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1. Hepatobiliary System Part 1 2. Liver - Functions Tufts OpenCourseWare © 2008 Tufts University Hepatobiliary System I OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 1

1. Hepatobiliary System Part 1 2. Liver - Functions

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1. Hepatobiliary System Part 1

2. Liver - Functions

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 1

3. Liver Diseases – Overview

4. Normal Liver

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 2

5. Normal Liver – Histology

6. Normal Liver - Histology

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 3

7. Normal Liver - Histology

8. Five Basic Liver Responses to Injury

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 4

9. Liver Cell Necrosis – Councilman Body

10. Fatty Change

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 5

11. Jaundice (icterus)

12. Normal Bilirubin Metabolism and Excretion

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 6

13. Jaundice

14. Jaundice

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 7

15. Unconjugated Hyperbilirubinemia – Kernicterus Brain

16. Causes of Hyperbilirubinemia

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 8

17. Hereditary Disorders of Bilirubin Metabolism

18. Liver Failure

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 9

19. Liver – Massive Necrosis

20. Liver - Massive Necrosis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 10

21. Hepatic Failure Consequences

22. Hemodynamic and Vascular Abnormalities of the Liver

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 11

23. Chronic Passive Congestion - Nutmeg Liver

24. Liver Infarct

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 12

25. Hemodynamic and Vascular Abnormalities of Liver

26. Budd-Chiari Syndrome

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 13

27. Hemodynamic and Vascular Abnormalities of Liver

28. Hemodynamic and Vascular Abnormalities of Liver

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 14

29. Portal Hypertension - - - > Caput Medusae

30. Portal Hypertension - - - >Red (Zahn) Infarct

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 15

31. Clinical Consequences of Portal Hypertension

32. Hepatic Circulatory Disorders &#8211

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 16

33. Viral Hepatitis

34. Viral Hepatitis

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 17

35. Hepatitis A (HAV)

36. Sequence of Serological Markers in Hepatitis A

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 18

37. Hepatitis B (HBV)

38. Hepatitis B

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 19

39. Hepatitis B

40. Sequence of Serologic Markers

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 20

41. Potential Outcomes of Hepatitis B in Adults

42. Hepatitis C

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 21

43. Hepatitis C

44. Potential Outcomes of Hepatitis C Infection in Adults

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 22

45. Hepatitis D

46. Differing Clinical Consequences

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 23

47. Hepatitis E

48. Hepatitis G

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 24

49. Acute Viral Hepatitis

50. Acute Viral Hepatitis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 25

51. Chronic Hepatitis

52. Chronic Hepatitis

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 26

53. Chronic Active Hepatitis

54. Chronic Hepatitis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 27

55. Chronic Carrier Hepatitis

56. Chronic Hepatitis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 28

57. Acute vs. Chronic Hepatitis

58. Cholangitis, Pericholangitis and Liver Abscesses

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 29

59. Cholangitis – Concentric Fibrosis

60. Liver Parasitic Infections

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 30

61. Liver Amebiasis - Abscess

62. Schistosomiasis Ova – Liver

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 31

63. Drug-induced Liver Damage

64. Cirrhosis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 32

65. Normal Liver Architecture

66. Cirrhotic Liver

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 33

67. Micronodular Cirrhosis

68. Micronodular Cirrhosis

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 34

69. Macronodular Cirrhosis

70. Cirrhosis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 35

71. Cirrhosis

72. Alcoholic Cirrhosis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 36

73. Cirrhosis – Clinical Features

74. Cirrhosis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 37

75. Hemochromatosis

76. Hemochromatosis – Rusty Brown

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 38

77. Hemochromatosis

78. Wilson’s Disease

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 39

79. Kayser-Fleischer Rings

80. Toxic Liver Disease

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 40

81. Alcoholic Liver Disease

82. Alcoholic Liver Disease

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 41

83. Alcoholic Liver Disease – Fatty Liver

84. Alcoholic Liver Disease

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 42

85. Alcoholic Hepatitis

86. Alcoholic Hepatitis

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 43

87. Alcoholic Cirrhosis

88. Chronic Alcohol Exposure

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 44

89. Benign Tumors of the Liver

90. Liver Adenoma

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 45

91. Liver Hemangioma

92. Malignant Tumors of the Liver

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 46

93. Metastatic Carcinoma to the Liver

94. Malignant Tumors of the Liver

Tufts OpenCourseWare © 2008 Tufts University

Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 47

95. Hepatocellular Carcinoma

96. Hepatocellular Carcinoma

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 48

97. Hepatocellular Carcinoma

98. Reye’s Syndrome

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Hepatobiliary System I

OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 49