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PATENT ABSTRACTS 4760017 ARABINONUCLEIC ACID PROBES FOR DNA/RNA ASSAYS Randy M McCormick assigned to E I Du Pont de Nemours and Company A novel nucleic acid, arabinonucleic acid, is pro- vided as a probe in nucleic acid assays. The arabinose moiety of the probe can be detected with anti-arabinose antibody-label conjugates. 4760018 RAPID METHOD FOR THE DETECTION OF BETA- LACTAMASE IN BODY FLUIDS Stanley Charm assigned to Penicillin Assays Inc A rapid method for the detection of beta- lactamase in body fluids which method com- prises contacting a sample of a body fluid with charcoal, removing the charcoal and recovering an essentially charcoal free supernatant, adding a labeled beta-lactam compound such as CI4 penicillin to the supernatant for a defined period of time, adding a antibiotic sensitive micro- organism, incubating and thereafter removing the microorganism cells from the incubation broth, measuring the amount of C14 bound- labeled penicillin and comparing the measured amount with a controlled sample or standard data or graph to determine the amount of any beta-lactamase in the body fluid sample. 265 4761366 MEDIUM, APPARATUS AND METHOD FOR CELL SEPARATION Toru Nakajima, Masahiro Sato, Katsuhiko Nishimura, Sumiaki Tsuru, Tokyo, Japan as- signed to Asahi Kogaku Kogyo Kabushiki Kaisha A sintered hydroxycalcium apatite body having an average particle size of 50-2,000 mum is used to form a packing in a cell separating column for use in separating groups or populations of cells from a suspension of animal cells. 4761372 MUTANT ENTEROTOXIN OF E. COLI Werner K Maas, Carlton L Gyles assigned to New York University A plasmid which comprises genes coding for an immunogenic, non-toxic, heat-labile enterotoxin and/or a non-toxic, heat-stable enterotoxin are disclosed. The E. coli containing this plasmid is also described. The E. coli or the plasmids may additionally contain a colonization factor. Methods for producing the plasmid and the E. coli containing the same are described. A live vaccine is prepared with the E. coli and is useful for vaccinating humans and animals against cer- tain diarrheal diseases. 4760028 BIOREACTOR APPARATUS WITH SURFACE AERATOR SCREEN Norman deBruyne, Gregg Feldscher, Gregory MacMichael assigned to Techne Incorporated A bioreactor for cell culture medium is provided including a flask for holding the culture medium, a screen at or just below the surface of the culture medium, a mover for the screen to cause it to move generally parallel to the surface of the cul- ture medium, and an integral or separate im- peller to cause circulation of the culture medium to the surface of the liquid culture medium. The screen is preferably on a float, and is connected to be driven at different levels of the liquid in the flask. 4761378 MICROBIOLOGICAL TESTING APPARATUS James Godsey assigned to American Home Pro- ducts Corp (Del) An improved microbiological test tray is described which are provided with fasteners so that two or more of the trays may be joined together for ease in inoculation, incubation, lyophilization and reading. In another aspect of the invention an improved tray structure is described which provides openings for the flow of vapor during the lyophilization step so that a greater number of trays may be lyophilized at the

4760028 Bioreactor apparatus with surface aerator screen

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PATENT ABSTRACTS

4760017

A R A B I N O N U C L E I C A C I D P R O B E S F O R D N A / R N A A S S A Y S

Randy M McCormick assigned to E I Du Pont de Nemours and Company

A novel nucleic acid, arabinonucleic acid, is pro- vided as a probe in nucleic acid assays. The arabinose moiety of the probe can be detected with anti-arabinose antibody-label conjugates.

4760018

R A P I D M E T H O D F O R T H E D E T E C T I O N O F BETA-

L A C T A M A S E I N B O D Y F L U I D S

Stanley Charm assigned to Penicillin Assays Inc

A rapid method for the detection of beta- lactamase in body fluids which method com- prises contacting a sample of a body fluid with charcoal, removing the charcoal and recovering an essentially charcoal free supernatant, adding a labeled beta-lactam compound such as CI4 penicillin to the supernatant for a defined period of time, adding a antibiotic sensitive micro- organism, incubating and thereafter removing the microorganism cells from the incubation broth, measuring the amount of C14 bound- labeled penicillin and comparing the measured amount with a controlled sample or standard data or graph to determine the amount of any beta-lactamase in the body fluid sample.

265

4761366

M E D I U M , A P P A R A T U S A N D M E T H O D F O R C E L L

S E P A R A T I O N

Toru Nakajima, Masahiro Sato, Katsuhiko Nishimura, Sumiaki Tsuru, Tokyo, Japan as- signed to Asahi Kogaku Kogyo Kabushiki Kaisha

A sintered hydroxycalcium apatite body having an average particle size of 50-2,000 mum is used to form a packing in a cell separating column for use in separating groups or populations of cells from a suspension of animal cells.

4761372

M U T A N T E N T E R O T O X I N O F E. C O L I

Werner K Maas, Carlton L Gyles assigned to New York University

A plasmid which comprises genes coding for an immunogenic, non-toxic, heat-labile enterotoxin and/or a non-toxic, heat-stable enterotoxin are disclosed. The E. coli containing this plasmid is also described. The E. coli or the plasmids may additionally contain a colonization factor. Methods for producing the plasmid and the E. coli containing the same are described. A live vaccine is prepared with the E. coli and is useful for vaccinating humans and animals against cer- tain diarrheal diseases.

4760028

B I O R E A C T O R A P P A R A T U S W I T H S U R F A C E A E R A T O R S C R E E N

Norman deBruyne, Gregg Feldscher, Gregory MacMichael assigned to Techne Incorporated

A bioreactor for cell culture medium is provided including a flask for holding the culture medium, a screen at or just below the surface of the culture medium, a mover for the screen to cause it to move generally parallel to the surface of the cul- ture medium, and an integral or separate im- peller to cause circulation of the culture medium to the surface of the liquid culture medium. The screen is preferably on a float, and is connected to be driven at different levels of the liquid in the flask.

4761378

M I C R O B I O L O G I C A L T E S T I N G A P P A R A T U S

James Godsey assigned to American Home Pro- ducts Corp (Del)

An improved microbiological test tray is described which are provided with fasteners so that two or more of the trays may be joined together for ease in inoculation, incubation, lyophilization and reading. In another aspect of the invention an improved tray structure is described which provides openings for the flow of vapor during the lyophilization step so that a greater number of trays may be lyophilized at the