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Novel FasL signaling mechanism!

Why are T cells trapped in peripheral area of tumor?

Are those infiltrating T cells alive ?

Do infiltrating T cells affect tumor growth or metastasis?

Can they modulate consequent local immune reaction? ()On Tumor microenvironment and infiltrating T cells

On the protein called Zap70*

Working model for ZAP-70Anchor? *

Su CC, Lin HC, Lin YP, Shan YS, and Yang BC (2013) Expression of Th17-related genes in PHA/IL-2-activated human T cells by Fas signaling via caspase-1- and Stat3-dependent pathway. Cell Immunol. 281:101110Lin HC, Lai PY, Lin YP, Su CC, Huang JY, and Yang BC (2012) Fas ligand enhances the malignant behavior of tumor cells through interaction with Met, hepatocyte growth factor receptor, in lipid rafts. J Biol Chem. 287:2066420673.Hwang JY, Cheng YJ, Lin YP, Lin HC, Su CC, Juliano R, and Yang BC (2010) Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: a role of tenascin-C in immune suppression. J Immunol. 185:1450-1459..Lin YP, Cheng YJ, Huang JY, Lin HC, and Yang BC (2010) Zap70 controls the interaction of talin with integrin to regulate the chemotactic directionality of T cell migration. Mol Immunol. 47(11-12):2022-9. Lin YP, Su CC, Hwang JY, Lin HC, Cheng YJ, Liu MF, and Yang BC (2009) Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: implications for rheumatoid arthritis. Mol Immunol. 46(16):3328-35. Cheng YJ, Lee CH, Lin YP, Hwang JY, Su CC, Chang WT, and Yang BC (2008) Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through ERK pathway. Int J Cancer 123:1278-1285.Su CC, Lin YP, Cheng YJ, Huang JY, Chuang WJ, Shan YS, Yang BC (2007) Phosphatidylinositol 3-kinase/akt activation by integrin-tumor matrix interaction suppresses fas-mediated apoptosis in T cells. J Immunol. 179:4589-4597. *

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*http://www.youtube.com/watch?v=D9H0BRptMQwUnreasonable Behavior

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2012/08//08

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2012*A: ???

BC Nov 17, 2006!*

Papers on medical Sciences*

Papers on social Sciences*

2009* : Ref: U.S. National Science Board, Science and Engineering Indicators 2012

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Su CC, Lin HC, Lin YP, Shan YS, and Yang BC (2013) Expression of Th17-related genes in PHA/IL-2-activated human T cells by Fas signaling via caspase-1- and Stat3-dependent pathway. Cell Immunol. 281:101110Lin HC, Lai PY, Lin YP, Su CC, Huang JY, and Yang BC (2012) Fas ligand enhances the malignant behavior of tumor cells through interaction with Met, hepatocyte growth factor receptor, in lipid rafts. J Biol Chem. 287:2066420673.Hwang JY, Cheng YJ, Lin YP, Lin HC, Su CC, Juliano R, and Yang BC (2010) Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: a role of tenascin-C in immune suppression. J Immunol. 185:1450-1459..Lin YP, Cheng YJ, Huang JY, Lin HC, and Yang BC (2010) Zap70 controls the interaction of talin with integrin to regulate the chemotactic directionality of T cell migration. Mol Immunol. 47(11-12):2022-9. Lin YP, Su CC, Hwang JY, Lin HC, Cheng YJ, Liu MF, and Yang BC (2009) Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: implications for rheumatoid arthritis. Mol Immunol. 46(16):3328-35. Cheng YJ, Lee CH, Lin YP, Hwang JY, Su CC, Chang WT, and Yang BC (2008) Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through ERK pathway. Int J Cancer 123:1278-1285.Su CC, Lin YP, Cheng YJ, Huang JY, Chuang WJ, Shan YS, Yang BC (2007) Phosphatidylinositol 3-kinase/akt activation by integrin-tumor matrix interaction suppresses fas-mediated apoptosis in T cells. J Immunol. 179:4589-4597. *?

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: www.career.com.tw/caserecruit/index.asp, view date:2010/10/02*

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*Chen CW, Hsiue TR, Chen KW, Chang HY, Chen CR, and Yang BC (1996) Increased expression of IL-5 and IL-10 genes in cells of bronchoalveolar lavage fluid in patients with server obstructive lung disease as a result of taking vegetable Sauropus androgynus. J. Formosan Med. Assoc. 96: 699-702 (corresponding author).3T3-L1 6 mg/kg60 mg/kg GGKWistar2860 mg/kg GGK6 mg/kg GGKGGK35%31%GGKGGK, 2007 [] ()Wilson Wong

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20032005 * (2012) Biobank20126 133. 147 146-1562008167-193

*Potential risk of public trust (Dr. ): (2003-2005)

Survey items (2)agree%Blood donation to the biobank70%Monitoring system built by government55%Increasing government responsibility in monitoring48%Unknowing the monitoring system80%

National Sun Yat-sen University Research Center for Promoting Civic Literacy. Result of civic scientific literacy survey in Taiwan 2012 (conference report, Aug 15th, 2012).62163806.33.71* 2011

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