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280 PATENT ABSTRACTS methyl-3-cephem-4-carboxylic acid (7-ADCA) in a partially chlorinated lower alkane with a bi- cyclic amidine of the formula See Patent for Chemical Structure II wherein n is the integer 3, 4 or 5, and a halide of the formula See Patent for Tabular Presentation PS wherein X is halogen and RI has the above significance, if desired, treating the resulting compound of formula I in which R2 is hydrogen with an unprotected or op- tionally protected acylating agent, cleaving off a protecting group which may be present and, if desired, treating a resulting basic compound of formula I in which R2 is an acyl group into a pharmaceutically acceptable acid addition salt. 4716228 CONDENSED 2-SUBSTITUTED THIAZOLE DERIVATIVES Ugo Scarponi, Anna Lazzarini, Daniela Toti, Castiglione Roberto de, Arese, Italy assigned to Farmitalia Carlo Erba S p A A process for preparing compounds of the for- mula I See Patent for Chemical Structure (I) wherein either (i) each of RI and R2 indepen- dently represents H or an organic group, or (ii) NR1 R2 is a heterocyclic ring or (iii) R2 is H and R I is See Patent for Chemical Structure wherein each of R6 and R7 independently represents H or an organic group, m is 1 or 2, n is 0-3, X is O, S, NH, NR8, CHNO2 or CHSO2R4 wherein R8 and R4 are organic groups and R3 represents an organic group is characterized by the following reaction sequence: See Patent for Chemical Structure See Patent for Tabular Presentation See Patent for Tabular Presentation There are also provided new compounds of the formula I wherein n is 0 and m is 2 and pharmaceutical compositions containing them. These com- pounds and their pharmaceutically acceptable acid addition salts are active as anti-ulcer agents. 4716230 CERTAIN BIS(DI-2 OR 4- PYRIDYL-PHOSPHINO) ALKANES HAVING ANTI-TUMOR PROPERTIES David T Hill assigned to Smithkline Beckman Corporation Heterocyclic phosphine compounds, pharma- ceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which com- prises administering a tumor cell growth- inhibiting amount of such a compound to an animal afflicted by said tumor cells. 4717506 PYRAN DERIVATIVES AND PERFUME COMPOSITION CONTAINING THE SAME Hiroshi Takada, Shin'ichi Masuda, Motoki Nakajima, Wakayama, Japan assigned to Kao Corporation The present invention relates to a novel pyran derivative mixture represented by the following general formula (I): See Patent for Chemical Structure (I) wherein RI is H or CH3, R2 is CH2 or CH3, one of the bonds X, Y, or Z is a double bond and the remaining two bonds are single bonds. The present invention relates to a process for the preparation of the above-mentioned pyran derivative mixture. The pyran derivative compound (I) of the present invention is pro- duced by reacting a compound represented by the following formula (II): See Patent for Chem- &al Structure (II) with a compound represented by the general formula (III): See Patent for Chemical Structure (III) in the presence of an acid catalyst wherein R1 is as defined above. In addition, the present invention relates to a per- fume composition containing an effective aromal amount of the pyran derivative com- pound represented by the general formula (I) ab- ove, in the presence of an acceptable carrier therefore. 4717512 PREPARATION OF ACYLATED GLYCERO-PHOSPHOCHOLINES AND GLYCERO- PHOSPHOETHANOLAMINES Friedrich Paltauf, Albin Hermetter, Graz, Austria assigned to Chemie Linz Aktiengesel- Ischaft Preparation of chemically defined pure enan- tiomeric 1, 2-diacyl-sn-glycero-3- phosphocholines and 1, 2-diacyl-sn-glycero-3- phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of

4716230 Certain bis(DI-2 or 4-pyridyl-phosphino) alkanes having anti-tumor properties

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280 PATENT ABSTRACTS

methyl-3-cephem-4-carboxylic acid (7-ADCA) in a partially chlorinated lower alkane with a bi- cyclic amidine of the formula See Patent for Chemical Structure II wherein n is the integer 3, 4 or 5, and a halide of the formula See Patent for Tabular Presentation PS wherein X is halogen and RI has the above significance, if desired, treating the resulting compound of formula I in which R2 is hydrogen with an unprotected or op- tionally protected acylating agent, cleaving off a protecting group which may be present and, if desired, treating a resulting basic compound of formula I in which R2 is an acyl group into a pharmaceutically acceptable acid addition salt.

4716228

C O N D E N S E D 2 - S U B S T I T U T E D T H I A Z O L E D E R I V A T I V E S

Ugo Scarponi, Anna Lazzarini, Daniela Toti, Castiglione Roberto de, Arese, Italy assigned to Farmitalia Carlo Erba S p A

A process for preparing compounds of the for- mula I See Patent for Chemical Structure (I) wherein either (i) each of RI and R2 indepen- dently represents H or an organic group, or (ii) NR1 R2 is a heterocyclic ring or (iii) R2 is H and R I is See Patent for Chemical Structure wherein each of R6 and R7 independently represents H or an organic group, m is 1 or 2, n is 0-3, X is O, S, NH, NR8, CHNO2 or CHSO2R4 wherein R8 and R4 are organic groups and R3 represents an organic group is characterized by the following reaction sequence: See Patent for Chemical Structure See Patent for Tabular Presentation See Patent for Tabular Presentation There are also provided new compounds of the formula I wherein n is 0 and m is 2 and pharmaceutical compositions containing them. These com- pounds and their pharmaceutically acceptable acid addition salts are active as anti-ulcer agents.

4716230

CERTAIN BIS(DI-2 OR 4- PYRIDYL-PHOSPHINO) A L K A N E S

H A V I N G A N T I - T U M O R PROPERTIES

David T Hill assigned to Smithkline Beckman Corporation

Heterocyclic phosphine compounds, pharma- ceutical compositions containing an effective,

tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which com- prises administering a tumor cell growth- inhibiting amount of such a compound to an animal afflicted by said tumor cells.

4717506

P Y R A N D E R I V A T I V E S A N D P E R F U M E C O M P O S I T I O N C O N T A I N I N G T H E S A M E

Hiroshi Takada, Shin'ichi Masuda, Motoki Nakajima, Wakayama, Japan assigned to Kao Corporation

The present invention relates to a novel pyran derivative mixture represented by the following general formula (I): See Patent for Chemical Structure (I) wherein RI is H or CH3, R2 is CH2 or CH3, one of the bonds X, Y, or Z is a double bond and the remaining two bonds are single bonds. The present invention relates to a process for the preparation of the above-mentioned pyran derivative mixture. The pyran derivative compound (I) of the present invention is pro- duced by reacting a compound represented by the following formula (II): See Patent for Chem- &al Structure (II) with a compound represented by the general formula (III): See Patent for Chemical Structure (III) in the presence of an acid catalyst wherein R1 is as defined above. In addition, the present invention relates to a per- fume composition containing an effective aromal amount of the pyran derivative com- pound represented by the general formula (I) ab- ove, in the presence of an acceptable carrier therefore.

4717512

P R E P A R A T I O N O F A C Y L A T E D G L Y C E R O - P H O S P H O C H O L I N E S

A N D G L Y C E R O - P H O S P H O E T H A N O L A M I N E S

Friedrich Paltauf, Albin Hermetter, Graz, Austria assigned to Chemie Linz Aktiengesel- Ischaft

Preparation of chemically defined pure enan- tiomeric 1, 2-diacyl-sn-glycero-3- phosphocholines and 1, 2-diacyl-sn-glycero-3- phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of