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8/16/2019 2.1.Anatomi Ginjal&Nefron
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THIRD CLASS
MR. RAYMOND ARIEF
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EXCRETION SYSTEM
• URINARY SYSTEM
• ENDOCRINE SYSTEM• REPRODUCTION SYSTEM
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Major Parts of the Machine
food, water intake oxygen intake
elimination
of carbon
dioxide
Digestive System Respiratory System
Circulatory SystemUrinary System
elimination of
excess water
salts, wastes
rapid transport to and from all
living cells
Elimination of food
residues
nutrients,
water,
salts carbon
dioxide
watersolutes
oxygen
Based on: Starr, C., Biology:
Concepts and Applications,
Brooks/Cole
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Urinary system
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Renal/Urinary System Summary
Functions:
1. Remove wastes from the body (urine)
2. Regulates fluid balance, maintains homeostasis
Structures:
• 2 kidneys - filter blood, produce urine
• 2 ureters - transport urine (kidneys to bladder)
• bladder - reservoir for urine
• urethra - transport of urine
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Anatomy Urinary System
20-2
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Anatomical structures
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Kidneys
• Reddish-brown incolor
• Shaped like akidney bean
• Measuring 4inches long and 2inches wide, andweighing less than
1/2 pound• The hilum (Latin)
• is where the renalartery enters andthe renal veins andureter exit thekidney
• The renal capsulesurrounds thekidney
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Ureters
•
25 cm long• extend downward posteriorto the parietal peritoneum• parallel to vertebral column• in pelvic cavity, join urinarybladder• wall of ureter
• mucous coat• muscular coat• fibrous coat
•Opening where the ureter joins the bladder•The ureter wall contracts
every 30 seconds to propelurine into the bladder, aprocess known as peristalsis
20-31
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Bladder
20-31
• A reservoir for storing urine
• Located in the pelvic cavity
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Bladder
Longitudinal section and posterior view of male urinary bladder
20-33
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Urethra
20-31
Urethra
• A tube that carries urine
from the bladder to the
outside of the body
• The external urethral
sphincter helps to
release or hold backurine
• The urethral meatus is
where the urethra opens
to the outside of the
body
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Cross Section of Urethra
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Urinary Bladder
Figure 25.18a, b
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Male and Female Urethras
20-35
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Let to see... Our main chapter
It’s about
1. KIDNEY
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Position of the Kidneys
CT abdomen with contrast MRI coronal abdomen
18
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Kidneys
20-4
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• Kidney – macro
anatomy
– Cortex
– Medulla
• Pyramids
• Papilla
– Hilum – Pelvis
• Calyx
• Ureter
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Structure - macro
• Enclosed in a strong fibrous capsule which passes over the lips of the sinusand becomes continuous with the walls of the calices.
• Kidney + capsule are surrounded by pararenal fat
• Each kidney has superior and inferior poles, medial and lateral borders/margins and anterior and posterior surfaces
• Reddish-brown in colour when fresh – colour varies between cortex andmedulla
• Measure ~12x6x3cm (left often slightly longer than right)
• Weigh ~130g each
• Ovoid in outline but indented medially (the renal sinus) bean-shapedappearance
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Imaging of Kidneys
20-3
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Structure - macro
• Hilum
– At the concave part of each kidney
– Renal vein exits (anteriorly)
– Renal artery enters (posterior to renal vein)
– Renal pelvis exits (posterior to artery)
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Structure - macro
• Renal pelvis
– Funnel-shaped
– Lined with transitional epithelium with a smooth muscle
and connective tissue wall
–
Continuous inferiorly with ureter – Divides into major and minor calyces
• Urine collecting tubule minor calyx major calyx
renal pelvis ureters bladder
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Renal Cortex and Renal
Medulla
20-9
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Structure - macro
• Cortex
– Beneath capsule, extends towards the pelvis as
renal columns lying between pyramids of medulla
• Apices of several pyramids open together into a renal
papilla, each of which projects into a renal calyx
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Blood supply to the kidney
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URINARY
SYSTEMG
aa
ea
IA
G
G
BLOOD FLOW(KIDNEY)
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Renal arteries from abdominal aorta enter hilum and branch:
1. Interlobar arteries - pass through renal columns and reach junctionbetween medulla and cortex
2. Arcuate arteries run parallel with the base of the pyramids
3. Interlobular arteries move up into the cortex and branch to form theafferent arteriole
The peritubular capillaries unite to form the interlobular veins, arcuatevein, interlobar vein, renal vein
The renal vein exits at hilus and joins the IVC
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Blood supply to kidney p955
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• Kidney – microanatomy
– Nephron
• Glomerulus
• Bowman’s capsule
• Proximal collecting
tubule
• Henle’s loop
• Distal collecting tubule
• Collecting duct
Note:
cortex has everything
medulla has only:
loop of HenleCollecting tubules
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Structure - micro
• Nephrons
– Functional and histological subunit
– ~106 per kidney – = glomerulus + tubules
– glomerulus
• tuft of capillaries surrounded bypodocytes
• projects into Bowman’s capsule
– tubule system
• epithelium continuous with Bowman’scapsule
• proximal convoluted tubule Loop ofHenle distal convoluted tubule
collecting tubule and collecting duct – glomeruli and convoluted tubules are in
cortex
– ducts lie in the medulla
– glomerular capillaries supplied by afferentarteriole and drained by efferent arteriole
N
E
P
H
R
O
N
S
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Nephron= Functional unit of the kidney, ~ 1 million nephrons per kidney!
Tubular components:1. Glomerular (Bowman’s) capsule – double-walled cup – simple squamous epithelium
2. Proximal convoluted tubule - coiled 1st section – simple cuboidal epithelium with microvilli
3. Loop of Henle - hair-pin loop – thin descending limb, thick ascending limb
4. Distal convoluted tubule - last section – simple cuboidal epithelium
– specialised region - Juxta glomerular apparatus
Distal convoluted tubule opens into the collecting systemcollecting ducts papillary ducts minor calyx…
St t i
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Structure - micro
St t i
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Structure - micro
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Continue to
2. nephron
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Before i give explanation ... remember again our last
chapter about nephron
What functions ofnephrons ????
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• Production of filtrate
• Reabsorption of organic nutrients
• Reabsorption of water and ions
• Secretion of waste products into tubular fluid
Nephron functions include:
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Nephron
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Part of
nephron
GLOMERULAR (B ’ ) CAPSULE
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GLOMERULAR (Bowman’s) CAPSULE
Renal corpuscle
filters fluidPlasma is filtered
• Double walled epithelial cup surrounds glomerulus
• Visceral layer = filtration membrane with slits &pores
– Podocytes
• Between walls = Bowman’s (capsular) space
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Glomerular Capsule
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PROXIMAL CONVOLUTED TUBULE
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PROXIMAL CONVOLUTED TUBULE
PROXIMAL CONVOLUTED TUBULES
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PROXIMAL CONVOLUTED TUBULES
• Simple cuboidal
• epithelial cellswith prominentbrush bordersof microvilli.
DECENDING LIMB OF THE LOOP OF HENLE
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DECENDING LIMB OF THE LOOP OF HENLE
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DECENDING LIMB OF THE LOOP OF
HENLE
•Simple squamous
epithelial cells
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ASCENDING LIMB OF THE LOOP OF
HENLE
ASCENDING LIMB OF THE LOOP OF HENLE
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ASCENDING LIMB OF THE LOOP OF HENLE
• Simple cuboidal
• epthelial to low
•
columnar cells.
DISTAL CONVOLUTED TUBULE
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DISTAL CONVOLUTED TUBULE
DISTAL CONVOLUTED TUBULES
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DISTAL CONVOLUTED TUBULES
•Simple cuboidal
epthelial cells.
THE NEPHRON TISSUES
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THE NEPHRON TISSUES
1. Proximal convolutedtubule
2. Descending limb ofLoop of Henle
3. Ascending Limb ofLoop of Henle
4. Distal convolutedtubules
1. Simple cuboidalepithelial cells with
prominent brushborders of microvilli.2. Simple squamous
epithelial cells3. Simple cuboidal to
low columnarepithelial cells.
4. Simple cuboidalepthelial cells.
V l t f h
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Vascular component of nephron
(blood vesssel of nephron)
1. Glomerulus - network of capillaries within Bowman’s capsule
2. Afferent arteriole - leading into glomerulus
3. Efferent arteriole - leading out of glomerulus
4. Peritubular capillaries - surrounding tubules
5. Vasa recta - specialised loops of blood vessels around longLoop of Henle (juxtamedullary nephrons)
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Renal Blood Vessels
20-6
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Type of nephron
Nephrons: 85% are cortical, 15% are juxtamedullary Martini p957
TYPES OF NEPHRONS
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TYPES OF NEPHRONS
• Cortical nephron:
– Originates in outer 2/3of cortex.
– Involved in solutereabsorption.
• Juxtamedullary nephron:
– Originates in inner 1/3
cortex.
• Important in theability to produce aconcentrated urine.
– Has longer Loop of
Henle.
Insert fig. 17.6
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