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suicidality. The EO sample reports a lower level of PANSS positivesymptoms, mean value 17.8 (4.1 SD), versus the LO sample 19.5 (5.0SD), (p-value=0.03, Student's t-test). The EO sample more frequentlyinitiated psychosis treatment on an outpatient basis compared to theLO patients.Conclusions: This study suggests that patients with onset of psychosisin adolescence have a poorer premorbid functioning; they experiencelonger DUP and are at risk to experience longer treatment delays thanadults. These findings may implicate the need of a more age-specificdetection and case identification.
doi:10.1016/j.schres.2007.12.207
141 – REFERRAL PATTERNS OF 14–16 YEAR OLD PATIENTSTO LANCASHIRE CARE EARLY INTERVENTION PSYCHOSISSERVICE
F. Khan1, I. Chaudhry1,2.
1Lancashire Care Early Intervention Service, UK2University of Manchester, UK
Presenting Author details: [email protected], PR1 7LY Lancashire, United Kingdom,Tel.: +44 7796013455.
Background: First episode psychosis (FEP) in children andadolescents has a resemblance to the early onset psychosis in adults.However, research is required to enable professionals to identify itsspecific features in this age group. Early Intervention Service (EIS) inLancashire Care NHS Trust covers an age range of 14–35 years. Theservice follows the hub and spoke model and caters for a population of1.2 million. This service is unique as it has a Child and AdolescentMental Health Service (CAMHS) component catering for the 14–16and in some cases up to 18 years. The CAMHS component of theservice commenced in February 2007 and started accepting referrals inApril 2007. Referrals are accepted from local CAMHS teams. After acomprehensive joint assessment, a decision is made on the accept-ability of the young person. The aim of the study is to identify thereferral pattern of 14–16 year olds to the EIS in Lancashire Care NHSTrust.Methods: Information will be collected over an 8-month period usinga specially designed questionnaire by the professionals of the service.This will be used to gather information around the referral pattern ofyoung people aged 14–16. Areas explored are gender, ethnicity, familycomposition, educational status, source and reason of Referral,symptom clusters duration of symptoms, previous ICD-10 diagnosis,forensic history, drug and alcohol history, medications, investigationsand family history of a psychiatric illness.Results: Reporting of outcome of the study is in the posterpresentation as data is in the collection and compilation stage.Conclusions: The authors aspire that this project will providesignificant and useful information in improving mental healthprofessionals understanding of FEP presentation in children. Thusenabling them to identify and manage cases at an early stage in thecommunity.
doi:10.1016/j.schres.2007.12.208
142 – MALE–FEMALE ANTERO-POSTERIOR GRADIENT CANACCOUNT FOR THE SEX DIFFERENCE IN AGE OF ONSET INPSYCHOSIS
P. Paez1, T.J Crow1, R. Gimenes1.
1Prince of Wales International Centre, Department of Psychiatry,Oxford University, UK
Presenting Author details: [email protected] Hospital, Prince of Wales International Centre, OX3 7JXOxford, United Kingdom,Tel.: +44 1865 455914.
Background: There have been a number of reports that suggest asexual dimorphism in the corpus callosum. A failure of hemisphericdifferentiation in psychosis could lead to hemispheric misconnectivitythat differentiates the sexes. It is clear that age of onset in psychosis isearlier in males than in females but the reason still remains unclear.Methods: The literature on the corpus callosum, sex differences andschizophrenia was reviewed from 1986 to 2007 to yield 26 articles.Results:Avast majority of articles showed an overall reduction of sizeregardless of ventricular enlargement. However, 4 papers found noregional differences in the corpus callosum of schizophrenic patients.Conclusions:We proposed that the sex differences in age of onset canbe account as follows. (1) Greater asymmetries are associated withfewer connections. (Witelson's principle). (2) Pruning and possiblesubsequent myelination proceeds to antero-posterior gradient andfaster in females than in males. (3) Failure of lateralization(hyperconnectivity) is manifests earlier and more anteriorly in malesand later and posteriorly in females.
doi:10.1016/j.schres.2007.12.209
143 – PREMORBID ADJUSTMENT IN CHILDHOOD PREDICTSTRANSITION TO PSYCHOSIS IN ULTRA HIGH RISKINDIVIDUALS
K. Papageorgiou1, M.R. Schäfer1, J. Becker1, G.P. Amminger1,2.
1Department of Child- and Adolescent Psychiatry, MedicalUniversity, Vienna, Austria2ORYGEN Research Centre (incorporating EPPIC), University ofMelbourne, Australia
Presenting Author details: [email protected]ähringer Gürtel 18-20, 1090 Vienna, Austria,Tel.: +43 1 404002127; fax: +43 404002793.
Background: Even though the relationship between poor premorbidadjustment and poor clinical outcomes including poor social andoccupational functioning, cognitive impairment, and more severepositive and negative symptoms is well established in schizophrenia,premorbid adjustment has not been investigated in the prodromalphase of psychosis. We examined premorbid adjustment as predictorfor transition to psychosis in ultra high risk (UHR) individuals withsubthreshold symptoms.Methods: Premorbid adjustment was assessed using a modifiedversion of the Cannon-Spoor et al. Premorbid Adjustment Scale (PAS)
91ABSTRACTS / Schizophrenia Research 98 (2008) 3–199
