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J A C C : C A S E R E P O R T S V O L . 1 , N O . 5 , 2 0 1 9
ª 2 0 1 9 T H E A U T H O R S . P U B L I S H E D B Y E L S E V I E R O N B E H A L F O F T H E A M E R I C A N
C O L L E G E O F C A R D I O L O G Y F OU N D A T I O N . T H I S I S A N O P E N A C C E S S A R T I C L E U N D E R
T H E C C B Y - N C - N D L I C E N S E ( h t t p : / / c r e a t i v e c o mm o n s . o r g / l i c e n s e s / b y - n c - n d / 4 . 0 / ) .
CASE REPORT
CLINICAL CASE
A Case of Rota-Shock-Pella
Ka Chun Alan Chan, MBBS, Ngai Hong Vincent Luk, MBBS, Kang Yin Michael Lee, MBBS,Kam Tim Chan, MBBSABSTRACT
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Severe calcified coronary lesions are frequently encountered in today’s percutaneous coronary intervention practice and
remain a challenging entity in complex and high-risk patients. The present case illustrates the contemporary approach to
management of this coronary problem from hemodynamic support, optical coherence tomography assessment,
and plaque modification technique. (Level of Difficulty: Advanced.) (J Am Coll Cardiol Case Rep 2019;1:765–70)
© 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
PRESENTATION
A 74-year-old gentleman presented to the emergencydepartment for acute decompensated heart failure.He had 2-week history of progressive exertional dys-pnea and lower limb edema before admission. He didnot have angina, palpitation, or syncope.
MEDICAL HISTORY
The patient had history of hypertension, hyperlipid-emia, and diabetes mellitus. He was a nonsmoker.
EARNING OBJECTIVES
To understand the limitation of angiogramsand the usefulness of optical coherence to-mography in the assessment of coronarycalcification.To understand the latest contemporaryapproach of interventional treatment of se-vere coronary calcified disease.To be familiar with the latest technology fortreating calcified coronary disease by usingShockwave lithotripsy.
N 2666-0849
m the Department of Medicine, Queen Elizabeth Hospital, Hong Kong, C
ationships relevant to the contents of this paper to disclose. John W. Hirshf
per.
ormed consent was obtained for this case.
nuscript received September 23, 2019; revised manuscript received Octob
INVESTIGATION
Laboratory tests showed normal renal function andtroponin level. Electrocardiogram showed sinustachycardia whereas chest radiography revealed car-diomegaly and congested lung field. Echocardiogra-phy showed globally impaired left ventricularejection fraction of 25% to 30% and with multipleregional wall motion abnormalities. There was onlymild mitral regurgitation. Coronary angiography(Figure 1, Videos 1 and 2) performed as part of theischemic workup showed a nondominant LCX anddiffuse severe calcification along the left main, LAD,and RCA. There was severe stenosis in the distal leftmain, proximal LAD and proximal RCA. Mid LAD andmid RCA were totally occluded. Nuclear stress imag-ing showed multiple regions of ischemia withoutinfarct.
MANAGEMENT
The patient was stabilized with anti-heart failuremedication. The case was discussed among the heartteam, but bypass surgery posed too high risk andwas turned down as the distal targets were poor.High-risk percutaneous coronary intervention (PCI)
https://doi.org/10.1016/j.jaccas.2019.10.028
hina. The authors have reported that they have no
eld, Jr., MD, served as Guest Associate Editor for this
er 29, 2019, accepted October 31, 2019.
FIGUR
See Vi
ABBR EV I A T I ON S
AND ACRONYMS
CTO = chronic total occlusion
LAD = left anterior descending
artery
LCX = left circumflex artery
OCT = optical coherence
tomography
PCI = percutaneous coronary
intervention
RCA = right coronary artery
Chan et al. J A C C : C A S E R E P O R T S , V O L . 1 , N O . 5 , 2 0 1 9
A Case of Rota-Shock-Pella D E C E M B E R 1 8 , 2 0 1 9 : 7 6 5 – 7 0
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with Impella (Abiomed, Danvers, Massa-chusetts) support to the left main/LADchronic total occlusion (CTO) was performedat first stage and PCI to RCA CTO wasplanned in a staged procedure for completerevascularization. A hemodynamically sup-ported device was used for the first pro-cedure in view of poor left heart function, asingle surviving vessel, and anticipatedatherectomy for severe calcification. Afterusing the crossover technique for left com-mon femoral access and pre-close with 1
Proglide suture (Abbott Vascular Devices, Temecula,California), an Impella CP was implanted, and an 8-Fextra back up 3.5 guide (Medtronic, Minneapolis,Minnesota) from the right femoral was used toengage the left main (Video 3). Mid calcified LAD
E 1 Baseline Angiogram
deos 1 and 2.
CTO lesion was crossed using the Fielder XT-R(Asahi Intec, Nagoya, Japan) supported by theTurnpike Spiral microcatheter (Vascular Solutions,Minneapolis, Minnesota). The CTO segment wascrossed by the microcatheter with difficulty becauseof severe calcification, and an initial atherectomywas planned. Rotablation using a 1.5 mm (BostonScientific, Natick, Massachusetts) was used, and amultiple brief pecking motion was performed at160,000 rpm (Figure 2). There was brief stunning ofthe myocardium during rotablation, which was fullysupported by the Impella CP. Thrombolysis inmyocardial infarction 3 flow was established, andoptical coherence tomography (OCT) was performed.There was a thick (>0.5 mm), long (>5 mm), andcircumferential calcification along the whole LAD(Figure 3, Video 4). After wiring the big diagonal
FIGURE 2 Interventional Setup and Details
See Video 3.
J A C C : C A S E R E P O R T S , V O L . 1 , N O . 5 , 2 0 1 9 Chan et al.D E C E M B E R 1 8 , 2 0 1 9 : 7 6 5 – 7 0 A Case of Rota-Shock-Pella
767
branch and the small LCX artery, further lesionpreparation was performed by using a Shockwavelithotripsy balloon (Shockwave Medical, Fremont,California). A 2.5-mm Shockwave balloon was infla-ted to 4 atm, and therapy was given along the midLAD segment in 8 cycles of 10 pulses each, while a 3-mm Shockwave balloon was used to treat the distalleft main and proximal LAD in a similar fashion.Post-Shockwave OCT showed deep fracture of thecalcified plaque along the LAD and with satisfactoryluminal gain (Figure 4, Video 5). Left main to distalLAD were stented with long overlapping Xience Si-erra stents (3.5 mm, 3.0 mm, 2.5 mm, and 2.25 mm;Abbott Vascular). After adequate post-dilation, fin-ishing angiogram and OCT showed satisfactory resultwith good stent expansion and apposition (Figure 5,Videos 6, 7, and 8). The Impella CP was removed, and
left femoral access was closed with original Proglide(Abbott Vascular) sutures and 1 additional 8-F Angio-seal (Terumo, Somerset, New Jersey).
DISCUSSION
Patients with severe calcified coronary lesions pose atherapeutic challenge to interventional procedure.Coronary calcification is frequently underestimatedby angiography alone (1). Intracoronary imaging inparticular OCT has a higher sensitivity in detectingcoronary calcification (2). OCT allows quantitativeassessment of the degree of calcification bymeasuring the thickness, arc, length, and volume.Such diagnostic accuracy enables a better under-standing of the calcified plaque morphology beforecontemplating PCI. Fujino et al. (3) showed that OCT-
FIGURE 3 Post-Rotablation OCT
See Video 4. OCT ¼ optical coherence tomography.
FIGURE 4 Shockwave Lithotripsy and Post-Therapy OCT
See Video 5. OCT ¼ optical coherence tomography.
Chan et al. J A C C : C A S E R E P O R T S , V O L . 1 , N O . 5 , 2 0 1 9
A Case of Rota-Shock-Pella D E C E M B E R 1 8 , 2 0 1 9 : 7 6 5 – 7 0
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FIGURE 5 Final Angiogram and Optical Computed Tomography
See Videos 6, 7, and 8.
J A C C : C A S E R E P O R T S , V O L . 1 , N O . 5 , 2 0 1 9 Chan et al.D E C E M B E R 1 8 , 2 0 1 9 : 7 6 5 – 7 0 A Case of Rota-Shock-Pella
769
derived calcium scoring (in term of calcium thickness,length, and arc of involvement) could predict stentunderexpansion and provided a framework for usingan upfront plaque modification technique. Contem-porary rotational atherectomy techniques, includingchoice of burr size, rotational speed, short run ofpecking motion, and final polishing run, were welldescribed in both European and U.S. professionalsocieties (4,5). The latest paper by De Maria et al. (6)provided a comprehensive review of the latesttechnology and treatment algorithm for tacklingcalcified coronary lesions. Initial atherectomy wasrecommended for severe calcified disease that couldnot be crossed by a balloon. OCT could assess theresidual calcium plaque burden, as in the presentcase. Further balloon pre-dilation would usually be
required to break or fracture the calcium before stentimplantation. It was conventionally achieved bymeans of a high-pressure noncompliant balloon or bycutting or scoring balloon. It was not without risk ofperforation, and it was associated with a high risk ofhemodynamic compromise in such vulnerable, com-plex, and high-risk patients. It was shown in bothclinical (7) and OCT studies (8) that satisfactory lesionpreparation and calcium fracturing could be achievedby using Shockwave lithotripsy balloon. It onlyrequired a low inflation pressure and had minimalrisk of coronary perforation. Because of the profile ofthe current Shockwave balloon, it would not crossthose tight calcified lesions before rotablation andhence “Rota-shock” may become a very attractiveapproach in such scenario. Very satisfactory calcium
Chan et al. J A C C : C A S E R E P O R T S , V O L . 1 , N O . 5 , 2 0 1 9
A Case of Rota-Shock-Pella D E C E M B E R 1 8 , 2 0 1 9 : 7 6 5 – 7 0
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fracturing and acute luminal gain can finally be ach-ieved after Shockwave lithotripsy followed by excel-lent stenting result.
FOLLOW-UP. Follow-up echocardiography showedimproved left ventricular ejection fraction of 45% to50%. Successful PCI to RCA CTO using an antegradeapproach was performed 3 months later. The patientwas recently seen in the authors’ heart failure clinicand remained in New York Heart Association func-tional class I/II symptoms.
CONCLUSIONS
Severe calcified coronary lesion in complex and high-risk patients can be safely treated with an approachcombining Rota-Shock-Pella.
ADDRESS FOR CORRESPONDENCE: Dr. Ka Chun AlanChan, Department of Medicine, Queen ElizabethHospital, Hong Kong, China. E-mail: [email protected].
RE F E RENCE S
1. Mintz GS, Painter JA, Pichard AD, et al.Atherosclerosis in angiographically “normal” cor-onary artery reference segments: an intravascularultrasound study with clinical correlations. J AmColl Cardiol 1995;25:1479–85.
2. Wang X, Matsumura M, Mintz GS, et al.In vivo calcium detection by comparing opticalcoherence tomography, intravascular ultrasound,and angiography. J Am Coll Cardiol Img 2017;10:869–79.
3. Fujino A, Mintz GS, Matsumura M, et al.A new optical coherence tomography-basedcalcium scoring system to predict stent under-expansion. EuroIntervention 2018;13:e2182–9.
4. Emanuele Barbato, Didier Carrié, Petros Dar-das, et al. European expert consensus on rota-tional atherectomy. EuroIntervention 2015;11:30–6.
5. Sharma SK, Tomey MI, Teirstein PS, et al. NorthAmerican expert review of rotational atherectomy.Circ Cardiovasc Interv 2019;12:e007448.
6. De Maria GL, Scarsini R, Banning AP, et al.Management of calcific coronary artery lesions: isit time to change our interventional therapeuticapproach? J Am Coll Cardiol Intv 2019;12:1465–78.
7. Brinton TJ, Ali ZA, Hill JM, et al. Feasibility ofShockwave coronary intravascular lithotripsy for
the treatment of calcified coronary stenoses. Cir-culation 2019;139:834–6.
8. Ziad A. Ali, Todd J. Brinton, Jonathan M. Hill,et al. Optical coherence tomography character-ization of coronary lithoplasty for treatment ofcalcified lesions. J Am Coll Cardiol Img 2017;10:897–906.
KEY WORDS Impella, OCT, PCI, rotationalatherectomy, Shockwave lithotripsy
APPENDIX For supplemental videos,please see the online version of this paper.