BAB VPENUTUPKesimpulan Variasi konsentrasi CMC-Na dan PVP K-30 dalam formulasi bukal patch salbutamol sulfat tidak berpengaruh terhadap keseragaman bobot, folding endurance, surface pH dan keseragaman kandungan. Tetapi berpengaruh terhadap persentase swelling index dimana peningkatan konsentrasi PVP K-30 sampai 20% dapat meningkatkan persentase swelling index tetapi mengalami penurunan pada konsentrasi PVP K-30 sebesar 30%. Peningkatan konsentrasi PVP K-30 sampai 20% dapat memperbaiki dan meningkatkan pelepasan Salbutamol Sulfat dari patch tetapi mengalami penurunan pada konsentrasi PVP K-30 sebesar 30%. Pelepasan obat mengikuti kinetika orde nol dengan mekanisme pelepasan dikontrol oleh difusi melalui matriks dengan mengikuti mekanisme difusi Fick. Saran Perlu dilakukan uji in vivo sehingga dapat diketahui bioavailabilitas sediaan bukal patch salbutamol sulfat dan dapat dibuat korelasi in vivo dan in vitro. 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Data hasil keseragaman bobot.Formula patch (mg)Formula 1Formula 2Formula 3Formula 4Formula 5(Kontrol)(10:0)(9:1)(8:2)(7:3)109,0121,5116,2110,1102,7113,6121,8116,6110,9102,7119,2125,1116,8111,2104,6121,0126,8117,1112,9104,6121,8126,9117,1113,1105,3122,2127,1118,0116,2105,3123,6127,7118,2117,3105,6124,0128,8119,0118,9106,8124,4129,4119,7119,7107,0124,8130,6120,3120,0107,1124,8130,8120,8120,4107,3124,8131,6120,8121,9107,8125,2132,7121,2122,2107,8125,8133,6121,8122,2108,0126,8134,7123,3123,5108,1127,8135,1123,4123,8108,5128,4136,7123,8123,8108,7129,3138,0124,0124,0108,7130,6139,5124,3124,1109,0130,8139,5124,8124,4109,4Rata-rata123,9130,895120,36119,03106,75SD5,3295,3512,8954,9592,005CV (%)4,301 (%)4,088 (%)2,406 (%)4,166 (%)1,879 (%)range111,5055117,8055108,324107,12796,07510% BBrange136,2845143,9845132,396130,933117,42510% BArange99,116104,71696,28895,22485,420% BBrange148,674157,074144,432142,836128,120% BA86Perhitungan :( )( )Range 10 % :Range 20 % :87Lampiran 2. Data hasil folding enduranceFormulaFormula 1Formula 2Formula 3Formula 4Formula 5patch(kontrol)(10:0)(9:1)(8:2)(7:3)R 1>300>300>300>300>300R 2>300>300>300>300>300R 3>300>300>300>300>30088Lampiran 3. Data hasil surface pHFormulaFormula 1Formula 2Formula 3Formula 4Formula 5patch(kontrol)(10:0)(9:1)(8:2)(7:3)R 16-76-76-76-76-7R 26-76-76-76-76-7R 36-76-76-76-76-7total6,56,56,56,56,589Lampiran 4. Data hasil swelling index1.Formula 1 (kontrol)WADAHWADAH+060120180KOSONGPATCHMENITMENITMENITMENIT13,577213,69390,11670,31820,35090,382113,894514,00740,11290,27530,28710,371415,370715,48370,1130,26110,30020,3643% swelling% swelling% swelling(60 menit)(120 menit)(180 menit)172,665200,686227,421143,844154,296228,964131,062165,664222,389Rata rata149,190173,548226,2582.Formula 2 (10:0)WADAHWADAH+060120180KOSONGPATCHMENITMENITMENITMENIT14,257714,38220,12450,24260,26480,303815,901216,02820,12700,24770,26220,296413,248113,37490,12680,24580,27240,2881% swelling% swelling% swelling(60 menit)(120 menit)(180 menit)94,859112,691144,01695,039106,457133,38693,849114,826127,208Rata-rata94,582111,325134,870903.Formula 3 (9:1)WADAHWADAH+060120180KOSONGPATCHMENITMENITMENITMENIT16,511916,63420,12230,29410,3260,375213,376113,50210,12600,30420,33720,383814,521914,64710,12520,299890,33620,3830% swelling% swelling% swelling(60 menit)(120 menit)(180 menit)140,474166,558206,787141,429167,619204,603139,529168,530205,911Rata-rata140,477167,569205,7674.Formula 4 (8:2)WADAHWADAH+060120180KOSONGPATCHMENITMENITMENITMENIT13,736213,84500,10880,36680,41040,458114,498114,60280,10470,31240,33550,408713,743613,85020,10660,37910,42050,4813% swelling% swelling% swelling(60 menit)(120 menit)(180 menit)237,132277,206321,048198,376220,439290,353255,629294,465351,501Rata-rata230,379264,037320,9675.Formula 5 (7:3)WADAHWADAH+060120180KOSONGPATCHMENITMENITMENITMENIT13,784113,90760,12350,35650,39720,428113,745013,87210,12710,36420,43260,474615,385715,50680,12110,29260,34700,458091% swelling% swelling% swelling(60 menit)(120 menit)(180 menit)188,664221,619246,640186,546240,362273,407141,618186,540278,200Rata-rata172,276216,174266,082Perhitungan :92Lampiran 5. Data kurva bakukonsentrasi (ppm)absorbansi (y)slope (b)Intersep (a)320,2130,0067875-0,0022400,272480,322560,381640,43Berdasarkan data diatas, dengan regresi linier diperoleh persamaan :93Lampiran 6. Data hasil keseragaman kadar1. Formula 1 (kontrol)bobotkadar tiapXX%kadarpatch teoritisabsorbansipatch(ppm)(mg/ml)kadar(mg)(mg)126,88,187247780,06710,1950,01012,4531,020136,18,7877320420,07411,2270,01112,7751,123129,38,3486682810,0710,6370,01112,7411,064Rata-rata12,6561,069SD0,052CV (%)4,8662.Formula 2 (10:0)bobotkadar tiapXX%kadarpatch teoritisabsorbansipatch(ppm)(mg/ml)kadar(mg)(mg)138,18,4403529550,52477,5250,07891,8507,7521227,456358150,53679,2930,079106,3437,929129,37,9025172850,51476,0520,07696,2377,605rata-rata98,1437,762SD0,162CV (%)2,0913.Formula 3 (9:1)bobotkadar tiapXX%kadarpatch teoritisabsorbansipatch(ppm)(mg/ml)kadar(mg)(mg)112,67,4842140250,51876,6410,077102,4037,664113,77,5573280160,54680,7660,081106,8718,077119,47,9361914260,55381,7970,082103,0698,180rata-rata104,1157,973SD0,273CV (%)3,425944.Formula 4 (8:2)bobotkadar tiapXX%kadarpatch teoritisabsorbansipatch(ppm)(mg/ml)kadar(mg)(mg)113,67,6350499870,53679,2930,079103,8547,929112,17,5342350670,51876,6410,077101,7247,664114,97,7224229190,56783,8600,084108,5938,386rata-rata104,7237,993SD0,365CV (%)4,5665.Formula 5 (7:3)bobotkadar tiapXX%kadarpatch teoritisabsorbansipatch(ppm)(mg/ml)kadar(mg)(mg)106,67,9887587820,53579,1450,07999,0717,915112,58,4309133490,56783,8600,08499,4678,386112,28,4084309130,54180,0290,08095,1788,003rata-rata97,9058,101SD0,250CV (%)3,086Perhitungan :( )( )()95( )( )96Lampiran 7. Data hasil disolusiREPLIKASI 11.Formula 1 (kontrol)waktuAbsFPdosisXXkadar xfaktorkadar% kadar(menit)(mg)(ppm)(mg/250ml)fpkoreksikoreksiterdisolusi50,00917,7741,6500,4130,4130,0000,4135,306100,01117,7741,9450,4860,4860,0080,4946,360150,01017,7741,7970,4490,4490,0100,4595,905300,00817,7741,5030,3760,3760,0090,3854,948450,00917,7741,6500,4130,4130,0080,4205,403600,00917,7741,6500,4130,4130,0080,4215,4131200,01217,7742,0920,5230,5230,0080,5316,8341800,01317,7742,2390,5600,5600,0100,5707,3362400,01317,7742,2390,5600,5600,0110,5717,3463000,01417,7742,3870,5970,5970,0110,6087,8193600,01017,7741,7970,4490,4490,0120,4615,9344200,01117,7741,9450,4860,4860,0090,4956,3704800,00817,7741,5030,3760,3760,0100,3854,9582.Formula 2 (10:0)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,10617,00915,9413,9853,9850,0003,98556,858100,10617,00915,9413,9853,9850,0804,06557,995150,10717,00916,0884,0224,0220,0804,10258,520300,13217,00919,7724,9434,9430,0805,02371,668450,14617,00921,8345,4595,4590,0995,55779,288600,16117,00924,0446,0116,0110,1096,12087,3171200,17117,00925,5176,3796,3790,1206,50092,7301800,15417,00923,0135,7535,7530,1285,88183,9012400,15217,00922,7185,6805,6800,1155,79582,6723000,1517,00922,4245,6065,6060,1145,71981,6003600,1517,00922,4245,6065,6060,1125,71881,5794200,1517,00922,4245,6065,6060,1125,71881,5794800,1517,00922,4245,6065,6060,1125,71881,579973.Formula 3 (9:1)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,10317,64415,4993,8753,8750,0003,87550,687100,10417,64415,6463,9123,9120,0773,98952,183150,12517,64418,7404,6854,6850,0784,76362,311300,15117,64422,5715,6435,6430,0945,73675,041450,16617,64424,7816,1956,1950,1136,30882,518600,16817,64425,0766,2696,2690,1246,39383,6271200,18117,64426,9916,7486,7480,1256,87389,9101800,18617,64427,7276,9326,9320,1357,06792,4442400,19617,64429,2017,3007,3000,1397,43997,3103000,1917,64428,3177,0797,0790,1467,22594,5163600,18417,64427,4336,8586,8580,1427,00091,5674200,17417,64425,9596,4906,4900,1376,62786,6914800,17017,64425,3706,3436,3430,1306,47284,6674.Formula 4 (8:2)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,02117,82983,41800,85450,85450,00000,854510,9136100,03917,82986,07001,51751,51750,01711,534619,5992150,06417,82989,75322,43832,43830,03032,468731,5289300,15717,829823,45495,86375,86370,04885,912575,5124450,18917,829828,16947,04247,04240,11737,159691,4405600,20217,829830,08477,52127,52120,14087,662097,85701200,20817,829830,96877,74227,74220,15047,8926100,80171800,20717,829830,82147,70537,70530,15487,8602100,38782400,20617,829830,67407,66857,66850,15417,822699,90793000,20617,829830,67407,66857,66850,15347,821999,89853600,20617,829830,67407,66857,66850,15347,821999,89854200,20617,829830,67407,66857,66850,15347,821999,89854800,20617,829830,67407,66857,66850,15347,821999,8985985. Formula 5 (7:3)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,08218,24912,4053,1013,1010,0003,10137,596100,08918,24913,4363,3593,3590,0623,42141,474150,10918,24916,3834,0964,0960,0674,16350,466300,14618,24921,8345,4595,4590,0825,54067,166450,16618,24924,7816,1956,1950,1096,30476,426600,17418,24925,9596,4906,4900,1246,61480,1771200,18418,24927,4336,8586,8580,1306,98884,7131800,18818,24928,0227,0067,0060,1377,14386,5892400,18918,24928,1697,0427,0420,1407,18287,0713000,1918,24928,3177,0797,0790,1417,22087,5263600,18918,24928,1697,0427,0420,1427,18487,0894200,19518,24929,0537,2637,2630,1417,40489,7594800,20118,24929,9377,4847,4840,1457,63092,492REPLIKASI 21. Formula 1 (kontrol)waktuAbsFPdosisXXkadar xfaktorkadar% kadar(menit)(mg)(ppm)(mg/250ml)fpkoreksikoreksiterdisolusi50,0118,0771,7970,4490,4490,0000,4495,563100,00418,0770,9130,2280,2280,0090,2372,938150,00918,0771,6500,4130,4130,0050,4175,164300,01118,0771,9450,4860,4860,0080,4946,121450,0118,0771,7970,4490,4490,0100,4595,683600,01018,0771,7970,4490,4490,0090,4585,6741200,01118,0771,9450,4860,4860,0090,4956,1301800,00718,0771,3550,3390,3390,0100,3494,3152400,00418,0770,9130,2280,2280,0070,2352,9113000,00618,0771,2080,3020,3020,0050,3073,7963600,00518,0771,0610,2650,2650,0060,2713,3584200,01318,0772,2390,5600,5600,0050,5656,9974800,00918,0771,6500,4130,4130,0110,4245,246992.Formula 2 (10:0)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,09417,19314,1733,5433,5430,0003,54349,260100,10217,19315,3523,8383,8380,0713,90954,342150,10417,19315,6463,9123,9120,0773,98855,448300,11117,19316,6784,1694,1690,0784,24859,053450,12317,19318,4464,6114,6110,0834,69565,269600,16017,19323,8975,9745,9740,0926,06684,3381200,17217,19325,6656,4166,4160,1196,53690,8621800,15717,19323,4555,8645,8640,1285,99283,3042400,15417,19323,0135,7535,7530,1175,87081,6143000,15117,19322,5715,6435,6430,1155,75880,0473600,14817,19322,1295,5325,5320,1135,64578,4804200,14817,19322,1295,5325,5320,1115,64378,4494800,14817,19322,1295,5325,5320,1115,64378,4493.Formula 3 (9:1)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,10517,81015,7943,9483,9480,0003,94850,556100,10717,81016,0884,0224,0220,0794,10152,510150,11817,81017,7094,4274,4270,0804,50857,717300,14917,81022,2765,5695,5690,0895,65872,440450,17117,81025,5176,3796,3790,1116,49183,108600,18617,81027,7276,9326,9320,1287,05990,3891200,19017,81028,3177,0797,0790,1397,21892,4171800,19217,81028,6117,1537,1530,1427,29493,3982400,19617,81029,2017,3007,3000,1437,44395,3033000,18517,81027,5806,8956,8950,1467,04190,1543600,18717,81027,8756,9696,9690,1387,10790,9934200,17617,81026,2546,5646,5640,1396,70385,8244800,17117,81025,5176,3796,3790,1316,51183,3621004.Formula 4 (8:2)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,01818,3202,9760,7440,7440,0000,7448,942100,03418,3205,3331,3331,3330,0151,34816,204150,07318,32011,0792,7702,7700,0272,79633,611300,15718,32023,4555,8645,8640,0555,91971,143450,18318,32027,2856,8216,8210,1176,93983,397600,20618,32030,6747,6697,6690,1367,80593,8091200,20418,32030,3797,5957,5950,1537,74893,1271800,20918,32031,1167,7797,7790,1527,93195,3232400,20818,32030,9697,7427,7420,1567,89894,9253000,20818,32030,9697,7427,7420,1557,89794,9163600,20718,32030,8217,7057,7050,1557,86094,4734200,20718,32030,8217,7057,7050,1547,85994,4644800,20618,32030,6747,6697,6690,1547,82394,0225.Formula 5 (7:3)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,07917,96111,9632,9912,9910,0002,99137,570100,08417,96112,7003,1753,1750,0603,23540,635150,12517,96118,7404,6854,6850,0634,74959,651300,13717,96120,5085,1275,1270,0945,22165,583450,16817,96125,0766,2696,2690,1036,37180,037600,18117,96126,9916,7486,7480,1256,87386,3391200,18817,96128,0227,0067,0060,1357,14089,6981800,1917,96128,3177,0797,0790,1407,21990,6882400,19017,96128,3177,0797,0790,1427,22190,7063000,18917,96128,1697,0427,0420,1427,18490,2443600,19017,96128,3177,0797,0790,1417,22090,6974200,19917,96129,6437,4117,4110,1427,55294,8704800,19717,96129,3487,3377,3370,1487,48594,028101REPLIKASI 31. Formula 1 (kontrol)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,00717,7221,3550,3390,3390,0000,3394,388100,01217,7222,0920,5230,5230,0070,5306,861150,00817,7221,5030,3760,3760,0100,3865,000300,00817,7221,5030,3760,3760,0080,3834,962450,00817,7221,5030,3760,3760,0080,3834,962600,00817,7221,5030,3760,3760,0080,3834,9621200,00417,7220,9130,2280,2280,0080,2363,0541800,00617,7221,2080,3020,3020,0050,3073,9702400,01117,7221,9450,4860,4860,0060,4926,3743000,00817,7221,5030,3760,3760,0100,3854,9913600,01217,7222,0920,5230,5230,0080,5316,8704200,00317,7220,7660,1920,1920,0100,2022,6164800,00817,7221,5030,3760,3760,0040,3804,9152. Formula 2 (10:0)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,10317,38315,4993,8753,8750,0003,87552,484100,10917,38316,3834,0964,0960,0774,17356,527150,11517,38317,2674,3174,3170,0824,39959,580300,12117,38318,1514,5384,5380,0864,62462,633450,14217,38321,2455,3115,3110,0915,40273,170600,16517,38324,6346,1586,1580,1066,26584,8541200,17717,38326,4016,6006,6000,1236,72491,0711800,16317,38324,3396,0856,0850,1326,21784,2062400,15317,38322,8665,7165,7160,1225,83879,0773000,14417,38321,5405,3855,3850,1145,49974,4873600,14417,38321,5405,3855,3850,1085,49374,3974200,14317,38321,3925,3485,3480,1085,45673,8994800,14317,38321,3925,3485,3480,1075,45573,8891023.Formula 3 (9:1)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,118,22115,0573,7643,7640,0003,76445,790100,10518,22115,7943,9483,9480,0754,02448,946150,13118,22119,6244,9064,9060,0794,98560,640300,15418,22123,0135,7535,7530,0985,85171,178450,16918,22125,2236,3066,3060,1156,42178,104600,18118,22126,9916,7486,7480,1266,87483,6151200,18918,22128,1697,0427,0420,1357,17787,3071800,19718,22129,3487,3377,3370,1417,47890,9632400,19618,22129,2017,3007,3000,1477,44790,5873000,19418,22128,9067,2277,2270,1467,37389,6823600,18618,22127,7276,9326,9320,1457,07686,0804200,18418,22127,4336,8586,8580,1396,99785,1124800,17718,22126,4016,6006,6000,1376,73881,9584.Formula 4 (8:2)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,02618,3944,1551,0391,0390,0001,03912,374100,04418,3946,8071,7021,7020,0211,72220,520150,0618,3949,1642,2912,2910,0342,32527,699300,14918,39422,2765,5695,5690,0465,61566,892450,18518,39427,5806,8956,8950,1117,00683,470600,20518,39430,5277,6327,6320,1387,77092,5621200,2118,39431,2637,8167,8160,1537,96894,9321800,20918,39431,1167,7797,7790,1567,93594,5372400,20718,39430,8217,7057,7050,1567,86193,6503000,20718,39430,8217,7057,7050,1547,85993,6333600,20718,39430,8217,7057,7050,1547,85993,6334200,20718,39430,8217,7057,7050,1547,85993,6334800,20818,39430,9697,7427,7420,1547,89694,0721035. Formula 5 (7:3)waktuAbsFPdosisX (ppm)Xkadar xfaktorkadar% kadar(menit)(mg)(mg/250ml)fpkoreksikoreksiterdisolusi50,07718,37811,6692,9172,9170,0002,91734,819100,09318,37814,0263,5063,5060,0583,56542,549150,12118,37818,1514,5384,5380,0704,60855,000300,14818,37822,1295,5325,5320,0915,62367,116450,17418,37825,9596,4906,4900,1116,60178,784600,17418,37825,9596,4906,4900,1306,62079,0131200,1818,37826,8436,7116,7110,1306,84181,6501800,18318,37827,2856,8216,8210,1346,95683,0222400,19418,37828,9067,2277,2270,1367,36387,8843000,19518,37829,0537,2637,2630,1457,40888,4213600,19918,37829,6437,4117,4110,1457,55690,1884200,19318,37828,7597,1907,1900,1487,33887,5854800,19918,37829,6437,4117,4110,1447,55490,170WaktuRata-rata kadar terdisolusi (%)(menit)KONTROLF 10:0F 9:1F 8:2F 7:355,08652,86749,01110,74336,662105,38656,28851,21318,77541,553155,35657,84960,22230,94655,039305,34464,45172,88671,18366,621455,35072,57681,24486,10378,416605,35085,50385,87794,74381,8431205,34091,55489,87896,28785,3541805,20783,80492,26896,74986,7662405,54481,12194,40096,16188,5543005,53578,71191,45096,14988,7303605,38778,15289,54796,00289,3254205,32777,97685,87695,99990,7384805,03977,97283,32995,99792,230104Perhitungan disolusi :( )( )( )( )()105WaktuLog kadar terdisolusi (%)(menit)kontrolf 10:0f 9:1f 8:2f 7:350,70411,72241,68981,02731,5639100,70261,75031,70921,27141,6185150,72771,76211,77951,48921,7397300,72571,80781,86251,85181,8236450,72761,85941,90961,93461,8943600,72771,93191,93361,97641,91271200,70241,96171,95351,98331,93091800,69981,92331,96501,98551,93812400,71151,90911,97481,98281,94713000,72351,89571,96111,98281,94803600,71211,89261,95191,98211,95094200,68891,89161,93391,98211,95754800,70221,89161,92081,98211,9648Akar waktuKadar terdisolusi (%)(menit )KONTROLF 10:0F 9:1F 8:2F 7:32,2365,08652,86749,01110,74336,6623,1625,38656,28851,21318,77541,5533,8735,35657,84960,22230,94655,0395,4775,34464,45172,88671,18366,6216,7085,35072,57681,24486,10378,4167,7465,35085,50385,87794,74381,84310,9545,34091,55489,87896,28785,35413,4165,20783,80492,26896,74986,76615,4925,54481,12194,40096,16188,55417,3215,53578,71191,45096,14988,73018,9745,38778,15289,54796,00289,32520,4945,32777,97685,87695,99990,73821,9095,03977,97283,32995,99792,230106LogLog kadar terdisolusi (%)waktu(menit)kontrolf 10:0f 9:1f 8:2f 7:30,6990,7041,7221,6901,0271,5641,0000,7031,7501,7091,2711,6191,1760,7281,7621,7801,4891,7401,4770,7261,8081,8631,8521,8241,6530,7281,8591,9101,9351,8941,7780,7281,9321,9341,9761,9132,0790,7021,9621,9541,9831,9312,2550,7001,9231,9651,9851,9382,3800,7111,9091,9751,9831,9472,4770,7241,8961,9611,9831,9482,5560,7121,8931,9521,9821,9512,6230,6891,8921,9341,9821,9582,6810,7021,8921,9211,9821,965107Nilai AUC (area under curves) 1. Formula 1 (kontrol)REPLIKASIREPLIKASIREPLIKASIwaktu (menit)123513,2660913,9076610,970041029,1664521,2536428,121451530,6636320,2550229,652493081,4016984,6360874,720274577,6350788,5347974,434096081,1174285,1832774,43409120367,39496354,13914240,50140180425,10247313,37374210,73920240440,45323216,79532310,32807300454,95118201,20050340,94879360412,59444214,60657355,82988420369,10060310,63781284,57233480339,82044367,27162225,90647AUC total3122,667672291,795152261,158592. Formula 2 (10:0)REPLIKASIREPLIKASIREPLIKASIwaktu (menit)1235142,14428123,14984131,2097110287,13144259,00384272,5270615291,28804274,47309290,2678130976,41295858,75126916,60211451132,16734932,410741018,52661601249,534901122,051251185,182901205401,398445255,984125277,743531805298,928445224,953435258,286582404997,193714947,520654898,482613004928,144704849,820064606,927653604895,354304755,806304466,538244204894,723724707,877714448,877324804894,723724706,956014433,61109AUC total39389,1459838018,7583037204,783241083.Formula 3 (9:1)REPLIKASIREPLIKASIREPLIKASIwaktu (menit)1235126,71865126,38967114,4747510257,17621257,66514236,8395215286,23477275,56720273,96429301030,13586976,17625988,63172451181,692321166,609641119,61682601246,087561301,228781212,899181205206,083765484,198575127,680251805470,602915574,463435348,116952405692,625545661,049785446,506993005754,780315563,710875408,064983605582,481505434,397275272,845884205347,738825304,517745135,745014805140,748985075,601535012,08539AUC total42323,1071942201,5758740697,471734.Formula 4 (8:2)REPLIKASIREPLIKASIREPLIKASIwaktu (menit)123527,2838922,3561430,935411076,2819862,8672482,2355415127,82030124,53921120,5471830802,80954785,65681709,43454451252,146921159,048651127,72079601419,731131329,043861320,244361205959,760395608,089125624,821241806035,684865653,509715684,059262406008,871395707,430075645,620363005994,194545695,211675618,502513605993,912295681,665175617,975954205993,912295668,118685617,975954805993,912295654,572185631,13996AUC total45686,3218143152,1085142831,213061095. Formula 5 (7:3)REPLIKASIREPLIKASIREPLIKASIwaktu (menit)123593,9900793,9247387,0473510197,67384195,51150193,4209615229,84926250,71426243,8732530882,23857939,25195915,86997451076,938671092,145691094,25108601174,523131247,815521183,474611204946,708555281,086974819,890681805139,064485411,563694940,174292405209,791455441,823195127,194193005237,921495428,497905289,155013605238,457305428,220295358,265334205305,433605567,025325333,206244805467,516245666,964945332,67868AUC total40200,1066742044,5459639918,50166Perhitungan :()( )() ( )Nilai koefisien korelasi orde nolFormula PatchNilai rkontrol0,065Formula 10:00,504Formula 9:10,609Formula 8:20,639Formula 7:30,741110Nilai koefisien korelasi orde satuFormula PatchNilai rkontrol0,457Formula 10:00,533Formula 9:10,604Formula 8:20,582Formula 7:30,690Nilai koefisien korelasi orde satuFormula PatchNilai rkontrol0,042Formula 10:00,649Formula 9:10,751Formula 8:20,764Formula 7:30,849Nilai koefisien korelasi higuchiFormula PatchNilai rkontrol0,042Formula 10:00,649Formula 9:10,751Formula 8:20,764Formula 7:30,849Nilai koefisien korelasi dan nilai eksponensial difusi korsmeyer-peppasformularnkontrol0,276-0,0054610:00,8260,094429:10,890,131878:20,8650,420877:30,9280,18918111Lampiran 8. Data statistik swelling indexDescriptive StatisticsStd.MinimuMaximuNMeanDeviationmmswelling15191,567363,1356394,58320,97indexOne-Sample Kolmogorov-Smirnov TestswellingindexN15Normal Parametersa,bMean191,5673Std. Deviation63,13563Most ExtremeAbsolute,146DifferencesPositive,146Negative-,074Kolmogorov-Smirnov Z,564Asymp. Sig. (2-tailed),908Test distribution is Normal. Calculated from data. Test of Homogeneity of Variancesswelling indexLeveneStatisticdf1df2Sig.,481410,749ANOVAswelling indexSum ofMeanSquaresdfSquareFSig.Between41131,538410282,8857,008,006GroupsWithin Groups14673,965101467,396Total55805,50314112Multiple Comparisonsswelling index Scheffe(I) formula patch(J) formula patchMean95% Confidence IntervalDifferenceLowerUpper(I-J)Std. ErrorSig.BoundBoundkontrol10:069,4100031,27722,358-47,2511186,0711dimension39:111,7266731,27722,997-104,9344128,38778:2-88,7966731,27722,168-205,457727,86447:3-35,1766731,27722,861-151,837781,484410:0kontrol-69,4100031,27722,358-186,071147,2511dimension39:1-57,6833331,27722,525-174,344458,97778:2-158,20667*31,27722,008-274,8677-41,54567:3-104,5866731,27722,085-221,247712,07449:1kontrol-11,7266731,27722,997-128,3877104,9344dimensiodimension310:057,6833331,27722,525-58,9777174,3444n28:2-100,5233331,27722,102-217,184416,13777:3-46,9033331,27722,696-163,564469,75778:2kontrol88,7966731,27722,168-27,8644205,4577dimension310:0158,20667*31,27722,00841,5456274,86779:1100,5233331,27722,102-16,1377217,18447:353,6200031,27722,589-63,0411170,28117:3kontrol35,1766731,27722,861-81,4844151,8377dimension310:0104,5866731,27722,085-12,0744221,24779:146,9033331,27722,696-69,7577163,56448:2-53,6200031,27722,589-170,281163,0411*. The mean difference is significant at the 0.05 level.113Lampiran 9. Data statistik disolusi efisiensiDescriptive StatisticsStd.MinimuMaximuNMeanDeviationmmDE 4801569,44822833,67288894,728697,1634(%)One-Sample Kolmogorov-Smirnov TestDE 480(%)N15Normal Parametersa,bMean69,448228Std. Deviation33,6728889Most ExtremeAbsolute,371DifferencesPositive,205Negative-,371Kolmogorov-Smirnov Z1,435Asymp. Sig. (2-tailed),033Test distribution is Normal. Calculated from data. Test of Homogeneity of VariancesDE 480 (%)LeveneStatisticdf1df2Sig.2,804410,085ANOVADE 480 (%)Sum ofMeanSquaresdfSquareFSig.Between15738,47143934,618290,127,000GroupsWithin Groups135,6171013,562Total15874,08814114Multiple ComparisonsDE 480 (%)Scheffe(I) formula patch(J) formula patchMean95% Confidence IntervalDifferenceLowerUpper(I-J)Std. ErrorSig.BoundBoundkontrolformula 10:0-71,9380464*3,0068477,000-83,153306-60,722787dimension3formula 9:1-82,5485355*3,0068477,000-93,763795-71,333276formula 8:2-87,0842173*3,0068477,000-98,299477-75,868958formula 7:3-78,4988347*3,0068477,000-89,714094-67,283575formula 10:0kontrol71,9380464*3,0068477,00060,72278783,153306dimension3formula 9:1-10,61048913,0068477,066-21,825748,604770formula 8:2-15,1461709*3,0068477,008-26,361430-3,930912formula 7:3-6,56078823,0068477,373-17,7760484,654471formula 9:1kontrol82,5485355*3,0068477,00071,33327693,763795dimension2dimension3formula 10:010,61048913,0068477,066-,60477021,825748formula 8:2-4,53568183,0068477,691-15,7509416,679578formula 7:34,04970083,0068477,768-7,16555815,264960formula 8:2kontrol87,0842173*3,0068477,00075,86895898,299477dimension3formula 10:015,1461709*3,0068477,0083,93091226,361430formula 9:14,53568183,0068477,691-6,67957815,750941formula 7:38,58538263,0068477,165-2,62987719,800642formula 7:3kontrol78,4988347*3,0068477,00067,28357589,714094dimension3formula 10:06,56078823,0068477,373-4,65447117,776048formula 9:1-4,04970083,0068477,768-15,2649607,165558formula 8:2-8,58538263,0068477,165-19,8006422,629877*. The mean difference is significant at the 0.05 level.115Lampiran 10. Surat keterangan permintaan bahan116117Lampiran 11. Cetakan patch118Lampiran 12. Alat disolusi dan spektrofotometerAlat disolusiSpektrofotometer