1
795. Local anaesthetic allergy testing in pregnancy A. Govindarajan, M. Shields, S. Atkinson Royal Jubilee Maternity Hospital, Department of Anaesthesia, Belfast, UK Background: Local anaesthetic (LA) testing during pregnancy carries the risk of inducing an anaphylactic reaction which may be life threatening for the mother and foetus. However the risk has to be weighed against the safety of regional anaesthesia compared to general anaesthesia for the pregnant patient. We report the suc- cessful management of a pregnant woman with a history of sus- pected LA allergy. Case Report: A 32-year-old, para 2 female was referred at 34 weeks gestation with a history of severe allergic reaction to LA in childhood. There had been no follow up testing on this occasion. She had had two previous uneventful vaginal deliveries without regional analgesia. On examination she was Mallampatti grade III, short necked and had a BMI of 34. At 39 weeks gestation intrader- mal skin testing was performed. Intradermal skin testing was per- formed at 39 weeks gestation, with an obstetric team on standby, should caesarean section be required. Levobupivacaine 0.02ml of 1:10000 was injected. No weal or flare was observed after 15 minutes and so intradermal injections were repeated with 10 fold increases in drug concentration till neat drug was given. Following which 1 ml of 0.25% Levobupivacaine was injected. A negative response was obtained for every injection.Labour was induced at term and the lady delivered vaginally without systemic analgesia. Post delivery, she had an uneventful surgical repair of a third degree perineal tear under spinal anaesthesia using Levobupiva- caine 10mg. Discussion: Published case reports 1,2 suggest that the optimal time for testing is close to term with an obstetric team on standby. Based on a negative response to intradermal testing to Levobupivacaine near term, it was possible to avoid general anaesthesia in a patient with a anticipated difficult airway. Reference 1) Anesthesia & Analgesia 2003; 96:1489-90. 2) International Journal of Obstetric Anaesthesia 2003; 12 113-115. 828. Combined spinal- epidural anesthesia for cesarean section in a patient with dilated cardiomyopathy S. Arora, A. Kulshrestha Postgraduate Institute of Medical Education and Research, Department of Anaesthesia and Intensive Care, Chandigarh, India Background and Aim: The incidence of idiopathic dilated cardio- myopathy in pregnant patients is 5-8/100000 live births per year. This has poorer outcome as compared to peripartum cardiomyop- athy. The aim of this presentation is to report a case of Adriamycin induced dilated cardiomyopathy associated with left lung collapse and deranged renal function presenting for elective cesarean sec- tion. Case Report: A 24 years old primigravida at 32 weeks of gestation came to hospital for safe confinement in view of her worsening heart disease. She had history of right upper limb amputation and chemotherapy with Adriamycin for Ewing’s sarcoma of ulna six years ago. Following chemotherapy, she developed dyspnoea on exertion (NYHA class III) and was diagnosed to have dilated car- diomyopathy. Her condition improved with T. Digoxin 0.25 mg O.D and T. Lasix 20 mg B.D. As the pregnancy advanced her cardiac symptoms worsened (NYHA class III). On examination there was left lung collapse, deranged renal functions and one episode of paroxysmal ventricular tachycardia two days ago, which had re- solved by carotid massage. Her present echocardiography findings were ejection fraction of 30%, left ventricular systolic dysfunction and mild pericardial effusion. A combined spinal epidural anesthe- sia was planned. Only 25 ug of Fentanyl was given in the L3-4 subarachnoid space while epidural blockade was established in a graded fashion with the help of 2% Lidocaine. The patients he- modynamic status was monitored with direct intra-arterial blood pressure and central venous pressure measurements. The patient remained hemodynamically stable throughout the procedure and delivered a healthy baby (APGAR 9/10). Conclusion: An incremental combined spinal-epidural anesthetic technique with invasive monitoringmay be an acceptable anes- thetic alternative in patients suffering from dilated cardiomyopa- thy, undergoing Cesarean section. Posters Obstetrics 147

795: Local Anaesthetic Allergy Testing in Pregnancy

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Posters • Obstetrics 147

95. Local anaesthetic allergy testing inregnancy

. Govindarajan, M. Shields, S. Atkinsonoyal Jubilee Maternity Hospital, Department ofnaesthesia, Belfast, UK

ackground: Local anaesthetic (LA) testing during pregnancyarries the risk of inducing an anaphylactic reaction which may beife threatening for the mother and foetus. However the risk has toe weighed against the safety of regional anaesthesia compared toeneral anaesthesia for the pregnant patient. We report the suc-essful management of a pregnant woman with a history of sus-ected LA allergy.

ase Report: A 32-year-old, para 2 female was referred at 34eeks gestation with a history of severe allergic reaction to LA in

hildhood. There had been no follow up testing on this occasion.he had had two previous uneventful vaginal deliveries withoutegional analgesia. On examination she was Mallampatti grade III,hort necked and had a BMI of 34. At 39 weeks gestation intrader-al skin testing was performed. Intradermal skin testing was per-

ormed at 39 weeks gestation, with an obstetric team on standby,hould caesarean section be required. Levobupivacaine 0.02ml of:10000 was injected. No weal or flare was observed after 15inutes and so intradermal injections were repeated with 10 fold

ncreases in drug concentration till neat drug was given. Followinghich 1 ml of 0.25% Levobupivacaine was injected. A negative

esponse was obtained for every injection.Labour was induced aterm and the lady delivered vaginally without systemic analgesia.ost delivery, she had an uneventful surgical repair of a thirdegree perineal tear under spinal anaesthesia using Levobupiva-aine 10mg.

iscussion: Published case reports1,2 suggest that the optimal timeor testing is close to term with an obstetric team on standby. Basedn a negative response to intradermal testing to Levobupivacaineear term, it was possible to avoid general anaesthesia in a patientith a anticipated difficult airway.

eference) Anesthesia & Analgesia 2003; 96:1489-90.) International Journal of Obstetric Anaesthesia 2003; 12 113-115.

28. Combined spinal- epiduralnesthesia for cesarean section in a patientith dilated cardiomyopathy

. Arora, A. Kulshresthaostgraduate Institute of Medical Education andesearch, Department of Anaesthesia and Intensive Care,handigarh, India

ackground and Aim: The incidence of idiopathic dilated cardio-yopathy in pregnant patients is 5-8/100000 live births per year.

his has poorer outcome as compared to peripartum cardiomyop-thy. The aim of this presentation is to report a case of Adriamycinnduced dilated cardiomyopathy associated with left lung collapsend deranged renal function presenting for elective cesarean sec-ion.

ase Report: A 24 years old primigravida at 32 weeks of gestationame to hospital for safe confinement in view of her worseningeart disease. She had history of right upper limb amputation andhemotherapy with Adriamycin for Ewing’s sarcoma of ulna sixears ago. Following chemotherapy, she developed dyspnoea onxertion (NYHA class III) and was diagnosed to have dilated car-iomyopathy. Her condition improved with T. Digoxin 0.25 mg.D and T. Lasix 20 mg B.D. As the pregnancy advanced her cardiac

ymptoms worsened (NYHA class III). On examination there waseft lung collapse, deranged renal functions and one episode ofaroxysmal ventricular tachycardia two days ago, which had re-olved by carotid massage. Her present echocardiography findingsere ejection fraction of 30%, left ventricular systolic dysfunction

nd mild pericardial effusion. A combined spinal epidural anesthe-ia was planned. Only 25 ug of Fentanyl was given in the L3-4ubarachnoid space while epidural blockade was established in araded fashion with the help of 2% Lidocaine. The patient�s he-odynamic status was monitored with direct intra-arterial blood

ressure and central venous pressure measurements. The patientemained hemodynamically stable throughout the procedure andelivered a healthy baby (APGAR 9/10).

onclusion: An incremental combined spinal-epidural anestheticechnique with invasive monitoringmay be an acceptable anes-hetic alternative in patients suffering from dilated cardiomyopa-hy, undergoing Cesarean section.