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592 Jafmovich et al reported the association of pemphigus vulgaris and Kaposi's sarcoma for the first time. Hie et ai, /9 also from Israel, communicated the association of Kaposi's sarcoma and pemphigus foliaceus. It should be stressed that the Kaposi's sarcoma lesions developed in our third patient while he was undergoing treatment with high doses of steroids. The suggested possibility is that immune dysfunc- tion, perhaps induced by the use of steroids, con- tributed to the development of Kaposi's sarcoma. There is growing clinical evidence that immuno- suppressive therapy for nonneoplastic diseases is associated with the risk of developing Kaposi's sarcoma. 20 ,21 Although the incidence is rare, we believe that dermatologists should consider Kaposi's sarcoma among the differential diagnoses of ocular lesions. REFERENCES 1. Duke-Elder S: System of ophthalmology, vol. 8. London, 1965, Henry Kimpton, p. 1209. 2. Reese AR: Tumors of the eye. New York, 1951, Paul B. Hoeber, Inc., p, 360. 3. Graham TN: Idiopathic multiple hemorrhagic sarcoma (Kaposi): Report of an unusual case in which the initial lesion was on the eyelid. Areh Ophthalmol 28: 1188- 1192, 1942. 4. Sacks I: Kaposi's disease manifesting in the eye. Br J Ophthalmol 40:574, 1956. 5. Lerma NS, Pinsky A: Kaposi's sarcoma of the eyelid. Arch Ophthalmol 62:320-324, 1959. 6. McLaren DS: Kaposi's sarcoma of the eyelids of an Af- rican child. Arch Ophthaimol 63:859-861, 1960. 7. Alexander eM: Kaposi's sarcoma: With ocular manifes- tations. Am J Ophthalmol 55:625-629, 1963. Journal of the American Academy of Dermatology 8. Sezer N, Ercikan C: Kaposi's sarcoma with ocular man- ifestations. Br J Ophthalmol 48:223-226, 1964. 9. Mortada A: Conjunctival regressing Kaposi sarcoma. Br J Ophthalmol 51:275-280, 1967. 10. Lieberman PH, L10vere IN: Kaposi's sarcoma of the bulbar conjunctiva. Arch Ophthalmo] 88:44-45, 1972. II. Howard GM, Jacobiec FA, DeVoe AG: Kaposi's sarcoma of the conjunctiva. Am J Ophthalmol 79:420-423, 1975. 12. Wetter JJ, Jacobiec FA, Iwamoto T: The clinical and morphologic characteristics of Kaposi's sarcoma of the conjunctiva. Am J Ophthalmol 89:546-552, 1980. 13. Bedrick JJ, Savino PJ, Schatz NJ: Conjunctival Kaposi's sarcoma in a patient with myasthenia gravis. Arch Ophthalmol 99: 1607-1609, 1981. 14. Rosselet E, Deller M: Lesions chorioretiniennes dans l'angiosarcomatose de Kaposi. Ophthalmologica 133: 361-364, 1957. 15. Holland ON, Pepose JS, Pettit TH, et al: Acquired im- mune deficiency syndrome: Ocular manifestations. Oph- thalmology 90; 859-873, 1983. 16. Rosenberg PR, Uliss AE, Friedland GH, et al: Acquired immunodeficiency syndrome: Ophthalmic manifestations in ambulatory patients. Ophthalmology 90:874-878, 1983. 17. Macher AM, Palestine A, Masur H, et a1: Multicentric Kaposi's sarcoma of the conjunctiva in a male homo- sexual with the acquired immunodeficiency syndrome. Ophthalmology 90:879-884, 1983. 18. Rosenmann E: Kaposi's disease in a patient with pem- phigus vulgaris. Israel J Med Sci 2:269-274, 1966. 19. Hie B, Brenner S, Lipitz R, Krakowski A: Kaposi's sar- coma after steroid therapy for pemphigus foliaceus: Case report and short review of literatLll'e. Dermatologica 163:455-459, 1981. 20. Leung F, Fam AG, Osoba D: Kaposi's sarcoma compli- cating corticosteroids therapy for temporal arteritis. Am J Med 71:320-322, 1981. 21. Klein MR, Pereira FA, Kantor 1: Kaposi's sarcoma com- plicating systemic lupus crythcmatosus treated with im- munosuppression. Arch DermatoIllO:602-604, 1974. ABSTRACTS Failure of isonicotinic acid hydrazide to improve chronic psoriasis vulgaris (German text) Rowe E, Meffert H, Wischnewsky GO: Dermatol Monatsschr 171:376-379, 1985 Rowe et al examined the antipsoriatic effect of isoniazid, which supposedly slows down polyamine synthesis. Treat- ment of fifteen psoriatic patients with isoniazid, daily 10 mgt kg for 20 days, did not achieve any improvement of disease activity. For final judgment of the effect of isoniazid, the question arises if increased concentrations of polyamine in psoriasis are decisive for the disease course. Alfred Hollander. M.D. Treatment of gingivostomatitis herpetica with acyclovir (Zovirax) in a patient in the last trimester of pregnancy (German text) Landthaler M, Eberth- Willershausen W; Hautarzt 36:478-480, 1985 A 32-year-old woman in her 35th week of pregnancy with severe gingivostomatitis herpetica and systemic symptoms was successfully treated with acylovir in 8-hour intervals,S days long, with three times daily infusions, 250 mg in 250 ml physiologic salt solution. A healthy boy was born 3 weeks later. Alfred Hollander, M.D.

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592 Jafmovich et al

reported the association of pemphigus vulgaris andKaposi's sarcoma for the first time. Hie et ai, /9

also from Israel, communicated the association ofKaposi's sarcoma and pemphigus foliaceus.

It should be stressed that the Kaposi's sarcomalesions developed in our third patient while he wasundergoing treatment with high doses of steroids.The suggested possibility is that immune dysfunc­tion, perhaps induced by the use of steroids, con­tributed to the development of Kaposi's sarcoma.There is growing clinical evidence that immuno­suppressive therapy for nonneoplastic diseases isassociated with the risk of developing Kaposi'ssarcoma.20 ,21

Although the incidence is rare, we believe thatdermatologists should consider Kaposi's sarcomaamong the differential diagnoses of ocular lesions.

REFERENCES1. Duke-Elder S: System of ophthalmology, vol. 8. London,

1965, Henry Kimpton, p. 1209.2. Reese AR: Tumors of the eye. New York, 1951, Paul

B. Hoeber, Inc., p, 360.3. Graham TN: Idiopathic multiple hemorrhagic sarcoma

(Kaposi): Report of an unusual case in which the initiallesion was on the eyelid. Areh Ophthalmol 28: 1188­1192, 1942.

4. Sacks I: Kaposi's disease manifesting in the eye. Br JOphthalmol 40:574, 1956.

5. Lerma NS, Pinsky A: Kaposi's sarcoma of the eyelid.Arch Ophthalmol 62:320-324, 1959.

6. McLaren DS: Kaposi's sarcoma of the eyelids of an Af­rican child. Arch Ophthaimol 63:859-861, 1960.

7. Alexander eM: Kaposi's sarcoma: With ocular manifes­tations. Am J Ophthalmol 55:625-629, 1963.

Journal of theAmerican Academy of

Dermatology

8. Sezer N, Ercikan C: Kaposi's sarcoma with ocular man­ifestations. Br J Ophthalmol 48:223-226, 1964.

9. Mortada A: Conjunctival regressing Kaposi sarcoma. BrJ Ophthalmol 51:275-280, 1967.

10. Lieberman PH, L10vere IN: Kaposi's sarcoma of thebulbar conjunctiva. Arch Ophthalmo] 88:44-45, 1972.

II. Howard GM, Jacobiec FA, DeVoe AG: Kaposi's sarcomaof the conjunctiva. Am J Ophthalmol 79:420-423, 1975.

12. Wetter JJ, Jacobiec FA, Iwamoto T: The clinical andmorphologic characteristics of Kaposi's sarcoma of theconjunctiva. Am J Ophthalmol 89:546-552, 1980.

13. Bedrick JJ, Savino PJ, Schatz NJ: Conjunctival Kaposi'ssarcoma in a patient with myasthenia gravis. ArchOphthalmol 99: 1607-1609, 1981.

14. Rosselet E, Deller M: Lesions chorioretiniennes dansl'angiosarcomatose de Kaposi. Ophthalmologica 133:361-364, 1957.

15. Holland ON, Pepose JS, Pettit TH, et al: Acquired im­mune deficiency syndrome: Ocular manifestations. Oph­thalmology 90;859-873, 1983.

16. Rosenberg PR, Uliss AE, Friedland GH, et al: Acquiredimmunodeficiency syndrome: Ophthalmic manifestationsin ambulatory patients. Ophthalmology 90:874-878,1983.

17. Macher AM, Palestine A, Masur H, et a1: MulticentricKaposi's sarcoma of the conjunctiva in a male homo­sexual with the acquired immunodeficiency syndrome.Ophthalmology 90:879-884, 1983.

18. Rosenmann E: Kaposi's disease in a patient with pem­phigus vulgaris. Israel J Med Sci 2:269-274, 1966.

19. Hie B, Brenner S, Lipitz R, Krakowski A: Kaposi's sar­coma after steroid therapy for pemphigus foliaceus: Casereport and short review of literatLll'e. Dermatologica163:455-459, 1981.

20. Leung F, Fam AG, Osoba D: Kaposi's sarcoma compli­cating corticosteroids therapy for temporal arteritis. AmJ Med 71:320-322, 1981.

21. Klein MR, Pereira FA, Kantor 1: Kaposi's sarcoma com­plicating systemic lupus crythcmatosus treated with im­munosuppression. Arch DermatoIllO:602-604, 1974.

ABSTRACTS

Failure of isonicotinic acid hydrazide to improvechronic psoriasis vulgaris (German text)

Rowe E, Meffert H, Wischnewsky GO: DermatolMonatsschr 171:376-379, 1985

Rowe et al examined the antipsoriatic effect of isoniazid,which supposedly slows down polyamine synthesis. Treat­ment of fifteen psoriatic patients with isoniazid, daily 10 mgtkg for 20 days, did not achieve any improvement of diseaseactivity. For final judgment of the effect of isoniazid, thequestion arises if increased concentrations of polyamine inpsoriasis are decisive for the disease course.

Alfred Hollander. M.D.

Treatment of gingivostomatitis herpetica withacyclovir (Zovirax) in a patient in the lasttrimester of pregnancy (German text)

Landthaler M, Eberth-Willershausen W; Hautarzt36:478-480, 1985

A 32-year-old woman in her 35th week of pregnancy withsevere gingivostomatitis herpetica and systemic symptomswas successfully treated with acylovir in 8-hour intervals,Sdays long, with three times daily infusions, 250 mg in 250ml physiologic salt solution. A healthy boy was born 3 weekslater.

Alfred Hollander, M.D.