iv New Patents

(I) See Patent for Chemical Structure (I) wherein R 1 and R2 each independently represents hydro- gen, hydroxyl or alkoxy having from 1 to 6 carbon atoms, X is oxygen and Z is a double bondCH2 or double bondCH-COOR3 group, in which R3 is hydrogen or alkyl having from 1 to 6 carbon atoms; or X represents an double bondNR4 group, in which R4 is hydrogen or hydroxyl, and Z is a double bondCH-CN, double bondCH2 or double bondCH-COOR3 group, in which R3 is as defined above, and acid addition salts thereof. The compounds of for- mula (I) are pharmaceutically active, in par- ticular show antispasm, analgesic, gastric acid secretion inhibiting, sedative and hypnotic ac- tivity and effectively reduce the alcoholic nar- cosis time. According to a further aspect of the invention there is provided a process for the pre- paration of these compounds. The invention fur- ther relates to pharmaceutical compositions containing them as active ingredient.

4622336

3,3-DIALKYL-AND 3,3-ALKYLENE- INDOLINE DERIVATIVES, PROCESSES FOR THEIR

PRODUCTION AND PHARMACEUTICAL

COMPOSITIONS COMPRISING THEM

Roland Achini, Therwil, Switzerland assigned to Sandoz Ltd

3,3-Dialkyl- or 3,3-alkylene-indolines which are unsubstituted at the 1- and 2-positions and which are substituted at the 4- or 6-position by an optionally etherified hydroxy group or sub- stituted at the 5- or 7-position by an etherified hydroxy group, as well as their physiologically- hydrolyzable and -acceptable esters. The said in- dolines and esters as well as their pharmaceutically acceptable acid addition salts possess analgesic activity.

4622430

Pretoria, South Africa assigned to Noristan Limited

Pentacyclo(6.3.0.0.2,6.03,10.05,9)undecane and its derivatives are prepared. The compounds find use as antiviral agents.

4625494

METHOD AND APPARATUS FOR MAKING MIXTURES OF

PHARMACEUTICAL LIQUIDS

Peter Iwatschenko, Fritz Giebler, Neunkirchen, Federal Republic Of Germany assigned to Pfrimmer & Co Pharmazeutische Werke Er- langen

Method for the preparation of mixtures of pharmaceutical liquids, for example infusion solutions, from storage containers containing at least two of the individual mixture components, in an arrangement with a vacuum chamber to receive the containers to be filled and with a con- necting hose for each storage container as well as a tube connected to the container to be filled and also connected with the connection hoses of the storage containers via a hose connection, with the attainment of the desired predetermined amount of each mixture component being in- dicated by registering air intake into the in- dividual connection hoses, clamping the respective connecting tube and sealing and cut- ting the hose downstream from the clamping fol- lowing corresponding registration of air intake into all present connection hoses.

4628050

ANTINEPHRITIC PHARMACEUTICAL

COMPOSITION CONTAINING 24, 25-

DIHYDROXYCHOLECALCIFEROL AS AN ACTIVE INGREDIENT

DERIVATIVES OF PENTACYCLO UNDECANES, PROCESSES FOR

PREPARING THESE COMPOUNDS, AND PHARMACEUTICAL

COMPOSITIONS THEREOF

Theodor G Dekker, Douglas W Oliver, Friedrich O Snyckers, Schyf Cornelis van der,

Yuji Maeda, Hideyuki Yamato, Takayoshi Fujii, Yasuhiko Kobayashi, Kenichi Saito, Tadaaki Kato, Chikao Yoshikumi, Nagareyama, Japan assigned to Kureha Kagaku Kogyo Kabushiki Kaisha

Disclosed herein is a pharmaceutical composi- tion in dosage unit form, which comprises a dosage effective for treating nephritic disease of a compound of 24,25-dihydroxycholecalciferol

New Patents v

as an active ingredient and a pharmaceutically acceptable carrier.

4628052

PHARMACEUTICAL COMPOSITIONS CONTAINING DEHYDROEPIANDROSTERONE

AND OTHER ANESTHETIC STEROIDS IN THE TREATMENT

OF ARTHRITIS AND OTHER JOINT DISABILITIES

4628063

ANTIVIRAL PHARMACEUTICAL PREPARATIONS AND METHODS

FOR THEIR USE

Harold G Haines, Caroline B Dickens assigned to Brigham Dana

The present invention relates to a method and pharmaceutical composition for treating herpes group virus infections in mammals, and in par- ticular, in humans, by administering an effective antiviral amount of lidocaine or a pharma- ceutically acceptable salt thereof.

Raymond F Peat

The present invention is concerned with com- positions and methods of treating rheumatoid arthritis, osteoarthritis, and arthritis associated with psoriasis and with lupus and other auto- immune diseases, and also for treating non- specific joint pain associated with stress or incidental to another ailment, using dehy- droepiandrosterone and/or other anesthetic steroids dissolved in an oily vehicle, and pre- ferably administered topically or orally.

4628056

4629733

INDOLINONES AND PHARMACEUTICAL

COMPOSITIONS CONTAINING SAME

NOVEL OXOPYRIMIDINE DERIVATIVES,

PHARMACEUTICAL COMPOSITIONS CONTAINING

THEM AND THEIR USE AS ANTICONVULSANT,

ANTIANXIETY AND MUSCLE RELAXANT AGENTS

Barrie Levitt, Morris Stolar, Haifa, Israel as- signed to Taro Pharmaceutical Industries Ltd

There are disclosed novel oxopyrimidine derivatives of the general formula See Patent for Chemical Structure wherein R1 and R2 may be the same or different and are each hydrogen or lower alkyl optionally substituted by lower alkoxy, and R3 and R4 may be the same or dif- ferent and are each phenyl optionally substituted by lower alkyl or halogen, provided that when R1 and R2 are both hydrogen, R3 and R4 are each substituted phenyl. Pharmaceutical com- positions containing these compounds and their use as anticonvulsant, antianxiety and muscle relaxant agents are described.

Erich Muller, Josef Nickl, Josef Roch, Berthold Narr, Biberach, Federal Republic Of Germany assigned to Dr Karl Thomae GmbH

The present invention relates to novel in- dolinones of the general formula See Patent for Chemical Structure wherein R represents an aryl group having from 6 to 10 carbon atoms, unsub- stituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, sub- stituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pen- tamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.