6. Decreasing Parameters E

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<ol><li> 1. Decreasing Parameters Murad Mithani May 2015 No Medication </li><li> 2. Diabetes Blood Sugar </li><li> 3. HbA1c @ 28/11/2014 5.5 11.5 4.4 4.6 y = -0.0014x + 62.873 R = 0.1072 4 5 6 7 8 9 10 11 12 HbA1c Date HbA1c HbA1c 2 per. Mov. Avg. (HbA1c) Linear (HbA1c) </li><li> 4. HbA1c @ 05/2015 5.5 11.5 4.4 4.6 4.8 4.7 y = -0.0011x + 48.86 R = 0.1537 4 5 6 7 8 9 10 11 12 HbA1c Date HbA1c HbA1c 2 per. Mov. Avg. (HbA1c) Linear (HbA1c) </li><li> 5. Kidney </li><li> 6. Urine Albumin to Creatinine Ratio @ 28/11/2014 y = -0.0337x + 1389.3 R = 0.7563 0 5 10 15 20 25 30 UrineAlbumintoCreatinineRatio Date Urine Albumin to Creatinine Ratio Urine Albumin to Creatinine Ratio 2 per. Mov. Avg. (Urine Albumin to Creatinine Ratio) Linear (Urine Albumin to Creatinine Ratio) </li><li> 7. Urine Albumin to Creatinine Ratio http://labtestsonline.org.uk/understanding/anal ytes/microalbumin/tab/test/ A moderately increased ACR indicates an early phase of developing kidney disease. Very high values show that kidney disease is present in a more severe form. Very low values generally indicate that kidney function is normal if other tests of kidney function, e.g. the glomerular filtration rate, also show no abnormality. </li><li> 8. Urine Albumin @ 28/11/2014 y = -0.4123x + 16972 R = 0.5731 0 50 100 150 200 250 UrineAlbumin Date Urine Albumin Urine Albumin 2 per. Mov. Avg. (Urine Albumin) Linear (Urine Albumin) </li><li> 9. Urine Albumin @ 05/2015 y = -0.0999x + 4247.9 R = 0.5865 0 50 100 150 200 250 300 Urine Albumin Urine Albumin Linear (Urine Albumin) 2 per. Mov. Avg. (Urine Albumin) </li><li> 10. Urine Albumin http://www.healthline.com/health/microalbuminur ia-test#Risks6 Understanding Your Results The results of the microalbuminuria test will vary, depending on the laboratory where the sample was analyzed. Normal values are typically less than 30 mcg/mg (micrograms per milligram). A low level of albumin in the urine is an indication that your kidneys are functioning normally. </li><li> 11. Serum Globulin @ 05/2015 y = -0.0004x + 49.237 R = 0.0413 20.00 25.00 30.00 35.00 40.00 45.00 SerumGlobulin Date Serum Globulin Serum Globulin 2 per. Mov. Avg. (Serum Globulin) Linear (Serum Globulin) </li><li> 12. Serum Globulin http://www.patient.co.uk/doctor/globulins Increased total globulin level: Nephrotic syndrome. The kidneys of people with nephrotic syndrome don't work properly causing large amounts of protein to leak into their urine. </li><li> 13. Lipids </li><li> 14. Testosterone @ 28/11/2014 y = -0.0022x + 93.356 R = 0.9761 0 1 2 3 4 5 6 7 8 9 Testosterone Date Testosterone Testosterone 2 per. Mov. Avg. (Testosterone) Linear (Testosterone) Linear (Testosterone) </li><li> 15. Testosterone @ 05/2015 y = -0.0019x + 82.609 R = 0.9502 0 1 2 3 4 5 6 7 8 9 Testosterone Date Testosterone Testosterone 2 per. Mov. Avg. (Testosterone) Linear (Testosterone) Linear (Testosterone) How well this equation describes the data (the 'fit'), is expressed as a correlation coefficient, R2 (R-squared). The closer R2 is to 1.00, the better the fit. This too can be </li><li> 16. Testosterone Andropause or "male menopause" is a recognized medical condition brought about by declining testosterone or male hormone levels with. The World Health Organization reports that testosterone levels progressively decline with age. By age 70 they are about 10 percent of what they were at age 25. It is estimated that 30 percent of men in their 50s will have testosterone levels low enough to be causing symptoms or putting them at risk. </li><li> 17. Serum Triglycerides @ 28/11/2014 y = -0.0002x + 13.716 R = 0.1016 2.5 2.7 2.9 3.1 3.3 3.5 3.7 3.9 4.1 4.3 4.5 SerumTriglycerides Date Serum Triglycerides Serum Triglycerides 2 per. Mov. Avg. (Serum Triglycerides) Linear (Serum Triglycerides) </li><li> 18. Serum Triglycerides @ 05/2015 R = 0.1748 2.5 2.7 2.9 3.1 3.3 3.5 3.7 3.9 4.1 4.3 4.5 SerumTriglycerides Date Serum Triglycerides Serum Triglycerides 2 per. Mov. Avg. (Serum Triglycerides) Linear (Serum Triglycerides) </li><li> 19. Serum Triglycerides http://www.mayoclinic.org/diseases- conditions/high-blood-cholesterol/in- depth/triglycerides/art-20048186 Having a high level of triglycerides, a type of fat (lipid) in your blood, can increase your risk of heart disease. However, the same lifestyle choices that promote overall health can help lower your triglycerides, too. </li><li> 20. Serum Triglycerides http://www.jhsph.edu/news/news- releases/2000/cholesterol-kidney.html Link Found between Cholesterol and Kidney Disease Researchers at the Johns Hopkins School of Public Health have found that high levels of triglycerides and low levels of high-density (good) cholesterol in the blood predict the onset of chronic kidney disease. </li><li> 21. Serum Triglycerides https://www.kidney.org/atoz/content/cholesterol People with good LDL cholesterol, high HDL cholesterol, and normal triglycerides are less likely to have heart disease. </li><li> 22. Serum Cholesterol @ 28/11/2014 y = -0.0002x + 14.988 R = 0.0608 5 5.2 5.4 5.6 5.8 6 6.2 6.4 6.6 6.8 SerumCholesterol Date Serum Cholesterol Serum Cholesterol 2 per. Mov. Avg. (Serum Cholesterol) Linear (Serum Cholesterol) </li><li> 23. Serum Cholesterol @ 05/2015 R = 0.4078 4.5 5 5.5 6 6.5 7 7.5 SerumCholesterol Date Serum Cholesterol Serum Cholesterol 2 per. Mov. Avg. (Serum Cholesterol) Linear (Serum Cholesterol) </li><li> 24. Serum Cholesterol http://www.nhs.uk/Conditions/Cholesterol/Pages/Causes.aspx People with high blood pressure (hypertension) and diabetes often have high cholesterol. Some medical conditions can also cause raised levels of cholesterol. These include: kidney disease liver disease an underactive thyroid gland </li><li> 25. Serum Cholesterol http://medical- dictionary.thefreedictionary.com/Elevated+serum+c holesterol Elevated cholesterol also can be caused by an underlying disease that raises blood cholesterol levels such as diabetes mellitus, kidney disease, liver disease, or hypothyroidism. It also can be caused by an inherited disorder in which cholesterol is not metabolized properly by the body. </li><li> 26. Serum Cholesterol http://www.davita.com/kidney-disease/overview/assessing-your- risk/causes-of-low-cholesterol-in-people-with-kidney- disease/e/7811 For most people, a low cholesterol reading indicates less risk of cardiovascular disease. For a patient with kidney disease, the cause of a low cholesterol reading can be an indicator of underlying kidney disease complications, such as malnutrition and inflammation. Your doctor will examine all possible causes of your low cholesterol level so the right treatment is prescribed, and you can live a better quality of life with kidney disease. Low Cholesterol reduced risk of cardiovascular disease Low Cholesterol Kidney Disease </li><li> 27. Serum LDL Cholesterol R = 0.7596 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 SerumLDLCholesterol Date Serum LDL Cholesterol Serum LDL Cholesterol 2 per. Mov. Avg. (Serum LDL Cholesterol) Linear (Serum LDL Cholesterol) </li><li> 28. Serum LDL Cholesterol http://www.docsopinion.com/health-and- nutrition/lipids/ldl-c/ LDL-C is an important marker for the risk of developing heart disease. There is a strong and graded correlation between LDL-C and the risk of CVD, both in women and men, although this has been debated by some investigators. Available evidence suggests that lowering blood levels of LDL-C reduces the risk of CVD. </li><li> 29. Serum LDL Cholesterol https://www.kidney.org/atoz/content/cholesterol People with good LDL cholesterol, high HDL cholesterol, and normal triglycerides are less likely to have heart disease. </li><li> 30. Liver </li><li> 31. Serum Total Bilirubin @ 28/11/2014 y = -0.0005x + 32.81 R = 0.0451 8 9 10 11 12 13 14 15 16 17 18 SerumTotalBilirubin Date Serum Total Bilirubin Serum Total Bilirubin 2 per. Mov. Avg. (Serum Total Bilirubin) Linear (Serum Total Bilirubin) </li><li> 32. Serum Total Bilirubin @ 05/2015 R = 0.1793 8.00 9.00 10.00 11.00 12.00 13.00 14.00 15.00 16.00 17.00 18.00 SerumTotalBilirubin Date Serum Total Bilirubin Serum Total Bilirubin 2 per. Mov. Avg. (Serum Total Bilirubin) Linear (Serum Total Bilirubin) </li><li> 33. Serum Total Bilirubin http://www.nlm.nih.gov/medlineplus/ency/article/ 003479.htm The following liver problems may also cause jaundice or high bilirubin levels: Cirrhosis (scarring of the liver) Hepatitis Liver disease Gilbert's disease </li><li> 34. Serum Alkaline Phosphatase @ 28/11/2014 208 y = -0.0199x + 913.04 R = 0.3543 50 70 90 110 130 150 170 190 210 230 SerumAlkalinePhosphatase Date Serum Alkaline Phosphatase Serum Alkaline Phosphatase 2 per. Mov. Avg. (Serum Alkaline Phosphatase) Linear (Serum Alkaline Phosphatase) </li><li> 35. Serum Alkaline Phosphatase @ 05/2015 R = 0.2144 50.00 70.00 90.00 110.00 130.00 150.00 170.00 190.00 210.00 230.00 SerumAlkalinePhosphatase Date Serum Alkaline Phosphatase Serum Alkaline Phosphatase 2 per. Mov. Avg. (Serum Alkaline Phosphatase) Linear (Serum Alkaline Phosphatase) </li><li> 36. Serum Alkaline Phosphatase http://www.nlm.nih.gov/medlineplus/ency/artic le/003470.htm Higher-than-normal ALP levels Liver disease or hepatitis </li><li> 37. Pituitary </li><li> 38. Serum FSH R = 1 0 0.5 1 1.5 2 2.5 3 3.5 4 SerumFSH Date Serum FSH Serum FSH Linear (Serum FSH) </li><li> 39. IGF-1 @ 28/11/2014 y = -0.0907x + 3710.1 R = 0.8182 0 20 40 60 80 100 120 140 160 180 IGF-1 Date IGF-1 IGF-1 2 per. Mov. Avg. (IGF-1) Linear (IGF-1) </li><li> 40. IGF-1 @ 05/2015 R = 0.5453 0 50 100 150 200 250 300 350 IGF-1 Date IGF-1 IGF-1 2 per. Mov. Avg. (IGF-1) Linear (IGF-1) </li><li> 41. IGF-1 http://labtestsonline.org/understanding/analytes/igf1/tab/test/ Decreased IGF-1 If the IGF-1 level is decreased, then it is likely that there is a GH deficiency or an insensitivity to GH. If this is in a child, the GH deficiency may have already caused short stature and delayed development and may be treated with GH supplementation. Adults will have an age-related decrease in production, but lower than expected levels may reflect a GH deficiency or insensitivity. If a decrease in IGF-1 is suspected to be due to a more general decrease in pituitary function (hypopituitarism), then several other endocrine glands and their pituitary regulating hormones will need to be evaluated to decide on appropriate treatment. Reduced pituitary function may be due to inherited defects or can develop as a result of pituitary damage following conditions such as trauma, infections, and inflammation. Decreased levels of IGF-1 also may be seen with nutritional deficiencies (including anorexia nervosa), chronic kidney or liver disease, inactive/ineffective forms of GH, and with high doses of estrogen. Increased IGF-1 Elevated levels of IGF-1 usually indicate an increased production of GH. Since GH levels vary throughout the day, IGF-1 levels are a reflection of average GH production, not of the actual amount of GH in the blood at the time that the sample for the IGF-1 measurement was taken. This is accurate up to the point at which the liver's capacity to produce IGF-1 is reached. With severely increased GH production, the IGF-1 level will stabilize at an elevated maximum level. Increased levels of GH and IGF-1 are normal during puberty and pregnancy but otherwise are most frequently due to pituitary tumors (usually benign). </li><li> 42. Rates of decrease </li><li> 43. Rate Calculation Could be considered fascinating/of particular interest, as some people can go several years without seeing a Doctor. Rate calculation approach of data analysis provides evidence based material upon which to reach conclusions as to which parameters are changing. Which parameters are increasing Which parameters are decreasing Only the end point of death can indicate for certain the significance of increasing parameters and decreasing parameters. </li><li> 44. Rates of decrease Rates of decrease 6 months 3 years 28/11/2014 28/05/2015 28/01/2018 Comments Urine Albumin to Creatinine Ratio 0.0337 Testosterone 0.0022 0.0019 13.6% Decrease ALT/SGPT Serum level 0.0030 Serum FSH 0.0003 IGF-1 0.0907 Serum Alkaline Phosphatase 0.0199 0.0127 HbA1c 0.0014 0.0011 21.4% Decrease Serum Triglycerides 0.0002 0.0002 Serum Cholesterol 0.0002 0.0005 150% Increase Serum LDL Cholesterol 0.0009 Serum Total Bilirubin 0.0005 0.0008 Serum Globulin 0.0006 Urine Albumin 0.4123 0.0999 As at May 2015, I believe that I have enough data to say with some confidence that the parameters below are decreasing </li><li> 45. What is going wrong vs What went wrong Working out what went wrong is a lot easier than working out what is going wrong, based upon the biochemical evidence. i.e. if I were to die tomorrow, cause of death could be the following; Decreasing Testosterone Of course, for others, it might be different, and they could experience decreasing blood sugar (HbA1c) before death, whereas in me raised blood sugar has proved nearly fatal, so in me the lower the better. </li><li> 46. Sir David Frost's family talk of their devastation after his eldest son, Miles, 31, died suddenly while jogging and reveal how 'he was the leader of the pack since Dad died' http://www.dailymail.co.uk/news/article- 3168786/Sir-David-Frost-s-eldest-son-dies- just-31-Fitness-fanatic-collapsed-morning- run-family-s-Oxfordshire-holiday-home.html </li><li> 47. Miles Frost, 31, was a keen athlete and had shown no signs of ill health 'I had breakfast with him last Thursday and he was in great form. There was no signs that anything was wrong. 'It just underscores the fragility of life. There will be a post mortem examination but all we know is that he collapsed while jogging. </li><li> 48. Case Study In the case of my grandmother; If she were to die tomorrow, and there was sufficient biochemical evidence, you could say with a degree of certainty that As her Kidney failed, She lost a lot of weight, And then eventually died. </li><li> 49. Cause of death Once biochemical tests have indicated that there is organ failure Scans could confirm this. With the combination of scans and biochemical evidence, we could work out for certain what the cause of death was; for those interested. Cause of death may not be such a straightforward task, as the slides I hope would indicate that errors in the testing procedures could lead to misleading results. </li><li> 50. Cause of death </li></ol>

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