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1. Understanding Liver Function Tests 2. Types of Liver Disease Tufts OpenCourseWare © 2007 Tufts University Liver Function Tests OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 1

1. Understanding Liver Function Tests 2. Types of Liver Disease

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Page 1: 1. Understanding Liver Function Tests 2. Types of Liver Disease

1. Understanding Liver Function Tests

2. Types of Liver Disease

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 1

Page 2: 1. Understanding Liver Function Tests 2. Types of Liver Disease

3. Liver Function Tests

4. Caveats About LFT’s

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 2

Page 3: 1. Understanding Liver Function Tests 2. Types of Liver Disease

5. Liver Function Tests

6. Bilirubin Synthesis

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 3

Page 4: 1. Understanding Liver Function Tests 2. Types of Liver Disease

7. Liver Function Tests: Slide 7

8. Liver Function Tests: Slide 8

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 4

Page 5: 1. Understanding Liver Function Tests 2. Types of Liver Disease

9. Liver Function Tests: Slide 9

10. Liver Function Tests: Slide 10

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 5

Page 6: 1. Understanding Liver Function Tests 2. Types of Liver Disease

11. Liver Function Tests: Slide 11

12. Liver Function Tests: Slide 12

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 6

Page 7: 1. Understanding Liver Function Tests 2. Types of Liver Disease

13. Enterohepatic and Systemic Circulation

14. Types of Bilirubin

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 7

Page 8: 1. Understanding Liver Function Tests 2. Types of Liver Disease

15. Serum Bilirubin Elevations

16. Liver Function Tests

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 8

Page 9: 1. Understanding Liver Function Tests 2. Types of Liver Disease

17. Tests of Biosynthesis: Serum Albumin

18. Tests of Biosynthesis

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 9

Page 10: 1. Understanding Liver Function Tests 2. Types of Liver Disease

19. Serum Clotting Factors (INR/PT)

20. Serum Globulins and Other Proteins

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 10

Page 11: 1. Understanding Liver Function Tests 2. Types of Liver Disease

21. Liver Function Tests

22. Enzyme Tests: Aminotransferases

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 11

Page 12: 1. Understanding Liver Function Tests 2. Types of Liver Disease

23. Likelihood of Hepatocellular Liver Disease Based on AST Data...

24. AST:ALT Ratio In Liver Disease

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 12

Page 13: 1. Understanding Liver Function Tests 2. Types of Liver Disease

25. ALT & AST in Liver

26. AST:ALT Ratio in Liver and Serum

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 13

Page 14: 1. Understanding Liver Function Tests 2. Types of Liver Disease

27. AST/ALT after Hepatitis C in ETOH Liver Disease

28. Liver Function Tests

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 14

Page 15: 1. Understanding Liver Function Tests 2. Types of Liver Disease

29. Alkaline Phosphatase Isoenzymes

30. Evaluation of Isolated Alkaline Phosphatase (AP) Elevation...

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 15

Page 16: 1. Understanding Liver Function Tests 2. Types of Liver Disease

31. Serum vs. Age in Men and Women

32. Evaluation of Elevated AP

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 16

Page 17: 1. Understanding Liver Function Tests 2. Types of Liver Disease

33. Evaluation of Chronically Elevated AP

34. Source of Alkaline Phosphatase (AP) Elevation

Tufts OpenCourseWare © 2007 Tufts University

Liver Function Tests

OCW: Gastrointestinal Pathophysiology (M. Kaplan) Page - 17

Page 18: 1. Understanding Liver Function Tests 2. Types of Liver Disease

35. Isolated or Inappropriate AP Elevation

36. Gamma Glutamyl Transferase

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Liver Function Tests

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Page 19: 1. Understanding Liver Function Tests 2. Types of Liver Disease

37. Disease Tests

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Liver Function Tests

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