1
$344 Wednesday, November 9, 2005 Poster Abstracts Results: Following selective motor resections (including resections in the Hand Motor Area), severe motor deficit occurred in the immediate postoperative period. Gradual improvement started one month postop on average. Substantial improvement was found at 6 months of follow- up. Long term sequelae included impaired fine hand movements and toe movements. Following sensory resections, severe sensory deficit occurred in the immediate postoperative period. Long term sequelae included im- paired position sense. Conclusion: Selective surgical resections within the PSMC are possible. The proposed mechanisms for functional recovery will be discussed, including reorganization within the ipsilateral PSMC, substitution of the ipsilateral PSMC by the non-primary motor areas and recruitment of the contralateral PSMC. 0959 Frems in Hemiplegic Patients' Management Colonna, F. Rehabilitation Hospital ASL/BR1 San Raffaele Foundation -Ceglie Messapiea (Brindisi) Spastic hypertone and tile pain syndrome of tile upper limb are cerebrovascular complications which certainly require a particular commitment because they are usually combined. F.R.E.M.S. (Frequency and width Electromagnetic Modulated neural Stimulation), a newly-born therapeutic proposal, enables us to intervene in treating spastic hypertone. Tiffs therapy, through different sequences and stimulation levels, aims at acting on proprioceptive sensory systems, modulating hypertonic nmscle fibers contraction while stimulating the sympathetic afferences of antagonist muscles and also guaranteeing local vascularization and a modulation of nociceptive afferences. 28 patients (118M, l0 F), affected by pyramidal hemi-s?aldrome were enrolled in tiffs study. All patients revealed a muscular tone disorder, whereas 20 of them had it in combination with an upper limb algo- dystrophic syndrome. Patients underwent clinical trial at the time of enrolment, at the end of treatment and 3 months from it. Ashworffi Scale for appraising hypertone, Spasm Frequency Score as a scale for muscular spasms and Visual Analogue Scale (VAS) for quantifying pain were used for functional evaluations. The statistical data, at the end of the treatment and in the 3 month follow up, respectively indicate a significance with a p < 0,022 and a p < 0,048 for the Ashworth Scale, a p < 0,04 and no significance for tile Spasnl Frequency Score, a p < 0,006 and a p < 0,05 for tile VAS. The objective and undisputable evidence is represented by an "unconventional" rehabilitation approach to spastic hypertone in patients affected by ischemic cerebral stroke. The results achieved, to be regarded as preliminary, enable us, however, to make some remarks on spastic hypertone and upper limb pain management in hemJplegic patients: - FREMS is a new, non-invasive technique which proved to be effective in treating spasticity - No subject showed adverse events or undesirable effects during treatment No subject showed a deterioration in spastic hypertone and pain Statistical analysis highlighted therapeutic effectiveness, supported by statistical significance, in reducing hypertone, muscular spasms and pain With regard to spasticity and pain, results were confirmed at tile follow-up. 0960 "Robotic in hand rehabilitation" Am innovation in haml therapy Griesholi~r, P, Scherer, R, Peichl, M. Klinik dudendorfStrassengel, Austria The development of the hand robotic System after 4 years of research and 3 years of engineering has produced a crucial improvement in hand rehabilitation Therapy. Our robotic hand and finger movement orthosis is being used successfully our clinic as a prototype of the institute of neurorehabilitation and research. This hand robotic system is tile first driven orthosis that assists finger movements of -upper limb impaired patients. The theoretical background is the experience of the locomotion therapy. This automated process relieves therapists of the manual labour, therefore, tile training sessions can be longer and more repeatable. The therapy is more efficient and the patients achieve their goals faster. Even in the early phases of the rehabilitation, one therapist can accomplish the training. We are using this hand robotic system as a prototype about halve a year and our clinic practice shows after view patients that rehabilitation of tile hand could be accelerate. We know we need more experience and daters but we want to The hand robotic System is the result of 4 years of intensive cooperation between tile Technical University of Graz and the Clinic Judendorf Strassengel. 0961 Music therapy in Parkinson's disease: Improvement of parkinsonian gait and depression with rhytlmfic auditory stimulation HayaSlfi, A. Neurology" & Rehabilitation, ,,runtendo University, Tokyo, Japan Background: Gait disturbance is one of the most frequent intractable motor disturbances in Parkinson's disease (PD). The main treatments are antiparkinsonian drugs and surgery, however, the effects are not perfect. Ill order to maintain the quality of life, the role of rehabilitation is also very important. It is known that gait training vdth rhythmic sound is effective for parkinsonian gait. However, there have been no trials investigating rhythmic auditory stimulation alone without gait training in PD. The aim of this study was determine the potential efficacy of dlyttmffc auditory stimulation without gait training for the gait disturbance in PD, and effect on depression in tile disorder was studied. Method: The subjects were 25 PD outpatients who had gait disturbance. The patient's task was simply to listen to rhythmic auditory stimulation (120/min.) embedded in familiar styles of music at home, without gait training, for at least one hour a day for three to four weeks. Results: After tile task, patients' gait speed and step length were significantly improved (iJ < 0.0001,p < 0.001, respectively). The self- rating depression scale was also significantly improved (p < 0.05). On self-assessment of patients, for example, with regard to depression, 24 out of 25 patients felt that their feelings had lifted. Conclusion: Our study indicates that music embedded by rhyttmffc auditory stimulation without gait training is very effective for treating the gait disturbance and depression associated with PD. 0962 Glucose-Dependent Insulinotropic Polypeptide Induces Progenitor Cell Prolil~ration in Adult Hippocanlpus 1 1 Max Albert Itietala, Jenny Nyberg , Michelle F. Anderson 1, Bjorn Meister 3, Ann-Marie Alborn ~, Anna-Karin Strom a, Anke Brederlau 2, Ann-C.hristin Illerskog4, Ola Nilsson 4, Timothy J. Kieffer, Anne Ricksten, and Peter S. Eriksson :. llnst Of Clinical Neurosciences; 2Institute of Anatomy and Cell Biology," 3Department of Neuroscience, Karolinska Instituter; .4 Department of Pathology The hippocampal dentate gyrus (DG) is an area of active proliferation and neurogenesis within the adult brain. It has been reported that adult rats from the strains Sprague Dawley (SD) and spontaneously hypertensive (SHR) have a difference in proliferation rates of cells in tile lffppocampal DG. To exploit tiffs natural variability and identify potential regulators of cell genesis in tile tffppocampus, lffppocampal

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Page 1: 0959 Frems in hemiplegic patients' management

$344 Wednesday, November 9, 2005 Poster Abstracts

Results: Following selective motor resections (including resections in the Hand Motor Area), severe motor deficit occurred in the immediate postoperative period. Gradual improvement started one month postop on average. Substantial improvement was found at 6 months of follow- up. Long term sequelae included impaired fine hand movements and toe movements.

Following sensory resections, severe sensory deficit occurred in the immediate postoperative period. Long term sequelae included im- paired position sense. Conclusion: Selective surgical resections within the PSMC are possible. The proposed mechanisms for functional recovery will be discussed, including reorganization within the ipsilateral PSMC, substitution of the ipsilateral PSMC by the non-primary motor areas and recruitment of the contralateral PSMC.

0959 Frems in Hemiplegic Patients' Management

Colonna, F. Rehabilitation Hospital ASL/BR1 San Raffaele Foundation -Ceglie Messapiea (Brindisi)

Spastic hypertone and tile pain syndrome of tile upper limb are cerebrovascular complications which certainly require a particular commitment because they are usually combined.

F.R.E.M.S. (Frequency and width Electromagnetic Modulated neural Stimulation), a newly-born therapeutic proposal, enables us to intervene in treating spastic hypertone. Tiffs therapy, through different sequences and stimulation levels, aims at acting on proprioceptive sensory systems, modulating hypertonic nmscle fibers contraction while stimulating the sympathetic afferences of antagonist muscles and also guaranteeing local vascularization and a modulation of nociceptive afferences.

28 patients (118 M, l0 F), affected by pyramidal hemi-s?aldrome were enrolled in tiffs study. All patients revealed a muscular tone disorder, whereas 20 of them had it in combination with an upper limb algo- dystrophic syndrome.

Patients underwent clinical trial at the time of enrolment, at the end of treatment and 3 months from it. Ashworffi Scale for appraising hypertone, Spasm Frequency Score as a scale for muscular spasms and Visual Analogue Scale (VAS) for quantifying pain were used for functional evaluations.

The statistical data, at the end of the treatment and in the 3 month follow up, respectively indicate a significance with a p < 0,022 and a p < 0,048 for the Ashworth Scale, a p < 0,04 and no significance for tile Spasnl Frequency Score, a p < 0,006 and a p < 0,05 for tile VAS.

The objective and undisputable evidence is represented by an "unconventional" rehabilitation approach to spastic hypertone in patients affected by ischemic cerebral stroke.

The results achieved, to be regarded as preliminary, enable us, however, to make some remarks on spastic hypertone and upper limb pain management in hemJplegic patients:

- FREMS is a new, non-invasive technique which proved to be effective in treating spasticity

- No subject showed adverse events or undesirable effects during treatment No subject showed a deterioration in spastic hypertone and pain Statistical analysis highlighted therapeutic effectiveness, supported by statistical significance, in reducing hypertone, muscular spasms and pain

With regard to spasticity and pain, results were confirmed at tile follow-up.

0960 "Robotic in hand rehabilitation" Am innovation in haml therapy

Griesholi~r, P, Scherer, R, Peichl, M. Klinik dudendorfStrassengel, Austria

The development of the hand robotic System after 4 years of research and 3 years of engineering has produced a crucial improvement in hand rehabilitation Therapy. Our robotic hand and finger movement orthosis is being used successfully our clinic as a prototype of the institute of neurorehabilitation and research.

This hand robotic system is tile first driven orthosis that assists finger movements of -upper limb impaired patients. The theoretical background is the experience of the locomotion therapy. This automated process relieves therapists of the manual labour, therefore, tile training sessions can be longer and more repeatable. The therapy is more efficient and the patients achieve their goals faster. Even in the early phases of the rehabilitation, one therapist can accomplish the training. We are using this hand robotic system as a prototype about halve a year and our clinic practice shows after view patients that rehabilitation of tile hand could be accelerate. We know we need more experience and daters but we want to The hand robotic System is the result of 4 years of intensive cooperation between tile Technical University of Graz and the Clinic Judendorf Strassengel.

0961 Music therapy in Parkinson's disease: Improvement of parkinsonian gait and depression with rhytlmfic auditory stimulation

HayaSlfi, A. Neurology" & Rehabilitation, ,,runtendo University, Tokyo, Japan

Background: Gait disturbance is one of the most frequent intractable motor disturbances in Parkinson's disease (PD). The main treatments are antiparkinsonian drugs and surgery, however, the effects are not perfect. Ill order to maintain the quality of life, the role of rehabilitation is also very important. It is known that gait training vdth rhythmic sound is effective for parkinsonian gait. However, there have been no trials investigating rhythmic auditory stimulation alone without gait training in PD. The aim of this study was determine the potential efficacy of dlyttmffc auditory stimulation without gait training for the gait disturbance in PD, and effect on depression in tile disorder was studied. Method: The subjects were 25 PD outpatients who had gait disturbance. The patient's task was simply to listen to rhythmic auditory stimulation (120/min.) embedded in familiar styles of music at home, without gait training, for at least one hour a day for three to four weeks. Results: After tile task, patients' gait speed and step length were significantly improved (iJ < 0.0001,p < 0.001, respectively). The self- rating depression scale was also significantly improved (p < 0.05). On self-assessment of patients, for example, with regard to depression, 24 out of 25 patients felt that their feelings had lifted. Conclusion: Our study indicates that music embedded by rhyttmffc auditory stimulation without gait training is very effective for treating the gait disturbance and depression associated with PD.

0962 Glucose-Dependent Insulinotropic Polypeptide Induces Progenitor Cell Prolil~ration in Adult Hippocanlpus

1 1 Max Albert I t ie ta la , Jenny Nyberg , Michelle F. Anderson 1, Bjorn Meister 3, Ann-Marie Alborn ~, Anna-Karin Strom a, Anke Brederlau 2, Ann-C.hristin Illerskog 4, Ola Nilsson 4, Timothy J. Kieffer, Anne Ricksten, and Peter S. Eriksson :. llnst Of Clinical Neurosciences; 2Institute of Anatomy and Cell Biology," 3Department of Neuroscience, Karolinska Instituter; .4 Department of Pathology

The hippocampal dentate gyrus (DG) is an area of active proliferation and neurogenesis within the adult brain. It has been reported that adult rats from the strains Sprague Dawley (SD) and spontaneously hypertensive (SHR) have a difference in proliferation rates of cells in tile lffppocampal DG. To exploit tiffs natural variability and identify potential regulators of cell genesis in tile tffppocampus, lffppocampal