AdenoPlus Brochure US-1

7/15/2019 AdenoPlus Brochure US-1

http://slidepdf.com/reader/full/adenoplus-brochure-us-1 1/5RAPID RESULTS FOR A CONFIDENT DIAGNOSIS

New AdenoPlus™ aids in the

rapid dierential diagnosisof acute conjunctivitis, allowingfor appropriate managementbased on diagnostic evidence

DECODE THE RED EYE


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Overlap in clinical signs and symptoms of acute conjunctivitis5,9,10

Viral, bacterial, or allergic—the signs and symptomso acute conjunctivitis can be indistinguishable

• It has been estimated that at least 6 million cases o acute conjunctivitis are diagnosedin the U.S. each year1

• Viral, bacterial, and allergic are the most common types and present similarly2-4

• Diferential diagnosis using only signs and symptoms can be challenging5-8

“Treatment of conjunctivitis is ideally directed at the root cause. Indiscriminate use

of topical antibiotics or corticosteroids should be avoided, because antibiotics can induce toxicity and corticosteroids can potentially prolong adenoviral infections…”18

— American Academy of Ophthalmology (AAO), Preferred Practice Pattern®

, 2011

Redness

81%

83%

38%

Itching

38%

33%

86%

Irritation/foreign

body sensation

19%

17%

52%Watery

discharge/tearing

50%

39%

48%

Follicles

47%

42%

8%

ucoid

scharge

19%

17%

18%

Purulent

discharge

25%

28%

N/A

Viral

Bacterial

Allergic

Early, accurate diagnosis o acute conjunctivitismay prevent serious consequences

• Adenovirus causes approximately 1 out o every 4 acute conjunctivitis casesseen by eye care proessionals and is ot en misdiagnosed2-5,11,12

• Adenovirus is associated with signicant morbidity, including11,13-15

— Decreased visual acuity— Light sensitivity— Chronic excessive tear production— Visual loss— Presence o subepithelial inltrates

Contagion with adenovirus is fast and widespread

• Inected patients are contagious or up to 3 weeks16

• Between close contacts the inection rate is up to 50%16

• Adenovirus can live on inanimate suraces or up to 28 days17,18

Studies indicate that eye care professionals make an accurate dierentdiagnosis for acute conjunctivitis approximately 50% of the time2-4

• The majority o acute conjunctivitis cases result in a prescription or antibiotics,even when they are unnecessary19

• Unnecessary antibiotic use may increase adverse efects and promote resistance11

“While some cases of acute conjunctivitis are more obviously associated

with one etiology or another, the majority of cases have similar presentation, making the differential diagnosis challenging.”

— Kelly Nichols, OD, MPH, PhD, FAAO



RAPID RESULTS FOR A CONFIDENT DIAGDECODE THE RED EYE

Introducing AdenoPlus™—the rst in-oceimmunoassay that aids in the rapid diferentialdiagnosis o acute conjunctivitis

Fast

• ≤ 2 minutes to complete test; results in just 10 minutes

Accurate

• Identies adenovirus (which accounts or 90% o all viralconjunctivitis2,20,21) with 90% sensitivity and 96% specicity

Easy

• Completed in the oce in 4 simple steps

An objective diagnosis may enhance the patient experience2

• Patients know i their red eye is adenovirus beore leaving the clinician’s oce

• They know whether or not they can return to work

• They may avoid paying or unnecessary treatments such as antibiotics

“With AdenoPlus

™

, practices benefit from a laboratory-quality diagnosis at the point of care.”

— Paul Karpecki, OD, FAAO

AdenoPlus™ eatures proprietary technology utilizing direct samplemicroltration with a lateral ow assay strip, enabling a small sample

o ocular uid to aid in a rapid diferential diagnosis in the oce.

AdenoPlus™ in practice—aiding in makingan accurate diagnosis or better patient care

With AdenoPlus™, eye care proessionals can:

• Quickly obtain accurate evidence or a diferential diagnosis22

• Comply with AAO guidelines by counseling contagious patients to minimizeor prevent spread o the disease in the community18

• Signicantly reduce cost to the U.S. healthcare system12

— A published cost-efectiveness study ound that incorporating AdenoPlus™ as aroutine, point-o-care test or the red eye could save more than $400 million annually

• More efectively and eciently manage their patients with red eye2,11,22

Providing accurate results in 4 simple steps

1. Use a “dab and drag”motion in 6 to 8 locationson the palpebralconjunctiva (lower eyelid)to collect a tear sample.

2. Snap the sample collectorinto the test cassette andpress rmly where indicated.

3. Dip the test cassetteinto the provided bufervial or 20 seconds.Replace the cap.

4. Read the results: 2 line(1 red, 1 blue) = positiv1 line (blue) = negative

“ [AdenoPlus™

] helps reduce the number of misdiagnoses and leads to better patient management and treatment.”2

— Terrence P. O’Brien, MD



RAPID RESULTS FOR A CONFIDENT DIAGDECODE THE RED EYE

THE RED EYE PROTOCOL*

AdenoPlus™ helps provide eective diagnosis and managementof the conjunctivitis patient11,18

AdenoPlus™—a ast and convenient wayto aid in a rapid diferential diagnosis

• The only CLIA-waived, in-oce diagnostic tool or acute conjunctivitis

• Can be perormed by nurses, technicians, or any trained medical oce personnel

• Reimbursable in the U.S. with CPT code 87809QW

• Cost efective, requiring no ancillary equipment

Reimbursement for AdenoPlus™

• Facilities must obtain CLIA-waived certication or reimbursement

“The most important reason for early detection of conjunctivitis is that prompt,

appropriate treatment…speeds resolution of the disease, minimizing boththe sequelae of untreated conjunctivitis and time away from work or school.”18

— American Academy of Ophthalmology (AAO), Preferred Practice Pattern®

, 2011

Red Eye Room Isolation• Identication and isolation

o patient by ront oce

History and Evaluation• Clinical signs and symptoms and their duration (itching, tearing,

discharge, irritation, pain, photophobia, blurred vision)• Recent exposure to inected individual• Recent upper respiratory inection• Trauma, contact lens wear, or presence o systemic conditions• Use o medicationsIf acute conjunctivitis is determined,

perform AdenoPlus™ test

Diagnostic Testing• Technician perorms AdenoPlus™ (≤ 2 min to complete; results in just 10 minutes)

Positive• Consider nonantibiotic therapy• Patient counseling: isolation (7 to 10 days); hand washing;

no towel sharing or close contact• Supportive care: articial tears, antihistamines, cold compresses,

or topical corticosteroids with close patient monitoring• Implementation o CDC guidelines or decontamination

o exposed suraces and equipment in the ECP oce

Negative• Continue the diferential diagnosis

(with adenovirus ruled out) to determinelikelihood o bacterial or allergic

• Consider topical antibiotic or antihistaminetherapy, or a combination

• Follow up or reer i decreased vision or pain,or lack o improvement over 7 days

ECP interprets test results and determines appropriate treatment based on diagnostic evidence

“Implementation of an in-office red eye protocol and point-of-care diagnostic

tools, such as AdenoPlus™ , can greatly improve the treatment and management of conjunctivitis patients.”

— Mile Brujic, OD

CDC=Centers or Disease Control

*The Red Eye Protocol was developed based on published literature o best practices in managing the acute red eye.CLIA=Clinical Laboratory Improvement Amendments

Reimbursement guide for AdenoPlus™

1. Enter CLIA-waived certication number

2. Modify the master bill:

• Enter AdenoPlus™ test description “Inectious agent antigen detection by immunoassaywith direct optical observation; adenovirus”

• Enter CPT code and qualier: 87809QW

3. Enter an appropriate ICD-9 code



Introducing AdenoPlus™—rapid resultsor a condent diagnosis

• Fast: Results in just 10 minutes

• Accurate: 90% sensitivity and 96% specicity• Easy: Complete in the oce in 4 simple steps

• RED EYE PROTOCOL: Helps provideefective diagnosis and management

References: 1. Data on fle, Nicox Ophthalmic Diagnostics. 2. O’Brien TP, Jeng BH, McDonald M, et al. Acute conjunctivitis: truth and misconceptions. Curr Med Res Opin . 2009;25(8):1953-1961.

3. Leibowitz HM, Pratt MV, Flagstad IJ, et al. Human conjunctivitis. Arch Ophthalmol . 1976;94:1747-1749. 4. Stenson S, Newman R, Fedukowicz H. Laboratory studies in acute conjunctivitis. Arch

Ophthalmol . 1982;100:1275-1277. 5. Fitch CP, Rapoza PA, Owens S, et al. Epidemiology and diagnosis o acute conjunctivitis at an inner-city hospital. Ophthalmology . 1989;96:1215-1220.

6. Rietveld RP, ter Riet G, Bindels PJE, et al. Predicting bacterial cause in inectious conjunctivitis: cohort study on inormativeness o combinations o signs and symptoms. BMJ . 2004;329:206.

7. Rietveld RP, vanWeert CPM, ter Riet G, et al. Diagnostic impact o signs and symptoms in acute inectious conjunctivitis: systematic literature search. BMJ . 2003;327:789. 8. Gigliotti F, Williams

WT, Hayden FG, et al. Etiology o acute conjunctivitis in children. J Pediatrics . 1981;98(4):531-536. 9. Solomon AS. Symptoms o allergic conjunctivitis. Arch Ophthalmol. 1985;103(7):891.

10. Kosrirukvongs P, Visitsunthorn N, Vichyanond P, et al. Allergic conjunctivitis. Asian Pac J Allergy . 2001;19:237-244. 11. Sambursky R, Tauber S, Schirra F, et al. The RPS Adeno Detector

or diagnosing adenoviral conjunctivitis. Ophthalmology . 2006;113:1758-1764. 12. Udeh BL, Schneider JE, Ohseldt RL. Cost eectiveness o a point-o-care test or adenoviral conjunctivitis.

Am J Med Sci . 2008;336(3):254-264. 13. Butt AL, Chodosh J. Adenoviral keratoconjunctivitis in a tertiary care eye clinic. Cornea . 2006;25(2):199-202. 14. Hyde KJ, Berger ST. Epidemic

keratoconjunctivitis and lacrimal excretory system obstruction. Ophthalmology . 1988;95(10):1447-1449. 15. Hammer LH, Perry HD, Donneneld ED, et al. Symblepharon ormation in epidemic

keratoconjunctivitis. Cornea . 1990;9(4):338-340. 16. Kauman HE. Adenovirus advances: new diagnostic and therapeutic options. Curr Opin Ophthalmol . 2011;22:290-293. 17. Gordon YJ,

Gordon RY, Romanowski E, et al. Prolonged recovery o desiccated adenoviral serotypes 5, 8, and 19 rom plastic and metal suraces in vitro. Ophthalmology . 1993;100(12):1835-1840.

18. American Academy o Ophthalmology Cornea/External Disease Panel. Preerred Practice Patt ern®

Guidelines. Conjunctivitis–Limited Revision. San Francisco, CA: American Academy

o Ophthalmology; 2011. Available at: www.aao.org/ppp. 19. Everitt H, Little P. How do GPs diagnose and manage acute inective conjunctivitis? A GP survey. Fam Pract . 2002;19(6):658-660.

20. Matsui K, Shimizu H, Yoshida A, et al. Monitoring o adenovirus rom conjunctival scrapings in Japan during 2005–2006. J Med Virol . 2008;80:997-1003. 21. Woodland RM, Darougar S,

Thaker U, et al. Causes o conjunctivitis and keratoconjunctivitis in Karachi, Pakistan. Royal Soc Tropical Medicine Hygiene . 1992;86(3):317-320. 22. Sambursky RP, Fram N, Cohen EJ.

The prevalence o adenoviral conjunctivitis at the Wills Eye Hospital emergency room. Optometry . 2007;78:236-239.

AdenoPlus is a trademark of Rapid Pathogen Screening, Inc.

© 2012 Nicox, Inc. All rights reserved. www.Nicox.com

RAPID RESULTS FOR A CONFIDENT DIAGNOSIS

For more inormation or to order AdenoPlus™, contact your local

Ophthalmic Account Manager or call 1.855.MY.NICOX (1.855.696.4269).

Documents

AdenoPlus Brochure US-1