REGU-MATE ® (altrenogest) Solution 0.22% oral progestin CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Description: REGU-MATE ® (altrenogest) Solution 0.22% contains the active synthetic progastin, al trenogest The chem- ical name is 17 -Allyl- 178 -hydroxyestra-4,9,11- trien-3-one.

The chemica~ structure is: CH~ OH

o ~ C H CH CH 2 = ,

Each mL of REGU-MATE "~ (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution,

Actions: REGU-MATE ~ (altreoogest) Solution 0.22% produces a progestational effect in mares. Indications: REGU-MATE ~ (altrenogest) Solution 0,22% is indi- cated to suppress estrus in mares. Suppression of estrus allows for a predictable occurr- ence of estrus following drug withdrawal. This facili~ tates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Suppression of estrus will also facili- tate management of prolonged estrus conditions. Suppression of estrus may be used to faclldate sched uled breeding during the physiological breeding season. Contreindicatlons: REGU-MATE ~ (altrenogest) Solution 0,22% is contrain- dicated in pregnant mares, The safety of the drug in pregnant mares has not been established, Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses manyfold greater than the recom- mended equine dose caused fetal anomalies, specifi- cally masculinazation of the female genitalia. WARNING:Do not use in horses intended for food. Pregnant women and others of childbearing age should exercise extreme caution when handling this product. Accidental absorption could lead to a disruption of the menstrual cycle or prolon- gation Of pregnancy. Direct contact with the skin should therefore be avoided. Accidental spillage on the skin should be washed Off immediately with soap and water. CAUTION: For oral use in horses only. Dosage & Administration: Administer orally at the rate of I mL per 110 pounds body weight (0.044 mg/kg) to be given one dose daily for 15 consecutive days, Administer directly on the posterio-dorsal surface of of mare's tongue using a dose syringe or suitable plastic syringe. The drug may also be administered on the usual grain ration, Dosage Chart Approximate

Weight in Iba. Dose in mL 770 7 880 8 990 9 1100 10 1210 11 1320 12

Which Mares will Respond to REGU-MATE" (altrenogast) Solution 0.22%: Extensive clinical trials have demonstrated that estrus will be suppressed in approximately 95% ol the mares within three days; however, the post-treatment re- sponse depended on the level of ovarian activity when treatment was initiated. Estrus in mares exhibiting regular estrus cycles during the breeding season will be suppressed during treatment; these mares return to estrus four to five days following treatment and con- tinue to cycle normally. Mares in winter anestrus with small follicles continued in anestrus and failed to exhibit normal estrus following withdrawal.

Response in mares in the transition phase between winter anestrus and the summer breeding season de- pended on the degree of follicular activity. Mares with inactive ovaries and small follicles failed to respond with normal cycles post treatment, whereas a higher proportion of mares with ovarian follicles 20 mm or greater in diameter exhibited normal estrus cycles post-treatment.

REGU-MATE • (altrenogest) Solution 0.22% was very effective for suppressing the prolonged estrus be- havior frequently observed in mares during the trans- ition peroid (February, March, and April). in addition, a high proportion of these mares responded with reg- ular estrus cycles post-treatment. STORE AT ROOM TEMPERATURE. HOW Supplied: REGU-MATE* (a[trenogest) Solution 0.22% (2.2 mg/mL). Each mL contains 2.2 mg altrenogest in a oil solution. Available in 1000 mL plastic bottles.

Hoechst-Roussel Agri-Vet Company Route 202-206 Norlh • Somerville, New Jersey 08876

Hoechst ~J Roussel J~

The ,4me at¢110go HOECHST m ~ w K I t r 4 f f ~ o~ HCGO'lJ AG Thl ~ alld ~o R(~U~L ~ ¢ l l q ~ fmd~Bl~ll ~ Rotl~ U¢~ S./L.

LIMBS OF THE EQUINE, by LeRoy Amos; published by Ashberry Acres Publications, PC) Box 184, Navarre, Ohio 44662, 1986; 22 pages; poster-size paperback; $23.95.

The author, a Standardbred farrier from Ohio, originally began with the idea of an illustrated poster to point out the various muscles, tendons, ligaments, and bones of the equine limb. As the idea grew, the result was a beautiful atlas of the horse's legs and feet, published for the horse owner who does not understand the anatomy of the horse limbs and feel

The text portion of the atlas contains non-technical descriptions of the muscles and ligaments, as well as a cursory description of various lamenesses. Lamenesses described are capped elbow, knee spavin, capped knee, splints, fractured splint bones, bucked shins, bowed tendons, sprained suspensory, osselets, windpuffs, sesamoiditis, ringbone, pedal osteitis, vavicular disease, sidebones, and thrush.

The atlas has semi-transparent overlays showing how the muscles and tendons fit over the bones. Color printing enhances the illustrations. This booklet is nice for client eduction. WJ

BOOK STALL Reference Material ~'he for the Equine Practitioner

LIMBS OF THE EQUINE By LeRoy Amos

This unique book on the anatomy of the horse's legs is different from any previ- ous publication on the subject. Series of colored overlays drawn on translucent sheets depict the bones, muscles, teen- dons, and ligaments of the forelimb, hind limb and hoof. Not only are the flip chart and illustrations easily interpreted; the text is written in a comprehensive un- complicated style. 22 pages $23.95 US.

Available from Ashberry Acres Publications

P.O. Box 184 Navarre, OH 446623

EQUINE SPORTS MEDICINE Edited and Contributions by

William E. Jones, D.V.M., PhD

This is a brand new book for a brand new discipline. It introduces equine sports medicine, skillfully integrating elements of equine physiology, diagno- sis and treatment of equine sports inju- des, and scientific training techniques. About 329 pages, $49.50 US

Available from: Lea & Febiger

600 Washington Square Philadelphia, PA 19106

1-800-433-3850

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