - 6.9 C 6.42 0.18 3.2 - 4.2 C 3.65 0.05 2.7 - 3.7 C 3.2 0.0 4.5 - 5.5 C 5.02 0.2 4Vital Diagnostics Envoy & Vital Diagnostic Envoy 24 5.1 - 6.1 C 5.6 0.07 6.0 - 7.0 C 6.45 0.05 3.1 - 4.1 C 3.63 0.04 2.7 - 3.7 C 3.18 0.08 4.7 - 5.7 C 5.15 0.11 4Initial Grouping by ReagentAbaxis Piccolo 25 5.3 - 6.3 C 5.8 0.0 6.2 - 7.2 C 6.7 0.0 3.2 - 4.2 C 3.7 0.21 2.6 - 3.6 C 3.05 0.26 4.7 - 5.7 C 5.18 0.13 4Abbott Architect 26 5.1 - 6.1 C 5.64 0.05 6.1 - 7.1 C 6.59 0.04 3.2 - 4.2 C 3.68 0.04 2.7 - 3.7 C 3.19 0.03 4.7 - 5.7 C 5.15 0.06 19Alfa Wassermann 27 5.3 - 6.3 C 5.76 0.13 6.2 - 7.2 C 6.74 0.1 3.2 - 4.2 C 3.7 0.08 2.7 - 3.7 C 3.16 0.07 4.7 - 5.7 C 5.19 0.05 17Beckman Coulter 28 5.1 - 6.1 C 5.55 0.07 6.0 - 7.0 C 6.5 0.12 3.2 - 4.2 C 3.65 0.07 2.7 - 3.7 C 3.15 0.06 4.6 - 5.6 C 5.07 0.08 30Beckman Olympus 29 5.0 - 6.0 C 5.49 0.08 5.9 - 6.9 C 6.44 0.1 3.1 - 4.1 C 3.62 0.05 2.7 - 3.7 C 3.16 0.05 4.5 - 5.5 C 5.03 0.06 59Carolina 30 5.1 - 6.1 C 5.58 0.17 6.1 - 7.1 C 6.58 0.17 3.2 - 4.2 C 3.65 0.11 2.7 - 3.7 C 3.16 0.09 4.6 - 5.6 C 5.05 0.12 11Diamond Diagnostics 31 5.0 - 6.0 C 5.49 0.12 5.9 - 6.9 C 6.4 0.15 3.1 - 4.1 C 3.63 0.12 2.7 - 3.7 C 3.18 0.07 4.5 - 5.5 C 5.0 0.13 7Horiba ABX 32 5.0 - 6.0 C 5.49 0.12 5.9 - 6.9 C 6.4 0.15 3.1 - 4.1 C 3.63 0.05 2.7 - 3.7 C 3.19 0.03 4.5 - 5.5 C 5.03 0.07 7Medica Easy RA 33 5.0 - 6.0 C 5.49 0.09 5.9 - 6.9 C 6.39 0.12 3.1 - 4.1 C 3.56 0.05 2.6 - 3.6 C 3.13 0.05 4.5 - 5.5 C 5.0 0.09 10Medica EasyLyte 34 5.2 - 6.2 C 5.65 0.11 6.1 - 7.1 C 6.6 0.19 3.2 - 4.2 C 3.73 0.09 2.7 - 3.7 C 3.23 0.05 4.7 - 5.7 C 5.2 0.07 4Ortho Vitros 35 5.2 - 6.2 C 5.71 0.08 6.2 - 7.2 C 6.69 0.1 3.2 - 4.2 C 3.74 0.06 2.8 - 3.8 C 3.25 0.06 4.7 - 5.7 C 5.22 0.07 50Pointe Scientific 36 5.0 - 6.0 C 5.45 0.09 5.8 - 6.8 C 6.3 0.12 3.0 - 4.0 C 3.53 0.05 2.5 - 3.5 C 3.03 0.05 4.4 - 5.4 C 4.9 0.07 4Roche Cobas dil ISE 37 5.2 - 6.2 C 5.66 0.09 6.1 - 7.1 C 6.61 0.13 3.2 - 4.2 C 3.71 0.08 2.7 - 3.7 C 3.22 0.09 4.7 - 5.7 C 5.16 0.09 34Roche Cobas und ISE 38 5.1 - 6.1 C 5.63 0.11 6.0 - 7.0 C 6.52 0.13 3.2 - 4.2 C 3.72 0.07 2.7 - 3.7 C 3.22 0.07 4.6 - 5.6 C 5.13 0.11 6SDI Biomed 39 5.0 - 6.0 C 5.54 0.1 6.0 - 7.0 C 6.46 0.2 3.2 - 4.2 C 3.66 0.14 2.7 - 3.7 C 3.24 0.1 4.6 - 5.6 C 5.12 0.04 5Siemens QuickLYTE IMT 40 5.1 - 6.1 C 5.62 0.06 6.1 - 7.1 C 6.56 0.08 3.2 - 4.2 C 3.66 0.06 2.7 - 3.7 C 3.17 0.05 4.6 - 5.6 C 5.13 0.07 89Siemens dil ISE 41 5.1 - 6.1 C 5.55 0.05 5.9 - 6.9 C 6.42 0.18 3.2 - 4.2 C 3.65 0.05 2.7 - 3.7 C 3.2 0.0 4.5 - 5.5 C 5.02 0.2 4Vital Diagnostics Envoy 42 5.1 - 6.1 C 5.6 0.07 6.0 - 7.0 C 6.45 0.05 3.1 - 4.1 C 3.63 0.04 2.7 - 3.7 C 3.18 0.08 4.7 - 5.7 C 5.15 0.11 4Initial Grouping by Sensitivity or PrincipleUndiluted ISE results 43 5.1 - 6.1 C 5.64 0.12 6.1 - 7.1 C 6.59 0.15 3.2 - 4.2 C 3.68 0.08 2.7 - 3.7 C 3.19 0.07 4.7 - 5.7 C 5.15 0.1 199Colorimetric/turbidimetric 44 5.1 - 6.1 C 5.56 0.17 6.0 - 7.0 C 6.5 0.22 3.1 - 4.1 C 3.63 0.18 2.5 - 3.5 C 3.03 0.05 4.5 - 5.5 C 5.04 0.17 9Diluted ISE results 45 5.1 - 6.1 C 5.56 0.12 6.0 - 7.0 C 6.51 0.14 3.2 - 4.2 C 3.66 0.08 2.7 - 3.7 C 3.17 0.07 4.6 - 5.6 C 5.08 0.11 170Total PopulationWhole Population 46 5.1 - 6.1 C 5.61 0.14 6.1 - 7.1 C 6.56 0.17 3.2 - 4.2 C 3.67 0.1 2.7 - 3.7 C 3.18 0.09 4.6 - 5.6 C 5.11 0.15 381

SodiumInitial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 140 - 148 C 144.3 0.8 150 - 158 C 154.2 0.7 119 - 127 C 122.7 0.6 113 - 121 C 117.4 0.7 135 - 143 C 138.9 0.7 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 143 - 151 C 146.8 2.5 153 - 161 C 157.4 1.6 117 - 125 C 121.4 1.3 111 - 119 C 114.9 1.2 134 - 142 C 138.4 1.0 16Beckman Coulter & Beck Coult Unicel DXC 3 139 - 147 C 142.6 1.5 149 - 157 C 152.9 1.8 119 - 127 C 123.1 1.4 114 - 122 C 117.8 1.4 134 - 142 C 138.4 1.7 17Beckman Coulter & Beck Olym AU 400/600/5400 4 138 - 146 C 141.5 1.4 146 - 154 C 150.0 2.6 118 - 126 C 121.5 1.4 113 - 121 C 116.7 1.5 133 - 141 C 136.7 1.1 6Beckman Coulter & Beckman AU 480 5 139 - 147 C 143.1 1.0 150 - 158 C 153.9 2.0 119 - 127 C 123.3 1.2 114 - 122 C 117.7 1.0 134 - 142 C 138.4 1.3 7Beckman Olympus & Beck Olym AU 400/600/5400 6 138 - 146 C 141.6 1.6 147 - 155 C 151.4 1.7 117 - 125 C 121.4 1.3 112 - 120 C 116.2 1.1 133 - 141 C 136.8 1.3 35Beckman Olympus & Beck Olympus AU 2700 7 139 - 147 C 142.5 0.5 149 - 157 C 152.5 1.1 118 - 126 C 121.5 1.1 112 - 120 C 116.0 1.0 133 - 141 C 137.0 0.7 4Beckman Olympus & Beckman AU 480 8 138 - 146 C 141.5 1.6 148 - 156 C 151.7 1.7 118 - 126 C 121.7 0.8 112 - 120 C 116.4 1.4 133 - 141 C 136.8 1.4 22Carolina & Beckman Synchron CX3/7/9/L 9 138 - 146 C 142.4 2.2 149 - 157 C 153.0 2.8 119 - 127 C 122.6 2.2 113 - 121 C 117.4 2.6 134 - 142 C 138.2 2.8 5Diamond Diagnostics & Beck Olym AU 400/600/5400 10 138 - 146 C 141.5 1.1 148 - 156 C 151.5 1.1 117 - 125 C 121.3 0.8 112 - 120 C 115.5 0.9 133 - 141 C 136.5 0.9 4Horiba ABX & Horiba ABX 400 11 142 - 150 C 145.6 1.8 153 - 161 C 156.7 1.7 119 - 127 C 122.9 1.4 113 - 121 C 117.1 1.6 136 - 144 C 139.6 1.3 7Medica Easy RA & Medica Easy RA 12 142 - 150 C 145.6 1.5 151 - 159 C 155.4 1.8 119 - 127 C 122.8 1.0 114 - 122 C 117.8 0.9 136 - 144 C 140.0 1.3 10Ortho Vitros & Ortho Vitros 3600, 5600 13 146 - 154 C 150.2 2.5 159 - 167 C 163.4 1.8 122 - 130 C 126.4 1.6 116 - 124 C 120.4 1.5 140 - 148 C 144.4 1.7 17Ortho Vitros & Ortho Vitros not DT or ECi 14 146 - 154 C 150.4 1.8 159 - 167 C 163.0 1.8 122 - 130 C 125.9 1.8 116 - 124 C 120.2 1.6 141 - 149 C 144.8 1.9 27Roche Cobas dil ISE & Roche Cobas 6000 15 140 - 148 C 143.9 1.5 150 - 158 C 153.6 2.1 119 - 127 C 122.9 1.8 114 - 122 C 117.9 1.9 135 - 143 C 138.5 1.6 8Roche Cobas dil ISE & Roche Cobas Integra 16 139 - 147 C 142.8 1.1 149 - 157 C 153.2 1.2 118 - 126 C 122.3 1.1 113 - 121 C 116.8 1.0 133 - 141 C 137.4 1.1 12

Roche Cobas dil ISE & Roche e/c, 1XX, X000, Elecseries 17 140 - 148 C 143.6 1.3 151 - 159 C 154.6 1.3 119 - 127 C 122.9 1.8 114 - 122 C 117.6 2.0 135 - 143 C 138.6 2.0 14

SDI Biomed & SDI CA-240, 480 18 140 - 148 C 144.4 0.5 151 - 159 C 155.0 1.4 122 - 130 C 125.8 0.7 115 - 123 C 118.8 1.5 135 - 143 C 139.2 1.5 5Siemens QuickLYTE IMT & Siemens Dim RxL, RxLMax 19 138 - 146 C 142.3 0.8 147 - 155 C 150.8 1.8 118 - 126 C 122.3 1.6 113 - 121 C 117.3 1.5 133 - 141 C 136.5 0.9 4

Siemens QuickLYTE IMT & Siemens Dimension EXL 20 140 - 148 C 144.4 1.2 150 - 158 C 153.5 1.3 120 - 128 C 124.4 1.1 116 - 124 C 119.5 1.1 135 - 143 C 139.3 1.2 58Siemens QuickLYTE IMT & Siemens DimensionXpand 21 141 - 149 C 144.5 1.3 150 - 158 C 153.7 1.6 121 - 129 C 124.6 1.1 116 - 124 C 119.7 0.9 135 - 143 C 139.3 1.3 23

Siemens dil ISE & Siemens Advia 22 140 - 148 C 144.3 0.8 150 - 158 C 154.3 0.4 120 - 128 C 124.0 0.7 114 - 122 C 118.3 0.8 135 - 143 C 138.8 0.8 4Vital Diagnostics Envoy & Vital Diagnostic Envoy 23 139 - 147 C 143.0 1.0 150 - 158 C 153.5 1.1 119 - 127 C 123.0 1.2 113 - 121 C 117.3 1.9 135 - 143 C 138.5 1.8 4Initial Grouping by ReagentAbaxis Piccolo 24 138 - 146 C 141.8 3.5 149 - 157 C 153.3 2.7 120 - 128 C 123.8 2.2 117 - 125 C 120.8 0.8 137 - 145 C 140.8 0.8 4Abbott Architect 25 140 - 148 C 144.3 0.8 150 - 158 C 154.2 0.7 119 - 127 C 122.7 0.6 113 - 121 C 117.4 0.7 135 - 143 C 138.9 0.7 19Alfa Wassermann 26 143 - 151 C 146.8 2.5 153 - 161 C 157.4 1.6 117 - 125 C 121.4 1.3 111 - 119 C 114.9 1.2 134 - 142 C 138.4 1.0 16Beckman Coulter 27 139 - 147 C 142.5 1.5 149 - 157 C 152.6 2.4 119 - 127 C 122.8 1.5 114 - 122 C 117.6 1.4 134 - 142 C 138.0 1.7 30Beckman Olympus 28 138 - 146 C 141.6 1.5 148 - 156 C 151.6 1.7 118 - 126 C 121.5 1.1 112 - 120 C 116.3 1.2 133 - 141 C 136.8 1.3 61Carolina 29 138 - 146 C 142.4 2.0 148 - 156 C 152.2 3.2 117 - 125 C 121.4 2.3 113 - 121 C 116.6 2.5 134 - 142 C 137.7 2.5 10Diamond Diagnostics 30 138 - 146 C 142.2 2.0 148 - 156 C 152.4 2.1 118 - 126 C 121.8 1.6 113 - 121 C 116.5 1.8 134 - 142 C 137.5 1.8 6Horiba ABX 31 142 - 150 C 145.6 1.8 153 - 161 C 156.7 1.7 119 - 127 C 122.9 1.4 113 - 121 C 117.1 1.6 136 - 144 C 139.6 1.3 7Medica Easy RA 32 142 - 150 C 145.6 1.5 151 - 159 C 155.4 1.8 119 - 127 C 122.8 1.0 114 - 122 C 117.8 0.9 136 - 144 C 140.0 1.3 10Medica EasyLyte 33 145 - 153 C 148.8 1.5 155 - 163 C 159.0 3.1 123 - 131 C 126.7 1.2 117 - 125 C 121.3 2.1 140 - 148 C 143.8 1.9 4Ortho Vitros 34 146 - 154 C 150.3 2.0 159 - 167 C 163.1 1.8 122 - 130 C 126.1 1.7 116 - 124 C 120.2 1.6 141 - 149 C 144.6 1.9 50Pointe Scientific 35 146 - 154 C 149.5 1.1 154 - 162 C 157.8 1.3 122 - 130 C 125.8 0.8 117 - 125 C 120.5 0.5 138 - 146 C 142.3 1.3 4Roche Cobas dil ISE 36 139 - 147 C 143.4 1.4 150 - 158 C 153.9 1.6 119 - 127 C 122.6 1.6 113 - 121 C 117.4 1.7 134 - 142 C 138.2 1.7 34Roche Cobas und ISE 37 141 - 149 C 144.7 2.3 152 - 160 C 156.2 3.7 119 - 127 C 122.7 1.1 113 - 121 C 117.0 1.6 135 - 143 C 139.3 1.7 6SDI Biomed 38 140 - 148 C 144.4 0.5 151 - 159 C 155.0 1.4 122 - 130 C 125.8 0.7 115 - 123 C 118.8 1.5 135 - 143 C 139.2 1.5 5Siemens QuickLYTE IMT 39 140 - 148 C 144.3 1.3 150 - 158 C 153.5 1.5 120 - 128 C 124.4 1.2 116 - 124 C 119.6 1.2 135 - 143 C 139.2 1.4 89Siemens dil ISE 40 140 - 148 C 144.3 0.8 150 - 158 C 154.3 0.4 120 - 128 C 124.0 0.7 114 - 122 C 118.3 0.8 135 - 143 C 138.8 0.8 4Vital Diagnostics Envoy 41 139 - 147 C 143.0 1.0 150 - 158 C 153.5 1.1 119 - 127 C 123.0 1.2 113 - 121 C 117.3 1.9 135 - 143 C 138.5 1.8 4Initial Grouping by Sensitivity or PrincipleUndiluted ISE 42 142 - 150 C 146.2 3.1 153 - 161 C 156.8 4.4 120 - 128 C 124.3 2.0 115 - 123 C 118.9 2.2 137 - 145 C 140.6 2.9 199Colorimetric 43 142 - 150 C 145.6 4.7 153 - 161 C 156.7 4.4 120 - 128 C 124.2 2.3 117 - 125 C 120.6 0.7 138 - 146 C 141.5 1.3 9Diluted ISE 44 139 - 147 C 142.6 1.9 149 - 157 C 152.8 2.4 118 - 126 C 122.2 1.6 113 - 121 C 116.9 1.7 134 - 142 C 137.7 1.9 171Total PopulationWhole Population 45 141 - 149 C 144.6 3.3 151 - 159 C 155.0 4.2 119 - 127 C 123.4 2.3 114 - 122 C 118.1 2.4 135 - 143 C 139.4 2.9 381

Protein, TotalInitial Grouping by Reagent and InstrumentAbbott & Abbott Architect c, ci, i 1 5.6 - 6.9 P 6.24 0.1 6.6 - 8.1 P 7.38 0.09 3.6 - 4.4 P 3.98 0.08 3.1 - 3.8 P 3.41 0.06 5.1 - 6.3 P 5.69 0.08 21Alfa Wassermann & Alfa Wasser Axcel/Alera 2 5.7 - 6.9 P 6.28 0.14 6.6 - 8.1 P 7.37 0.15 3.7 - 4.5 P 4.08 0.1 3.2 - 3.9 P 3.53 0.13 5.2 - 6.3 P 5.74 0.15 17All refractometers & All other refractometers 3 7.1 - 8.6 P 7.84 0.13 8.2 - 10.0 P 9.11 0.16 4.8 - 5.8 P 5.28 0.11 4.2 - 5.1 P 4.66 0.16 6.5 - 7.9 P 7.18 0.14 286All refractometers & Reichert TS Meter-DSP 4 7.0 - 8.6 P 7.82 0.14 8.2 - 10.0 P 9.1 0.14 4.8 - 5.8 P 5.31 0.12 4.2 - 5.1 P 4.67 0.1 6.5 - 7.9 P 7.19 0.15 89Beckman Olympus & Beck Olym AU 400/600/5400 5 5.4 - 6.6 P 6.03 0.18 6.3 - 7.7 P 7.03 0.23 3.5 - 4.3 P 3.92 0.15 3.1 - 3.7 P 3.4 0.14 5.0 - 6.1 P 5.5 0.18 31Beckman Olympus & Beck Olympus AU 2700 6 5.4 - 6.6 P 5.98 0.08 6.4 - 7.8 P 7.08 0.08 3.6 - 4.3 P 3.95 0.05 3.1 - 3.8 P 3.45 0.05 5.0 - 6.1 P 5.5 0.07 4Beckman Olympus & Beckman AU 480 7 5.4 - 6.6 P 6.01 0.16 6.3 - 7.7 P 7.04 0.18 3.5 - 4.3 P 3.92 0.11 3.1 - 3.7 P 3.39 0.09 5.0 - 6.1 P 5.52 0.13 24Beckman rate & Beck Coult Unicel DXC 8 5.6 - 6.8 P 6.19 0.08 6.5 - 7.9 P 7.19 0.09 3.6 - 4.4 P 4.04 0.09 3.1 - 3.8 P 3.49 0.08 5.1 - 6.2 P 5.66 0.09 8Beckman unc & Beck Coult Unicel DXC 9 5.6 - 6.8 P 6.17 0.12 6.5 - 7.9 P 7.22 0.1 3.6 - 4.4 P 4.03 0.04 3.1 - 3.8 P 3.49 0.06 5.1 - 6.2 P 5.62 0.04 9Carolina & Beck Olym AU 400/600/5400 10 5.5 - 6.7 P 6.08 0.15 6.5 - 8.0 P 7.25 0.16 3.6 - 4.4 P 3.97 0.07 3.1 - 3.8 P 3.45 0.08 5.1 - 6.2 P 5.62 0.12 6Carolina & Beckman Synchron CX3/7/9/L 11 5.3 - 6.5 P 5.9 0.06 6.2 - 7.6 P 6.92 0.13 3.5 - 4.2 P 3.86 0.1 3.1 - 3.8 P 3.42 0.1 4.9 - 6.0 P 5.44 0.15 5Horiba ABX & Horiba ABX 400 12 5.6 - 6.8 P 6.2 0.09 6.5 - 7.9 P 7.2 0.12 3.7 - 4.5 P 4.06 0.09 3.2 - 3.9 P 3.51 0.08 5.0 - 6.1 P 5.57 0.1 7Ortho Vitros & Ortho Vitros 3600, 5600 13 5.4 - 6.6 P 6.01 0.2 6.2 - 7.6 P 6.92 0.2 3.6 - 4.4 P 4.01 0.12 3.1 - 3.8 P 3.48 0.11 5.0 - 6.1 P 5.55 0.14 18Ortho Vitros & Ortho Vitros 5,1 FS 14 5.4 - 6.6 P 6.0 0.1 6.3 - 7.6 P 6.95 0.11 3.6 - 4.4 P 3.98 0.04 3.2 - 3.9 P 3.53 0.04 5.0 - 6.1 P 5.57 0.04 4Ortho Vitros & Ortho Vitros not DT or ECi 15 5.4 - 6.6 P 5.97 0.15 6.2 - 7.6 P 6.94 0.19 3.6 - 4.4 P 4.01 0.1 3.2 - 3.9 P 3.51 0.1 5.0 - 6.1 P 5.53 0.14 25Reichert TS Meter-DSP & Reichert TS Meter-DSP 16 7.1 - 8.6 P 7.86 0.15 8.2 - 10.0 P 9.1 0.16 4.8 - 5.8 P 5.3 0.1 4.2 - 5.1 P 4.66 0.1 6.5 - 7.9 P 7.2 0.17 228Roche Cobas & Roche Cobas 6000 17 5.6 - 6.9 P 6.27 0.12 6.6 - 8.0 P 7.3 0.13 3.7 - 4.5 P 4.08 0.08 3.2 - 3.9 P 3.58 0.08 5.2 - 6.4 P 5.78 0.12 9Roche Cobas & Roche Cobas Integra 18 5.6 - 6.8 P 6.17 0.14 6.5 - 7.9 P 7.17 0.18 3.6 - 4.4 P 4.04 0.13 3.1 - 3.8 P 3.49 0.1 5.1 - 6.2 P 5.66 0.15 13Roche Cobas & Roche e/c, 1XX, X000, Elec series 19 5.6 - 6.8 P 6.22 0.12 6.5 - 8.0 P 7.27 0.15 3.7 - 4.5 P 4.08 0.08 3.2 - 3.9 P 3.54 0.07 5.1 - 6.3 P 5.71 0.13 19SDI Biomed & SDI CA-240, 480 20 5.6 - 6.8 P 6.18 0.07 6.5 - 8.0 P 7.26 0.08 3.7 - 4.5 P 4.1 0.06 3.2 - 3.9 P 3.56 0.05 5.2 - 6.3 P 5.76 0.17 5Sekisui & Beck Olym AU 400/600/5400 21 5.6 - 6.9 P 6.23 0.19 6.5 - 8.0 P 7.25 0.18 3.6 - 4.5 P 4.05 0.09 3.2 - 3.9 P 3.5 0.07 5.1 - 6.2 P 5.68 0.08 4Siemens Dimension & Siemens Dim RxL, RxL Max 22 5.8 - 7.1 P 6.43 0.04 6.8 - 8.3 P 7.53 0.04 3.8 - 4.6 P 4.2 0.07 3.3 - 4.0 P 3.65 0.05 5.3 - 6.5 P 5.9 0.07 4Siemens Dimension & Siemens Dimension EXL 23 5.8 - 7.1 P 6.41 0.11 6.7 - 8.2 P 7.49 0.12 3.8 - 4.6 P 4.21 0.09 3.3 - 4.0 P 3.65 0.09 5.3 - 6.5 P 5.87 0.09 52Siemens Dimension & Siemens Dimension Xpand 24 5.7 - 7.0 P 6.35 0.16 6.7 - 8.2 P 7.45 0.17 3.8 - 4.6 P 4.17 0.1 3.3 - 4.0 P 3.64 0.1 5.3 - 6.4 P 5.85 0.12 22

Siemens biuret based & Siemens Advia 25 5.8 - 7.1 P 6.42 0.15 6.8 - 8.3 P 7.5 0.16 3.8 - 4.6 P 4.2 0.14 3.2 - 4.0 P 3.6 0.08 5.3 - 6.5 P 5.9 0.14 4Siemens biuret based & Siemens Dimension EXL 26 5.8 - 7.1 P 6.41 0.1 6.8 - 8.3 P 7.53 0.1 3.8 - 4.7 P 4.24 0.09 3.3 - 4.0 P 3.66 0.07 5.3 - 6.5 P 5.87 0.09 7Initial Grouping by ReagentAbbott 27 5.6 - 6.9 P 6.24 0.1 6.6 - 8.1 P 7.38 0.09 3.6 - 4.4 P 3.98 0.08 3.1 - 3.8 P 3.41 0.06 5.1 - 6.3 P 5.69 0.08 21Alfa Wassermann 28 5.7 - 6.9 P 6.28 0.14 6.6 - 8.1 P 7.37 0.15 3.7 - 4.5 P 4.08 0.1 3.2 - 3.9 P 3.53 0.13 5.2 - 6.3 P 5.74 0.15 17All refractometers 29 7.0 - 8.6 P 7.83 0.13 8.2 - 10.0 P 9.11 0.16 4.8 - 5.8 P 5.28 0.11 4.2 - 5.1 P 4.66 0.15 6.5 - 7.9 P 7.18 0.14 377Beckman Olympus 30 5.4 - 6.6 P 6.02 0.17 6.3 - 7.7 P 7.04 0.21 3.5 - 4.3 P 3.92 0.13 3.1 - 3.7 P 3.4 0.12 5.0 - 6.1 P 5.51 0.15 59Beckman rate 31 5.6 - 6.8 P 6.2 0.08 6.5 - 7.9 P 7.2 0.09 3.6 - 4.4 P 4.04 0.08 3.2 - 3.9 P 3.5 0.08 5.1 - 6.2 P 5.67 0.08 9Beckman unc 32 5.5 - 6.8 P 6.15 0.12 6.5 - 7.9 P 7.2 0.12 3.6 - 4.4 P 4.01 0.06 3.1 - 3.8 P 3.48 0.06 5.0 - 6.2 P 5.61 0.05 10Carolina 33 5.4 - 6.7 P 6.05 0.23 6.4 - 7.8 P 7.08 0.2 3.5 - 4.3 P 3.93 0.1 3.1 - 3.8 P 3.42 0.08 5.0 - 6.1 P 5.54 0.17 16Horiba ABX 34 5.6 - 6.8 P 6.2 0.09 6.5 - 7.9 P 7.2 0.12 3.7 - 4.5 P 4.06 0.09 3.2 - 3.9 P 3.51 0.08 5.0 - 6.1 P 5.57 0.1 7Ortho Vitros 35 5.4 - 6.6 P 5.98 0.17 6.2 - 7.6 P 6.93 0.18 3.6 - 4.4 P 4.01 0.1 3.1 - 3.9 P 3.5 0.1 5.0 - 6.1 P 5.54 0.13 50Pointe Scientific 36 5.6 - 6.9 P 6.26 0.21 6.6 - 8.1 P 7.33 0.29 3.6 - 4.4 P 4.03 0.14 3.2 - 3.9 P 3.51 0.17 5.1 - 6.3 P 5.72 0.25 9Reichert TS Meter-DSP 37 7.1 - 8.6 P 7.86 0.15 8.2 - 10.0 P 9.1 0.16 4.8 - 5.8 P 5.3 0.1 4.2 - 5.1 P 4.66 0.1 6.5 - 7.9 P 7.2 0.17 230Roche Cobas 38 5.6 - 6.8 P 6.21 0.13 6.5 - 8.0 P 7.24 0.16 3.7 - 4.5 P 4.07 0.1 3.2 - 3.9 P 3.53 0.09 5.1 - 6.3 P 5.71 0.14 41SDI Biomed 39 5.6 - 6.8 P 6.17 0.07 6.5 - 8.0 P 7.25 0.08 3.7 - 4.5 P 4.08 0.07 3.2 - 3.9 P 3.53 0.07 5.1 - 6.3 P 5.7 0.21 6Sekisui 40 5.6 - 6.9 P 6.26 0.16 6.6 - 8.1 P 7.34 0.18 3.7 - 4.5 P 4.09 0.08 3.2 - 3.9 P 3.53 0.07 5.2 - 6.3 P 5.73 0.1 7Siemens Dimension 41 5.8 - 7.0 P 6.39 0.13 6.7 - 8.2 P 7.48 0.13 3.8 - 4.6 P 4.2 0.09 3.3 - 4.0 P 3.64 0.09 5.3 - 6.4 P 5.86 0.1 81Siemens biuret based 42 5.8 - 7.1 P 6.42 0.11 6.8 - 8.3 P 7.52 0.12 3.8 - 4.6 P 4.22 0.11 3.3 - 4.0 P 3.64 0.08 5.3 - 6.5 P 5.88 0.11 12Synermed 43 5.9 - 7.2 P 6.58 0.28 7.0 - 8.6 P 7.8 0.37 3.9 - 4.8 P 4.35 0.21 3.4 - 4.2 P 3.78 0.16 5.5 - 6.7 P 6.08 0.28 4Initial Grouping by Sensitivity or PrincipleBichromatic-no sam blanks 44 5.6 - 6.8 P 6.17 0.26 6.5 - 8.0 P 7.23 0.31 3.6 - 4.4 P 4.02 0.2 3.1 - 3.8 P 3.48 0.18 5.1 - 6.2 P 5.64 0.23 134All refractometer users 45 7.0 - 8.6 P 7.83 0.13 8.2 - 10.0 P 9.11 0.16 4.8 - 5.8 P 5.28 0.11 4.2 - 5.1 P 4.66 0.15 6.5 - 7.9 P 7.18 0.14 377Rate 46 5.5 - 6.7 P 6.1 0.2 6.4 - 7.8 P 7.12 0.18 3.6 - 4.4 P 3.97 0.11 3.1 - 3.8 P 3.45 0.09 5.0 - 6.1 P 5.59 0.16 25Uncorrected 47 5.5 - 6.7 P 6.1 0.29 6.4 - 7.8 P 7.1 0.33 3.6 - 4.4 P 4.04 0.18 3.2 - 3.9 P 3.52 0.16 5.1 - 6.2 P 5.63 0.26 87Other 48 6.6 - 8.0 P 7.3 0.87 7.7 - 9.4 P 8.55 0.96 4.6 - 5.6 P 5.13 0.83 3.9 - 4.7 P 4.3 0.58 6.0 - 7.4 P 6.7 0.81 4Bichromatic-sample blanked 49 5.8 - 7.1 P 6.41 0.19 6.8 - 8.3 P 7.5 0.21 3.8 - 4.6 P 4.21 0.13 3.3 - 4.0 P 3.65 0.13 5.3 - 6.4 P 5.85 0.18 82Just sample blanked 50 5.6 - 6.8 P 6.21 0.13 6.5 - 8.0 P 7.24 0.16 3.7 - 4.5 P 4.07 0.1 3.2 - 3.9 P 3.53 0.09 5.1 - 6.3 P 5.71 0.14 41Total PopulationWhole Population 51 6.5 - 8.0 P 7.24 0.89 7.6 - 9.2 P 8.39 0.97 4.4 - 5.3 P 4.84 0.66 3.8 - 4.7 P 4.26 0.64 6.0 - 7.3 P 6.63 0.82 980

TriglyceridesInitial Grouping by Reagent and InstrumentAbbott & Abbott Architect c, ci, i 1 83 - 138 P 110.3 1.6 99 - 165 P 131.6 1.9 49 - 82 P 65.3 1.7 40 - 67 P 53.3 1.6 75 - 124 P 99.5 1.9 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 87 - 145 P 116.3 4.7 104 - 173 P 138.1 4.9 55 - 92 P 73.3 3.1 47 - 78 P 62.1 3.0 80 - 134 P 107.1 3.8 16Beckman GPO glycerol-unc & Beck Coult UnicelDXC 3 92 - 153 P 122.2 4.9 110 - 183 P 146.7 4.6 54 - 89 P 71.5 3.7 44 - 73 P 58.5 2.9 82 - 137 P 109.5 4.3 13

Beckman Olympus & Beck Olym AU 400/600/5400 4 83 - 138 P 110.1 2.6 98 - 164 P 131.2 3.5 49 - 82 P 65.4 2.1 40 - 68 P 54.0 2.4 74 - 124 P 98.9 3.6 25Beckman Olympus & Beck Olympus AU 2700 5 82 - 137 P 109.5 0.9 98 - 163 P 130.3 1.9 49 - 82 P 65.8 0.8 41 - 68 P 54.5 1.1 75 - 125 P 100.0 2.4 4Beckman Olympus & Beckman AU 480 6 84 - 140 P 111.7 4.2 100 - 166 P 132.7 4.7 50 - 84 P 67.1 2.9 42 - 69 P 55.4 2.3 76 - 126 P 101.0 3.4 23Carolina & Beck Olym AU 400/600/5400 7 73 - 121 P 96.8 11.5 95 - 158 P 126.7 12.5 43 - 72 P 57.5 12.5 36 - 61 P 48.4 7.9 64 - 107 P 85.8 15.3 6Carolina & Beckman Synchron CX3/7/9/L 8 85 - 142 P 113.4 3.0 101 - 169 P 135.2 13.9 49 - 82 P 65.6 5.4 40 - 67 P 53.4 4.2 75 - 125 P 100.2 2.1 5Horiba ABX & Horiba ABX 400 9 84 - 140 P 111.8 2.2 98 - 164 P 131.3 1.3 51 - 85 P 68.0 2.4 40 - 66 P 53.0 2.5 74 - 123 P 98.5 3.6 5Ortho Vitros & Ortho Vitros 3600, 5600 10 89 - 148 P 118.2 5.7 108 - 180 P 144.2 6.4 51 - 84 P 67.4 3.9 41 - 68 P 54.6 3.2 79 - 132 P 105.6 4.9 18Ortho Vitros & Ortho Vitros 5,1 FS 11 90 - 150 P 119.8 1.9 110 - 183 P 146.8 1.5 51 - 86 P 68.5 1.1 43 - 72 P 57.3 1.6 82 - 137 P 109.5 3.9 4Ortho Vitros & Ortho Vitros not DT or ECi 12 90 - 150 P 119.8 4.6 110 - 183 P 146.1 5.3 51 - 85 P 67.8 2.4 41 - 69 P 55.2 2.4 81 - 135 P 107.9 4.2 25Pointe Scientific & Other spectrophotometers 13 74 - 124 P 99.2 1.6 86 - 143 P 114.0 1.1 46 - 77 P 61.2 3.5 39 - 65 P 52.0 2.3 68 - 113 P 90.4 5.1 5Pointe Scientific & Pointe Sci 180/Sterl 2000 14 72 - 120 P 96.0 0.0 85 - 141 P 113.0 0.0 37 - 62 P 49.8 6.5 34 - 57 P 45.3 4.7 64 - 107 P 85.5 12.5 4Roche Cobas & Roche Cobas 6000 15 88 - 146 P 117.1 2.9 103 - 172 P 137.6 3.4 55 - 91 P 73.0 2.2 45 - 75 P 60.1 2.1 80 - 133 P 106.5 2.6 8Roche Cobas & Roche Cobas Integra 16 85 - 142 P 113.6 3.1 100 - 166 P 133.2 3.4 52 - 87 P 69.4 2.4 43 - 71 P 57.1 1.6 77 - 129 P 102.8 2.6 13Roche Cobas & Roche e/c, 1XX, X000, Elec series 17 87 - 146 P 116.5 2.9 103 - 171 P 137.0 3.2 54 - 90 P 71.8 1.8 44 - 74 P 59.1 1.7 79 - 132 P 105.9 2.6 17SDI Biomed & SDI CA-240, 480 18 69 - 114 P 91.5 4.6 91 - 152 P 121.3 2.6 47 - 78 P 62.3 1.5 39 - 65 P 52.0 1.0 68 - 113 P 90.8 3.6 4Sekisui & Beck Olym AU 400/600/5400 19 84 - 139 P 111.5 2.5 100 - 166 P 132.8 5.8 52 - 86 P 68.8 3.1 42 - 71 P 56.5 3.4 75 - 125 P 99.8 2.5 4Siemens Dimension & Siemens Dim RxL, RxL Max 20 80 - 134 P 107.0 2.7 96 - 161 P 128.5 1.7 45 - 76 P 60.5 1.1 36 - 60 P 48.3 0.8 73 - 121 P 96.8 1.1 4Siemens Dimension & Siemens Dimension EXL 21 80 - 133 P 106.3 2.1 96 - 160 P 128.3 2.2 45 - 75 P 60.0 2.1 35 - 59 P 47.2 1.7 71 - 119 P 94.8 2.3 54Siemens Dimension & Siemens Dimension Xpand 22 80 - 134 P 106.8 2.8 97 - 162 P 129.5 2.9 46 - 77 P 61.8 2.9 36 - 60 P 48.0 3.0 72 - 119 P 95.5 2.7 22Sterling Diagnostic & Other spectrophotometers 23 80 - 133 P 106.0 6.4 97 - 162 P 129.3 7.9 49 - 82 P 65.9 4.5 41 - 68 P 54.2 5.3 73 - 122 P 97.7 11.7 9Sterling Diagnostic & Pointe Sci 180/Sterl 2000 24 80 - 134 P 107.3 3.1 99 - 165 P 131.9 4.9 50 - 83 P 66.3 3.9 40 - 66 P 52.7 3.2 73 - 122 P 97.3 3.7 7Vital Diagnostics Envoy & Vital Diagnostic Envoy 25 85 - 141 P 113.0 2.9 100 - 166 P 132.7 3.1 53 - 88 P 70.3 1.7 41 - 69 P 55.0 8.7 80 - 133 P 106.7 0.5 4Initial Grouping by ReagentAbbott 26 83 - 138 P 110.3 1.6 99 - 165 P 131.6 1.9 49 - 82 P 65.3 1.7 40 - 67 P 53.3 1.6 75 - 124 P 99.5 1.9 19Alfa Wassermann 27 87 - 145 P 116.3 4.7 104 - 173 P 138.1 4.9 55 - 92 P 73.3 3.1 47 - 78 P 62.1 3.0 80 - 134 P 107.1 3.8 16

Beckman GPO glycerol-unc 28 90 - 150 P 120.1 6.7 108 - 180 P 143.9 7.7 53 - 88 P 70.5 4.1 43 - 72 P 57.6 3.2 81 - 135 P 107.6 6.1 17Beckman Olympus 29 83 - 138 P 110.8 3.5 99 - 165 P 131.8 4.1 50 - 83 P 66.2 2.5 41 - 68 P 54.7 2.4 75 - 125 P 99.9 3.6 52Carolina 30 78 - 129 P 103.5 11.7 95 - 159 P 127.3 15.0 46 - 76 P 61.1 9.7 38 - 63 P 50.6 6.3 69 - 115 P 91.7 12.4 15Horiba ABX 31 84 - 140 P 111.8 2.2 98 - 164 P 131.3 1.3 51 - 85 P 68.0 2.4 40 - 66 P 53.0 2.5 74 - 123 P 98.5 3.6 5Ortho Vitros 32 89 - 149 P 119.2 4.9 109 - 182 P 145.4 5.5 51 - 85 P 67.8 3.0 41 - 69 P 55.1 2.7 80 - 134 P 107.2 4.6 49Pointe Scientific 33 72 - 121 P 96.5 4.7 85 - 142 P 113.5 4.9 43 - 71 P 57.1 6.3 37 - 61 P 48.9 4.2 66 - 110 P 87.9 7.1 16Roche Cobas 34 87 - 145 P 115.7 3.3 102 - 170 P 135.9 3.8 53 - 89 P 71.2 2.5 44 - 73 P 58.6 2.1 79 - 131 P 104.9 3.0 39SDI Biomed 35 69 - 114 P 91.5 4.6 91 - 152 P 121.3 2.6 47 - 78 P 62.3 1.5 39 - 65 P 52.0 1.0 68 - 113 P 90.8 3.6 4Sekisui 36 82 - 137 P 109.6 3.6 98 - 163 P 130.3 6.1 50 - 84 P 67.0 3.1 42 - 70 P 55.9 3.3 74 - 123 P 98.3 3.8 9Siemens Dimension 37 80 - 134 P 107.1 4.0 97 - 162 P 129.3 4.1 46 - 76 P 61.0 3.5 36 - 60 P 48.0 3.4 72 - 120 P 95.8 4.2 83Siemens Express 38 80 - 133 P 106.0 2.1 97 - 161 P 129.0 1.9 45 - 76 P 60.4 3.2 36 - 60 P 48.2 1.3 72 - 119 P 95.4 1.0 5Sterling Diagnostic 39 80 - 133 P 106.6 5.3 98 - 163 P 130.4 6.9 50 - 83 P 66.1 4.3 40 - 67 P 53.6 4.6 73 - 122 P 97.5 9.1 16Synermed 40 92 - 153 P 122.8 5.5 112 - 186 P 149.0 4.1 54 - 91 P 72.5 3.2 44 - 74 P 59.3 4.0 83 - 138 P 110.5 4.6 4Vital Diagnostics Envoy 41 85 - 141 P 113.0 2.9 100 - 166 P 132.7 3.1 53 - 88 P 70.3 1.7 41 - 69 P 55.0 8.7 80 - 133 P 106.7 0.5 4Initial Grouping by Sensitivity or PrincipleGly-unc/visible/GPO-based 42 83 - 139 P 111.0 7.9 100 - 167 P 133.4 9.4 49 - 82 P 65.3 5.8 40 - 67 P 53.2 5.2 75 - 125 P 100.0 7.7 341Gly-unc/visible/INT-based 43 87 - 145 P 116.3 4.7 104 - 173 P 138.1 4.9 55 - 92 P 73.3 3.1 47 - 78 P 62.1 3.0 80 - 134 P 107.1 3.8 16Gly-cor/visible/GPO-based 44 84 - 140 P 112.3 5.8 99 - 165 P 131.8 6.9 51 - 86 P 68.6 3.0 42 - 70 P 55.8 3.9 76 - 126 P 101.1 6.5 10Gly-unc/340nm/GDH-based 45 80 - 133 P 106.0 2.1 97 - 161 P 129.0 1.9 45 - 76 P 60.4 3.2 36 - 60 P 48.2 1.3 72 - 119 P 95.4 1.0 5Total PopulationWhole Population 46 83 - 138 P 110.3 10.0 99 - 165 P 132.3 11.7 49 - 82 P 65.4 7.2 40 - 67 P 53.5 5.7 76 - 126 P 100.7 10.7 375

Urea Nitrogen (BUN)Initial Grouping by Reagent and InstrumentAbbott & Abbott Architect c, ci, i 1 28 - 34 P 30.9 0.4 35 - 42 P 38.9 0.6 13 - 17 C 14.6 0.5 8 - 12 C 10.4 0.5 24 - 29 P 26.8 0.4 19Alfa Wassermann & Alfa Wasser Axcel/Alera 2 27 - 32 P 29.7 1.3 34 - 41 P 37.5 1.4 12 - 16 C 14.3 0.7 9 - 13 C 10.5 0.7 24 - 29 P 26.2 1.2 19Beckman GLDH-rate & Beck Coult Unicel DXC 3 29 - 35 P 31.7 0.7 37 - 44 P 40.2 0.7 13 - 17 C 15.4 0.6 9 - 13 C 11.0 0.0 25 - 30 P 27.9 0.6 16Beckman Olympus & Beck Olym AU 400/600/5400 4 27 - 33 P 30.1 1.0 35 - 41 P 38.0 1.4 12 - 16 C 14.3 0.7 8 - 12 C 10.4 0.5 24 - 28 P 26.1 1.0 30Beckman Olympus & Beck Olympus AU 2700 5 27 - 32 P 29.8 0.4 34 - 40 P 37.0 0.7 13 - 17 C 14.8 0.4 9 - 13 C 10.8 0.4 23 - 28 P 25.8 0.8 4Beckman Olympus & Beckman AU 480 6 28 - 33 P 30.5 1.0 35 - 42 P 38.3 1.2 13 - 17 C 14.5 0.5 9 - 13 C 10.6 0.5 24 - 29 P 26.6 0.8 24Carolina & Beck Olym AU 400/600/5400 7 29 - 35 P 31.7 0.9 35 - 43 P 39.0 1.6 13 - 17 C 15.3 0.4 9 - 13 C 11.0 0.0 25 - 30 P 27.8 0.8 4Carolina & Beckman Synchron CX3/7/9/L 8 27 - 33 P 30.2 1.9 34 - 41 P 37.8 2.8 13 - 17 C 15.4 1.4 9 - 13 C 11.4 1.2 24 - 29 P 26.8 1.9 5Horiba ABX & Horiba ABX 400 9 26 - 31 P 28.6 0.7 33 - 39 P 36.1 1.0 11 - 15 C 13.4 0.5 8 - 12 C 9.7 0.5 23 - 27 P 24.9 0.6 7Medica & Medica Easy RA 10 29 - 35 P 31.7 0.7 36 - 43 P 39.2 1.2 14 - 18 C 15.9 0.6 10 - 14 C 11.6 0.7 25 - 30 P 27.7 0.9 9Ortho Vitros & Ortho Vitros 3600, 5600 11 22 - 27 P 24.7 0.7 29 - 35 P 31.9 0.7 10 - 14 C 11.6 0.5 6 - 10 C 8.1 0.5 19 - 23 C 21.3 0.5 18Ortho Vitros & Ortho Vitros 5,1 FS 12 23 - 27 P 24.8 0.4 29 - 35 P 31.8 0.4 10 - 14 C 11.5 0.5 6 - 10 C 8.3 0.4 20 - 24 C 21.5 0.5 4Ortho Vitros & Ortho Vitros not DT or ECi 13 23 - 27 P 24.9 0.6 29 - 35 P 31.9 1.0 10 - 14 C 11.7 0.5 6 - 10 C 8.3 0.5 20 - 24 C 21.5 0.6 27Roche Cobas & Roche Cobas 6000 14 28 - 33 P 30.6 0.7 35 - 42 P 38.1 0.7 13 - 17 C 14.6 0.5 9 - 13 C 10.6 0.5 24 - 29 P 26.6 0.7 9Roche Cobas & Roche Cobas Integra 15 27 - 32 P 29.8 1.0 35 - 42 P 38.2 1.3 12 - 16 C 14.1 0.6 8 - 12 C 10.4 0.5 24 - 29 P 26.4 0.7 14Roche Cobas & Roche e/c, 1XX, X000, Elec series 16 28 - 33 P 30.5 0.9 35 - 42 P 38.3 1.3 13 - 17 C 14.5 0.5 8 - 12 C 10.4 0.5 24 - 29 P 26.6 0.7 19SDI Biomed & SDI CA-240, 480 17 30 - 36 P 32.6 1.4 37 - 45 P 41.2 1.7 13 - 17 C 15.4 0.5 9 - 13 C 11.2 0.7 25 - 31 P 28.0 0.6 5Sekisui & Beck Olym AU 400/600/5400 18 27 - 33 P 30.2 2.1 34 - 41 P 37.2 2.4 12 - 16 C 14.2 1.1 8 - 12 C 10.2 0.7 24 - 29 P 26.2 1.9 6Siemens GLDH-endpt & Siemens Dimension EXL 19 28 - 33 P 30.5 1.1 35 - 43 P 39.0 0.7 12 - 16 C 14.3 0.4 8 - 12 C 10.0 0.0 24 - 28 P 26.0 0.7 4Siemens GLDH-rate & Siemens Advia 20 28 - 34 P 30.8 0.4 35 - 43 P 39.0 1.2 13 - 17 C 15.3 1.1 9 - 13 C 10.8 0.4 25 - 30 P 27.5 0.9 4Siemens GLDH-rate & Siemens Dim RxL, RxL Max 21 28 - 34 P 30.8 0.4 35 - 42 P 38.3 0.8 13 - 17 C 14.8 0.8 9 - 13 C 10.5 0.5 23 - 28 P 25.3 1.9 4Siemens GLDH-rate & Siemens Dimension EXL 22 28 - 34 P 31.0 0.8 35 - 42 P 38.7 1.3 13 - 17 C 14.9 0.7 9 - 13 C 10.6 0.7 25 - 29 P 27.0 0.9 55Siemens GLDH-rate & Siemens Dimension Xpand 23 28 - 34 P 30.8 0.8 35 - 42 P 38.5 1.0 13 - 17 C 14.5 0.6 9 - 13 C 10.6 0.6 24 - 29 P 26.9 1.0 22Sterling Diagnostic & Other spectrophotometers 24 25 - 30 P 27.7 0.5 30 - 36 P 33.3 0.5 13 - 17 C 14.8 2.4 9 - 13 C 11.0 1.3 22 - 26 P 23.8 2.3 5Synermed & Synermed IR500 25 26 - 32 P 29.0 3.7 32 - 39 P 35.7 5.0 11 - 15 C 12.8 1.0 8 - 12 C 10.2 1.3 23 - 28 P 25.3 3.2 6Initial Grouping by ReagentAbaxis Piccolo 26 25 - 30 P 27.3 1.3 32 - 39 P 35.5 1.5 11 - 15 C 13.3 0.8 8 - 12 C 9.5 0.5 22 - 26 P 24.0 0.7 4Abbott 27 28 - 34 P 30.9 0.4 35 - 42 P 38.9 0.6 13 - 17 C 14.6 0.5 8 - 12 C 10.4 0.5 24 - 29 P 26.8 0.4 19Alfa Wassermann 28 27 - 32 P 29.7 1.3 34 - 41 P 37.5 1.4 12 - 16 C 14.3 0.7 9 - 13 C 10.5 0.7 24 - 29 P 26.2 1.2 19Beckman GLDH-rate 29 29 - 34 P 31.5 1.3 36 - 43 P 39.9 1.4 13 - 17 C 15.3 0.8 9 - 13 C 10.9 0.5 25 - 30 P 27.6 1.3 19Beckman Olympus 30 27 - 33 P 30.2 1.0 35 - 42 P 38.1 1.3 12 - 16 C 14.4 0.6 9 - 13 C 10.5 0.5 24 - 29 P 26.3 0.9 58Carolina 31 28 - 34 P 30.9 2.0 35 - 42 P 38.4 2.1 13 - 17 C 15.2 0.9 9 - 13 C 11.0 0.9 25 - 29 P 27.0 1.5 14Horiba ABX 32 26 - 31 P 28.6 0.7 33 - 39 P 36.1 1.0 11 - 15 C 13.4 0.5 8 - 12 C 9.7 0.5 23 - 27 P 24.9 0.6 7Medica 33 29 - 35 P 31.7 0.7 36 - 43 P 39.2 1.2 14 - 18 C 15.9 0.6 10 - 14 C 11.6 0.7 25 - 30 P 27.7 0.9 9Ortho Vitros 34 23 - 27 P 24.8 0.6 29 - 35 P 31.9 0.9 10 - 14 C 11.6 0.5 6 - 10 C 8.3 0.5 19 - 23 C 21.4 0.6 51Pointe Scientific 35 28 - 33 P 30.3 0.8 34 - 41 P 37.9 0.8 13 - 17 C 15.4 1.2 9 - 13 C 11.1 0.3 25 - 30 P 27.5 1.3 8Roche Cobas 36 28 - 33 P 30.3 1.0 35 - 42 P 38.2 1.2 12 - 16 C 14.4 0.6 8 - 12 C 10.4 0.5 24 - 29 P 26.5 0.7 42SDI Biomed 37 30 - 36 P 32.6 1.4 37 - 45 P 41.2 1.7 13 - 17 C 15.4 0.5 9 - 13 C 11.2 0.7 25 - 31 P 28.0 0.6 5

Sekisui 38 28 - 33 P 30.5 1.8 34 - 40 P 37.1 2.0 12 - 16 C 14.2 0.9 9 - 13 C 10.5 0.7 24 - 28 P 25.9 1.6 10Siemens GLDH-endpt 39 28 - 34 P 30.8 1.2 36 - 43 P 39.2 0.7 13 - 17 C 14.6 0.8 8 - 12 C 10.2 0.4 24 - 29 P 26.2 0.7 5Siemens GLDH-rate 40 28 - 34 P 30.9 0.8 35 - 42 P 38.7 1.2 13 - 17 C 14.8 0.7 9 - 13 C 10.6 0.6 24 - 29 P 26.9 1.1 88Sterling Diagnostic 41 25 - 30 P 27.3 1.6 30 - 36 P 32.8 2.3 13 - 17 C 14.7 2.4 9 - 13 C 11.1 1.4 22 - 26 P 23.7 2.4 8Synermed 42 27 - 32 P 29.4 3.6 33 - 39 P 36.1 4.8 11 - 15 C 13.2 1.2 8 - 12 C 10.3 1.3 23 - 28 P 25.6 3.0 7Initial Grouping by Sensitivity or PrincipleGlutamate DH-rate methods 43 28 - 33 P 30.5 1.4 35 - 42 P 38.3 1.8 13 - 17 C 14.6 0.9 9 - 13 C 10.6 0.7 24 - 29 P 26.6 1.3 312Glutamate DH-endpoint meths 44 29 - 34 P 31.4 1.2 36 - 43 P 39.2 1.3 13 - 17 C 15.3 1.2 9 - 13 C 11.1 0.8 25 - 30 P 27.2 1.1 18Ammonia (NH3) diffusion 45 23 - 27 P 24.8 0.6 29 - 35 P 31.9 0.9 10 - 14 C 11.6 0.5 6 - 10 C 8.3 0.5 19 - 23 C 21.4 0.6 51Hypochlorite (ClO)-based 46 25 - 30 P 27.3 1.6 30 - 36 P 32.8 2.3 13 - 17 C 14.7 2.4 9 - 13 C 11.1 1.4 22 - 26 P 23.7 2.4 8Total PopulationWhole Population 47 27 - 32 P 29.7 2.6 34 - 41 P 37.2 3.7 12 - 16 C 14.3 1.4 8 - 12 C 10.3 1.1 24 - 28 P 25.9 2.2 392

Uric AcidInitial Grouping by Reagent and InstrumentAbbott Architect & Abbott Architect c, ci, i 1 6.7 - 9.4 P 8.06 0.08 8.4 - 11.8 P 10.08 0.1 3.3 - 4.6 P 3.94 0.05 2.4 - 3.4 P 2.92 0.04 5.8 - 8.2 P 7.04 0.08 15Alfa Wassermann & Alfa Wasser Axcel/Alera 2 6.4 - 9.0 P 7.72 0.31 8.0 - 11.2 P 9.58 0.33 3.5 - 4.9 P 4.16 0.12 2.8 - 3.9 P 3.32 0.12 5.6 - 7.9 P 6.79 0.41 10Beckman Coulter & Beck Coult Unicel DXC 3 5.8 - 8.2 P 7.04 0.07 7.2 - 10.2 P 8.73 0.1 3.0 - 4.2 P 3.57 0.06 2.2 - 3.1 P 2.64 0.05 5.2 - 7.3 P 6.24 0.08 16Beckman Coulter & Beck Olym AU 400/600/5400 4 6.1 - 8.6 P 7.35 0.15 7.6 - 10.7 P 9.13 0.11 3.0 - 4.3 P 3.65 0.05 2.2 - 3.2 P 2.7 0.07 5.4 - 7.5 P 6.45 0.09 4Beckman Coulter & Beckman AU 480 5 6.0 - 8.5 P 7.26 0.16 7.5 - 10.6 P 9.06 0.12 3.0 - 4.2 P 3.6 0.09 2.2 - 3.1 P 2.64 0.05 5.3 - 7.5 P 6.42 0.07 5Beckman Olympus & Beck Olym AU 400/600/5400 6 6.2 - 8.7 P 7.42 0.17 7.7 - 10.8 P 9.25 0.26 3.0 - 4.3 P 3.67 0.11 2.3 - 3.2 P 2.73 0.08 5.4 - 7.6 P 6.5 0.18 22Beckman Olympus & Beck Olympus AU 2700 7 6.2 - 8.7 P 7.43 0.19 7.7 - 10.8 P 9.25 0.27 3.1 - 4.3 P 3.68 0.08 2.2 - 3.2 P 2.7 0.07 5.4 - 7.6 P 6.5 0.19 4Beckman Olympus & Beckman AU 480 8 6.2 - 8.7 P 7.43 0.15 7.7 - 10.8 P 9.27 0.15 3.1 - 4.3 P 3.69 0.07 2.2 - 3.2 P 2.71 0.06 5.4 - 7.6 P 6.51 0.11 16Carolina & Beck Olym AU 400/600/5400 9 6.2 - 8.8 P 7.52 0.34 7.8 - 11.0 P 9.38 0.48 3.2 - 4.4 P 3.8 0.19 2.3 - 3.3 P 2.83 0.16 5.6 - 7.9 P 6.72 0.34 6Carolina & Beckman Synchron CX3/7/9/L 10 5.7 - 8.0 P 6.88 0.2 7.1 - 9.9 P 8.5 0.24 2.8 - 4.0 P 3.4 0.12 2.1 - 2.9 P 2.48 0.08 5.1 - 7.2 P 6.12 0.21 5Horiba ABX & Horiba ABX 400 11 6.1 - 8.6 P 7.32 0.25 7.5 - 10.6 P 9.08 0.29 3.0 - 4.2 P 3.57 0.09 2.2 - 3.1 P 2.65 0.11 5.2 - 7.4 P 6.3 0.14 6Ortho Vitros & Ortho Vitros 3600, 5600 12 6.1 - 8.6 P 7.39 0.12 7.7 - 10.8 P 9.24 0.18 3.1 - 4.3 P 3.69 0.07 2.2 - 3.2 P 2.7 0.07 5.4 - 7.6 P 6.47 0.14 16Ortho Vitros & Ortho Vitros not DT or ECi 13 6.0 - 8.5 P 7.27 0.21 7.5 - 10.6 P 9.03 0.2 3.0 - 4.2 P 3.58 0.16 2.2 - 3.1 P 2.62 0.16 5.3 - 7.4 P 6.36 0.18 19Roche Cobas & Roche Cobas 6000 14 6.2 - 8.7 P 7.46 0.26 7.7 - 10.9 P 9.31 0.15 3.1 - 4.3 P 3.69 0.13 2.2 - 3.1 P 2.69 0.13 5.4 - 7.7 P 6.56 0.19 8Roche Cobas & Roche Cobas Integra 15 6.2 - 8.7 P 7.43 0.19 7.7 - 10.8 P 9.27 0.28 3.0 - 4.3 P 3.64 0.12 2.2 - 3.1 P 2.66 0.08 5.4 - 7.6 P 6.5 0.19 12Roche Cobas & Roche e/c, 1XX, X000, Elec series 16 6.2 - 8.7 P 7.46 0.17 7.7 - 10.9 P 9.32 0.27 3.0 - 4.2 P 3.62 0.08 2.2 - 3.1 P 2.66 0.07 5.4 - 7.6 P 6.53 0.18 18SDI Biomed & SDI CA-240, 480 17 6.5 - 9.1 P 7.78 0.07 7.8 - 11.0 P 9.42 0.04 3.4 - 4.8 P 4.08 0.07 2.5 - 3.6 P 3.05 0.08 5.6 - 8.0 P 6.8 0.06 6Sekisui & Beck Olym AU 400/600/5400 18 6.6 - 9.2 P 7.9 0.2 8.0 - 11.2 P 9.6 0.3 3.5 - 4.9 P 4.22 0.13 2.6 - 3.7 P 3.13 0.05 6.0 - 8.5 P 7.23 0.38 4Siemens Advia & Siemens Advia 19 6.3 - 9.0 P 7.65 0.11 8.0 - 11.2 P 9.58 0.18 3.1 - 4.4 P 3.75 0.05 2.3 - 3.2 P 2.77 0.04 5.5 - 7.8 P 6.68 0.08 4Siemens Dimension & Siemens Dim RxL, RxL Max 20 6.0 - 8.4 P 7.18 0.13 7.5 - 10.5 P 8.98 0.18 2.8 - 4.0 P 3.43 0.08 2.1 - 3.0 P 2.53 0.04 5.1 - 7.3 P 6.2 0.12 4Siemens Dimension & Siemens Dimension EXL 21 5.9 - 8.3 P 7.13 0.14 7.4 - 10.4 P 8.91 0.17 2.9 - 4.1 P 3.53 0.09 2.1 - 3.0 P 2.59 0.08 5.2 - 7.3 P 6.22 0.12 55Siemens Dimension & Siemens Dimension Xpand 22 5.8 - 8.2 P 7.03 0.21 7.3 - 10.3 P 8.84 0.3 2.9 - 4.1 P 3.48 0.11 2.1 - 3.0 P 2.57 0.12 5.1 - 7.2 P 6.19 0.18 19Sterling Diagnostic & Pointe Sci 180/Sterl 2000 23 6.0 - 8.4 P 7.18 0.5 7.6 - 10.7 P 9.13 0.15 3.1 - 4.4 P 3.74 0.42 2.3 - 3.3 P 2.8 0.3 5.3 - 7.5 P 6.38 0.65 5Initial Grouping by ReagentAbbott Architect 24 6.7 - 9.4 P 8.06 0.08 8.4 - 11.8 P 10.08 0.1 3.3 - 4.6 P 3.94 0.05 2.4 - 3.4 P 2.92 0.04 5.8 - 8.2 P 7.04 0.08 15Alfa Wassermann 25 6.4 - 9.0 P 7.72 0.31 8.0 - 11.2 P 9.58 0.33 3.5 - 4.9 P 4.16 0.12 2.8 - 3.9 P 3.32 0.12 5.6 - 7.9 P 6.79 0.41 10Beckman Coulter 26 5.9 - 8.4 P 7.14 0.17 7.4 - 10.4 P 8.86 0.2 3.0 - 4.2 P 3.59 0.07 2.2 - 3.1 P 2.65 0.06 5.2 - 7.4 P 6.31 0.12 25Beckman Olympus 27 6.2 - 8.7 P 7.42 0.16 7.7 - 10.8 P 9.26 0.23 3.1 - 4.3 P 3.68 0.09 2.3 - 3.2 P 2.72 0.07 5.4 - 7.6 P 6.5 0.16 42Carolina 28 6.0 - 8.5 P 7.25 0.42 7.4 - 10.5 P 8.95 0.55 3.0 - 4.2 P 3.62 0.25 2.2 - 3.1 P 2.66 0.21 5.3 - 7.5 P 6.37 0.42 16Horiba ABX 29 6.1 - 8.6 P 7.32 0.25 7.5 - 10.6 P 9.08 0.29 3.0 - 4.2 P 3.57 0.09 2.2 - 3.1 P 2.65 0.11 5.2 - 7.4 P 6.3 0.14 6Ortho Vitros 30 6.1 - 8.6 P 7.33 0.18 7.6 - 10.7 P 9.13 0.22 3.0 - 4.3 P 3.64 0.14 2.2 - 3.1 P 2.67 0.13 5.3 - 7.5 P 6.42 0.17 38Pointe Scientific 31 6.3 - 9.0 P 7.65 0.34 7.9 - 11.1 P 9.49 0.39 3.2 - 4.5 P 3.86 0.24 2.5 - 3.5 P 3.0 0.24 5.6 - 7.9 P 6.79 0.39 8Roche Cobas 32 6.2 - 8.7 P 7.45 0.2 7.7 - 10.9 P 9.3 0.26 3.0 - 4.3 P 3.64 0.11 2.2 - 3.1 P 2.66 0.09 5.4 - 7.6 P 6.53 0.19 38SDI Biomed 33 6.5 - 9.1 P 7.78 0.07 7.8 - 11.0 P 9.42 0.04 3.4 - 4.8 P 4.08 0.07 2.5 - 3.6 P 3.05 0.08 5.6 - 8.0 P 6.8 0.06 6Sekisui 34 6.6 - 9.3 P 7.93 0.24 8.0 - 11.3 P 9.68 0.34 3.4 - 4.8 P 4.07 0.19 2.5 - 3.6 P 3.04 0.18 5.9 - 8.2 P 7.05 0.34 8Siemens Advia 35 6.3 - 9.0 P 7.65 0.11 8.0 - 11.2 P 9.58 0.18 3.1 - 4.4 P 3.75 0.05 2.3 - 3.2 P 2.77 0.04 5.5 - 7.8 P 6.68 0.08 4Siemens Dimension 36 5.9 - 8.3 P 7.11 0.17 7.4 - 10.4 P 8.88 0.23 2.9 - 4.1 P 3.51 0.1 2.1 - 3.0 P 2.58 0.09 5.2 - 7.3 P 6.21 0.13 80Sterling Diagnostic 37 6.0 - 8.4 P 7.18 0.5 7.6 - 10.7 P 9.13 0.15 3.1 - 4.4 P 3.74 0.42 2.3 - 3.3 P 2.8 0.3 5.3 - 7.5 P 6.38 0.65 5Initial Grouping by Sensitivity or PrincipleEndpt-corrected(bic or SB) 38 6.2 - 8.8 P 7.49 0.32 7.8 - 10.9 P 9.35 0.42 3.1 - 4.4 P 3.74 0.2 2.3 - 3.2 P 2.76 0.19 5.4 - 7.7 P 6.56 0.29 117Rate 39 6.0 - 8.4 P 7.21 0.26 7.5 - 10.5 P 9.0 0.35 3.0 - 4.2 P 3.57 0.15 2.2 - 3.1 P 2.63 0.13 5.3 - 7.4 P 6.33 0.26 160Endpoint-uncorrected 40 6.4 - 9.0 P 7.69 0.38 7.9 - 11.1 P 9.52 0.35 3.3 - 4.6 P 3.95 0.27 2.5 - 3.5 P 2.97 0.23 5.7 - 8.0 P 6.81 0.43 35Total PopulationWhole Population 41 6.1 - 8.6 P 7.39 0.4 7.6 - 10.8 P 9.2 0.49 3.1 - 4.3 P 3.69 0.28 2.3 - 3.2 P 2.73 0.26 5.4 - 7.6 P 6.46 0.48 312