Upload
dominick-crawford
View
229
Download
0
Tags:
Embed Size (px)
Citation preview
Ahmad ata Ahmad ata 11
Ahmad ata Ahmad ata 22
Objectives Objectives List and discuss the 6 functions of bone tissue.List and discuss the 6 functions of bone tissue.
Illustrate the major features of a long bong Illustrate the major features of a long bong including the following: diaphysis, epiphyses, including the following: diaphysis, epiphyses, epiphyseal line, periosteum, endosteum, epiphyseal line, periosteum, endosteum, medullary cavity, nutrient foramen and note the medullary cavity, nutrient foramen and note the locations of spongy bone, compact bone, yellow locations of spongy bone, compact bone, yellow marrow, red marrow and articular cartilage.marrow, red marrow and articular cartilage.
Compare and contrast the organic and inorganic Compare and contrast the organic and inorganic components of bone matrix, in terms of structure components of bone matrix, in terms of structure and function. and function.
Discuss the different types of bone cells in terms Discuss the different types of bone cells in terms of origin, location and functionof origin, location and function
Ahmad ata Ahmad ata 33
ObjectivesObjectives
Distinguish between the axial and Distinguish between the axial and appendicular skeleton.appendicular skeleton.
Identify the types of fracturesIdentify the types of fractures Identify the clinical condition of bone Identify the clinical condition of bone
disease disease Discuss the Haversian System as the Discuss the Haversian System as the
structural unit of compact bone using the structural unit of compact bone using the following terms: osteocytes, lacunae, following terms: osteocytes, lacunae, lamellae, Haversian canal, blood vessels, lamellae, Haversian canal, blood vessels, bone matrix, and canaliculi.bone matrix, and canaliculi.
Ahmad ata Ahmad ata 44
THE SKELETAL SYSTEM: THE SKELETAL SYSTEM: OVERVIEWOVERVIEW
I.I. INTRODUCTIONINTRODUCTION The organs of the skeletal system The organs of the skeletal system
include the bones and the structures include the bones and the structures that connect bones to other that connect bones to other structures, including ligaments, structures, including ligaments, tendons, and cartilages.tendons, and cartilages.
The adult skeleton is composed of The adult skeleton is composed of 206 separate bones.206 separate bones.
Ahmad ata Ahmad ata 55
Division of skeleton Division of skeleton
– Axial skeletonAxial skeleton Includes the bones of:Includes the bones of: skull, vertebral column, and rib cage.skull, vertebral column, and rib cage. These bones are involved in protection, support, These bones are involved in protection, support,
and carrying other body parts.and carrying other body parts.
– Appendicular skeletonAppendicular skeleton Bones of upper & lower limbs and the girdles Bones of upper & lower limbs and the girdles
(shoulder bones and hip bones) that attach them (shoulder bones and hip bones) that attach them to the axial skeleton.to the axial skeleton.
Involved in locomotion and manipulation of the Involved in locomotion and manipulation of the environment.environment.
Ahmad ata Ahmad ata 66
AXIAL SKELETONAXIAL SKELETON
AppendicularAppendicular SKELETONSKELETON
Ahmad ata Ahmad ata 77
AXIAL SKELETONAXIAL SKELETON
1) Skull: 28 irregular shaped bones 1) Skull: 28 irregular shaped bones from the skull.from the skull.
The skull consists of two major The skull consists of two major division:division:
a)a) Cranium is formed by eight bones.Cranium is formed by eight bones.
b)b) Face is formed by fourteen bones.Face is formed by fourteen bones.
Ahmad ata Ahmad ata 88
AXIAL SKELETONAXIAL SKELETON
2) VERTEBRAL COLUMN2) VERTEBRAL COLUMN
Divided into 5 main regionsDivided into 5 main regions
1.1. Cervical spine (7)Cervical spine (7)
2.2. Thoracic spine (12)Thoracic spine (12)
3.3. Lumbar spine (5) Lumbar spine (5)
4.4. Sacrum (5)Sacrum (5)
5.5. Coccyx (4)Coccyx (4)
The 5 sacrum The 5 sacrum vertebrae and 4 coccyx vertebrae and 4 coccyx vertebrae are fused to form vertebrae are fused to form one solid bone.one solid bone.
Ahmad ata Ahmad ata 99
Cervical, Thoracic, Lumbar, Cervical, Thoracic, Lumbar, Sacrum Sacrum
and Coccyxand Coccyx
Ahmad ata Ahmad ata 1010
AXIAL SKELETONAXIAL SKELETON
THORAXTHORAX 12 pairs of ribs12 pairs of ribs Joined to thoracic Joined to thoracic
vertebraevertebrae Top 10 ribs joined Top 10 ribs joined
to sternumto sternum Remaining two Remaining two
have “free” ends – have “free” ends – ‘floating’‘floating’
Ahmad ata Ahmad ata 1111
APPENDICULAR SKELETONAPPENDICULAR SKELETON
Forms mainly the Forms mainly the extremities of the extremities of the body and their body and their connections to the connections to the axial skeletonaxial skeleton
Consists ofConsists of
- limbs (arms & legs)- limbs (arms & legs)
- shoulder and pelvic - shoulder and pelvic girdlesgirdles
Ahmad ata Ahmad ata 1212
Bone Bone ClassificationClassification
4 types of bones:4 types of bones:– Long Bones Long Bones
Much longer than they Much longer than they are wide.are wide.
All bones of the limbs All bones of the limbs except for the patella except for the patella (kneecap), (kneecap), and the and the bones of the wrist and bones of the wrist and ankle.ankle.
Consists of a shaft plus 2 Consists of a shaft plus 2 expanded ends.expanded ends.
– Short BonesShort Bones Roughly cube shaped.Roughly cube shaped. Bones of the wrist and the Bones of the wrist and the
ankle.ankle.
Femur
Carpal Bones
Ahmad ata Ahmad ata 1313
Bone ClassificationBone Classification
Types of bones:Types of bones:– Flat BonesFlat Bones
Thin, flattened, and Thin, flattened, and usually a bit curved.usually a bit curved.
Scapulae, sternum, Scapulae, sternum, (shoulder blades), ribs (shoulder blades), ribs and most bones of the and most bones of the skull.skull.
– Irregular BonesIrregular Bones Have weird shapes that Have weird shapes that
fit none of the 3 previous fit none of the 3 previous classes.classes.
Vertebrae, hip bones, 2 Vertebrae, hip bones, 2 skull bones ( sphenoid skull bones ( sphenoid and the ethmoid bones).and the ethmoid bones).
Sternum
Sphenoid Bone
Ahmad ata Ahmad ata 1414
Parts of long bone Parts of long bone
1) diaphysis: main shaft like structure, 1) diaphysis: main shaft like structure, its hollow cylindrical shape, its its hollow cylindrical shape, its functions of providing strong support functions of providing strong support bone.bone.
2) epiphysis: both end of long bone, 2) epiphysis: both end of long bone, epiphysis have a bulbous shape that epiphysis have a bulbous shape that provide generous space near joint. provide generous space near joint.
For muscle attachment and give For muscle attachment and give stability of joint.stability of joint.
Ahmad ata Ahmad ata 1515
Parts of long boneParts of long bone
3) articular cartilage thin layer of hyaline 3) articular cartilage thin layer of hyaline cartilage that covers joint surface.cartilage that covers joint surface.
4) Periosteum: dense white fibrous 4) Periosteum: dense white fibrous membrane that cover bone except at membrane that cover bone except at joint surface and anchoring bone to joint surface and anchoring bone to muscles.muscles.
5) Marrow cavity: a tubelike hollow space 5) Marrow cavity: a tubelike hollow space in the diaphysis of long bone.in the diaphysis of long bone.
6) endosteum: a thin epithelial 6) endosteum: a thin epithelial membrane that line the medullry cavity.membrane that line the medullry cavity.
Ahmad ata Ahmad ata 1616
Long Long Bone Bone
StructureStructure
Ahmad ata Ahmad ata 1717
Composition of bone matrix Composition of bone matrix
1)1) Inorganic saltsInorganic salts: the hardness of bone : the hardness of bone result from the deposition of high result from the deposition of high specialized chemical crystal of calcium and specialized chemical crystal of calcium and phosphorous called hydroxyapatite, the phosphorous called hydroxyapatite, the process called calcification in addition to process called calcification in addition to mg, Na, sulphate and fluoride.mg, Na, sulphate and fluoride.
2)2) Organic substance:Organic substance: collagenous fiber and collagenous fiber and mixture protein and poly saccarids called mixture protein and poly saccarids called ground substance, provide support and ground substance, provide support and adhesion between cellular and fiberous.adhesion between cellular and fiberous.
Chondroitin and glucosamine are required Chondroitin and glucosamine are required for repair and maintenance of bone and for repair and maintenance of bone and cartilage.cartilage.
Ahmad ata Ahmad ata 1818
Composition of bone matrixComposition of bone matrix
Ahmad ata Ahmad ata 1919
This bone:
a. Has been demineralized
b. Has had its organic component removed
Ahmad ata Ahmad ata 2020
11. Osteoblasts. Osteoblasts Bone-forming cells Bone-forming cells
found in all bone found in all bone surfaces surfaces Bone-building Bone-building cells.cells.
Synthesize and Synthesize and secrete collagen fibers secrete collagen fibers and other organic and other organic components of bone components of bone matrix. matrix.
serve as a framework serve as a framework for the deposition of for the deposition of calcium and calcium and phosphate phosphate calcificationcalcification
The blue arrows indicate the osteoblasts. The yellow arrows indicate the bone matrix they’ve just secreted.
Types of bone cellsTypes of bone cells
Ahmad ata Ahmad ata 2121
Types of bone Types of bone cellscells
22. Osteoclasts. Osteoclasts Giant multinucleate Giant multinucleate
cellscells Responsible for the Responsible for the
active erosion of active erosion of bone mineralsbone minerals
Contain large Contain large numbers of numbers of mitochondria and mitochondria and lysosomeslysosomes
Ahmad ata Ahmad ata 2222
Types of bone cellsTypes of bone cells
3. Osteocytes—mature, nondividing 3. Osteocytes—mature, nondividing osteoblast surrounded by matrix, osteoblast surrounded by matrix, lying within lacunae lying within lacunae
Ahmad ata Ahmad ata 2323
Ahmad ata Ahmad ata 2424
Bone MarrowBone Marrow
Specialized type of soft, diffuse Specialized type of soft, diffuse connective tissue; called connective tissue; called myeloid myeloid tissuetissue
Site for the production of blood cellsSite for the production of blood cells Found in medullary cavities of long Found in medullary cavities of long
bones and in the spaces of spongy bones and in the spaces of spongy bonebone
Ahmad ata Ahmad ata 2525
Microscopic Structure of Compact BoneMicroscopic Structure of Compact Bone
– Contains many cylinder-Contains many cylinder-shaped structural units shaped structural units calledcalled osteons, osteons, oror Haversian Haversian systemssystems
– Four types of structures Four types of structures make up each osteon:make up each osteon: Lamella—concentric, Lamella—concentric,
cylinder-shaped layers of cylinder-shaped layers of calcified matrixcalcified matrix
Lacunae—small spaces Lacunae—small spaces containing tissue fluid in containing tissue fluid in which bone cells are which bone cells are located between hard located between hard layers of the lamellalayers of the lamella
Ahmad ata Ahmad ata 2626
Microscopic Structure of Microscopic Structure of Compact BoneCompact Bone
Canaliculi—ultrasmall Canaliculi—ultrasmall canals radiating in all canals radiating in all directions from the directions from the lacunae and connecting lacunae and connecting them to each other and them to each other and to the Haversian canalto the Haversian canal
Haversian canal—Haversian canal—extends lengthwise extends lengthwise through the center of through the center of each osteon and contains each osteon and contains blood vessels and blood vessels and lymphatic vesselslymphatic vessels
Ahmad ata Ahmad ata 2727
Microscopic Structure of Microscopic Structure of Compact BoneCompact Bone
Ahmad ata Ahmad ata 2828
Bone MarrowBone Marrow
Two types of marrow are present during a Two types of marrow are present during a person’s lifetime:person’s lifetime:– Red marrowRed marrow
Found in virtually all bones in an infant’s or child’s Found in virtually all bones in an infant’s or child’s bodybody
Functions to produce red blood cellsFunctions to produce red blood cells
– Yellow marrowYellow marrow As an individual ages, red marrow is replaced by As an individual ages, red marrow is replaced by
yellow marrowyellow marrow Marrow cells become saturated with fat and are no Marrow cells become saturated with fat and are no
longer active in blood cell productionlonger active in blood cell production
Ahmad ata Ahmad ata 2929
Bone MarrowBone Marrow
The main bones in an adult that still The main bones in an adult that still contain red marrow include the ribs, contain red marrow include the ribs, bodies of the vertebrae, the bodies of the vertebrae, the humerus, the pelvis, and the femurhumerus, the pelvis, and the femur
Yellow marrow can alter to red Yellow marrow can alter to red marrow during times of decreased marrow during times of decreased blood supply, such as with anemia, blood supply, such as with anemia, exposure to radiation, and certain exposure to radiation, and certain diseasesdiseases
Ahmad ata Ahmad ata 3030
Functions of BoneFunctions of Bone Support—bones form the framework of the body Support—bones form the framework of the body
and contribute to the shape, alignment, and and contribute to the shape, alignment, and positioning of the body partspositioning of the body parts
Protection—bony “boxes” protect the delicate Protection—bony “boxes” protect the delicate structures they enclosestructures they enclose
Movement—bones with their joints constitute Movement—bones with their joints constitute levers that move as muscles contractlevers that move as muscles contract
Mineral storage—bones are the major reservoir Mineral storage—bones are the major reservoir for calcium, phosphorus, and other mineralsfor calcium, phosphorus, and other minerals
Hematopoiesis—blood cell formation is carried Hematopoiesis—blood cell formation is carried out by myeloid tissueout by myeloid tissue
Ahmad ata Ahmad ata 3131
Regulation of Blood Calcium Regulation of Blood Calcium LevelsLevels
Skeletal system (cont.)Skeletal system (cont.)– Homeostasis of calcium ion Homeostasis of calcium ion
concentration essential for the following:concentration essential for the following: Bone formation, remodeling, and repairBone formation, remodeling, and repair Blood clottingBlood clotting Transmission of nerve impulsesTransmission of nerve impulses Maintenance of skeletal and cardiac muscle Maintenance of skeletal and cardiac muscle
contractioncontraction
Ahmad ata Ahmad ata 3232
Regulation of Blood Calcium Regulation of Blood Calcium LevelsLevels
Mechanisms of calcium homeostasisMechanisms of calcium homeostasis– Parathyroid hormoneParathyroid hormone
Primary regulator of calcium homeostasisPrimary regulator of calcium homeostasis Stimulates osteoclasts to initiate breakdown Stimulates osteoclasts to initiate breakdown
of bone matrix and increase blood calcium of bone matrix and increase blood calcium levelslevels
Increases renal absorption of calcium from Increases renal absorption of calcium from urineurine
Stimulates vitamin D synthesisStimulates vitamin D synthesis
Ahmad ata Ahmad ata 3333
Mechanisms of calcium homeostasis Mechanisms of calcium homeostasis (cont.)(cont.)– CalcitoninCalcitonin
Protein hormone produced in the thyroid glandProtein hormone produced in the thyroid gland Produced in response to high blood calcium Produced in response to high blood calcium
levelslevels Stimulates bone deposition by osteoblastsStimulates bone deposition by osteoblasts Inhibits osteoclast activityInhibits osteoclast activity Far less important in homeostasis of blood Far less important in homeostasis of blood
calcium levels than parathyroid hormonecalcium levels than parathyroid hormone
Ahmad ata Ahmad ata 3434
Fracture TypesFracture Types
– Open (compound) Open (compound) bone ends penetrate bone ends penetrate the skin.the skin.
– Closed (simple) Closed (simple) bone ends don’t bone ends don’t penetrate the skin.penetrate the skin.
– Spiral Spiral ragged break caused by excessive ragged break caused by excessive twisting forces. Sports injury/Injury of abusetwisting forces. Sports injury/Injury of abuse
– Greenstick Greenstick bone breaks incompletely. One bone breaks incompletely. One side bent, one side broken. Common in side bent, one side broken. Common in children whose bone contains more collagen children whose bone contains more collagen and are and are less mineralizedless mineralized
Ahmad ata Ahmad ata 3535
Ahmad ata Ahmad ata 3636
Clinical Clinical ConditionsConditions
OsteomalaciaOsteomalacia– Literally “soft bones.”Literally “soft bones.”– Includes many disorders in which Includes many disorders in which
osteoid is produced but osteoid is produced but inadequately mineralized.inadequately mineralized.
Causes can include insufficient Causes can include insufficient dietary calciumdietary calcium
Insufficient vitamin D Insufficient vitamin D fortification or insufficient fortification or insufficient exposure to sun light.exposure to sun light.
RicketsRickets– Children's form of osteomalaciaChildren's form of osteomalacia– More detrimental due to the fact More detrimental due to the fact
that their bones are still growing.that their bones are still growing.– Signs include bowed legs, and Signs include bowed legs, and
deformities of the pelvis, ribs, and deformities of the pelvis, ribs, and skull.skull.
What about the above x-ray is indicative of rickets?
Ahmad ata Ahmad ata 3737
Clinical Clinical ConditionsConditions
OsteomyelitisOsteomyelitis– Inflammation of Inflammation of
bone and bone bone and bone marrow caused by marrow caused by pus-forming bacteria pus-forming bacteria that enter the body that enter the body via a wound (e.g., via a wound (e.g., compound fracture) compound fracture) or migrate from a or migrate from a nearby infection.nearby infection.
– Fatal before the Fatal before the advent of antibiotics.advent of antibiotics.
Ahmad ata Ahmad ata 3838
Any Any question ???question ???
The endThe end