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PATENT ABSTRACTS 113 5190873 5190931 HYBRID TRYPTOPHAN APOREPRESSOR CONTAINING LIGAND BINDING SITES Waldema Lernhardt, Mario Bourdon, Phil Youderian, Jar, 2431 N assigned to California Institute of Biological Research Hybrid proteins containing repressor proteins and substituted receptor binding sites, amino acid and DNA sequences encoding the hybrid proteins are provided. Methods for preparing the hybrid proteins are also described. 5190874 METHOD FOR PRODUCING PENICILLINASE AND XYLANASE Koki Horikoshi, Tokyo, Japan assigned to Rikagaku Kenkyusho A novel plasmid pXPI02-3 which is constructed from Aernmonas sp. No. 212 chromosomal DNA fragment coding for production of xylanase and a vector plasmid pEAP2 carrying a DNA fragment coding for production and secre- tion of penicillinase. A novel microorganism, Escherichia coli HBI01 (pXPI02-3), containing the plasmid pXP102-3 and being capable of prn- ducing and secreting penicillinase and xylanase. A method for cultivation of the microorganism characterized in that it is cultured in a broth con- raining NaCI for 12 to 48 hours. 5190877 SACCHAROMYCES STRAINS FOR MALTOSE FERMENTATION REGULATION OF GENE EXPRESSION BY EMPLOYING TRANSLATIONAL INHIBITION OF MRNA UTILIZING INTERFERING COMPLEMENTARY MRNA Masayori Inouye assigned to The Research Foundation of State University of New York Gene expression in a cell can be regulated or in- hibited by incorporating into or associating with the genetic material of the cell a non-native nucleic acid sequence which is transcribed to produce an mRNA which is complementary to and capable of binding to the mRNA produced by the genetic material of said cell. 5192538 STABLE FORMS OF ANTIGENIC TAENIA OVIS POLYPEPTIDES Gavin B L Harrison, Robert P Dempster, Michael D Rickard, Marshall Lightowlers, David D Heath, Stephen Lawrence, Kim L O'Hoy, Tokyo, assigned to Pitman-Moore New Zealand Limited; The University of Melbour- neHer Majesty The Queen in right of New Zealand through the Ministry of Agriculture & Fisheri This invention relates to stable forms of peptide antigens ofT. ovis suitable for use in vaccines to protect ruminants against infection by cestode parasites. The antigens are preferably obtained by expression of DNA coding therefor in a recombinant host cell. Aspects of the invention include DNA encoding the antigens, vectors containing the DNA and hosts which express the antigens. Klaas Osinga, Robert Beudeker, Platt Johannes Van der, Hollander Johannes de, Tokyo, as- signed to Gist-brocades N V Methods and compositions are provided relating to yeasts capable of improved fermenta- tion of sugars. Particularly, genes from the MAL locus are used for transformation of yeast hosts, where the genes are under the wild-type pro- moter or a strong promoter which provides for regnlatable or constitive expression under the conditions of fermentation. Particularly, the yeast hosts find use in the leavening of dough. 5192658 COMPOSITIONS AND PROTOCOLS APPLICABLE TO GENETIC ANALYSIS Zvi G Loewy, Nancy Y Ip, Howard J Baum, Susan L Leafy, Stadt Ingrid L van de assigned to Lifeeodes Corporation Polynucleotide sequences and other composi- tions useful for DNA polymorphism and other

5190931 Regulation of gene expression by employing translational inhibition of mRNA utilizing interfering complementary mRNA

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PATENT ABSTRACTS 113

5190873 5190931

H Y B R I D T R Y P T O P H A N A P O R E P R E S S O R C O N T A I N I N G

L I G A N D B I N D I N G S I T E S

Waldema Lernhardt, Mario Bourdon, Phil Youderian, Jar, 2431 N assigned to California Institute of Biological Research

Hybrid proteins containing repressor proteins and substituted receptor binding sites, amino acid and DNA sequences encoding the hybrid proteins are provided. Methods for preparing the hybrid proteins are also described.

5190874

M E T H O D F O R P R O D U C I N G P E N I C I L L I N A S E A N D X Y L A N A S E

Koki Horikoshi, Tokyo, Japan assigned to Rikagaku Kenkyusho

A novel plasmid pXPI02-3 which is constructed from Aernmonas sp. No. 212 chromosomal DNA fragment coding for production of xylanase and a vector plasmid pEAP2 carrying a DNA fragment coding for production and secre- tion of penicillinase. A novel microorganism, Escherichia coli HBI01 (pXPI02-3), containing the plasmid pXP102-3 and being capable of prn- ducing and secreting penicillinase and xylanase. A method for cultivation of the microorganism characterized in that it is cultured in a broth con- raining NaCI for 12 to 48 hours.

5190877

S A C C H A R O M Y C E S S T R A I N S F O R M A L T O S E F E R M E N T A T I O N

R E G U L A T I O N O F G E N E E X P R E S S I O N BY E M P L O Y I N G T R A N S L A T I O N A L I N H I B I T I O N

O F M R N A U T I L I Z I N G I N T E R F E R I N G

C O M P L E M E N T A R Y M R N A

Masayori Inouye assigned to The Research Foundation of State University of New York

Gene expression in a cell can be regulated or in- hibited by incorporating into or associating with the genetic material of the cell a non-native nucleic acid sequence which is transcribed to produce an mRNA which is complementary to and capable of binding to the mRNA produced by the genetic material of said cell.

5192538

S T A B L E F O R M S O F A N T I G E N I C T A E N I A O V I S P O L Y P E P T I D E S

Gavin B L Harrison, Robert P Dempster, Michael D Rickard, Marshall Lightowlers, David D Heath, Stephen Lawrence, Kim L O'Hoy, Tokyo, assigned to Pitman-Moore New Zealand Limited; The University of Melbour- neHer Majesty The Queen in right of New Zealand through the Ministry of Agriculture & Fisheri

This invention relates to stable forms of peptide antigens ofT. ovis suitable for use in vaccines to protect ruminants against infection by cestode parasites. The antigens are preferably obtained by expression of DNA coding therefor in a recombinant host cell. Aspects of the invention include DNA encoding the antigens, vectors containing the DNA and hosts which express the antigens.

Klaas Osinga, Robert Beudeker, Platt Johannes Van der, Hollander Johannes de, Tokyo, as- signed to Gist-brocades N V

Methods and compositions are provided relating to yeasts capable of improved fermenta- tion of sugars. Particularly, genes from the MAL locus are used for transformation of yeast hosts, where the genes are under the wild-type pro- moter or a strong promoter which provides for regnlatable or constitive expression under the conditions of fermentation. Particularly, the yeast hosts find use in the leavening of dough.

5192658

C O M P O S I T I O N S A N D P R O T O C O L S A P P L I C A B L E T O

G E N E T I C A N A L Y S I S

Zvi G Loewy, Nancy Y Ip, Howard J Baum, Susan L Leafy, Stadt Ingrid L van de assigned to Lifeeodes Corporation

Polynucleotide sequences and other composi- tions useful for DNA polymorphism and other