2003-2004Review of Anticoagulants,

Thrombolytics and Anti-platelet Drugs

April 20, 202306:30 AM

Abciximab

Antiplatelet

Anti-GPIIb/IIIa receptor antibody

Adalimumab

TNF inhibitor

Anti-TNF antibodyUsed in rheumatoid arthritis

Allopurinol

AntigoutAntineoplastic (supporting

agent)

Folic acid analogueXanthine oxidase inhibitor

Aminocaproic acid (EACA)

Procoagulant

Inhibitor of plasminogen activation

(decreases fibrinolysis)

Anistreplase

Thrombolytic

Streptokinase + plasminogen

Aprotinin

Procoagulant

Fibrinolytic inhibitorSerine protease inhibitor

(“serpin”)Streptokinase inhibitor

Argatroban

Anticoagulant

Direct thrombin inhibitor

Aspirin(Acetylsalicylic acid, ASA)

NSAID (acetylsalicylate)Analgesic, Anti-inflammatory

Antipyretic, Antiplatelet

Irreversible cyclooxygenase inhibitor

Atorvastatin

Antihyperlipidemic

HMG-CoA reductase inhibitor

Auranofin

Disease modifyinganti-rheumatic drug (DMARD)

Gold saltOral

Aurothioglucose

Disease modifyinganti-rheumatic drug (DMARD)

Gold saltParenteral

Balsalazide

NSAID (salicylate)

Treatment of IBD

Beclomethasone

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidInhaled

Betamethasone

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidNot by inhalation

Bivalirudin

Anticoagulant

Direct thrombin inhibitor

Bradykinin

Inflammatory mediator

Plasma, hypotension, pain

Budesonide

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidInhaled OR treatment of IBD

C3a, C5a

Inflammatory mediators

Anaphylatoxins Low molecular weight

complement cleavage products

Celecoxib

NSAIDAnti-inflammatory

Cyclooxygenase 2 (COX-2) inhibitor

Cholestyramine

Antihyperlipidemic

Bile acid binding resin (BABR)

Clofibrate

Antihyperlipidemic

Lipoprotein lipase activator

Clopidogrel

Antiplatelet

ADP receptor antagonist

Colchicine

Antigout onlyAnti-inflammatory

Microtubule inhibitor

Colestipol

Antihyperlipidemic

Bile acid binding resin (BABR)

Cortisol (Hydrocortisone)

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroid

Cromolyn sodium

Mast cell stabilizer

Inhibits release ofmast cell mediators

Used prophylactically in asthma

Dalteparin

Anticoagulant

LMW HeparinATIII activator

Dexamethasone

AdrenocorticosteroidGlucocorticoidAntineoplastic

Antiemetic

Anti-inflammatory steroidNot by inhalation

Diflunisal

NSAIDAnalgesic, Anti-inflammatory

Antipyretic

Cyclooxygenase inhibitor

Dipyridamole

Antiplatelet

Phosphodiesterase inhibitor(increases cAMP)

Drotrecogin alfa(Activated Protein C)

Anticoagulant

Many actionsTreatment for septic shock

Enoxaparin

Anticoagulant

LMW HeparinATIII activator

Eptifibatide

Antiplatelet

GPIIb/IIIa antagonist

Erythropoietin (EPO)

Cytokine

Primary regulator of RBC synthesis

Etanercept

TNF inhibitor

Tumor necrosis factor receptor+ Fc portion of IgG

Used in rheumatoid arthritis

Ezitimibe

Antihyperlipidemic

Cholesterol absorption inhibitor

Fenofibrate

Antihyperlipidemic

Lipoprotein lipase activator

Flunisolide

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidInhaled

Fluticasone

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidInhaled

Fluvastatin

Antihyperlipidemic

HMG-CoA Reductase Inhibitor

Gemfibrozil

Antihyperlipidemic

Lipoprotein lipase activator

Gold salts

Disease modifying anti-rheumatic drugs (DMARD)

auranofin, aurothioglucose

Granulocyte-Colony Stimulating Factor (G-

CSF)

Cytokine

Granulocyte synthesis stimulator

Granulocyte/Monocyte-Colony Stimulating Factor

(GM-CSF)

Cytokine

WBC (granulocytes and monocyte) synthesis stimulator

Heparin

Anticoagulant

ATIII activator

Hirudin

Anticoagulant

Direct thrombin inhibitor(DTI)

Histamine

Inflammatory mediator

Stored in mast cells and basophils

Hydrocortisone

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroid

Hydroxychloroquine

Disease modifyinganti-rheumatic drug (DMARD)

4-Hydroxycoumarin

Oral anticoagulant

Vitamin K synthesis inhibitor

Ibuprofen

NSAIDAnalgesic, Anti-inflammatory

Antipyretic

Reversible cyclooxygenase inhibitor

Indomethacin

NSAIDAnalgesic, Anti-inflammatory,

Antipyretic

Cyclooxygenase inhibitorTocolytic

Uterine relaxant

Infliximab

TNF inhibitor

Anti-TNF monoclonal antibodyTreatment of IBD

Interferon alpha

Antiviral for hepatitisAntineoplastic

Cytokine

Anti-angiogenesis

Interleukin 2

Cytokine Antineoplastic

Interleukin 11

Cytokine Antineoplastic (supporting

agent)

Kallidin

Inflammatory mediator

Plasma, hypotension, pain

Ketoprofen

NSAIDAnalgesic, Anti-inflammatory,

Antipyretic

Cyclooxygenase inhibitor

Lepirudin

Anticoagulant

Direct thrombin inhibitor (DTI)

Leukotriene B4 (LTB4)

Inflammatory mediator

Lipoxygenase productof arachidonate metabolism

Chemotactic

Leukotrienes C4, D4, E4

(LTC4, LTD4, LTE4)

Inflammatory mediators

Cysteinyl leukotrienesPeptidyl leukotrienes

SRS-ALipoxygenase products ofarachidonate metabolism

Lovastatin

Antihyperlipidemic

HMG-CoA reductase inhibitor

Meclofenamate

NSAIDAnalgesic, Anti-inflammatory,

Antipyretic

Cyclooxygenase inhibitor

Mesalamine(5-ASA)

NSAID (salicylate)

Treatment of IBD

Methylprednisolone

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidNot by inhalation

Montelukast

Leukotriene inhibitor

LTR1 and LTD4 antagonistAsthma treatment

Naproxen

NSAIDAnalgesic, Anti-inflammatory,

Antipyretic

Cyclooxygenase inhibitor

Nedocromil

Mast cell stabilizer

Inhibits release of mast cell mediators

Used prophylactically in asthma

Nicotinic acid

Antihyperlipidemic

Inhibition of VLDL secretion (?)

Non-steroidalAnti-inflammatory Drugs

(NSAIDs)

Analgesic, Anti-inflammatory, Antipyretic

Cyclooxygenase inhibitors

Olsalazine

NSAID (salicylate)

Treatment of IBD

Phytonadione

Vitamin K

Warfarin antagonist

Piroxicam

NSAIDAnalgesic, Anti-inflammatory,

Antipyretic

Cyclooxygenase inhibitor

Platelet Activating Factor (PAF)

Inflammatory mediator

LipidHypotensive

Pravastatin

Antihyperlipidemic

HMG-CoA reductase inhibitor

Prednisone

AdrenocorticosteroidGlucocorticoid Antineoplastic

Anti-inflammatoryNot by inhalation

Probenecid

Uricosuric

Adjunct in penicillin therapy

Probucol

Antihyperlipidemic

LDL oxidation inhibitor

Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost)

Oxytocic prostaglandinInflammatory mediator

Cyclooxygenase product of arachidonate metabolism

Uterine stimulantCervical ripener

Prostaglandin F2 (PGF2)

Inflammatory mediator

Cyclooxygenase product of arachidonate metabolism

Prostaglandin I2 (PGI2)

Inflammatory mediator

Inhibits platelet aggregation

Cyclooxygenase product of arachidonate metabolism

Prostacyclin

Protamine Sulfate

Heparin antagonist

Rofecoxib

NSAIDAnti-inflammatory

Cyclooxygenase 2 (COX-2) inhibitor

Simvastatin

Antihyperlipidemic

HMG-CoA reductase inhibitor

Streptokinase

Thrombolytic

Rofecoxib

NSAIDAnti-inflammatory

Cyclooxygenase 2 (COX-2) inhibitor

Sulfasalazine

Disease modifyinganti-rheumatic drug (DMARD)

Metabolized to sulfonamide+ salicylate (NSAID)

Treatment of IBD

Sulfinpyrazone

Uricosuric

Anti-gout

Sulindac

NSAIDAnalgesic, Anti-inflammatory,

Antipyretic

Cyclooxygenase inhibitor

Thrombopoietin

Cytokine

Platelet synthesis stimulator

Thromboxane A2 (TXA2)

Autacoid

Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism

Ticlopidine

Antiplatelet

ADP receptor antagonist

Tissue plasminogen activators

Thrombolytics

alteplase, reteplase, tenecteplase

Triamcinolone

AdrenocorticosteroidGlucocorticoid

Anti-inflammatory steroidInhaled

Tumor necrosis factor

CytokineAntineoplastic

Urokinase

Thrombolytic

Warfarin

Anticoagulant

Vitamin K synthesis inhibitor

Zafirlukast

Leukotriene inhibitor

LTR1 and LTD4 antagonistAsthma treatment

Zileuton

Leukotriene inhibitor

5-lipoxygenase inhibitorUsed in asthma