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Tishk International University Science Faculty Medical Analysis Department Pathology Fourth Grade- Spring Semester 2020-2021 Dr. Jalal A. Jalal Assistant Professor of Pathology Hemodynamic disorders - 2, Thrombosis

2, Thrombosis - Lecture Notes - TIU - Lecture Notes

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Page 1: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Tishk International

University Science

Faculty

Medical Analysis Department

Pathology

Fourth Grade- Spring Semester 2020-2021

Dr. Jalal A. Jalal

Assistant Professor of Pathology

Hemodynamic disorders - 2,

Thrombosis

Page 2: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Thrombosis

2

Objectives:

To define thrombosis.

To explain how this process occurs.

To describe it’s histological changes and clinical

significance .

Page 3: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Thrombosis

• It is a process by which a thrombus is formed.

• A thrombus is a solid mass of blood constituents

which develops in artery or vein.

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Page 4: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Thrombosis

Pathogenesis :

Virchow's triad:

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Page 5: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Endothelial injury

Endothelial cell loss:

1. Ulcerated atherosclerotic arterial plaques.

2. Traumatic vascular injury

3. Vasculitis

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Page 6: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Endothelial dysfunction:

1. Hypertension

2. Hypercholesterolemia

3. Products absorbed from cigarette smoke

4. Turbulent flow over deformed cardiac valves

5. Bacterial toxins

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Page 7: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Alterations in Normal Blood Flow

• Turbulence

Contributes to arterial and cardiac thrombosis

by causing endothelial injury or dysfunction, as

well as by forming countercurrents and local

pockets of stasis.

• Stasis

Is a major contributor to the development of

venous thrombi.

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Page 8: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Stasis and turbulence effect:

1. Disrupt laminar flow and bring platelets into

contact with the endothelium.

2. Prevent dilution of activated clotting factors by

fresh-flowing blood.

3. Retard the inflow of clotting factor inhibitors

and permit the buildup of thrombi.

4. Promote endothelial cell activation, resulting in

local thrombosis, leukocyte adhesion, etc.

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Page 9: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Hypercoagulable States

1. Primary (Genetic):

• Mutation in factor V gene

• Mutation in prothrombin gene

• Antithrombin III deficiency

• Protein C deficiency

• Protein S deficiency

• Fibrinolysis defects

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Page 10: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

2. Secondary(Acquired) Hypercoagulable States

• A. High risk for thrombosis:

• Prolonged bed rest or immobilization

• Myocardial infarction,

• Atrial fibrillation

• Tissue damage (surgery, fracture, burns)

• Cancer

• Prosthetic cardiac valves

• Disseminated intravascular coagulation

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Page 11: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

B. Lower risk for thrombosis

• Cardiomyopathy,

• Nephrotic syndrome,

• Hyperestrogenic states (pregnancy),

• Oral contraceptive use,

• Sickle cell anemia,

• Smoking.

• Obesity

• Advancing age.

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Page 12: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Morphology of thrombus

Thrombi may develop anywhere in the

cardiovascular system: the cardiac chambers,

valve cusps, arteries, veins, or capillaries.

They vary in size and shape, depending on the

site of origin.

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Page 13: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Arterial or cardiac thrombi usually begin at a

site of endothelial injury (e.g., atherosclerotic

plaque) or turbulence (vessel bifurcation)

Venous thrombi characteristically occur in sites

of stasis.

Page 14: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Thrombi (cont.)

Thrombi may have grossly (and

microscopically) apparent laminations, called

lines of Zahn;

These are produced by alternating pale layers of

platelets admixed with some fibrin and darker

layers containing more red cells.

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Page 15: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

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When arterial thrombi arise in heart chambers or in the aortic

lumen, they usually adhere to the wall of the underlying structure

and are termed mural thrombi

Page 16: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Lines of Zahn

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Page 17: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Fate of the Thrombus

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Page 18: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Clinical Consequences

• Thrombi are significant because they cause

obstruction of arteries and veins, and are sources

of emboli, which effect depends on the site of the

thrombosis.

• Venous thrombi can cause congestion and

edema in vascular beds distal to an obstruction,

but they are far more worrisome for their capacity

to embolize to the lungs and cause death.

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Page 19: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Conversely, although arterial thrombi can

embolize and cause downstream infarctions, a

thrombotic occlusion at a critical site (e.g., a

coronary artery) can have more serious clinical

consequences.

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Page 20: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes

Summary

• Thrombus is a solid mass of blood constituents.

• Pathogenesis of thrombus include endothelial

injury, abnormal blood flow and

hypercoagulability.

• Venous thrombi are worrisome for embolization.

• Arterial thrombi may cause thrombotic occlusion

at a critical site (e.g. coronary arteries).

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Page 21: 2, Thrombosis - Lecture Notes - TIU - Lecture Notes