ACADEMIC DEPARTMENT

FACULTY ACADEMIC PROFILE/ CV

Full name of the faculty member: Dr. Sanghamitra Sengupta

Designation: Assistant Professor

Specialisation : Molecular Genetics

Contact information :

Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata

700 019; sanghamitrasg@yahoo.com; 9830340481

Academic qualifications:

College/ university from which the

degree was obtained

Abbreviation of the degree

B. Sc (Chemistry Hons) University of Calcutta

M. Sc (Biochemistry) University of Calcutta

PhD (Biochemistry) University of Calcutta

Positions held/ holding:

Assistant Professor

Research interests:

To elucidate mechanisms underlying prostate cancer growth and progression.

To identify critical host determinants of P. falciparum malaria pathogenesis in

human.

Research guidance:

Number of researchers awarded Ph.D degrees : 3

Number of researchers pursuing Ph.D : 7

Projects:

Completed projects:

Elucidation of rhizosphere-effect of Arachis hypogaea, DBT, Govt of West Bengal

Impact of Polymorphisms in the Candidate Genes on Prostate Cancer: Association &

Functional Analyses, CSIR Extra mural scheme, New Delhi

Understanding the Genetic and Molecular Basis of Immune Responses in Malarial

Pathogenesis, UGC Major Research Project, New Delhi

Investigating the Molecular Dynamics of Progression of Prostate Cancer, Modern Biology

–UPE Scheme- University of Calcutta

Investigating Molecular Principles of Species Interaction in Rhizosphere Biochemical and

Metagenomic Approaches, Modern Biology –UPE Scheme- University of Calcutta, as Co-

PI

Role of SNPs in the central MHC complex in malarial pathogenesis, DST-SERC-FastTrack

program for young scientists, New Delhi

Current projects:

Towards understanding host gene regulation in P. falciparum malaria, DST-SERB, New

Delhi

P falciparum merozoite invasion of human erythrocytes, DBT, WB

Decoding the genetics of host-parasite interaction during erythrocyte invasion by

P.falciparum in human malaria, UGC- MRP, New Delhi

TGFβ signaling and Prostate cancer, ICMR, New Delhi

Select list of publications:

a) Journals:

1. Majumder S, Bhowal A, Basu S, Mukherjee P, Chatterji U, Sengupta S. Deregulated

E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGFβ Signaling in

Prostate Cancer. J Cell Physiol. 2016 Feb 25. doi: 10.1002/jcp.25361

2. Bag S, Pal M, Chaudhary A, Das RK, Paul RR, Sengupta S, Chatterjee J. Connecting cyto-

nano-architectural attributes and epithelial molecular expression in oral submucous fibrosis

progression to cancer. J Clin Pathol. 2015 Aug; 68(8):605-13.

3. Haldar SR, Chakrabarty A, Chowdhury S, Haldar A, Sengupta S, Bhattacharyya M.

Oxidative stress-related genes in type 2 diabetes: association analysis and their clinical

impact. Biochem Genet. 2015 Jun; 53(4-6):93-119. doi: 10.1007/s10528-015-9675-z. Epub

2015 May 20.

4. Basu S, Majumder S, Bhowal A, Ghosh A, Naskar S, Nandy S, Mukherjee S, Sinha RK,

Basu K, Karmakar D, Banerjee S, Sengupta S. A study of molecular signals deregulating

mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia. PLoS

One. 2015 May 4;10(5)

5. Haldar S, Sengupta S. Plant-microbe Cross-talk in the Rhizosphere: Insight and

Biotechnological Potential. Open Microbiol J. 2015 Mar 31;9:1-7.

6. Haldar S, Sengupta S. Impact of plant development on the rhizobacterial population of

Arachis hypogaea: a multifactorial analysis. J Basic Microbiol. 2015 Jul;55(7):922-8.

7. Das RK, Anura A, Pal M, Bag S, Majumdar S, Barui A, Chakraborty C, Ray AK,

Sengupta S, Paul RR, Chatterjee J. Epithelio-mesenchymal transitional attributes in oral

sub-mucous fibrosis. Exp Mol Pathol. 2013 Dec;95(3):259-69.

8. Basu M, Maji AK, Mitra M, Sengupta S. Natural selection and population genetic

structure of domain-I of Plasmodium falciparum apical membrane antigen-1 in India.

Infect Genet Evol. 2013 Aug;18:247-56.

9. Barui A, Mandal N, Majumder S, Das RK, Sengupta S, Banerjee P, Ray AK,

RoyChaudhuri C, Chatterjee J. Assessment of molecular events during in vitro re-

epithelialization under honey-alginate matrix ambience. Mater Sci Eng C Mater Biol Appl.

2013 Aug 1;33(6):3418-25.

10. Basu M, Das T, Ghosh A, Majumder S, Maji AK, Kanjilal SD, Mukhopadhyay I,

Roychowdhury S, Banerjee S, Sengupta S. Gene-gene interaction and functional impact of

polymorphisms on innate immune genes in controlling Plasmodium falciparum blood

infection level. PLoS One. 2012;7(10

11. Haldar S, Roy Choudhury S, Sengupta S. Genetic and functional diversities of bacterial

communities in the rhizosphere of Arachis hypogaea. Antonie Van Leeuwenhoek. 2011

Mar 5

12. Das RK, Pal M, Barui A, Paul RR, Chakraborty C, Ray AK, Sengupta S, Chatterjee J.

Assessment of malignant potential of oral submucous fibrosis through evaluation of p63, E-

cadherin and CD105 expression. J Clin Pathol. 2010 Oct;63(10):894-9

13. Basu M, Maji AK, Chakraborty A, Banerjee R, Mullick S, Saha P, Das S, Kanjilal SD,

Sengupta S. Genetic association of Toll-like-receptor 4 and tumor necrosis factor-alpha

polymorphisms with Plasmodium falciparum blood infection levels. Infect Genet Evol.

2010 July 20; 10(5):686-96

14. Adak S, Sengupta S, Chowdhury S, and Bhattacharyya M. Co-existence of risk and

protective haplotypes of Calpain 10 gene to type 2 diabetes in Eastern Indian population.

Diab Vasc Dis Res 2010 Jan; 7(1): 63-68

Membership of Learned Societies:

Life member, Indian Association of Cancer Research

Life member, Society of Biological Chemists

Life member, Indian Science Congress Association

Life member, Society of Human Genetics, Calcutta Chapter

Invited lectures delivered:

National:

Delivered lectures on

1. “Human Genome Project & After-math” at School of Medical science and Technology at IIT,

Kharagpur, 2009

2. Capillary Sequencing and DNA Profiling in Human Identification in Forensic Sciences at

Centre for Forensic Laboratory, Kolkata, 2009

3. Fundamentals of Genetics & Human Genome Project” at Centre for Health Care Science and

Technology (CHEST), BESU in April 2011.

4. MicroRNAs and Cancer, at Oral Pathology, Guru Nanak Institute of Dental Sciences and

Research & Hospital, Kolkata, 2011

5. Microbiome and Oral Diseases, at Oral Pathology, Guru Nanak Institute of Dental Sciences and

Research & Hospital, Kolkata, 2012

6. Microbiome, intestinal integrity and disease pathogenesis at AIFH, School of Medical science

and Technology at IIT, Kharagpur, March 20015

7. Hypoxia mediated epigenetic deregulation of DNA mismatch repair and EMT pathways in

prostate cancer in the Global Cancer Summit at IISc, Bangalore, 2015

8. Epigenetic deregulation of DNA mismatch repair and epithelial-messenchymal transition

pathways in prostate cancer, at APPICON 2015, AIIMS Jodhpur, 2015

9. Altered E2F5/p38/SMAD3 axis reinforces the pro-tumorigenic switch of TGFβ signaling in

prostate cancer at IACR 2016, New Delhi, 2016

Other notable activities:

1. UGC visiting fellow under UGC-SAP-DRS I program in the School of Studies in Anthropology,

Pandit Ravi Shankar Shukla University, Raipur for delivering lectures and hands-on-training in

Molecular Genetics and Bioinformatics in the years 2009, 2016

2. Participated in the science promotion camps for secondary and higher secondary students

organized by JBNSTS, Kolkata

3. Member of Ethical Committee, Guru Nanak Institute of Dental Sciences and Research