Upload
madeleine-craig
View
217
Download
4
Embed Size (px)
Citation preview
A Small Dose of Alcohol – 04/03/10
An Introduction To The Health Effects of Alcohol
A Small Dose of Alcohol
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
What Is This?
CH
H
H
OHC
H
H
(CH3-CH2-OH)
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Ethanol
CH
H
H
OH
Ethyl Alcohol
C
H
H
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Methanol
CH
H
H
OH
Methyl Alcohol
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
"You will conceive and bear a son…now then be careful to take no wine or strong drink and to eat nothing unclean".
Bible - Judges 13:3-4
Ancient Awareness
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
’T is not the drinking that is to be blamed, but the excess.
John Selden (1584–1654)
In “Table Talk” 1689
Historical Perspective
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
“Alcohol is the number one drug of choice among our Nation’s youth. Yet the seriousness of this issue does not register with the general public or policymakers.”
Enoch Gordis, M.D. Director, National Institute on Alcohol Abuse and Alcoholism.
Current Views
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
7.4% of adult population in U.S. alcoholic $185 Billion – cost of alcohol abuse in U.S. 100,000 deaths annual in U.S. related to $1.2 Billion spent on wine, beer and liquor
advertisements in U.S.
Some Current Facts
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Production of Alcohol
Fermentation – Sugar to Alcohol and Carbon dioxide
C6H12O6→ 2(CH3-CH2-OH) + 2CO2
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Health Effects
What are the pleasant effects of alcohol?
The adverse effects (toxicity)?
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
• CNS Depressant• Depression of inhibitory control• Vasodilation, warm, flushed, reddish skin• Emotional outbursts• Decreased memory & concentration• Poor judgment• Decreased reflexes
Acute Effects
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Obvious• Alcoholism, death, cancer (oral cavity,
esophagus, liver), fetal effects (FAS)
Alcoholism• Cirrhosis of liver, appetite loss, poor
judgment Subtle
• Lost productivity, impaired performance, motor impairment, cost to society
Long Term Adverse Effects
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Alcohol & Cancer
Ethanol consumption increases risk of cancer
Oral CavityPharynx and Larynx
EsophagusLiver
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Fetal Alcohol Syndrome (FAS)
Most common preventable cause of adverse CNS development
4,000-12,000 infants per year in US
CharacteristicsGrowth retardation
Facial malformationsSmall head
Greatly reduce intelligence
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Fetal Alcohol Syndrome (FAS)
1 to 3 births per 1,000 world wide??
1968 first association by French researchers at the University of Nantes
Early 1970’s FAS as condition – University of Washington, Seattle WA, USA
4,000-12,000 infants per year in US
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Fetal Alcohol Effect (FAE)
Milder form of FAS
7,000-36,000 infants per year in US
CharacteristicsGrowth deficiency
Learning dysfunctionNervous systems disabilities
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Effects of Prenatal Alcohol
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Effects of Prenatal Alcohol
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10FAS Child (National Geographic, George Steinmetz, Feb 1992)
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Mouse – Scanning EM
(National Geographic, George Steinmetz, Feb 1992)
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Rapidly absorbed from stomach, small intestine, and colon
Maximal blood concentration within 30 to 90 minutes
Can be absorbed through the lungs
Absorption
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Uniformly distributed throughout tissues and body fluids
Readily crosses placenta, to exposure fetus
Distribution
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Urinary ExcretionExhalationMetabolism
Elimination
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Metabolism I
CH OH
Ethanol
H
H
C
H
H
CH
H
H
C O
H
=
Acetaldehyde
(ADH – Alcohol Dehydrogenase)
ADH
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Metabolism II
CH
H
H
C O
H
=
Acetaldehyde(ALDH – Acetaldehyde Dehydrogenase)
ALDH
Acetate
CH
H
H
C O
OH
=
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Metabolism III
80-90% Metabolized Rate is constant (not increased
by concentrations in the blood) About 30 ml (1 oz) in 3 hours
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Gender Differences
Females higher blood alcohol levels than males
Males have higher stomach metabolism of alcohol than females
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Genetic Variation in ALDH
Acetaldehyde Dehydrogenase (ALDH) varies in Caucasians, Blacks and Asians.
50% of Asians have inactive ALDH
Elevated acetaldehyde cause increased flushing, tachycardia (elevated heart rate), nausea, vomiting & hyperventilation.
Disulfiram – inhibits ALDH
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Alcoholism - Disulfiram
Alcoholism Treatment with Disulfiram
Inhibits acetaldehyde dehydrogenase (ALDH)
Elevated acetaldehyde cause increased flushing, tachycardia (elevated heart rate),
nausea, vomiting & hyperventilation.
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Alcoholism – Alcohol Dependence
Characterized by the following:
• Craving: A strong need, or compulsion, to drink. • Loss of control: The inability to limit one’s drinking
on any given occasion. • Physical dependence: Withdrawal symptoms, such
as nausea, sweating, shakiness, and anxiety, occur when alcohol use is stopped after a period of heavy drinking.
• Tolerance: The need to drink greater amounts of alcohol in order to “get high.”
(from: U.S. Alcohol & Drug Information - http://ncadi.samhsa.gov/)
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Alcoholism – Alcohol Dependence
Approximately 14 million Americans—7.4 percent of the population —meet the diagnostic criteria for alcohol
abuse or alcoholism
(from: U.S. Alcohol & Drug Information - http://ncadi.samhsa.gov/)
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
• Tremor• Nausea• Irritability• Agitation• Tachycardia• Hypertension• Seizers• Hallucinations
Alcohol Withdrawal Effects
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Ethanol as Antidote
Antidote for Poisoning by:
Methanol
Ethylene glycol
Diethylene glycol
Inhibits metabolic activation by alcohol dehydrogenase (ADH)
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
U.S. Government Warning
The Alcoholic Beverage Labeling Act of 1988 requires that the following health warning statement appear on the labels of all containers of alcohol beverages offered for sale or distribution in the United States:
U.S. GOVERNMENT WARNING: (1) According to the Surgeon General, women should not drink alcoholic beverages during pregnancy because of the risk of birth defects. (2) Consumption of alcoholic beverages impairs your ability to drive a car or operate machinery, and may cause health problems.
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
• 1981 - U.S. Surgeon General first advised that women should not drink alcoholic beverages during pregnancy.
• 1988 - U.S. requires warning labels on all alcoholic beverages sold in the United States.
• 1990 - U.S. Dietary Guidelines state that women who are pregnant or planning to become pregnant should not drink alcohol.
• 1998 - 19 states require the posting of alcohol health warning signs where alcoholic beverages are sold
Regulatory Status
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
A Small Dose of ™ Alcohol
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Additional Information
Web Sites• England – Department of Health (DOH) Alcohol
Misuse Information. Online: <http://www.dh.gov.uk/en/publichealth/healthimprovement/alcoholmisuse/index.htm> (accessed: 3 April 2010).
• Health Canada – Fetal Alcohol Spectrum Disorder. Online: <http://www.phac-aspc.gc.ca/fasd-etcaf/index-eng.php> (accessed: 3 April 2010).
A Small Dose of Toxicology A Small Dose of Alcohol – 04/03/10
Authorship Information
For Additional Information ContactSteven G. Gilbert, PhD, DABT
E-mail: [email protected]: www.asmalldoseof.org
This presentation is supplement to “A Small Dose of Toxicology”