Click here to load reader

AHMED, Rafi - · PDF fileand attenuated viruses by rescue of mutations from DI particles. Virology 111: 351-363. 8. ... variants of lymphocytic choriomeningitis virus in spleens of

  • View
    213

  • Download
    0

Embed Size (px)

Text of AHMED, Rafi - · PDF fileand attenuated viruses by rescue of mutations from DI particles....

Copyright 2012 Japan Science and Technology Agency. All Rights Reserved.

AHMED, Rafi

Charles Howard Candler Professor, Microbiology and Immunology,

Emory University

Director, Emory Vaccine Center, Emory University School of Medicine

Georgia Research Alliance Eminent Scholar, in Vaccine Research and

Professor, Microbiology and Immunology, Emory University School of

Medicine

Associate Director, Emory/Atlanta Center, for AIDS Research, Emory

University

EDUCATION

1981 Harvard University, Cambridge, MA, Ph.D./Microbiology, Molecular Genetics

1974 Idaho State University, Pocatello, ID, M.S./Microbiology

1972 Idaho State University, Pocatello, ID, B.S./Microbiology

1968 Osmania University, Hyderabad, India, B.Sc./Chemistry

POSITIONS

1992-1995 Professor, Department of Microbiology & Immunology, UCLA School of Medicine,

Los Angeles, California

1988-1992 Associate Professor, Department of Microbiology & Immunology, UCLA

School of Medicine, Los Angeles, California

1984-1988 Assistant Professor, Department of Microbiology & Immunology, UCLA School of

Medicine, Los Angeles, California

1984 Assistant Member, Department of Immunology, Scripps Clinic and Research Foundation, La Jolla,

California,

1981-1984 Research Fellow, Department of Immunology, Scripps Clinic and Research

Foundation, La Jolla, California

EDITORIAL BOARD

1995-2009 Editor-in-Chief, Microbial Pathogenesis

1990-1996 Editorial Board, Virology

1996- 2006 Editor, Virology

1997-1999 Associate Editor, Immunity

2005 Immunology Reviews

2005 Current Topics in Microbiology & Immunology

Copyright 2012 Japan Science and Technology Agency. All Rights Reserved.

PUBLICATIONS

1. Ahmed, R. and A.F. Graham. 1977. Persistent infection in L cells with its mutants of

reovirus. J. Virol. 23: 250-262

2. Fields, B.N., H.L. Weiner, R.F. Ramig and R. Ahmed. 1978. Genetics of reovirus: Aspects

related to virulence and viral persistence. In Persistent Viruses, J.G. Stevens, G.J. Todaro and

C.F. Fox (eds.), Academic Press, New York, pp. 389-398.

3. Chakraborty, P.R., R. Ahmed, and B.N. Fields. 1979. Genetics of reovirus: The relationship

of interference to complementation and reassortment of its mutants at nonpermissive

temperature. Virology 94:119-127.

4. Ahmed,R., P.R. Chakraborty, and B.N. Fields. 1980. Genetic variation during lytic reovirus

infection: High passage stocks of wild type reovirus contain temperature-sensitive mutants. J.

Virol. 34: 285-287.

5. Ahmed, R., P. R. Chakraborty, A.F. Graham, R.F. Ramig and B.N. Fields. 1980. Genetic

variation during persistent reovirus infection: Presence of extragenically suppressed its lesions

in wild type virus isolated from persistently infected cells. J. Virol. 34:383-389.

6. Fields, B.N., H.L. Weiner, D.T. Drayna, A.H. Sharpe, D. Hardy, D. Rubin, S. Burstin, R.

Ahmed,

J. Gentsch and H. Donis-Keller. 1980. The molecular basis of reovirus virulence. In

ICN-UCLA Symposia on Animal Virus Genetics, B.N. Fields, R. Jaenish and C.F. Fox (eds.),

Academic Press, New York, pp. 663-671.

7. Ahmed, R. and B.N. Fields. 1981. Reassortment of genome segments between reovirus

defective interfering particles and infectious virus: Construction of temperature-sensitive

and attenuated viruses by rescue of mutations from DI particles. Virology 111: 351-363.

8. Ahmed, R., W.M. Canning, R.S. Kauffman, A.S. Sharpe, J. Hallum, and B.N. Fields. 1981.

Role of the host cell in persistent viral infection: Coevolution of L cells and reovirus during

persistent infection. Cell 25: 325-332.

9. Ahmed, R., and B.N. Fields. 1982. Role of the S4 gene in the establishment of persistent

reovirus infection in L cells. Cell 28: 605-612.

10. Ramig, R.F., R. Ahmed, and B.N. Fields, 1983. A genetic map of reovirus: Assignment of

the newly defined mutant groups H, I and J to genome segments. Virology 125:299-313.

11. Ahmed, R., R. S. Kauffman, and B.N. Fields. 1983. Genetic variation during persistent

reovirus infection: Isolation of cold-sensitive and temperature sensitive mutants from

persistently infected L cells. Virology 131: 71-78.

Copyright 2012 Japan Science and Technology Agency. All Rights Reserved.

12. Kauffman, R.S., R. Ahmed, and B.N. Fields, 1983. Selection of a mutant S1 gene during

reovirus persistent infection of L cells: Role in maintenance of the persistent state. Virology

131: 79-87.

13. Byrne, J.A., R. Ahmed, and M.B.A. Oldstone. 1984. Biology of cloned cytotoxic T

lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition

of virus strains and H-2b mutants. J. Immunol. 133:433-439.

14. Ahmed, R., J. A. Byrne and M.B.A. Oldstone. 1984. Virus specificity of cytotoxic T

lymphocytes generated during acute LCMV infection: Role of the H-2 region in determining

cross-reactivity for different LCMV strains. J. Virol. 51:34-41.

15. Ahmed, R., A. Salmi, and M.B.A. Oldstone. 1984 Mechanism of persistent LCMV infection

in mice: Role of LCMV variants in suppression of LCMV specific cytotoxic T cell response

and maintenance of the carrier state. In Negative Strand Viruses, R. Compans and D. Bishop

(eds.), Academic Press, New York, pp. 333-339.

16. Ahmed, R., A. Salmi, L.D. Butler, J. Chiller, and M.B.A. Oldstone. 1984. Selection of genetic

variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice: Role

in suppression of cytotoxic T lymphocyte response and viral persistence. J.Exp.Med. 60:

521-540.

17. Ahmed, R. and M.B.A. Oldstone. 1984. Mechanisms and biological implications of virus

induced polyclonal B cell activation. In Concepts in Viral Pathogenesis, A.L. Notkins and

M.B.A. Oldstone (eds.), Springer-Verlag, New York, pp. 231-238.

18. Oldstone, M.B.A., R. Ahmed, J. Byrne, M. Buchmeier, Y. Riviere, and P. Southern. 1985.

Virus and immune responses: Lymphocytic choriomeningitis virus as a prototype model of

viral pathogenesis. Brit. Med. Bull. 41:70-74.

19. Ahmed, R., P. Southern, P. Blount, J. Byrne, and M.B.A. Oldstone. 1985. Viral genes,

cytotoxic T lymphocytes and immunity. In Modern Approaches to Vaccines: Molecular and

chemical basis of resistance to viral, bacterial, and parasitic diseases, R. Lerner and R.

Chanock (eds.), Cold Spring Harbor Laboratory, New York.

20. Oldstone, M.B.A., R. Ahmed, M.J. Buchmeier, P. Blount, and A. Tishon. 1985.

Perturbation of differentiated functions during viral infection in vivo. I. Relationship of

LCMV and host strains to growth hormone deficiency. Virology 142: 158-174.

21. Riviere, Y., R. Ahmed, P. Southern, and M.B.A. Oldstone. 1985. Perturbation of

differentiated functions during viral infection in vivo. II. Viral reassortants map growth

hormone defect to the S RNA of the LCMV genome. Virology 142: 175-182.

22. Riviere, Y., R. Ahmed, P.J. Southern, M.J. Buchmeier, F.J. Dutko, and M.B.A. Oldstone.

1985. The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein

Copyright 2012 Japan Science and Technology Agency. All Rights Reserved.

and glycoproteins 1 and 2. J. Virol. 53: 966-968.

23. Riviere, Y., R. Ahmed, P.J. Southern, M.J. Buchmeier, and M.B.A. Oldstone. 1985. Genetic

mapping of LCMV pathogenecity: Virulence in guinea pigs is associated with the L RNA

segment. J. Virol. 55:704-709.

24. Ahmed, R. and M.B.A. Oldstone. 1986. Role of virus variants and T cell immunity. In

Genetically Altered Viruses and the Environment. Banbury Center. Cold Spring Harbor

Laboratory, pp. 223-233.

25. Riviere, Y., P.J. Southern, R. Ahmed, and M.B.A.Oldstone. 1986. Biology of cloned

cytotoxic T lymphocytes specific for LCMV. V. Recognition is restricted to the viral S RNA

segment and the genes it encodes. J. Immunol.136:304-307.

26. Southern, P.J., M.J. Buchmeier, R. Ahmed, S.J. Francis, B. Parekh, T. Riviere, M.K. Singh,

and M.B.A. Oldstone. 1986. Molecular pathogenesis of arenavirus infections. In Vaccines 86:

New approaches to immunization, R. Lerner and R. Chanock (eds.), Cold Spring

Harbor Laboratory, New York 239-245.

27. Ahmed, R., C.C. King, and M.B.A. Oldstone. 1987. Virus-lymphocyte interaction: T cells of

the helper subset are infected with lymphocytic choriomeningitis virus during persistent

infection in vivo. J. Virol. 61:1571-1576.

28. Ahmed, R., B.D. Jamieson, and D.D. Porter. 1987. Immune therapy of a persistent and

disseminated viral infection. J. Virol. 61:3920-3929.

29. Jamieson, B.D., L.D. Butler, and R. Ahmed. 1987. Effective clearance of a persistent viral

infection requires cooperation between virus specific Lyt2+ T cells and non-specific bone

marrow derived cells. J. Virol. 61:3930-3937.

30. Jamieson, B.D. and R. Ahmed. 1988. T cell tolerance: Exposure to virus in utero does not

cause a permanent deletion of specific T cells. Proc. Natl. Acad. Sci. (USA) 85:2265-2268.

31. Ahmed, R., L.D. Butler, and L. Bhatti. 1988. T4+ T helper cell functio